PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12370375-3	2002	Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R, initiates Jak-dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor, STAT6.	Tyrosine	106-114	interleukin 13	Mus musculus	55-60	
7744881-8	1995	Both IL-13 and IL-4 induced low levels of tyrosine phosphorylation of Tyk-2 and Jak-1.	Tyrosine	42-50	interleukin 13	Mus musculus	5-10	
7492780-6	1995	IL-13 and IL-4 stimulation of murine L cell fibroblasts, which endogenously express the IL-4 receptor (IL-4R alpha) and lack expression of the IL-2 receptor gamma subunit (IL-2R gamma), resulted in tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1)/4PS.	Tyrosine	198-206	interleukin 13	Mus musculus	0-5	
7744881-12	1995	However, both IL-13 and IL-4 induced tyrosine phosphorylation of the IL-4-140 kDa receptor chain, suggesting that this is a component of both receptors in these cells and accounts for the similarities in signaling pathways shared by IL-13 and IL-4.	Tyrosine	37-45	interleukin 13	Mus musculus	14-19	
34769439-7	2021	In addition, IL-4 and IL-13 stimulate tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1).	Tyrosine	38-46	interleukin 13	Mus musculus	22-27	
34769439-8	2021	Prolonged treatment with these cytokines leads to increased IRS-1 abundance, which, in turn, amplifies IL-4- and IL-13-stimulated IRS-1 tyrosine phosphorylation.	Tyrosine	136-144	interleukin 13	Mus musculus	113-118	
34769439-9	2021	Through signaling crosstalk between IL-4/IL-13 and insulin, a hormone routinely included in mammary cultures, IRS-1 tyrosine phosphorylation is further enhanced.	Tyrosine	116-124	interleukin 13	Mus musculus	41-46	
27330190-1	2016	Insulin receptor substrate 2 (IRS2) is an adaptor protein that becomes tyrosine-phosphorylated in response to the cytokines interleukin-4 (IL-4) and IL-13, which results in activation of the phosphoinositide 3-kinase (PI3K)-Akt pathway.	Tyrosine	71-79	interleukin 13	Mus musculus	149-154