PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24240055-3	2014	We found that triggering TLR2/1 complex-signalling with Pam3CSK4, in common with that induced via GPVI, and in contrast to that provoked by PARs, involves tyrosine phosphorylation of the adaptor protein LAT as well as of PLCgamma2 in a src- and Syk-dependent manner.	Tyrosine	155-163	toll like receptor 2	Homo sapiens	25-31	
17392283-7	2007	TLR2 and TLR4 agonists induced TLR tyrosine phosphorylation in HEK293 cells overexpressing CD14, MD-2, and TLR4 or TLR2.	Tyrosine	35-43	toll like receptor 2	Homo sapiens	0-4	
17392283-7	2007	TLR2 and TLR4 agonists induced TLR tyrosine phosphorylation in HEK293 cells overexpressing CD14, MD-2, and TLR4 or TLR2.	Tyrosine	35-43	toll like receptor 2	Homo sapiens	115-119	
11101877-7	2000	Tyrosine phosphorylation of TLR2 is required for assembly of a multiprotein complex that is necessary for subsequent NF-kappa B transcriptional activity.	Tyrosine	0-8	toll like receptor 2	Homo sapiens	28-32	
25022196-4	2014	Nevertheless, it is clear that many TLRs require, for signaling, ligand-dependent phosphorylation of specific Tyr residues in their cytoplasmic domains; the list includes TLR2, TLR3, TLR4, TLR5, TLR8 and TLR9.	Tyrosine	110-113	toll like receptor 2	Homo sapiens	171-175	
16439361-6	2006	Activation of THP-1 monocytic cells with the TLR4 agonist LPS and the TLR2 agonist macrophage-activating lipopeptide-2 induced phosphorylation of Mal on tyrosine residues.	Tyrosine	153-161	toll like receptor 2	Homo sapiens	70-74	
16439361-9	2006	Our study therefore provides the first demonstration of the key role of Mal phosphorylation on tyrosine during signaling by TLR2 and TLR4 and identifies a novel function for Btk as the kinase involved.	Tyrosine	95-103	toll like receptor 2	Homo sapiens	124-128	
24743304-7	2014	These inhibitory effects were accompanied by tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) of CEACAM1 and by recruitment of the phosphatase SHP-1, which could negatively regulate Toll-like receptor 2-dependent activation of the phosphatidylinositol 3-OH kinase-Akt kinase pathway.	Tyrosine	45-53	toll like receptor 2	Homo sapiens	219-239	
24743304-7	2014	These inhibitory effects were accompanied by tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) of CEACAM1 and by recruitment of the phosphatase SHP-1, which could negatively regulate Toll-like receptor 2-dependent activation of the phosphatidylinositol 3-OH kinase-Akt kinase pathway.	Tyrosine	92-100	toll like receptor 2	Homo sapiens	219-239	
23659921-5	2013	Data presented herein demonstrate that TLR2 enhanced the tyrosine phosphorylation of Dok1 and Dok2 in astrocytes and microglia, and that knockdown of these adaptors using small interfering RNA robustly elevated TLR2-induced ERK activation.	Tyrosine	57-65	toll like receptor 2	Homo sapiens	39-43	
22992740-6	2012	Confirming these predictions, biochemical assays demonstrated that R753Q TLR2 exhibits deficient agonist-induced tyrosine phosphorylation, hetero-dimerization with TLR6, and recruitment of Mal and MyD88.	Tyrosine	113-121	toll like receptor 2	Homo sapiens	73-77	
22992740-8	2012	Thus, the R753Q polymorphism renders TLR2 signaling-incompetent by impairing its tyrosine phosphorylation, dimerization with TLR6, and recruitment of Mal and MyD88.	Tyrosine	81-89	toll like receptor 2	Homo sapiens	37-41	
21188584-12	2011	Peptides insert their two N -terminal arginines or their C-terminal tyrosines in the TLR-2 coil.	Tyrosine	68-77	toll like receptor 2	Homo sapiens	85-90	
18836450-4	2008	These inhibitory effects were mediated by tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif of CEACAM1 and by recruitment of the phosphatase SHP-1, which negatively regulated Toll-like receptor 2-dependent activation of the phosphatidylinositol 3-OH kinase-Akt kinase pathway.	Tyrosine	42-50	toll like receptor 2	Homo sapiens	204-224	
18836450-4	2008	These inhibitory effects were mediated by tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif of CEACAM1 and by recruitment of the phosphatase SHP-1, which negatively regulated Toll-like receptor 2-dependent activation of the phosphatidylinositol 3-OH kinase-Akt kinase pathway.	Tyrosine	89-97	toll like receptor 2	Homo sapiens	204-224