PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9126327-5 1997 A beta(1-40) induced phosphorylation of p44 and p42 MAP kinases (Erk1 and Erk2) at tyrosine-204, and PD98059, a MEK1 inhibitor, inhibited A beta(1-40)-induced CREB phosphorylation at serine-133. Tyrosine 83-91 amyloid beta precursor protein Rattus norvegicus 0-6 9452012-2 1997 Deleterious effects of Abeta on neurons have been linked to the inappropriate activation of signaling pathways within the cell (reviewed in Yankner, 1996), including tyrosine phosphorylation of focal adhesion kinase (FAK) (Zhang et al., 1994, 1996a,b). Tyrosine 166-174 amyloid beta precursor protein Rattus norvegicus 23-28 9452012-5 1997 Treatment of the rat central nervous system B103 cell line with aggregates of Abeta was found to induce the tyrosine phosphorylation of paxillin within 30 min, nearly 24 hr prior to significant cell death. Tyrosine 108-116 amyloid beta precursor protein Rattus norvegicus 78-83 9452012-11 1997 The rapid tyrosine phosphorylation and cytoskeletal mobilization of paxillin links Abeta to the activation of focal contact signaling events that may influence neuronal cytoskeletal architecture, gene expression, synaptic plasticity and cell viability. Tyrosine 10-18 amyloid beta precursor protein Rattus norvegicus 83-88 9374197-3 1997 In an attempt to understand the molecular mechanisms underlying such effects, we have recently reported that nanomolar doses of A beta can stimulate protein tyrosine phosphorylation and activate phosphatidylinositol-3-kinase in neuronal cells. Tyrosine 157-165 amyloid beta precursor protein Rattus norvegicus 128-134 7488741-3 1995 We have recently shown that physiologic levels of a beta increase tyrosine phosphorylation and induce increases in cytosolic calcium. Tyrosine 66-74 amyloid beta precursor protein Rattus norvegicus 50-56 8916088-3 1996 We have recently shown that nanomolar doses of A beta can stimulate tyrosine phosphorylation and activate phosphatidylinositol-3-kinase in neuronal cells. Tyrosine 68-76 amyloid beta precursor protein Rattus norvegicus 47-53 8817572-1 1996 Neurotoxicity of the amyloid beta protein (A beta) is known to correlate with a selective change in protein tyrosine phosphorylation (Tyr(P)) of focal adhesion kinase (FAK) (Zhang et al., J. Biol. Tyrosine 108-116 amyloid beta precursor protein Rattus norvegicus 43-49 8817572-1 1996 Neurotoxicity of the amyloid beta protein (A beta) is known to correlate with a selective change in protein tyrosine phosphorylation (Tyr(P)) of focal adhesion kinase (FAK) (Zhang et al., J. Biol. Tyrosine 134-137 amyloid beta precursor protein Rattus norvegicus 43-49 34818135-7 2021 Amantadine (N-methyl-D-aspartate (NMDA) receptor noncompetitive antagonist), NVP-AAM077 (GluN2A-containing NMDA receptor selective inhibitor) and Ro25-6981 (GluN2B-containing NMDA receptor selective inhibitor) also suppressed the Abeta25-35-induced PSD-95 tyrosine phosphorylation.Conclusion: These results suggest that Abeta oligomers induce the tyrosine phosphorylation of PSD-95 by SrcPTKs, which is mediated by the activation of GluN2A- and GluN2B-containing NMDA receptors.Section: Disease-Related Neuroscience. Tyrosine 256-264 amyloid beta precursor protein Rattus norvegicus 320-325 7552293-4 1995 Application of a beta 25-35 or a beta 1-40 induces a dose-dependent increase in the tyrosine phosphorylation in both whole cells and in vitro. Tyrosine 84-92 amyloid beta precursor protein Rattus norvegicus 15-21 7552293-4 1995 Application of a beta 25-35 or a beta 1-40 induces a dose-dependent increase in the tyrosine phosphorylation in both whole cells and in vitro. Tyrosine 84-92 amyloid beta precursor protein Rattus norvegicus 31-37 7552293-5 1995 The increase in tyrosine phosphorylation is both rapid and sensitive, being stimulated by picomolar doses of a beta and occurring within 1 min of application. Tyrosine 16-24 amyloid beta precursor protein Rattus norvegicus 109-115 7552293-6 1995 Calcium imaging experiments provide further support for the role of tyrosine phosphorylation in the action of a beta. Tyrosine 68-76 amyloid beta precursor protein Rattus norvegicus 110-116 34818135-7 2021 Amantadine (N-methyl-D-aspartate (NMDA) receptor noncompetitive antagonist), NVP-AAM077 (GluN2A-containing NMDA receptor selective inhibitor) and Ro25-6981 (GluN2B-containing NMDA receptor selective inhibitor) also suppressed the Abeta25-35-induced PSD-95 tyrosine phosphorylation.Conclusion: These results suggest that Abeta oligomers induce the tyrosine phosphorylation of PSD-95 by SrcPTKs, which is mediated by the activation of GluN2A- and GluN2B-containing NMDA receptors.Section: Disease-Related Neuroscience. Tyrosine 347-355 amyloid beta precursor protein Rattus norvegicus 320-325 20441772-6 2010 These results suggest that the activation of NMDA receptors after Abeta treatment promotes the formation of NR2A-PSD-95-Src complex and thus increases the tyrosine phosphorylation of NR2A by Src kinases, which up-regulates the function of NMDA receptors. Tyrosine 155-163 amyloid beta precursor protein Rattus norvegicus 66-71 26865271-0 2016 Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11alpha by Src kinase regulates the trafficking of amyloid precursor protein. Tyrosine 10-18 amyloid beta precursor protein Rattus norvegicus 114-139 20484629-6 2010 Treatment of cultured rat neurons with Abeta or intrahippocampal injection of mice with Abeta both induces tyrosine phosphorylation of STAT3 in neurons. Tyrosine 107-115 amyloid beta precursor protein Rattus norvegicus 39-44 16969627-4 2007 In agreement with Abeta regulatory actions on glial-neuronal networks, the present paper reports new findings demonstrating that intrastriatal injections of Abeta peptides reduce striatal tyrosine hydroxylase, increase striatal GFAP immunoreactivities and lower pain threshold in experimental rats. Tyrosine 188-196 amyloid beta precursor protein Rattus norvegicus 157-162 14646244-1 2003 To explore cellular signaling molecules that respond to amyloid beta protein (A beta), we investigated the effect of A beta on tyrosine phosphorylation of cellular proteins in cultured rat cortical astrocytes. Tyrosine 127-135 amyloid beta precursor protein Rattus norvegicus 117-123 14646244-3 2003 The A beta-induced increase in tyrosine phosphorylation of 44-kDa protein was blocked by U0126, a specific inhibitor of the extracellular signal-regulated kinase (ERK) kinase MEK. Tyrosine 31-39 amyloid beta precursor protein Rattus norvegicus 4-10 14646244-4 2003 Western blotting with anti-phospho-ERK1/2 antibody and anti-ERK1/2 antibody demonstrated that A beta 1-40 or A beta 25-35 induced an increase in the dually (tyrosine and threonine) phosphorylated form of ERK1 and ERK2, with no change in total ERK1/2 level. Tyrosine 157-165 amyloid beta precursor protein Rattus norvegicus 94-100 14646244-4 2003 Western blotting with anti-phospho-ERK1/2 antibody and anti-ERK1/2 antibody demonstrated that A beta 1-40 or A beta 25-35 induced an increase in the dually (tyrosine and threonine) phosphorylated form of ERK1 and ERK2, with no change in total ERK1/2 level. Tyrosine 157-165 amyloid beta precursor protein Rattus norvegicus 109-115 14646244-6 2003 These results suggest that A beta specifically promotes tyrosine phosphorylation and nuclear translocation of ERK in astrocytes. Tyrosine 56-64 amyloid beta precursor protein Rattus norvegicus 27-33 10037491-6 1999 PKC-delta was tyrosine-phosphorylated by the treatment of microglia for 10 min with A beta (25-35) at 10 nM. Tyrosine 14-22 amyloid beta precursor protein Rattus norvegicus 84-90 16497436-7 2006 Tyrosine phosphorylation levels of 110 and 60 kDa proteins (pp110 and pp60) increased upon Abeta plus glutamate treatment under a normal Cl(-), but not low Cl(-), condition. Tyrosine 0-8 amyloid beta precursor protein Rattus norvegicus 91-96 16001231-4 2005 Application of Abeta caused tyrosine phosphorylation of wild-type p75 and induced the Ras-ERK pathway as has been reported for nerve growth factor (NGF). Tyrosine 28-36 amyloid beta precursor protein Rattus norvegicus 15-20 11290384-5 2001 In microglia stimulated with Abeta, tyrosine phosphorylation of PKC-delta was evident at the membrane fraction without an overt translocation of PKC-delta. Tyrosine 36-44 amyloid beta precursor protein Rattus norvegicus 29-34 10037491-7 1999 Other PKC isoforms alpha and epsilon were tyrosine-phosphorylated by A beta (25-35), but only to a small extent. Tyrosine 42-50 amyloid beta precursor protein Rattus norvegicus 69-75