PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19011627-1 2009 Here we have identified a surface protein, TIGIT, containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif that was expressed on regulatory, memory and activated T cells. Tyrosine 141-149 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 43-48 34694361-1 2021 The co-stimulatory and co-inhibitory immunoreceptors DNAX accessory molecule-1 (DNAM-1) and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) are paired activating and inhibitory receptors on T cells and natural killer (NK) cells. Tyrosine 153-161 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 194-199 34992684-3 2022 Binding of T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) among other immune checkpoints on natural killer (NK) and T cells to CD155/CD112 in tumors is supposed to be inhibitory; however, the mechanism by which changes in CD155 and CD112 expression affect tumor immunity remains unclear. Tyrosine 52-60 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 92-97 34659197-1 2021 T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is an immunosuppressive receptor expressed on the surface of immune cells, suppressing immune responses by activating the intracellular negative regulatory signals. Tyrosine 41-49 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 81-86 34707863-3 2021 As CMV infection modifies natural killer (NK) cell properties and NK cells contribute to protection against HIV-1 infection, we considered the role of T-cell immunoreceptor with immunoglobulin and intracellular tyrosine inhibitory motif domains (TIGIT) in NK cell-based HIV-1 immunotherapy and elimination strategies. Tyrosine 211-219 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 246-251 34625514-5 2021 RESULTS: The results of both TCGA and validation data suggested that high expression of programmed cell death 1 ligand 1 (PD-L1), T-cell immunoglobulin and mucin-domain-containing-3 (TIM3), and T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) was associated with poor overall survival (OS) of patients with ESCC. Tyrosine 235-243 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 275-280 34105506-1 2021 TIGIT is an inhibitory receptor containing T cell immunoglobulin and immune receptor protein tyrosine inhibitory motif domain. Tyrosine 93-101 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 0-5 35467979-3 2022 Computational, preclinical, and patient tumor multiplexed analyses revealed that tumor-associated focal adhesion kinase (FAK) activation regulates CD155 expression, a checkpoint ligand for TIGIT (T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains). Tyrosine 257-265 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 189-194 35273697-3 2022 Recently, T cell immunoglobulin and immune receptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) have been identified as coinhibitory receptors, similar to PD-1. Tyrosine 52-60 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 99-104 35265633-2 2021 An immunosuppressive receptor, T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) is specifically expressed in NK cells. Tyrosine 72-80 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 119-124 33855917-3 2021 T-cell immunoglobulin, as well as immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT)/CD155 pathway, possesses critical parts in the development of normal pregnancy by promoting regulatory T (Treg) cells. Tyrosine 49-57 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 96-101 33670993-4 2021 T cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) has received considerable attention in cancer immunotherapy. Tyrosine 49-57 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 97-102 32804915-3 2020 T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is an immune inhibitory receptor expressed by regulatory T cells and activated T cells and natural killer cells. Tyrosine 41-49 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 81-86 30382432-3 2019 Our previous study showed that T cell immunoglobulin and immunoreceptor tyrosine-based inhibition motif (ITIM) domain (TIGIT) plays a critical role in regulating CD4 + T cell functions. Tyrosine 72-80 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 119-124 32265229-5 2020 Anti-TIGIT treatment selectively affects CD226hiCD8+ T cells by promoting CD226 phosphorylation at tyrosine 322. Tyrosine 99-107 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 5-10 32122675-2 2020 T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) and programmed cell death protein 1 (PD-1) are identified to be abnormally overexpressed in various types of cancers including GC. Tyrosine 41-49 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 88-93 29512870-5 2018 Blockade of T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domains (TIGIT) using a neutralizing antibody also selectively inhibited Th2 cell responses. Tyrosine 73-81 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 114-119 30402886-1 2019 The T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is a co-inhibitory receptor mainly expressed on T cells. Tyrosine 45-53 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 85-90 24905442-2 2014 T cell immunoglobulin and ITIM (immunoreceptor tyrosine-based inhibition motif) domain (TIGIT) is an inhibitory receptor, which exhibits inhibitory functions on the immune response. Tyrosine 47-55 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 88-93 28629373-1 2017 BACKGROUND: T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) and programmed cell death protein 1 (PD-1) are important inhibitory receptors that associate with T cell exhaustion in acute myeloid leukemia (AML). Tyrosine 53-61 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 100-105 28282368-0 2017 Elevated Expression of Immunoreceptor Tyrosine-Based Inhibitory Motif (TIGIT) on T Lymphocytes is Correlated with Disease Activity in Rheumatoid Arthritis. Tyrosine 38-46 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 71-76 28282368-2 2017 T cell immunoreceptors with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (TIGIT) have immunosuppressive co-stimulatory molecules that mediate inhibitory effects, but their roles in RA are poorly understood. Tyrosine 67-75 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 100-105 26683997-3 2016 In this study, we investigated the role of T cell immunoglobulin and ITIM (immunoreceptor tyrosine-based inhibition motif) domain (TIGIT) in RA. Tyrosine 90-98 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 131-136 26250578-3 2015 Here we show that a previously unidentified subset of human circulating T follicular helper cells expressing TIGIT, the T-cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory domains, exhibit strong B-cell help functions. Tyrosine 169-177 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 109-114 23974203-9 2013 In support of the view that methylation limits access of FOXP3 to its DNA targets, we showed that increased expression of the immune suppressive receptor T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT), which delineated Treg from activated effector T cells, was associated with hypomethylation and FOXP3 binding at the TIGIT locus. Tyrosine 195-203 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 235-240 23974203-9 2013 In support of the view that methylation limits access of FOXP3 to its DNA targets, we showed that increased expression of the immune suppressive receptor T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT), which delineated Treg from activated effector T cells, was associated with hypomethylation and FOXP3 binding at the TIGIT locus. Tyrosine 195-203 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 359-364 23154388-2 2013 T-cell immunoglobulin and ITIM (immunoreceptor tyrosine-based inhibition motif) domain (TIGIT) was recently identified as a new inhibitory receptor on T and NK cells that suppressed their effector functions. Tyrosine 47-55 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 88-93 23154388-3 2013 TIGIT harbors the immunoreceptor tail tyrosine (ITT)-like and ITIM motifs in its cytoplasmic tail. Tyrosine 38-46 T cell immunoreceptor with Ig and ITIM domains Homo sapiens 0-5