PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Tyrosine 37-40 gonadotropin releasing hormone 1 Homo sapiens 55-92 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Tyrosine 83-86 gonadotropin releasing hormone 1 Homo sapiens 27-57 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Tyrosine 83-86 gonadotropin releasing hormone 1 Homo sapiens 59-63 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Tyrosine 37-40 gonadotropin releasing hormone 1 Homo sapiens 94-98 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Tyrosine 37-40 gonadotropin releasing hormone 1 Homo sapiens 167-171 24264576-6 2014 Using the Ishikawa cell line as a model of endometrial cancer, we demonstrate that GnRH-(1-5) stimulates epidermal growth factor release, increases the phosphorylation of EGFR (P < .05) at three tyrosine sites (992, 1045, 1068), and promotes cellular migration. Tyrosine 198-206 gonadotropin releasing hormone 1 Homo sapiens 83-92 3514603-1 1986 The primary structure of gonadotropin-releasing hormone (GnRH) isolated from whole brains of lamprey is pGlu-His-Tyr-Ser-Leu-Glu-Trp-Lys-Pro-Gly-NH2. Tyrosine 113-116 gonadotropin releasing hormone 1 Homo sapiens 25-55 3514603-1 1986 The primary structure of gonadotropin-releasing hormone (GnRH) isolated from whole brains of lamprey is pGlu-His-Tyr-Ser-Leu-Glu-Trp-Lys-Pro-Gly-NH2. Tyrosine 113-116 gonadotropin releasing hormone 1 Homo sapiens 57-61 3530729-3 1986 This monoclonal antibody seems to belong to IgG2b as it was eluted from protein A-Sepharose CL-4B with citrate buffer pH 3.5. competitive binding experiment using fragment peptides of LHRH indicated the binding site of LRH13 was a region around serine and tyrosine, and modification of mammalian LHRH by radioiodination caused a marked decrease in the binding activity. Tyrosine 256-264 gonadotropin releasing hormone 1 Homo sapiens 184-188 3530729-3 1986 This monoclonal antibody seems to belong to IgG2b as it was eluted from protein A-Sepharose CL-4B with citrate buffer pH 3.5. competitive binding experiment using fragment peptides of LHRH indicated the binding site of LRH13 was a region around serine and tyrosine, and modification of mammalian LHRH by radioiodination caused a marked decrease in the binding activity. Tyrosine 256-264 gonadotropin releasing hormone 1 Homo sapiens 296-300 3530729-5 1986 Chicken LHRH-II, where tyrosine is replaced for histidine, has a lower affinity (0.3X) than that of mammalian LHRH. Tyrosine 23-31 gonadotropin releasing hormone 1 Homo sapiens 8-12 3530729-5 1986 Chicken LHRH-II, where tyrosine is replaced for histidine, has a lower affinity (0.3X) than that of mammalian LHRH. Tyrosine 23-31 gonadotropin releasing hormone 1 Homo sapiens 110-114 6394691-6 1984 Amino acid composition and sequence analyses confirmed the structure of this form of chicken LHRH as pGlu-His-Trp-Ser-Tyr-Gly-Leu-Gln-Pro-Gly-NH2. Tyrosine 118-121 gonadotropin releasing hormone 1 Homo sapiens 93-97 25404067-1 2014 Using the chain-build-up method based on Empirical Conformational Energies of Peptides Program including solvation, we have computed, the low energy conformations of gonadotrpin-releasing hormone, GnRH, whose sequence is Pyro-Glu(PG)-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. Tyrosine 246-249 gonadotropin releasing hormone 1 Homo sapiens 197-201 24264576-3 2014 The zinc metalloendopeptidase, EC 3.4.24.15 (EP24.15), can cleave GnRH at the Tyr(5)-Gly(6) bond to form the pentapeptide, GnRH-(1-5). Tyrosine 78-81 gonadotropin releasing hormone 1 Homo sapiens 66-70 24264576-3 2014 The zinc metalloendopeptidase, EC 3.4.24.15 (EP24.15), can cleave GnRH at the Tyr(5)-Gly(6) bond to form the pentapeptide, GnRH-(1-5). Tyrosine 78-81 gonadotropin releasing hormone 1 Homo sapiens 123-132 7050119-9 1982 These studies indicate that the structure of chicken hypothalamic LH-RH is: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Gln-Pro-Gly-NH2. Tyrosine 93-96 gonadotropin releasing hormone 1 Homo sapiens 66-71 7041967-1 1982 The substrate specificity of a peptidase from anterior pituitaries that is capable of hydrolyzing luteinizing hormone-releasing hormone (LH-RH; less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) at the Tyr5-Gly6 peptide bond has been investigated by using inhibitors and model substrates. Tyrosine 170-173 gonadotropin releasing hormone 1 Homo sapiens 98-135 7041967-1 1982 The substrate specificity of a peptidase from anterior pituitaries that is capable of hydrolyzing luteinizing hormone-releasing hormone (LH-RH; less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) at the Tyr5-Gly6 peptide bond has been investigated by using inhibitors and model substrates. Tyrosine 170-173 gonadotropin releasing hormone 1 Homo sapiens 137-142 29232843-1 2017 The decapeptide gonadotropin-releasing hormone, also referred to as luteinizing hormone-releasing hormone with the sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) plays an important role in regulating the reproductive system. Tyrosine 142-145 gonadotropin releasing hormone 1 Homo sapiens 16-46 19210292-5 2009 GnRH-I is processed by a zinc metalloendopeptidase EC 3.4.24.15 (EP24.15), which cleaves the hormone at the covalent bond between the fifth and sixth residue of the decapeptide (Tyr(5)-Gly(6)) to form GnRH-(1-5). Tyrosine 178-181 gonadotropin releasing hormone 1 Homo sapiens 0-4 19210292-5 2009 GnRH-I is processed by a zinc metalloendopeptidase EC 3.4.24.15 (EP24.15), which cleaves the hormone at the covalent bond between the fifth and sixth residue of the decapeptide (Tyr(5)-Gly(6)) to form GnRH-(1-5). Tyrosine 178-181 gonadotropin releasing hormone 1 Homo sapiens 201-205 19755481-4 2010 LHRH-I is processed by a zinc metalloendopeptidase EC 3.4.24.15 (EP24.15) that cleaves the hormone at the fifth and sixth bond of the decapeptide (Tyr(5)-Gly(6)) to form LHRH-(1-5). Tyrosine 147-150 gonadotropin releasing hormone 1 Homo sapiens 0-6 19755481-4 2010 LHRH-I is processed by a zinc metalloendopeptidase EC 3.4.24.15 (EP24.15) that cleaves the hormone at the fifth and sixth bond of the decapeptide (Tyr(5)-Gly(6)) to form LHRH-(1-5). Tyrosine 147-150 gonadotropin releasing hormone 1 Homo sapiens 0-4 17202595-4 2007 LHRH-I is processed by a zinc metalloendopeptidase EC 3.4.24.15 (EP24.15) that cleaves the hormone at the Tyr(5)-Gly(6) bond. Tyrosine 106-109 gonadotropin releasing hormone 1 Homo sapiens 0-6 18927217-3 2009 We found that its amino acid sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH(2)) was identical to that of mammalian GnRH. Tyrosine 56-59 gonadotropin releasing hormone 1 Homo sapiens 122-126 18222967-4 2008 LHRH-I is processed by a zinc metalloendopeptidase EC 3.4.24.15 (EP24.15) that cleaves the hormone at the fifth and sixth bond of the decapeptide (Tyr(5)-Gly(6)) to form LHRH-(1-5). Tyrosine 147-150 gonadotropin releasing hormone 1 Homo sapiens 0-6 18222967-4 2008 LHRH-I is processed by a zinc metalloendopeptidase EC 3.4.24.15 (EP24.15) that cleaves the hormone at the fifth and sixth bond of the decapeptide (Tyr(5)-Gly(6)) to form LHRH-(1-5). Tyrosine 147-150 gonadotropin releasing hormone 1 Homo sapiens 0-4 15544487-1 2004 Gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) hypothalamic hormone that acts upon 7-trans membrane spanning GnRH receptors in the pituitary. Tyrosine 121-124 gonadotropin releasing hormone 1 Homo sapiens 0-30 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Tyrosine 201-204 gonadotropin releasing hormone 1 Homo sapiens 42-46 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Tyrosine 201-204 gonadotropin releasing hormone 1 Homo sapiens 115-119 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Tyrosine 201-204 gonadotropin releasing hormone 1 Homo sapiens 115-119 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Tyrosine 124-127 gonadotropin releasing hormone 1 Homo sapiens 42-46 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Tyrosine 124-127 gonadotropin releasing hormone 1 Homo sapiens 115-119 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Tyrosine 124-127 gonadotropin releasing hormone 1 Homo sapiens 115-119 15544487-1 2004 Gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) hypothalamic hormone that acts upon 7-trans membrane spanning GnRH receptors in the pituitary. Tyrosine 121-124 gonadotropin releasing hormone 1 Homo sapiens 32-36 15544487-1 2004 Gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) hypothalamic hormone that acts upon 7-trans membrane spanning GnRH receptors in the pituitary. Tyrosine 121-124 gonadotropin releasing hormone 1 Homo sapiens 212-216 10684817-1 2000 In the brain of all vertebrate classes, chicken (c) GnRH-II ([His(5), Trp(7),Tyr(8)]GnRH, cGnRH-II) is expressed in the mesencephalon. Tyrosine 77-80 gonadotropin releasing hormone 1 Homo sapiens 52-56 12429984-3 2002 The proliferation of MCF-7 human breast cancer cells in vitro is inhibited by AN-152 and this effect can be augmented by the up-regulation of LH-RH receptor expression through stimulation of tyrosine phosphorylation with epidermal growth factor (EGF). Tyrosine 191-199 gonadotropin releasing hormone 1 Homo sapiens 142-147 12429984-10 2002 These results suggest that the activation of LH-RH receptors by compounds that increase tyrosine phosphorylation could further improve the response to targeted chemotherapy with AN-152. Tyrosine 88-96 gonadotropin releasing hormone 1 Homo sapiens 45-50 11356684-14 2001 As shown by quantitative Western blotting, EGF-induced tyrosine autophosphorylation of EGF receptors was reduced 45-63% after LHRH (100 nM) treatment (P < 0.001). Tyrosine 55-63 gonadotropin releasing hormone 1 Homo sapiens 126-130 11356684-18 2001 The tumor LHRH receptor activates a PTP counteracting EGF-induced tyrosine autophosphorylation of EGF receptor, resulting in down-regulation of mitogenic signal transduction and cell proliferation. Tyrosine 66-74 gonadotropin releasing hormone 1 Homo sapiens 10-14 14559894-6 2004 GnRH induction of cytoskeletal remodeling was correlated with significant increases in the tyrosine phosphorylation status of a series of cytoskeletal associated proteins, e.g. focal adhesion kinase (FAK), c-Src, and microtubule-associated protein kinase (MAPK or ERK1/2). Tyrosine 91-99 gonadotropin releasing hormone 1 Homo sapiens 0-4 11255560-1 2000 Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes. Tyrosine 73-76 gonadotropin releasing hormone 1 Homo sapiens 0-30 11255560-1 2000 Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes. Tyrosine 73-76 gonadotropin releasing hormone 1 Homo sapiens 32-36 21541621-6 1996 This inhibitory effect of the LHRH agonist on EGF-induced net tyrosine phosphorylation was partly antagonized by exposure to 100 mu M sodium vandate, an inhibitor of phosphotyrosine phosphatase. Tyrosine 62-70 gonadotropin releasing hormone 1 Homo sapiens 30-34 9886842-4 1999 To this purpose, the effects of the LHRH agonist Zoladex (LHRH-A) on 1) the mitogenic action of IGF-I, 2) the tyrosine phosphorylation of type 1 IGF-I receptor (IGF-IR), 3) the concentration of IGF-IR, and 4) the secretion of IGF-binding protein-3 were studied. Tyrosine 110-118 gonadotropin releasing hormone 1 Homo sapiens 36-40 9886842-4 1999 To this purpose, the effects of the LHRH agonist Zoladex (LHRH-A) on 1) the mitogenic action of IGF-I, 2) the tyrosine phosphorylation of type 1 IGF-I receptor (IGF-IR), 3) the concentration of IGF-IR, and 4) the secretion of IGF-binding protein-3 were studied. Tyrosine 110-118 gonadotropin releasing hormone 1 Homo sapiens 58-62 9886842-5 1999 The results obtained show that in DU 145 cells, LHRH-A 1) counteracts the mitogenic action of IGF-I in a dose-dependent manner, 2) prevents the IGF-I-induced tyrosine phosphorylation of the IGF-IR, 3) reduces the concentration of IGF-IR without affecting its Kd value, and 4) does not affect the secretion of IGF-binding protein-3 in the conditioned medium from these cells. Tyrosine 158-166 gonadotropin releasing hormone 1 Homo sapiens 48-52 9396187-4 1997 To this purpose, the effects of LHRH agonist, Zoladex (LHRH-A), on the mitogenic action of EGF, on EGF-activated intracellular signaling mechanisms (tyrosine phosphorylation of EGF receptor and c-fos proto-oncogene expression), and on the concentration of EGF receptors have been evaluated in both LNCaP and DU 145 cells. Tyrosine 149-157 gonadotropin releasing hormone 1 Homo sapiens 32-36 9396187-4 1997 To this purpose, the effects of LHRH agonist, Zoladex (LHRH-A), on the mitogenic action of EGF, on EGF-activated intracellular signaling mechanisms (tyrosine phosphorylation of EGF receptor and c-fos proto-oncogene expression), and on the concentration of EGF receptors have been evaluated in both LNCaP and DU 145 cells. Tyrosine 149-157 gonadotropin releasing hormone 1 Homo sapiens 55-59 9396187-5 1997 The results of these "in vitro" studies show that in LNCaP cells LHRH-A counteracts the mitogenic action of EGF, abrogates the EGF-induced c-fos expression and reduces the concentration of EGF-binding sites, without modifying the EGF induced tyrosine phosphorylation. Tyrosine 242-250 gonadotropin releasing hormone 1 Homo sapiens 65-69 9396187-6 1997 In DU 145 cells, LHRH-A antagonizes the proliferative action of EGF, inhibits tyrosine phosphorylation of EGF receptor induced by EGF and significantly reduces the number of EGF binding sites, without altering the stimulation of c-fos expression induced by EGF. Tyrosine 78-86 gonadotropin releasing hormone 1 Homo sapiens 17-21 7761629-7 1995 The amino acid sequence of sturgeon GnRH is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. Tyrosine 61-64 gonadotropin releasing hormone 1 Homo sapiens 36-40 8923840-7 1996 In DU 145 cells, LHRH-A antagonizes the proliferative action of EGF, inhibits the tyrosine phosphorylation of the EGF receptor induced by EGF, and significantly reduces the number of EGF-binding sites. Tyrosine 82-90 gonadotropin releasing hormone 1 Homo sapiens 17-21 1672452-0 1991 Regulation of luteinizing hormone-releasing hormone receptor binding by heterologous and autologous receptor-stimulated tyrosine phosphorylation. Tyrosine 120-128 gonadotropin releasing hormone 1 Homo sapiens 14-51 1805795-2 1991 The azotization at histidine and or tyrosine of GnRH was carried out and characterized extensively. Tyrosine 36-44 gonadotropin releasing hormone 1 Homo sapiens 48-52 1672042-0 1991 Effects of epidermal growth factor and analogues of luteinizing hormone-releasing hormone and somatostatin on phosphorylation and dephosphorylation of tyrosine residues of specific protein substrates in various tumors. Tyrosine 151-159 gonadotropin releasing hormone 1 Homo sapiens 52-89