PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10051489-9 1999 Our results suggest that the anti-inflammatory effect of glucocorticoids on the inflammatory pathways induced by TNF-alpha can be explained, at least in part, by modulating JNK activity through a direct protein-protein interaction; the JNK phosphorylation and tyrosine-phosphorylation state of GR may be regulatory steps also involved in that effect. Tyrosine 260-268 mitogen-activated protein kinase 8 Rattus norvegicus 173-176 10051489-9 1999 Our results suggest that the anti-inflammatory effect of glucocorticoids on the inflammatory pathways induced by TNF-alpha can be explained, at least in part, by modulating JNK activity through a direct protein-protein interaction; the JNK phosphorylation and tyrosine-phosphorylation state of GR may be regulatory steps also involved in that effect. Tyrosine 260-268 mitogen-activated protein kinase 8 Rattus norvegicus 236-239 25548285-5 2015 Coadministration of insulin and FFAs, however, abolished hepatocyte proliferation and triggered CD95-dependent apoptosis due to a JNK-dependent association of the activated EGFR with CD95, subsequent CD95 tyrosine phosphorylation and formation of the death-inducing signaling complex (DISC). Tyrosine 205-213 mitogen-activated protein kinase 8 Rattus norvegicus 130-133 30486685-5 2020 Activation of JNK, NFkappaB, p38MAPK and insulin signaling from tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and serine phosphorylation of Akt were assessed in myotubes after Malathion exposure by western blot and was compared with those in controls. Tyrosine 64-72 mitogen-activated protein kinase 8 Rattus norvegicus 14-17 27068033-7 2016 In addition, it was demonstrated that inhibition of p38, JNK and JAK prevented STAT3 tyrosine phosphorylation induced by PM, while blocking ERK did not. Tyrosine 85-93 mitogen-activated protein kinase 8 Rattus norvegicus 57-60 27068033-8 2016 MAPKs (p38 and JNK) could regulate tyrosine STAT3 phosphorylation, which suggested that the JAK2/STAT3 pathway might be the downstream of p38/JNK MAPK pathways. Tyrosine 35-43 mitogen-activated protein kinase 8 Rattus norvegicus 15-18 27068033-8 2016 MAPKs (p38 and JNK) could regulate tyrosine STAT3 phosphorylation, which suggested that the JAK2/STAT3 pathway might be the downstream of p38/JNK MAPK pathways. Tyrosine 35-43 mitogen-activated protein kinase 8 Rattus norvegicus 142-145 25548285-6 2015 JNK inhibition restored the proliferative insulin effect in presence of FFAs and prevented EGFR/CD95 association, CD95 tyrosine phosphorylation and DISC formation. Tyrosine 119-127 mitogen-activated protein kinase 8 Rattus norvegicus 0-3 22982470-5 2012 IKKalpha/beta pS and JNK theronine/tyrosine phosphorylation was increased (P<0.05) in the obese animals. Tyrosine 35-43 mitogen-activated protein kinase 8 Rattus norvegicus 21-24 18330891-4 2008 EGFR tyrosine phosphorylation triggered phosphorylation of its down-stream target Shc and the activation of the c-Jun N-terminal kinase (JNK) pathway. Tyrosine 5-13 mitogen-activated protein kinase 8 Rattus norvegicus 112-135 19553664-8 2009 When, however, a JNK signal was induced by coadministration of cycloheximide or hydrogen peroxide (H2O2), activated EGFR associated with CD95 and triggered EGFR-mediated CD95-tyrosine phosphorylation and subsequent formation of the death-inducing signaling complex. Tyrosine 175-183 mitogen-activated protein kinase 8 Rattus norvegicus 17-20 18330891-4 2008 EGFR tyrosine phosphorylation triggered phosphorylation of its down-stream target Shc and the activation of the c-Jun N-terminal kinase (JNK) pathway. Tyrosine 5-13 mitogen-activated protein kinase 8 Rattus norvegicus 137-140 12949729-8 2003 However, the latter compound as well as NAC, genistein, inhibition of JNK, or protein kinase C inhibited CD95 tyrosine phosphorylation, membrane trafficking, and DISC formation. Tyrosine 110-118 mitogen-activated protein kinase 8 Rattus norvegicus 70-73 17258167-4 2007 The NADPH oxidase-derived ROS signal then allows via Yes, JNK, and EGFR activation for CD95 tyrosine phosphorylation as a prerequisite for CD95 targeting to the plasma membrane and formation of the death inducing signalling complex. Tyrosine 92-100 mitogen-activated protein kinase 8 Rattus norvegicus 58-61 17120084-3 2007 The hormone also stimulates JNK 1/2 tyrosine phosphorylation, in a dose-dependent fashion, this effect being maximal at 10 nM. Tyrosine 36-44 mitogen-activated protein kinase 8 Rattus norvegicus 28-31 18029441-9 2008 Treatment of H4IIE liver cells with anisomycin inhibited insulin-induced tyrosine phosphorylation of IRS-2; inhibition was reversed by pretreatment with the JNK and GSK-3 inhibitors. Tyrosine 73-81 mitogen-activated protein kinase 8 Rattus norvegicus 157-160 18029441-10 2008 Moreover, overexpression of JNK and GSK-3 in H4IIE cells reduced insulin-induced tyrosine phosphorylation of IRS-2 and its association with the p85 regulatory subunit of phosphatidylinositol 3-kinase. Tyrosine 81-89 mitogen-activated protein kinase 8 Rattus norvegicus 28-31 15198936-7 2004 Normalization of JNK activity in hepatocytes isolated from HSD rats improved insulin-stimulated tyrosine phosphorylation of insulin receptor substrate (IRS) proteins and insulin suppression of glucose release. Tyrosine 96-104 mitogen-activated protein kinase 8 Rattus norvegicus 17-20 15044612-7 2004 Ang II-stimulated tyrosine phosphorylation of Src and Cas and activation of ERK1/2 and JNK, but not p38, were potently inhibited by Src family tyrosine kinase inhibitors, herbimycin A (HA) and PP2. Tyrosine 18-26 mitogen-activated protein kinase 8 Rattus norvegicus 87-90 11583816-3 2001 H(2)O(2) (100 microM) significantly induces the tyrosine phosphorylation of JNK1 with a peak 25 min after the stimulation. Tyrosine 48-56 mitogen-activated protein kinase 8 Rattus norvegicus 76-80 12586732-10 2003 The data suggest that moderate hyperosmolarity or CD95L trigger oxidative stress and EGFR activation followed by a JNK-dependent EGFR/CD95association and CD95 tyrosine phosphorylation, probably through EGFR tyrosine kinase activity. Tyrosine 159-167 mitogen-activated protein kinase 8 Rattus norvegicus 115-118