PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23640056-7 2013 By promoting integrin-mediated cell adhesion to FN, TG2 physically associates with and recruits c-Src, which in turn phosphorylates beta-catenin at Tyr(654), releasing it from E-cadherin and rendering it available for transcriptional regulation. Tyrosine 148-151 catenin beta 1 Homo sapiens 132-144 23499736-4 2013 CEACAM1 expression in Jurkat cells leads to the re-distribution of beta-catenin to the actin cytoskeleton as well as inhibition of beta-catenin tyrosine phosphorylation and its degradation after Fas stimulation. Tyrosine 144-152 catenin beta 1 Homo sapiens 131-143 23382837-5 2013 Upon specific Tyr::Cre-driven activation of Wnt/beta-catenin signaling at the time of cell fate specification, melanocytes replaced the SMC2 population of the DA, suggesting that SMC2 and melanocytes have a common precursor. Tyrosine 14-17 catenin beta 1 Homo sapiens 48-60 22480520-7 2012 KEY FINDINGS: In EOC cell lines, ET-1 induced Src-dependent EGFR transactivation, causing tyrosine (Y) phosphorylation of beta-catenin at the residue Y654, its dissociation from E-cadherin complexes and the accumulation as an active form. Tyrosine 90-98 catenin beta 1 Homo sapiens 122-134 22956765-7 2012 Moreover, on thrombin challenge, we find prolonged elevation in tyrosine phosphorylation levels of VE-cadherin-associated beta-catenin in SHP2-depleted cells. Tyrosine 64-72 catenin beta 1 Homo sapiens 122-134 22126602-0 2012 Y654 of beta-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of beta-catenin. Tyrosine 55-63 catenin beta 1 Homo sapiens 8-20 23100427-3 2012 PTPRZ1 constitutively promotes the tyrosine dephosphorylation of beta-catenin and, thus, beta-catenin participation in T cell factor (TCF)-mediated transcription. Tyrosine 35-43 catenin beta 1 Homo sapiens 65-77 23100427-3 2012 PTPRZ1 constitutively promotes the tyrosine dephosphorylation of beta-catenin and, thus, beta-catenin participation in T cell factor (TCF)-mediated transcription. Tyrosine 35-43 catenin beta 1 Homo sapiens 89-101 22582758-6 2012 By using immunoprecipitations, LPA was shown to induce increased tyrosine phosphorylation of beta-catenin and alter the balance of beta-catenin-bound SFK and PTP1B (phosphotyrosine phosphatase 1B). Tyrosine 65-73 catenin beta 1 Homo sapiens 93-105 22641100-6 2012 PECAM-1 is also tyrosine-phosphorylated, an event associated with recruitment of the phosphatase SHP-2 (Src homology 2 domain-containing protein phosphatase) to PECAM-1, beta-catenin release from PECAM-1, and reassociation of beta-catenin with the AJ. Tyrosine 16-24 catenin beta 1 Homo sapiens 170-182 22641100-6 2012 PECAM-1 is also tyrosine-phosphorylated, an event associated with recruitment of the phosphatase SHP-2 (Src homology 2 domain-containing protein phosphatase) to PECAM-1, beta-catenin release from PECAM-1, and reassociation of beta-catenin with the AJ. Tyrosine 16-24 catenin beta 1 Homo sapiens 226-238 22126602-2 2012 Tyrosine phosphorylation of beta-catenin affects the cell adhesion, migration, and gene transcription in many types of human cancer cells, including acute myeloid leukemia cells with FLT3 internal tandem duplication (FLT3/ITD-AML). Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 22126602-3 2012 Here, we investigated the relationship between three tyrosine residues (Y86, Y142, and Y654) in beta-catenin and oncogenic FLT3/ITD kinase. Tyrosine 53-61 catenin beta 1 Homo sapiens 96-108 22126602-7 2012 These results explain how FLT3/ITD affects the tyrosine phosphorylation, nuclear localization, and transcriptional activity of beta-catenin. Tyrosine 47-55 catenin beta 1 Homo sapiens 127-139 21195420-9 2012 Finally, beta-catenin tyrosine phosphorylation (p-Y) among tumors was variably increased, despite the increased amount of total beta-catenin in tumors. Tyrosine 22-30 catenin beta 1 Homo sapiens 9-21 21726809-6 2011 We found that, on tyrosine dephosphorylation by SHP2, parafibromin acquires the ability to stably bind beta-catenin. Tyrosine 18-26 catenin beta 1 Homo sapiens 103-115 21997484-6 2012 The early tyrosine phosphorylation of VE-cadherin was linked to the dissociation of VE-cadherin-p120-catenin/beta-catenin complexes and VE-cadherin internalization, whereas low OxPAPC doses promoted the formation of VE-cadherin-p120-catenin/beta-catenin complexes. Tyrosine 10-18 catenin beta 1 Homo sapiens 109-121 21997484-6 2012 The early tyrosine phosphorylation of VE-cadherin was linked to the dissociation of VE-cadherin-p120-catenin/beta-catenin complexes and VE-cadherin internalization, whereas low OxPAPC doses promoted the formation of VE-cadherin-p120-catenin/beta-catenin complexes. Tyrosine 10-18 catenin beta 1 Homo sapiens 241-253 22065111-9 2012 Investigation of the relationship between PTN and VEGF revealed that PTN, through the PTN/RPTPbeta/zeta signaling pathway, increased tyrosine phosphorylation of beta-catenin, leading to an increase in VEGF. Tyrosine 133-141 catenin beta 1 Homo sapiens 161-173 22110128-9 2012 The Arm R10-12 sequence facilitated transport even when beta-catenin was bound to the Arm-binding partner LEF-1, and its activity was stimulated by phosphorylation at Tyr-654. Tyrosine 167-170 catenin beta 1 Homo sapiens 56-68 22247700-6 2011 Most importantly, the link between the loss of the AJ complex and the increased proliferation in human schwannoma cells is connected by Src and platelet-derived growth factor receptor-induced tyrosine 654 phosphorylation on beta-catenin and associated with degradation of N-cadherin. Tyrosine 192-200 catenin beta 1 Homo sapiens 224-236 22247700-8 2011 Finally, we demonstrate that phosphorylation of tyrosine 654 is critical for the increased proliferation in human schwannoma cells because overexpression of a Y654F mutant beta-catenin reduces hyperproliferation of schwannoma cells. Tyrosine 48-56 catenin beta 1 Homo sapiens 172-184 21423209-3 2011 beta-Catenin has also been shown to be regulated through tyrosine phosphorylation by the receptor tyrosine kinases Met, Fer and Fyn. Tyrosine 57-65 catenin beta 1 Homo sapiens 0-12 21423209-6 2011 Our data also demonstrate that activation of Ron, through ligand binding by hepatocyte growth factor-like protein (HGFL), induces the tyrosine phosphorylation of beta-catenin, primarily on tyrosine residues Tyr 654 and Tyr 670. Tyrosine 134-142 catenin beta 1 Homo sapiens 162-174 21423209-6 2011 Our data also demonstrate that activation of Ron, through ligand binding by hepatocyte growth factor-like protein (HGFL), induces the tyrosine phosphorylation of beta-catenin, primarily on tyrosine residues Tyr 654 and Tyr 670. Tyrosine 189-197 catenin beta 1 Homo sapiens 162-174 21423209-6 2011 Our data also demonstrate that activation of Ron, through ligand binding by hepatocyte growth factor-like protein (HGFL), induces the tyrosine phosphorylation of beta-catenin, primarily on tyrosine residues Tyr 654 and Tyr 670. Tyrosine 207-210 catenin beta 1 Homo sapiens 162-174 21423209-6 2011 Our data also demonstrate that activation of Ron, through ligand binding by hepatocyte growth factor-like protein (HGFL), induces the tyrosine phosphorylation of beta-catenin, primarily on tyrosine residues Tyr 654 and Tyr 670. Tyrosine 219-222 catenin beta 1 Homo sapiens 162-174 21423209-7 2011 In addition, HGFL-mediated Ron activation induces both beta-catenin nuclear localization and transcriptional activity, with Tyr 654 and Tyr 670 residues of beta-catenin being critical for these processes. Tyrosine 136-139 catenin beta 1 Homo sapiens 156-168 21102519-9 2011 Thus, functional tyrosines are critical in stimulating the interactions between MUC1 and beta-catenin and their nuclear translocation to initiate the process of EMT. Tyrosine 17-26 catenin beta 1 Homo sapiens 89-101 20676135-4 2010 We previously reported that tyrosine phosphorylation of p68 RNA helicase mediates the effects of platelet-derived growth factor (PDGF) in induction of epithelial mesenchymal transition by promoting beta-catenin nuclear translocation. Tyrosine 28-36 catenin beta 1 Homo sapiens 198-210 20840866-2 2011 Tyrosine phosphorylation of beta-catenin is implicated as a means for its release from E-cadherin complexes and correlates with enhanced transcriptional activity. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 20840866-6 2011 Herein, we demonstrate that inhibition of tyrosine phosphatases with pervanadate induced both c-src-dependent tyrosine phosphorylation and nuclear translocation of beta-catenin. Tyrosine 42-50 catenin beta 1 Homo sapiens 164-176 20840866-7 2011 Moreover, ectopic expression of SHP-1 but not the inactive form of SHP-1 (C453S) inhibited src-induced tyrosine phosphorylation of beta-catenin on tyrosines 86 and 654. Tyrosine 103-111 catenin beta 1 Homo sapiens 131-143 20840866-7 2011 Moreover, ectopic expression of SHP-1 but not the inactive form of SHP-1 (C453S) inhibited src-induced tyrosine phosphorylation of beta-catenin on tyrosines 86 and 654. Tyrosine 147-156 catenin beta 1 Homo sapiens 131-143 20840866-8 2011 SHP-1 expression and mutations of tyrosine-86 and tyrosine-654 to phenylalanine significantly and similarly decreased the transactivation potential of beta-catenin on the TOPFLASH reporter. Tyrosine 34-42 catenin beta 1 Homo sapiens 151-163 20840866-9 2011 SHP-1 expression as well as mutations of tyrosine-86 and tyrosine-654 to phenylalanine also significantly interfered with the association of beta-catenin with TBP. Tyrosine 41-49 catenin beta 1 Homo sapiens 141-153 20840866-11 2011 In conclusion, SHP-1 negatively regulates beta-catenin transcriptional activity i) by dephosphorylating beta-catenin on tyrosines 86 and 654, ii) by impairing its capacity to interact with the basal transcriptional factor TBP and iii) by promoting beta-catenin degradation in a GSK3beta-dependent manner. Tyrosine 120-129 catenin beta 1 Homo sapiens 42-54 20840866-11 2011 In conclusion, SHP-1 negatively regulates beta-catenin transcriptional activity i) by dephosphorylating beta-catenin on tyrosines 86 and 654, ii) by impairing its capacity to interact with the basal transcriptional factor TBP and iii) by promoting beta-catenin degradation in a GSK3beta-dependent manner. Tyrosine 120-129 catenin beta 1 Homo sapiens 104-116 20840866-11 2011 In conclusion, SHP-1 negatively regulates beta-catenin transcriptional activity i) by dephosphorylating beta-catenin on tyrosines 86 and 654, ii) by impairing its capacity to interact with the basal transcriptional factor TBP and iii) by promoting beta-catenin degradation in a GSK3beta-dependent manner. Tyrosine 120-129 catenin beta 1 Homo sapiens 104-116 21349163-5 2011 The distribution of beta-catenin was found to be regulated by Tyr/Ser phosphorylation status of this protein. Tyrosine 62-65 catenin beta 1 Homo sapiens 20-32 21686228-4 2011 Given basic biochemical observations of others, we further hypothesized that activation of the receptors altered the barrier by phosphorylating tyrosines on an essential cadherin-complex component, beta-catenin. Tyrosine 144-153 catenin beta 1 Homo sapiens 198-210 20331626-9 2010 We found that Herceptin could reduce tyrosine phosphorylation levels of ErbB2 and beta-catenin. Tyrosine 37-45 catenin beta 1 Homo sapiens 82-94 19501458-5 2009 This reorganization is associated to phosphorylation of beta-catenin on tyrosine 142 residue. Tyrosine 72-80 catenin beta 1 Homo sapiens 56-68 20372837-0 2010 Collagen type I regulates beta-catenin tyrosine phosphorylation and nuclear translocation to promote migration and proliferation of gastric carcinoma cells. Tyrosine 39-47 catenin beta 1 Homo sapiens 26-38 20372837-7 2010 Tyrosine phosphorylation of beta-catenin dissociates it from E-cadherin and actin cytoskeleton and facilitates its entry into the nucleus, where beta-catenin acts as a transcriptional activator inducing genes involved in cell proliferation. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 20372837-7 2010 Tyrosine phosphorylation of beta-catenin dissociates it from E-cadherin and actin cytoskeleton and facilitates its entry into the nucleus, where beta-catenin acts as a transcriptional activator inducing genes involved in cell proliferation. Tyrosine 0-8 catenin beta 1 Homo sapiens 145-157 20302655-6 2010 EGF treatment increased phosphorylation of beta-catenin (tyrosine) and GSK-3beta(Ser-(9), resulting in a loss of beta-catenin association with E-cadherin. Tyrosine 57-65 catenin beta 1 Homo sapiens 43-55 19911372-3 2010 Moreover, GnT-V overexpression decreased cell calcium-independent adhesion and increased the tyrosine phosphorylation level of beta-catenin, in which RPTPkappa played an important role. Tyrosine 93-101 catenin beta 1 Homo sapiens 127-139 19911372-6 2010 In addition, the increased tyrosine phosphorylation level of beta-catenin was associated with the increased nuclear level of beta-catenin and downstream signaling molecules such as c-myc and cyclin D1 that were associated with cell proliferation. Tyrosine 27-35 catenin beta 1 Homo sapiens 61-73 19911372-6 2010 In addition, the increased tyrosine phosphorylation level of beta-catenin was associated with the increased nuclear level of beta-catenin and downstream signaling molecules such as c-myc and cyclin D1 that were associated with cell proliferation. Tyrosine 27-35 catenin beta 1 Homo sapiens 125-137 19711372-1 2009 We have previously shown that culturing HepG2 cells in pH 6.6 culture medium increases the c-Src-dependent tyrosine phosphorylation of beta-catenin and induces disassembly of adherens junctions (AJs). Tyrosine 107-115 catenin beta 1 Homo sapiens 135-147 19101982-14 2009 Finally, FL-HCC cases display a unique up-regulation of tyrosine-phosphorylated-beta-catenin, suggesting robust receptor tyrosine kinase signaling in this tumor type. Tyrosine 56-64 catenin beta 1 Homo sapiens 80-92 19661059-6 2009 Pleiotrophin increased the tyrosine phosphorylation of beta-catenin, promoted beta-catenin translocation into the nucleus, and activated T cell factor/lymphoid enhancer factor transcription factors. Tyrosine 27-35 catenin beta 1 Homo sapiens 55-67 19633358-5 2009 Additionally, treatment with VEGF caused ROS-dependent tyrosine phosphorylation of both vascular-endothelial (VE)-cadherin and beta-catenin. Tyrosine 55-63 catenin beta 1 Homo sapiens 127-139 19633358-8 2009 Collectively, these data suggest that VEGF leads to a Rac-mediated generation of ROS, which, in turn, elevates the tyrosine phosphorylation of VE-cadherin and beta-catenin, ultimately regulating adherens junction integrity. Tyrosine 115-123 catenin beta 1 Homo sapiens 159-171 19336574-3 2009 Herein, we describe for the first time that UVA-mediated EGFR activation results in beta-catenin tyrosine phosphorylation at the Y654 residue responsible for the dissociation of E-cadherin/alpha-catenin/beta-catenin complexes. Tyrosine 97-105 catenin beta 1 Homo sapiens 84-96 19336574-3 2009 Herein, we describe for the first time that UVA-mediated EGFR activation results in beta-catenin tyrosine phosphorylation at the Y654 residue responsible for the dissociation of E-cadherin/alpha-catenin/beta-catenin complexes. Tyrosine 97-105 catenin beta 1 Homo sapiens 203-215 19026486-4 2009 c-Src is associated with beta-catenin/E-cadherin complexes and beta-catenin tyrosine phosphorylation is enhanced. Tyrosine 76-84 catenin beta 1 Homo sapiens 63-75 19026486-5 2009 Blocking c-Src tyrosine kinase activity decreased beta-catenin tyrosine phosphorylation and restored localization of beta-catenin and E-cadherin at cell-cell junctions. Tyrosine 15-23 catenin beta 1 Homo sapiens 50-62 19026486-5 2009 Blocking c-Src tyrosine kinase activity decreased beta-catenin tyrosine phosphorylation and restored localization of beta-catenin and E-cadherin at cell-cell junctions. Tyrosine 15-23 catenin beta 1 Homo sapiens 117-129 19639172-0 2009 Tyrosine-phosphorylation of the 12th armadillo-repeat of beta-catenin is associated with cadherin dysfunction in human cancer. Tyrosine 0-8 catenin beta 1 Homo sapiens 57-69 19639172-1 2009 Tyrosine phosphorylation of beta-catenin, an intracytoplasmic cadherin-binding protein, causes disruption of the cadherin-mediated cell adhesion system in cancer cells. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 19639172-3 2009 We produced a monoclonal antibody, 4G7, which recognizes a phosphorylated-tyrosine residue (Tyr-654) located at arm12 of beta-catenin. Tyrosine 74-82 catenin beta 1 Homo sapiens 121-133 19639172-3 2009 We produced a monoclonal antibody, 4G7, which recognizes a phosphorylated-tyrosine residue (Tyr-654) located at arm12 of beta-catenin. Tyrosine 92-95 catenin beta 1 Homo sapiens 121-133 19033391-6 2008 Downregulation of N-cadherin levels in the plasma membrane was accompanied by a direct interaction of the EGFR-HER2 and N-cadherin-beta-catenin complexes, leading to tyrosine phosphorylation of beta-catenin. Tyrosine 166-174 catenin beta 1 Homo sapiens 131-143 19033391-6 2008 Downregulation of N-cadherin levels in the plasma membrane was accompanied by a direct interaction of the EGFR-HER2 and N-cadherin-beta-catenin complexes, leading to tyrosine phosphorylation of beta-catenin. Tyrosine 166-174 catenin beta 1 Homo sapiens 194-206 18553167-6 2008 Furthermore, enhanced binding of E-cadheirn with beta-catenin as well as alpha-catenin were observed in Fut8-transfectants, and reduction of tyrosine 654 phosphorylation on beta-catenin and its transcriptional activity were also noted at the same time. Tyrosine 141-149 catenin beta 1 Homo sapiens 173-185 19047464-6 2008 Fer or SHP-2 depletion results in elevated tyrosine phosphorylation of beta-catenin. Tyrosine 43-51 catenin beta 1 Homo sapiens 71-83 17637199-4 2007 Immunoblotting results indicated that TNF-alpha exposure resulted in tyrosine phosphorylation of junctional proteins such as vascular endothelial cadherin and beta-catenin, which was attenuated by ESM and its active ingredients DSS and Sal B. Tyrosine 69-77 catenin beta 1 Homo sapiens 159-171 18423982-4 2008 The acidic pHe-induced c-Src activation increased tyrosine phosphorylation of beta-catenin and decreased the amount of beta-catenin-associated E-cadherin. Tyrosine 50-58 catenin beta 1 Homo sapiens 78-90 18664491-1 2008 Tyrosine phosphorylation of beta-catenin, a component of adhesion complexes and of the Wnt pathway, affects cell adhesion, migration and gene transcription. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 18395972-4 2008 Furthermore, CD82 reduced tyrosine phosphorylation of beta-catenin on HGF stimulation. Tyrosine 26-34 catenin beta 1 Homo sapiens 54-66 17979184-8 2008 Analysis of the composition of adherens junctions (AJs) revealed that removal of N-glycans on E-cadherin resulted in elevated tyrosine phosphorylation level of beta-catenin and reduced beta- and alpha-catenins at AJs. Tyrosine 126-134 catenin beta 1 Homo sapiens 160-172 17949810-4 2008 Nuclear accumulation of beta-catenin is upregulated by its tyrosine phosphorylation, a process that can be exacerbated by deregulated expression of oncogenic tyrosine kinases. Tyrosine 59-67 catenin beta 1 Homo sapiens 24-36 17949810-6 2008 Beta-catenin was tyrosine-phosphorylated in cells with KIT activated by either gain-of-function mutation or incubation with the KIT ligand stem cell factor. Tyrosine 17-25 catenin beta 1 Homo sapiens 0-12 17949810-7 2008 Beta-catenin tyrosine phosphorylation depended on KIT activity but not on PI3K-AKT activation. Tyrosine 13-21 catenin beta 1 Homo sapiens 0-12 17949810-8 2008 Tyrosine phosphorylation of beta-catenin was associated with its nuclear localization and enhanced transcription of target genes c-myc and cyclin D1. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 17949810-9 2008 Endogenous KIT and beta-catenin were found to associate in mast cell leukemia cells, and in vitro kinase assay demonstrated that active KIT phosphorylates tyrosine residues of beta-catenin directly. Tyrosine 155-163 catenin beta 1 Homo sapiens 19-31 17949810-9 2008 Endogenous KIT and beta-catenin were found to associate in mast cell leukemia cells, and in vitro kinase assay demonstrated that active KIT phosphorylates tyrosine residues of beta-catenin directly. Tyrosine 155-163 catenin beta 1 Homo sapiens 176-188 18316596-5 2008 We show that RET binds to, and tyrosine phosphorylates, beta-catenin and show that the interaction between RET and beta-catenin can be direct and independent of cytoplasmic kinases, such as SRC. Tyrosine 31-39 catenin beta 1 Homo sapiens 56-68 18316596-5 2008 We show that RET binds to, and tyrosine phosphorylates, beta-catenin and show that the interaction between RET and beta-catenin can be direct and independent of cytoplasmic kinases, such as SRC. Tyrosine 31-39 catenin beta 1 Homo sapiens 115-127 18316596-6 2008 As a result of RET-mediated tyrosine phosphorylation, beta-catenin escapes cytosolic down-regulation by the adenomatous polyposis coli/Axin/glycogen synthase kinase-3 complex and accumulates in the nucleus, where it can stimulate beta-catenin-specific transcriptional programs in a RET-dependent fashion. Tyrosine 28-36 catenin beta 1 Homo sapiens 54-66 18316596-6 2008 As a result of RET-mediated tyrosine phosphorylation, beta-catenin escapes cytosolic down-regulation by the adenomatous polyposis coli/Axin/glycogen synthase kinase-3 complex and accumulates in the nucleus, where it can stimulate beta-catenin-specific transcriptional programs in a RET-dependent fashion. Tyrosine 28-36 catenin beta 1 Homo sapiens 230-242 17822871-7 2007 N3IC stimulated Wnt-independent T-cell factor (TCF, the target transcription factor in the Wnt pathway) activation which was associated with increased Tyr-142 phosphorylation of beta-catenin. Tyrosine 151-154 catenin beta 1 Homo sapiens 178-190 18231728-0 2007 Effective penetration of cell-permeable peptide mimic of tyrosine residue 654 domain of beta-catenin into human renal tubular epithelial cells. Tyrosine 57-65 catenin beta 1 Homo sapiens 88-100 18231728-1 2007 Phosphorylation of beta-catenin tyrosine residue 654 plays an important role in the epithelial to myofibroblast transition (EMT). Tyrosine 32-40 catenin beta 1 Homo sapiens 19-31 18231728-2 2007 Introducing mimic peptide of tyrosine residue 654 domain of beta-catenin into cells may influence phosphorylation of beta-catenin tyrosine residue 654. Tyrosine 29-37 catenin beta 1 Homo sapiens 60-72 18231728-2 2007 Introducing mimic peptide of tyrosine residue 654 domain of beta-catenin into cells may influence phosphorylation of beta-catenin tyrosine residue 654. Tyrosine 29-37 catenin beta 1 Homo sapiens 117-129 18231728-2 2007 Introducing mimic peptide of tyrosine residue 654 domain of beta-catenin into cells may influence phosphorylation of beta-catenin tyrosine residue 654. Tyrosine 130-138 catenin beta 1 Homo sapiens 60-72 18231728-2 2007 Introducing mimic peptide of tyrosine residue 654 domain of beta-catenin into cells may influence phosphorylation of beta-catenin tyrosine residue 654. Tyrosine 130-138 catenin beta 1 Homo sapiens 117-129 18231728-4 2007 A tyrosine 654 residue domain mimic peptide of beta-catenin (PM) with fused penetratin was constructed, purified and then detected for the penetration of the mimic peptide into human renal tubular epithelial cells (HK-2). Tyrosine 2-10 catenin beta 1 Homo sapiens 47-59 18231728-6 2007 It is concluded that a cell-permeable peptides mimic of tyrosine residue 654 domain of beta-catenin was successfully obtained, which may provide a useful reagent for interfering the human renal tubular epithelial-mesenchymal transition. Tyrosine 56-64 catenin beta 1 Homo sapiens 87-99 17851558-0 2007 FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells. Tyrosine 28-36 catenin beta 1 Homo sapiens 15-27 17851558-3 2007 Tyrosine phosphorylation of beta-catenin has been shown to promote its nuclear localization. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 17851558-10 2007 Finally, FLT3 inhibitor decreased tyrosine phosphorylation of beta-catenin in leukemia cells obtained from FLT3-ITD-positive AML patients. Tyrosine 34-42 catenin beta 1 Homo sapiens 62-74 17851558-11 2007 These data demonstrate that FLT3 activation induces beta-catenin tyrosine phosphorylation and nuclear localization, and thus suggest a mechanism for the association of FLT3 activation and beta-catenin oncogeneic signaling in AML. Tyrosine 65-73 catenin beta 1 Homo sapiens 52-64 17851558-11 2007 These data demonstrate that FLT3 activation induces beta-catenin tyrosine phosphorylation and nuclear localization, and thus suggest a mechanism for the association of FLT3 activation and beta-catenin oncogeneic signaling in AML. Tyrosine 65-73 catenin beta 1 Homo sapiens 188-200 17618275-4 2007 Complex formation results in Abl-mediated phosphorylation of beta-catenin on tyrosine 489, leading to a decrease in its affinity for N-cadherin, loss of N-cadherin function, and targeting of phospho-Y489-beta-catenin to the nucleus. Tyrosine 77-85 catenin beta 1 Homo sapiens 61-73 17618275-4 2007 Complex formation results in Abl-mediated phosphorylation of beta-catenin on tyrosine 489, leading to a decrease in its affinity for N-cadherin, loss of N-cadherin function, and targeting of phospho-Y489-beta-catenin to the nucleus. Tyrosine 77-85 catenin beta 1 Homo sapiens 204-216 18842495-12 2008 p130Cas may be involved in alterating the structure and function of E-cadherin/beta-catenin, by regulating tyrosine phosphorylation via the p130Cas-Src signal pathway. Tyrosine 107-115 catenin beta 1 Homo sapiens 79-91 18673450-4 2008 Previously, we have shown that among targets of tyrosine phosphorylation are beta-catenin, extracellular signal-regulated kinase 1/2 and the non-receptor tyrosine kinase Src. Tyrosine 48-56 catenin beta 1 Homo sapiens 77-89 18593907-6 2008 Our results show that FGF19 increases tyrosine phosphorylation of beta-catenin and causes loss of beta-catenin-E-cadherin binding. Tyrosine 38-46 catenin beta 1 Homo sapiens 66-78 18566211-3 2008 Tyrosine phosphorylation of beta-catenin dissociates it from E-cadherin and facilitates its entry into the nucleus, where beta-catenin acts as a transcriptional activator inducing genes involved in cell proliferation. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 18566211-3 2008 Tyrosine phosphorylation of beta-catenin dissociates it from E-cadherin and facilitates its entry into the nucleus, where beta-catenin acts as a transcriptional activator inducing genes involved in cell proliferation. Tyrosine 0-8 catenin beta 1 Homo sapiens 122-134 18566211-9 2008 Further, Src-mediated tyrosine phosphorylation of beta-catenin is a major mechanism for decreased beta-catenin interaction with E-cadherin in alpha-catenin-null cells. Tyrosine 22-30 catenin beta 1 Homo sapiens 50-62 18566211-9 2008 Further, Src-mediated tyrosine phosphorylation of beta-catenin is a major mechanism for decreased beta-catenin interaction with E-cadherin in alpha-catenin-null cells. Tyrosine 22-30 catenin beta 1 Homo sapiens 98-110 18065418-9 2008 Inhibition of CaR expression blocked the Ca(2+)(o)-induced tyrosine phosphorylation of beta-, gamma-, and p120-catenin, PI3K, and the tyrosine kinase Fyn and the association of Fyn with E-cadherin and PI3K. Tyrosine 59-67 catenin beta 1 Homo sapiens 87-118 18173748-0 2008 Defining the function of beta-catenin tyrosine phosphorylation in cadherin-mediated cell-cell adhesion. Tyrosine 38-46 catenin beta 1 Homo sapiens 25-37 18173748-1 2008 Beta-catenin is a key protein in cadherin-catenin cell adhesion complex and its tyrosine phosphorylation is believed to cause destruction of junctional apparatus. Tyrosine 80-88 catenin beta 1 Homo sapiens 0-12 18173748-4 2008 To directly evaluate the effect of beta-catenin tyrosine phosphorylation in cell adhesion, we utilized F9 cells in which expression of endogenous beta-catenin and its closely related protein plakoglobin were completely shut down. Tyrosine 48-56 catenin beta 1 Homo sapiens 35-47 18173748-6 2008 We show that beta-catenin with phosphorylation mutation at 654th tyrosine forms functional cadherin-catenin complex to mediate strong cadherin-mediated cell adhesion. Tyrosine 65-73 catenin beta 1 Homo sapiens 13-25 18173748-10 2008 We also demonstrate that tyrosine phosphorylation of beta-catenin might regulate cadherin-mediated cell adhesion in a more complicated way than previously expected. Tyrosine 25-33 catenin beta 1 Homo sapiens 53-65 17785844-3 2007 Numerous lines of evidence demonstrate that tyrosine phosphorylation of adherens junction proteins, such as vascular endothelial cadherin (VE-cadherin) and beta-catenin, correlates with the disassembly of junctions. Tyrosine 44-52 catenin beta 1 Homo sapiens 156-168 17785844-6 2007 Using phospho-specific Abs, we show that engagement of ICAM-1 induces phosphorylation of VE-cadherin on tyrosines 658 and 731, which correspond to the p120-catenin and beta-catenin binding sites, respectively. Tyrosine 104-113 catenin beta 1 Homo sapiens 168-180 17087658-3 2007 Treatment of cell monolayers with acetaldehyde induced redistribution of E-cadherin and beta-catenin from the intercellular junctions by a tyrosine phosphorylation-dependent mechanism. Tyrosine 139-147 catenin beta 1 Homo sapiens 88-100 17451824-5 2007 In addition, an induction of tyrosine phosphorylation of numerous cellular proteins including ZO-1, E-cadherin, and beta-catenin, components of tight and adherens junctions, was observed. Tyrosine 29-37 catenin beta 1 Homo sapiens 116-128 17306850-6 2007 In addition, concentration-dependent increases in tyrosine phosphorylation (PY) of beta-catenin and activation of protein kinase Calpha (PKCalpha) were observed. Tyrosine 50-58 catenin beta 1 Homo sapiens 83-95 17318191-0 2007 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. Tyrosine 72-80 catenin beta 1 Homo sapiens 19-31 17318191-2 2007 Although beta-catenin can be tyrosine (Y)-phosphorylated, the occurrence and biological relevance of this covalent modification in Bcr-Abl-associated leukemogenesis is unknown. Tyrosine 29-37 catenin beta 1 Homo sapiens 9-21 17332337-6 2007 We also found a strong up-regulation of tyrosine phosphorylation in beta-catenin and p120/delta-catenin in the Met-amplified EBC-1 and H1993 cell lines. Tyrosine 40-48 catenin beta 1 Homo sapiens 68-80 17087658-5 2007 Acetaldehyde treatment resulted in phosphorylation of beta-catenin on tyrosine residues, and abolished the interaction of beta-catenin with E-cadherin by a tyrosine kinase-dependent mechanism. Tyrosine 70-78 catenin beta 1 Homo sapiens 54-66 17087658-7 2007 Pairwise binding studies using purified proteins indicated that the direct interaction between E-cadherin and beta-catenin was reduced by tyrosine phosphorylation of beta-catenin, but was unaffected by tyrosine phosphorylation of E-cadherin-C. Tyrosine 138-146 catenin beta 1 Homo sapiens 110-122 17087658-7 2007 Pairwise binding studies using purified proteins indicated that the direct interaction between E-cadherin and beta-catenin was reduced by tyrosine phosphorylation of beta-catenin, but was unaffected by tyrosine phosphorylation of E-cadherin-C. Tyrosine 138-146 catenin beta 1 Homo sapiens 166-178 17087658-10 2007 Acetaldehyde increased the phosphorylation of beta-catenin on Tyr-331, Tyr-333, Tyr-654 and Tyr-670. Tyrosine 62-65 catenin beta 1 Homo sapiens 46-58 17087658-10 2007 Acetaldehyde increased the phosphorylation of beta-catenin on Tyr-331, Tyr-333, Tyr-654 and Tyr-670. Tyrosine 71-74 catenin beta 1 Homo sapiens 46-58 17087658-10 2007 Acetaldehyde increased the phosphorylation of beta-catenin on Tyr-331, Tyr-333, Tyr-654 and Tyr-670. Tyrosine 71-74 catenin beta 1 Homo sapiens 46-58 17087658-10 2007 Acetaldehyde increased the phosphorylation of beta-catenin on Tyr-331, Tyr-333, Tyr-654 and Tyr-670. Tyrosine 71-74 catenin beta 1 Homo sapiens 46-58 16953230-3 2007 Hepatocyte growth factor (HGF) stimulation prompts beta-catenin tyrosine phosphorylation and dissociation from Met, and upregulates beta-catenin expression via the phosphatidylinositol 3-kinase pathway in conditions that mimic those found by the invading and metastasizing cells. Tyrosine 64-72 catenin beta 1 Homo sapiens 51-63 16574648-3 2006 Tyrosine phosphorylation of beta-catenin was shown to decrease its binding to E-cadherin, leading to decreased cell adhesion and increased beta-catenin signaling. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 17113272-4 2007 Recently, the second vertebrate homologue of Legless, BCL9-2 (or B9L), was characterized and proposed to mediate Wnt signaling in a Pygopus-independent manner, by binding to a Tyrosine-142-phosphorylated form of beta-catenin. Tyrosine 176-184 catenin beta 1 Homo sapiens 212-224 17143483-2 2007 beta-catenin is a substrate of this kinase, and HER2-dependent phosphorylation of tyrosine 654 leads to dissociation of the E-cadherin-beta-catenin membrane complex and increased Wnt signaling. Tyrosine 82-90 catenin beta 1 Homo sapiens 0-12 17143483-2 2007 beta-catenin is a substrate of this kinase, and HER2-dependent phosphorylation of tyrosine 654 leads to dissociation of the E-cadherin-beta-catenin membrane complex and increased Wnt signaling. Tyrosine 82-90 catenin beta 1 Homo sapiens 135-147 17178895-6 2006 Furthermore, we show that Ron overexpression leads to receptor phosphorylation and is associated with elevated levels of tyrosine phosphorylated beta-catenin and the up-regulation of genes, including cyclin D1 and c-myc, which are associated with poor prognosis in patients with human breast cancers. Tyrosine 121-129 catenin beta 1 Homo sapiens 145-157 16767162-7 2006 Tyr phosphorylation of alpha-catenin enhances its translocation to the plasma membrane and its interaction with beta-catenin, leading to enhanced actin polymerization and stabilization of adherens junction-mediated intercellular adhesion, a phenomenon commensurate with loss of the transformation phenotype. Tyrosine 0-3 catenin beta 1 Homo sapiens 112-124 17114345-6 2006 FGF1-induced tyrosine phosphorylation of MUC1 was associated with increased binding of MUC1 to beta-catenin and targeting of MUC1 and beta-catenin to the nucleus. Tyrosine 13-21 catenin beta 1 Homo sapiens 95-107 17114345-6 2006 FGF1-induced tyrosine phosphorylation of MUC1 was associated with increased binding of MUC1 to beta-catenin and targeting of MUC1 and beta-catenin to the nucleus. Tyrosine 13-21 catenin beta 1 Homo sapiens 134-146 17030184-5 2006 This effect is preceded by GTN-induced tyrosine nitration of beta-catenin, together with its dephosphorylation on serine 33, 37, and 45 and threonine 41. Tyrosine 39-47 catenin beta 1 Homo sapiens 61-73 16831887-4 2006 We demonstrate that BDNF"s ability to mobilize synaptic vesicle clusters depends on the dissociation of cadherin-beta-catenin adhesion complexes that occurs after tyrosine phosphorylation of beta-catenin. Tyrosine 163-171 catenin beta 1 Homo sapiens 113-125 16574648-3 2006 Tyrosine phosphorylation of beta-catenin was shown to decrease its binding to E-cadherin, leading to decreased cell adhesion and increased beta-catenin signaling. Tyrosine 0-8 catenin beta 1 Homo sapiens 139-151 16489032-0 2006 SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. Tyrosine 101-109 catenin beta 1 Homo sapiens 129-141 16678166-5 2006 Following RAW/AMCM treatment, enhanced activation of c-Src was seen prior to increased tyrosine phosphorylation of beta-catenin, and this led to the destabilization of adherens junctions. Tyrosine 87-95 catenin beta 1 Homo sapiens 115-127 16651417-4 2006 This is due to the increased tyrosine phosphorylation of the complex protein beta-catenin, which correlates with collagen type I-dependent activation of the focal adhesion kinase and its association with the E-cadherin complex. Tyrosine 29-37 catenin beta 1 Homo sapiens 77-89 16371504-7 2006 Although five phospho-tyrosine residues can be identified on the N-cadherin cytoplasmic domain by mass spectrometry, site-specific mutagenesis indicates that Tyr-860 is the critical amino acid involved in beta-catenin binding. Tyrosine 158-161 catenin beta 1 Homo sapiens 205-217 16371504-9 2006 Together, the data suggest a novel role for tyrosine phosphorylation of N-cadherin by Src family kinases in the regulation of beta-catenin association during transendothelial migration of melanoma cells. Tyrosine 44-52 catenin beta 1 Homo sapiens 126-138 16489032-3 2006 In this report, pp60(c-Src) kinase and beta-catenin were found physically associated and constitutively activated on tyrosine residues in human colorectal cancer cells. Tyrosine 117-125 catenin beta 1 Homo sapiens 39-51 16489032-4 2006 The use of specific small-interfering RNAs (siRNA) validated pp60(c-Src) as the major kinase responsible for beta-catenin tyrosine phosphorylation in colorectal cancer. Tyrosine 122-130 catenin beta 1 Homo sapiens 109-121 16489032-10 2006 Thus, our results show that SKI-606 operates a switch between the transcriptional and adhesive function of beta-catenin by inhibiting its pp60(c-Src)-dependent tyrosine phosphorylation; this could constitute a new therapeutic target in colorectal cancer. Tyrosine 160-168 catenin beta 1 Homo sapiens 107-119 16211085-8 2005 It phosphorylates Bcr in the first exon sequence on tyrosines, which abrogates the binding of Bcr to beta-catenin. Tyrosine 52-61 catenin beta 1 Homo sapiens 101-113 16343437-4 2006 We determined that CIP4-V increased the beta-catenin tyrosine phosphorylation levels that mediate Fer/Fyn tyrosine kinases and induced beta-catenin mistrafficking from cell membrane to cytoplasmic aggresome. Tyrosine 53-61 catenin beta 1 Homo sapiens 40-52 16080193-5 2006 Additionally, TamR cells had increased levels of tyrosine-phosphorylated beta-catenin, whilst serine/threonine-phosphorylated beta-catenin was decreased. Tyrosine 49-57 catenin beta 1 Homo sapiens 73-85 16080193-7 2006 Inhibition of EGFR kinase activity in TamR cells reduced beta-catenin tyrosine phosphorylation, increased beta-catenin-E-cadherin association and promoted cell-cell adhesion. Tyrosine 70-78 catenin beta 1 Homo sapiens 57-69 16027153-0 2005 Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state. Tyrosine 0-8 catenin beta 1 Homo sapiens 70-82 16219695-4 2005 TGFbeta(1) treatment enhanced tyrosine phosphorylation of alpha- and beta-catenin, which resulted in dissociation of the E-cadherin/catenin complex from the actin cytoskeleton and reduced cell-cell adhesion. Tyrosine 30-38 catenin beta 1 Homo sapiens 69-81 16219695-6 2005 TGFbeta(1) treatment reduced the amount of PTEN bound to beta-catenin and markedly increased the tyrosine phosphorylation of beta-catenin. Tyrosine 97-105 catenin beta 1 Homo sapiens 125-137 16099633-0 2005 The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. Tyrosine 48-56 catenin beta 1 Homo sapiens 94-106 16099633-2 2005 The binding of beta-catenin to these partners is regulated by phosphorylation of at least three critical tyrosine residues. Tyrosine 105-113 catenin beta 1 Homo sapiens 15-27 16027153-3 2005 We show here that tyrosine phosphorylation of the adherens junction protein VE-cadherin at two critical tyrosines, Tyr-658 and Tyr-731, via tyrosine kinase activation or phosphatase inactivation was sufficient to prevent the binding of p120- and beta-catenin, respectively, to the cytoplasmic tail of VE-cadherin. Tyrosine 18-26 catenin beta 1 Homo sapiens 246-258 16027153-3 2005 We show here that tyrosine phosphorylation of the adherens junction protein VE-cadherin at two critical tyrosines, Tyr-658 and Tyr-731, via tyrosine kinase activation or phosphatase inactivation was sufficient to prevent the binding of p120- and beta-catenin, respectively, to the cytoplasmic tail of VE-cadherin. Tyrosine 115-118 catenin beta 1 Homo sapiens 246-258 15718285-4 2005 Acetaldehyde reduced the protein tyrosine phosphatase activity, thereby increasing the tyrosine phosphorylation of occludin, E-cadherin, and beta-catenin. Tyrosine 33-41 catenin beta 1 Homo sapiens 141-153 15987741-6 2005 Immunolocalization and immunoprecipitation studies indicate that N-cadherin became tyrosine-phosphorylated, resulting in the dissociation of beta-catenin from these contact regions. Tyrosine 83-91 catenin beta 1 Homo sapiens 141-153 15925565-5 2005 In previous studies, we demonstrated that beta-catenin and beta-adducin are targets of the PTN/RPTPbeta/zeta-signaling pathway and defined the mechanisms through which tyrosine phosphorylation of beta-catenin and beta-adducin disrupts cytoskeletal protein complexes. Tyrosine 168-176 catenin beta 1 Homo sapiens 42-54 15980970-5 2005 Two previously described beta-catenin mutations in codon 33 TCT(Ser) > TGT(Cys) and codon 37 TCT(Ser) > TTT(Phe), whereas three novel mutations in codon 41 ACC(Thr) > ATC(Ile), codon 33 TCT(Ser) > TAT(Tyr) and codon 32 GAC(Asp) > AAC(Asn) were observed. Tyrosine 213-216 catenin beta 1 Homo sapiens 25-37 15898100-5 2005 One of the targets of tyrosine phosphorylation turned out to be the adherens junction protein beta-catenin. Tyrosine 22-30 catenin beta 1 Homo sapiens 94-106 15898100-6 2005 Phosphorylation of beta-catenin on tyrosine residues caused its subcellular redistribution and its dissociation from cadherin and alpha-catenin as shown by coimmunoprecipitation studies. Tyrosine 35-43 catenin beta 1 Homo sapiens 19-31 15778498-0 2005 Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation. Tyrosine 13-21 catenin beta 1 Homo sapiens 116-128 15778498-5 2005 Moreover, VE-cadherin-associated beta-catenin is tyrosine-phosphorylated upon loss of cell-cell contact. Tyrosine 49-57 catenin beta 1 Homo sapiens 33-45 15778498-8 2005 These results implicate Pyk2 in the reduced cell-cell adhesion induced by the Rac-mediated production of ROS through the tyrosine phosphorylation of beta-catenin. Tyrosine 121-129 catenin beta 1 Homo sapiens 149-161 15797859-8 2005 In addition, inactivation of Src, MKK3, p38, or the EGF receptor blocked tyrosine phosphorylation of beta-catenin, a key signaling intermediate that is involved in the epithelial-mesenchymal transition and vimentin expression. Tyrosine 73-81 catenin beta 1 Homo sapiens 101-113 15925565-5 2005 In previous studies, we demonstrated that beta-catenin and beta-adducin are targets of the PTN/RPTPbeta/zeta-signaling pathway and defined the mechanisms through which tyrosine phosphorylation of beta-catenin and beta-adducin disrupts cytoskeletal protein complexes. Tyrosine 168-176 catenin beta 1 Homo sapiens 196-208 15371335-4 2004 The switch between beta-catenin"s adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of beta-catenin, which favors BCL9-2 binding and precludes interaction with alpha-catenin. Tyrosine 108-111 catenin beta 1 Homo sapiens 19-31 15371335-4 2004 The switch between beta-catenin"s adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of beta-catenin, which favors BCL9-2 binding and precludes interaction with alpha-catenin. Tyrosine 108-111 catenin beta 1 Homo sapiens 119-131 15004225-6 2004 Our results show that low concentrations of DCA (5 and 50 microM) significantly increase tyrosine phosphorylation of beta-catenin, induce urokinase-type plasminogen activator, uPAR, and cyclin D1 expression and enhance colon cancer cell proliferation and invasiveness. Tyrosine 89-97 catenin beta 1 Homo sapiens 117-129 12808048-7 2003 Consistent with this, ectopic expression of the dominant negative mutant caused an increase in tyrosine phosphorylation of beta-catenin, demonstrating that Pez regulates the level of tyrosine phosphorylation of adherens junction proteins, including beta-catenin. Tyrosine 95-103 catenin beta 1 Homo sapiens 123-135 14675348-3 2003 The tyrosine phosphorylation of alpha- and beta-catenin and FAK were examined by an immunoprecipitation. Tyrosine 4-12 catenin beta 1 Homo sapiens 43-55 14675348-4 2003 The expressions of alpha- and beta-catenin and E-cadherin were reduced in cervical carcinoma, and the tyrosine phosphorylation of alpha- and beta-catenin in cervical carcinoma was higher than in normal cervix and carcinoma in situ of cervix. Tyrosine 102-110 catenin beta 1 Homo sapiens 30-42 12927518-6 2003 IpaC-associated beta-catenin was phosphorylated at tyrosine residues. Tyrosine 51-59 catenin beta 1 Homo sapiens 16-28 12880414-2 2003 To investigate the existence of adherens-junction-mediated signaling, we used peroxovanadate to tyrosine phosphorylate plakoglobin and beta-catenin and to dissociate adherens junctions. Tyrosine 96-104 catenin beta 1 Homo sapiens 135-147 12880414-5 2003 Tyrosine phosphorylation of plakoglobin and beta-catenin resulted in their rapid translocation from the cell membrane to the nucleus. Tyrosine 0-8 catenin beta 1 Homo sapiens 44-56 15077188-7 2004 STAT3-Y705F-transfected HCT8/S11 cells display an increased tyrosine phosphorylation of the cell-cell adhesion regulator beta-catenin and its dissociation from the invasion suppressor E-cadherin at cell-cell contacts. Tyrosine 60-68 catenin beta 1 Homo sapiens 121-133 15031118-4 2004 FGF2 increases beta-catenin signaling through several different mechanisms including increased expression of beta-catenin mRNA, increased nuclear translocation of beta-catenin, increased phosphorylation of GSK-3beta, and tyrosine phosphorylation of beta-catenin. Tyrosine 221-229 catenin beta 1 Homo sapiens 15-27 15500294-3 2004 Results showed that retinoic acid treatment increases the amount of beta-catenin bound to E-cadherin by decreasing its tyrosine-phosphorylation level. Tyrosine 119-127 catenin beta 1 Homo sapiens 68-80 14642088-8 2003 We also observed that the tyrosine phosphorylation of p120(ctn) stimulated by EGF was accompanied by the nuclear translocation of p120(ctn); the similar translocation was also observed in beta-catenin after EGF stimulation. Tyrosine 26-34 catenin beta 1 Homo sapiens 188-200 14517306-0 2003 Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. Tyrosine 0-8 catenin beta 1 Homo sapiens 146-158 14517306-3 2003 Association of beta-catenin with E-cadherin and alpha-catenin is regulated by phosphorylation of specific tyrosine residues; modification of beta-catenin Tyr654 and Tyr142 decreases binding to E-cadherin and alpha-catenin, respectively. Tyrosine 106-114 catenin beta 1 Homo sapiens 15-27 14517306-5 2003 Protein tyrosine kinases present distinct specificities on beta-catenin and plakoglobin, and phosphorylation of beta-catenin-equivalent Tyr residues of plakoglobin affects its interaction with components of desmosomes or adherens junctions differently. Tyrosine 136-139 catenin beta 1 Homo sapiens 112-124 12841864-9 2003 At the invading front of cancers, the E-cadherin cell adhesion system is inactivated by tyrosine phosphorylation of beta-catenin; an oncogene product, c-erbB-2 protein, is found to associate directly with beta-catenin. Tyrosine 88-96 catenin beta 1 Homo sapiens 116-128 12841864-9 2003 At the invading front of cancers, the E-cadherin cell adhesion system is inactivated by tyrosine phosphorylation of beta-catenin; an oncogene product, c-erbB-2 protein, is found to associate directly with beta-catenin. Tyrosine 88-96 catenin beta 1 Homo sapiens 205-217 12808048-7 2003 Consistent with this, ectopic expression of the dominant negative mutant caused an increase in tyrosine phosphorylation of beta-catenin, demonstrating that Pez regulates the level of tyrosine phosphorylation of adherens junction proteins, including beta-catenin. Tyrosine 183-191 catenin beta 1 Homo sapiens 123-135 12740122-10 2003 These results suggest that Cdk5 activity regulates the affinity of beta-catenin for cadherin by changing the phosphorylation level of beta-catenin Tyr-654. Tyrosine 147-150 catenin beta 1 Homo sapiens 67-79 12802275-6 2003 Immunoprecipitation of beta-catenin from seven patient lesions showed the protein to be tyrosine phosphorylated. Tyrosine 88-96 catenin beta 1 Homo sapiens 23-35 12740122-10 2003 These results suggest that Cdk5 activity regulates the affinity of beta-catenin for cadherin by changing the phosphorylation level of beta-catenin Tyr-654. Tyrosine 147-150 catenin beta 1 Homo sapiens 134-146 12360290-3 2002 Loss of N-cadherin-mediated adhesion is accompanied by tyrosine phosphorylation of beta-catenin and its loss from the N-cadherin complex, concomitant with the formation of a supramolecular complex containing Robo, Abelson (Abl) kinase and N-cadherin. Tyrosine 55-63 catenin beta 1 Homo sapiens 83-95 12706873-7 2003 Thus, our findings suggest that tyrosine phosphorylation may play an important role in regulating beta-catenin signaling activity, and inhibition of this signaling pathway by STI-571 may be further explored as an important target for alternative/adjuvant treatments for a broader range of human cancer. Tyrosine 32-40 catenin beta 1 Homo sapiens 98-110 12500177-12 2002 Tyrosine phosphorylation of HGFR and beta-catenin occurs in the primary or passaged RPE cultures or proliferative ARPE-19 cells, but not freshly isolated RPE or differentiated ARPE-19 cells. Tyrosine 0-8 catenin beta 1 Homo sapiens 37-49 12388068-5 2002 Furthermore, neutrophil stimulation resulted in association of Src with the endothelial junction protein beta-catenin and beta-catenin tyrosine phosphorylation. Tyrosine 135-143 catenin beta 1 Homo sapiens 122-134 12169098-0 2002 Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress. Tyrosine 0-8 catenin beta 1 Homo sapiens 74-86 12169098-9 2002 These results show that oxidative stress induces tyrosine phosphorylation and cellular redistribution of occludin-ZO-1 and E-cadherin-beta-catenin complexes by a tyrosine-kinase-dependent mechanism. Tyrosine 49-57 catenin beta 1 Homo sapiens 134-146 12438242-4 2002 In particular, cell-cell adhesion can be negatively regulated through the tyrosine phosphorylation of beta-catenin. Tyrosine 74-82 catenin beta 1 Homo sapiens 102-114 12535670-8 2003 Tyrosine phosphorylation of beta-catenin and focal adhesion kinase was increased in endothelial cells overexpressing nonphosphorylatable PECAM-1. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 12856716-0 2003 Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin. Tyrosine 87-95 catenin beta 1 Homo sapiens 111-123 12856716-5 2003 Tyrosine-phosphorylated beta-catenin was constitutively associated with c-Met in the more metastatic cells, but was inducible only after HGF addition in the less metastatic cells. Tyrosine 0-8 catenin beta 1 Homo sapiens 24-36 12501215-6 2002 Tyrosine phosphorylation of beta-catenin by EGF or active SrcY527F did not disrupt the formation of the PCP-2-beta-catenin complex, while PCP-2 in this complex could cause a significant reduction in the phosphorylation level in beta-catenin. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 12176729-0 2002 Polyamines regulate beta-catenin tyrosine phosphorylation via Ca(2+) during intestinal epithelial cell migration. Tyrosine 33-41 catenin beta 1 Homo sapiens 20-32 12176729-3 2002 beta-Catenin is involved in cell-cell adhesion, and its tyrosine phosphorylation causes disassembly of adhesion junctions, enhancing the spreading of cells. Tyrosine 56-64 catenin beta 1 Homo sapiens 0-12 12176729-4 2002 The current study determined whether polyamines are required for the stimulation of epithelial cell migration by altering beta-catenin tyrosine phosphorylation. Tyrosine 135-143 catenin beta 1 Homo sapiens 122-134 12176729-5 2002 Migration of intestinal epithelial cells (IEC-6 line) after wounding was associated with an increase in beta-catenin tyrosine phosphorylation, which decreased the binding activity of beta-catenin to alpha-catenin. Tyrosine 117-125 catenin beta 1 Homo sapiens 104-116 12176729-5 2002 Migration of intestinal epithelial cells (IEC-6 line) after wounding was associated with an increase in beta-catenin tyrosine phosphorylation, which decreased the binding activity of beta-catenin to alpha-catenin. Tyrosine 117-125 catenin beta 1 Homo sapiens 183-195 11822879-7 2002 Instead, the loss of alpha-catenin from the junctional complexes coincided with the increased tyrosine phosphorylation of beta-catenin associated with VE-cadherin. Tyrosine 94-102 catenin beta 1 Homo sapiens 122-134 12123611-4 2002 Point mutations of beta-catenin"s tyrosine 654 altered the shaft/spine distribution: Y654F-beta-catenin-GFP (phosphorylation-prevented) was concentrated in spines, whereas Y654E-beta-catenin-GFP (phosphorylation-mimic) accumulated in dendritic shafts. Tyrosine 34-42 catenin beta 1 Homo sapiens 19-31 12123611-4 2002 Point mutations of beta-catenin"s tyrosine 654 altered the shaft/spine distribution: Y654F-beta-catenin-GFP (phosphorylation-prevented) was concentrated in spines, whereas Y654E-beta-catenin-GFP (phosphorylation-mimic) accumulated in dendritic shafts. Tyrosine 34-42 catenin beta 1 Homo sapiens 91-103 12123611-4 2002 Point mutations of beta-catenin"s tyrosine 654 altered the shaft/spine distribution: Y654F-beta-catenin-GFP (phosphorylation-prevented) was concentrated in spines, whereas Y654E-beta-catenin-GFP (phosphorylation-mimic) accumulated in dendritic shafts. Tyrosine 34-42 catenin beta 1 Homo sapiens 91-103 12000714-10 2002 Dissociation of the adherens junction protein from the TGF-beta 1 receptor was associated with increased beta-catenin tyrosine phosphorylation and decreased threonine phosphorylation. Tyrosine 118-126 catenin beta 1 Homo sapiens 105-117 11984870-7 2002 Tyrosine phosphorylation of beta-catenin is one such mechanism. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 11984870-8 2002 Enhanced phosphorylation of tyrosine residues on beta-catenin is almost invariably associated with loss of the cadherin-actin connection concomitant with loss of adhesive function. Tyrosine 28-36 catenin beta 1 Homo sapiens 49-61 11984870-10 2002 Our laboratory has focused on the role of the nonreceptor tyrosine phosphatase PTP1B in regulating the phosphorylation of beta-catenin on tyrosine residues. Tyrosine 58-66 catenin beta 1 Homo sapiens 122-134 11822879-9 2002 Thus, the functional interaction of alpha-catenin with VE-cadherin-bound beta-catenin is regulated by the extent of tyrosine phosphorylation of beta-catenin. Tyrosine 116-124 catenin beta 1 Homo sapiens 73-85 11822879-9 2002 Thus, the functional interaction of alpha-catenin with VE-cadherin-bound beta-catenin is regulated by the extent of tyrosine phosphorylation of beta-catenin. Tyrosine 116-124 catenin beta 1 Homo sapiens 144-156 11603724-5 2001 After stimulation of this integrin by mechanical stimulation, there is activation of a signal cascade, involving stretch-activated ion channels, the actin cytoskeleton and tyrosine phosphorylation of the focal adhesion complex molecules pp125 focal adhesion kinase and paxillin, and beta-catenin. Tyrosine 172-180 catenin beta 1 Homo sapiens 283-295 11795867-8 2002 The interaction of PTN and RPTP beta/zeta increases steady-state tyrosine phosphorylation of beta-catenin. Tyrosine 65-73 catenin beta 1 Homo sapiens 93-105 11777936-3 2002 Endogenous Rho activity increases in differentiating keratinocytes and is required for both Fyn kinase activation and increased tyrosine phosphorylation of beta- and gamma-catenin, which is associated with the establishment of keratinocyte cell-cell adhesion. Tyrosine 128-136 catenin beta 1 Homo sapiens 156-179 11777936-6 2002 Endogenous PRK2 kinase activity increases with keratinocyte differentiation, and, like activated Rho, increased PRK2 activity promotes keratinocyte cell-cell adhesion and induces tyrosine phosphorylation of beta- and gamma-catenin and Fyn kinase activation. Tyrosine 179-187 catenin beta 1 Homo sapiens 207-230 11710913-0 2001 Tyrosine phosphorylation of human keratinocyte beta-catenin and plakoglobin reversibly regulates their binding to E-cadherin and alpha-catenin. Tyrosine 0-8 catenin beta 1 Homo sapiens 47-59 11710913-1 2001 We show that tyrosine phosphorylation, produced by incubation of normal human keratinocytes with the tyrosine phosphatase inhibitor peroxovanadate, directly and reversibly regulates the association of beta-catenin and plakoglobin with E-cadherin and alpha-catenin. Tyrosine 13-21 catenin beta 1 Homo sapiens 201-213 11710913-3 2001 We observed that (i) binding of tyrosine phosphorylated beta-catenin and plakoglobin to E-cadherin and to alpha-catenin was substantially reduced, but could be restored in vitro by removal of phosphate from beta-catenin and plakoglobin with added tyrosine phosphatase, and (ii) tyrosine phosphorylation of beta-catenin and plakoglobin was associated with decreased cell-cell adhesion. Tyrosine 32-40 catenin beta 1 Homo sapiens 56-68 11710913-3 2001 We observed that (i) binding of tyrosine phosphorylated beta-catenin and plakoglobin to E-cadherin and to alpha-catenin was substantially reduced, but could be restored in vitro by removal of phosphate from beta-catenin and plakoglobin with added tyrosine phosphatase, and (ii) tyrosine phosphorylation of beta-catenin and plakoglobin was associated with decreased cell-cell adhesion. Tyrosine 32-40 catenin beta 1 Homo sapiens 207-219 11710913-3 2001 We observed that (i) binding of tyrosine phosphorylated beta-catenin and plakoglobin to E-cadherin and to alpha-catenin was substantially reduced, but could be restored in vitro by removal of phosphate from beta-catenin and plakoglobin with added tyrosine phosphatase, and (ii) tyrosine phosphorylation of beta-catenin and plakoglobin was associated with decreased cell-cell adhesion. Tyrosine 32-40 catenin beta 1 Homo sapiens 207-219 11710913-3 2001 We observed that (i) binding of tyrosine phosphorylated beta-catenin and plakoglobin to E-cadherin and to alpha-catenin was substantially reduced, but could be restored in vitro by removal of phosphate from beta-catenin and plakoglobin with added tyrosine phosphatase, and (ii) tyrosine phosphorylation of beta-catenin and plakoglobin was associated with decreased cell-cell adhesion. Tyrosine 247-255 catenin beta 1 Homo sapiens 56-68 11710913-4 2001 These findings support a direct and causal role for tyrosine phosphorylation of beta-catenin and plakoglobin in regulating adherens junction mediated cell-cell adhesion. Tyrosine 52-60 catenin beta 1 Homo sapiens 80-92 11710913-5 2001 We propose that tyrosine phosphorylation of specific and probably different residues is responsible for regulating the binding of beta-catenin or plakoglobin to (i) E-cadherin and (ii) alpha-catenin. Tyrosine 16-24 catenin beta 1 Homo sapiens 130-142 11710913-6 2001 Additionally, because beta-catenin and plakoglobin have both structural and regulatory functions, the data raise the possibility that beta-catenin or plakoglobin released from the adherens junctions by tyrosine phosphorylation may transduce a signal to the nucleus regarding the adhesive state of the cell. Tyrosine 202-210 catenin beta 1 Homo sapiens 22-34 11710913-6 2001 Additionally, because beta-catenin and plakoglobin have both structural and regulatory functions, the data raise the possibility that beta-catenin or plakoglobin released from the adherens junctions by tyrosine phosphorylation may transduce a signal to the nucleus regarding the adhesive state of the cell. Tyrosine 202-210 catenin beta 1 Homo sapiens 134-146 11716761-7 2001 We also show that the interaction of p85 and beta-catenin is direct, involves the N-terminal Src homology domain 2 of p85 and is regulated by tyrosine phosphorylation. Tyrosine 142-150 catenin beta 1 Homo sapiens 45-57 11600431-4 2001 c-Src activation was associated with an increase in the tyrosine phosphorylation state of beta-catenin, paxillin, and vinculin, three c-Src substrate proteins that localize to and regulate cell contact sites. Tyrosine 56-64 catenin beta 1 Homo sapiens 90-102 11328805-6 2001 Decompaction of breast cancer epithelial cells by HRG was accompanied by a transient physical association of the tyrosine-phosphorylated beta-catenin with the activated human epidermal growth factor receptor 2 and subsequent nuclear translocation of beta-catenin, as well as beta-catenin-dependent transactivation of T-cell factor.lymphoid enhancer factor-1. Tyrosine 113-121 catenin beta 1 Homo sapiens 137-149 11328805-6 2001 Decompaction of breast cancer epithelial cells by HRG was accompanied by a transient physical association of the tyrosine-phosphorylated beta-catenin with the activated human epidermal growth factor receptor 2 and subsequent nuclear translocation of beta-catenin, as well as beta-catenin-dependent transactivation of T-cell factor.lymphoid enhancer factor-1. Tyrosine 113-121 catenin beta 1 Homo sapiens 250-262 11328805-6 2001 Decompaction of breast cancer epithelial cells by HRG was accompanied by a transient physical association of the tyrosine-phosphorylated beta-catenin with the activated human epidermal growth factor receptor 2 and subsequent nuclear translocation of beta-catenin, as well as beta-catenin-dependent transactivation of T-cell factor.lymphoid enhancer factor-1. Tyrosine 113-121 catenin beta 1 Homo sapiens 250-262 11401329-0 2001 Tyrosine phosphorylation translocates beta-catenin from cell-->cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function. Tyrosine 0-8 catenin beta 1 Homo sapiens 38-50 11335725-2 2001 Although a correlation exists between the tyrosine phosphorylation of the adherens junction protein beta-catenin and loss of classical cadherin-mediated adhesion, the effects of tyrosine phosphorylation on the function of the adherens junction and desmosome-associated protein plakoglobin is unknown. Tyrosine 42-50 catenin beta 1 Homo sapiens 100-112 11279024-0 2001 Regulation of beta-catenin structure and activity by tyrosine phosphorylation. Tyrosine 53-61 catenin beta 1 Homo sapiens 14-26 11279024-2 2001 Phosphorylation of Tyr-654, a residue placed in the last armadillo repeat of beta-catenin, decreases its binding to E-cadherin. Tyrosine 19-22 catenin beta 1 Homo sapiens 77-89 11279024-3 2001 We show here that phosphorylation of Tyr-654 also stimulates the association of beta-catenin to the basal transcription factor TATA-binding protein. Tyrosine 37-40 catenin beta 1 Homo sapiens 80-92 11279024-6 2001 Phosphorylation of beta-catenin Tyr-654 decreases armadillo-C-terminal tail association, uncovering the last armadillo repeats. Tyrosine 32-35 catenin beta 1 Homo sapiens 19-31 11279024-9 2001 Thus, phosphorylation of Tyr-654 blocks the Ecadherin-beta-catenin interaction, even though the steric hindrance of the C-tail is no longer present. Tyrosine 25-28 catenin beta 1 Homo sapiens 54-66 11279024-10 2001 These results explain how phosphorylation of beta-catenin in Tyr-654 modifies the tertiary structure of this protein and the interaction with its different partners. Tyrosine 61-64 catenin beta 1 Homo sapiens 45-57 11502585-8 2001 Both ONOO(-) and SIN-1 nitrated tyrosine residues, including those on beta-catenin and actin, and oxidized proteins in PAEC. Tyrosine 32-40 catenin beta 1 Homo sapiens 70-82 11423982-7 2001 In addition, beta-catenin was tyrosine phosphorylated in HBx-expressing cells. Tyrosine 30-38 catenin beta 1 Homo sapiens 13-25 11352822-6 2001 Acetaldehyde increased tyrosine phosphorylation of three clusters of proteins with molecular masses of 30-50, 60-90, and 110-150 kDa; three of these proteins were ZO-1, E-cadherin, and beta-catenin. Tyrosine 23-31 catenin beta 1 Homo sapiens 185-197 11371122-3 2001 The present study aimed to confirm the hypothesis that EGF/epidermal growth factor receptor (EGFR) was related with the E-cadherin adhesion system in cervical cancer cells and that EGF might induce tyrosine phosphorylation of beta- and gamma-catenin. Tyrosine 198-206 catenin beta 1 Homo sapiens 226-249 11371122-6 2001 Tyrosine phosphorylation of beta- and gamma-catenin was also examined using immunoprecipitation. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-51 11371122-10 2001 The simultaneous expression of activated EGFR and tyrosine phosphorylation of beta- and gamma-catenin was found. Tyrosine 50-58 catenin beta 1 Homo sapiens 78-101 11371122-11 2001 CONCLUSIONS: EGF-induced scattering of the E-cadherin-positive cervical cancer cells might be the result of tyrosine phosphorylation of the beta- and gamma-catenin. Tyrosine 108-116 catenin beta 1 Homo sapiens 140-163 11245482-1 2001 Beta-catenin undergoes both serine and tyrosine phosphorylation. Tyrosine 39-47 catenin beta 1 Homo sapiens 0-12 11245482-3 2001 We examined the tyrosine phosphorylation status of beta-catenin in melanoma cells expressing proteasome-resistant beta-catenin, as well as the effects that perturbation of beta-catenin tyrosine phosphorylation had on its association with E-cadherin and on its transcriptional activity. Tyrosine 16-24 catenin beta 1 Homo sapiens 51-63 11245482-4 2001 Beta-catenin is tyrosine phosphorylated in three melanoma cell lines and associates with both the ErbB2 receptor tyrosine kinase and the LAR receptor tyrosine phosphatase. Tyrosine 16-24 catenin beta 1 Homo sapiens 0-12 11245482-6 2001 Geldanamycin also stimulated tyrosine dephosphorylation of beta-catenin and increased beta-catenin/E-cadherin association, resulting in substantially decreased cell motility. Tyrosine 29-37 catenin beta 1 Homo sapiens 59-71 11245482-8 2001 These findings were confirmed by transient transfection of two beta-catenin point mutants, Tyr-654Phe and Tyr-654Glu, which, respectively, mimic the dephosphorylated and phosphorylated states of Tyr-654, a tyrosine residue contained within the beta-catenin-ErbB2-binding domain. Tyrosine 91-94 catenin beta 1 Homo sapiens 63-75 11245482-8 2001 These findings were confirmed by transient transfection of two beta-catenin point mutants, Tyr-654Phe and Tyr-654Glu, which, respectively, mimic the dephosphorylated and phosphorylated states of Tyr-654, a tyrosine residue contained within the beta-catenin-ErbB2-binding domain. Tyrosine 206-214 catenin beta 1 Homo sapiens 63-75 11245482-9 2001 These data demonstrate that the functional activity of proteasome-resistant beta-catenin is regulated further by geldanamycin-sensitive tyrosine phosphorylation in melanoma cells. Tyrosine 136-144 catenin beta 1 Homo sapiens 76-88 11401329-2 2001 Tyrosine phosphorylation of beta-catenin has been shown to correlate with tumorigenesis, cell migration, and developmental processes. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 11401329-5 2001 Treatment with a PTPase inhibitor, pervanadate, increased the tyrosine phosphorylation of beta-catenin in a time-dependent manner and led to its relocation from cell-cell interfaces to the cytoplasm. Tyrosine 62-70 catenin beta 1 Homo sapiens 90-102 11401329-7 2001 However, tyrosine phosphorylation of beta-catenin does not change its binding affinity to LEF-1 nor enhance cyclin D1 transactivation, a nuclear target of beta-catenin/LEF-1. Tyrosine 9-17 catenin beta 1 Homo sapiens 37-49 11401329-8 2001 This result suggests that tyrosine phosphorylation of beta-catenin has effects on the binding to cadherins in the cytoplasm but not on its LEF-1-dependent transactivating function in the nucleus. Tyrosine 26-34 catenin beta 1 Homo sapiens 54-66 10801826-4 2000 Recently we demonstrated that PECAM-1/beta-catenin association functions to regulate beta-catenin localization and, moreover, to modulate beta-catenin tyrosine phosphorylation levels. Tyrosine 151-159 catenin beta 1 Homo sapiens 38-50 10921917-10 2000 Hypertonicity provoked Fyn-dependent tyrosine phosphorylation in beta-catenin, alpha-catenin, and p120(Cas) and caused the dissociation of beta-catenin from the contacts. Tyrosine 37-45 catenin beta 1 Homo sapiens 65-77 11035789-5 2000 We found that IGF-1 stimulation enhanced tyrosine phosphorylation of two proteins, beta-catenin and insulin-receptor substrate 1, which formed a complex with E-cadherin. Tyrosine 41-49 catenin beta 1 Homo sapiens 83-95 11035789-6 2000 Tyrosine phosphorylation of beta-catenin was accompanied by rapid (<1 min) dissociation from E-cadherin at the plasma membrane, followed by relocation to the cellular cytoplasm. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 10980594-11 2000 We suggest that the regulation of these cellular processes involves expression of MMP-2 and tyrosine phosphorylation of beta-catenin. Tyrosine 92-100 catenin beta 1 Homo sapiens 120-132 10951583-7 2000 The interaction of the APC protein with a protein tyrosine phosphatase may indirectly modulate the steady state levels of tyrosine phosphorylations of associated proteins, such as beta-catenin playing a major role in the regulation of cell division, migration and cell adhesion. Tyrosine 50-58 catenin beta 1 Homo sapiens 180-192 10706604-0 2000 Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Tyrosine 31-39 catenin beta 1 Homo sapiens 64-76 10759945-10 2000 When c-met staining was compared with E-cadherin and beta-catenin expression, a statistical significant correlation was established between c-met immunoreactivity and abnormal beta-catenin expression (P = 0.025) suggesting possible involvement of c-met in the downregulation of the E-cadherin-catenin complex, possibly through tyrosine phosphorylation of beta-catenin. Tyrosine 327-335 catenin beta 1 Homo sapiens 176-188 10759945-10 2000 When c-met staining was compared with E-cadherin and beta-catenin expression, a statistical significant correlation was established between c-met immunoreactivity and abnormal beta-catenin expression (P = 0.025) suggesting possible involvement of c-met in the downregulation of the E-cadherin-catenin complex, possibly through tyrosine phosphorylation of beta-catenin. Tyrosine 327-335 catenin beta 1 Homo sapiens 176-188 10706604-6 2000 We also have found that an active site-containing domain of RPTP beta/zeta both binds beta-catenin and functionally reduces its levels of tyrosine phosphorylation when added to lysates of pervanidate-treated cells. Tyrosine 138-146 catenin beta 1 Homo sapiens 86-98 10706604-8 2000 Finally, in parallel to its ability to inactivate endogenous RPTP beta/zeta, PTN sharply increases tyrosine phosphorylation of beta-catenin in PTN-treated cells. Tyrosine 99-107 catenin beta 1 Homo sapiens 127-139 10706604-9 2000 The results suggest that in unstimulated cells, RPTP beta/zeta is intrinsically active and functions as an important regulator in the reciprocal control of the steady-state tyrosine phosphorylation levels of beta-catenin by tyrosine kinases and phosphatases. Tyrosine 173-181 catenin beta 1 Homo sapiens 208-220 10706604-10 2000 The results also suggest that RPTP beta/zeta is a functional receptor for PTN; PTN signals through ligand-dependent receptor inactivation of RPTP beta/zeta to increase levels of tyrosine phosphorylation of beta-catenin to initiate downstream signaling. Tyrosine 178-186 catenin beta 1 Homo sapiens 206-218 10681592-5 2000 The loss of SHP2 from the cadherin complexes correlates with a dramatic increase in the tyrosine phosphorylation of beta-catenin, gamma-catenin, and p120-catenin complexed with VE-cadherin. Tyrosine 88-96 catenin beta 1 Homo sapiens 116-128 10681592-6 2000 We propose that thrombin regulates the tyrosine phosphorylation of VE-cadherin-associated beta-catenin, gamma-catenin, and p120-catenin by modulating the quantity of SHP2 associated with VE-cadherin complexes. Tyrosine 39-47 catenin beta 1 Homo sapiens 90-102 9786960-3 1998 Phosphorylation of beta-catenin on tyrosine residues plays a role in controlling this association and, therefore, cadherin function. Tyrosine 35-43 catenin beta 1 Homo sapiens 19-31 11217445-4 2000 The E-Cadherin-mediated cell-adhesion system is inactivated by tyrosine phosphorylation of beta-Catenin at the invading front of cancers with high metastatic ability. Tyrosine 63-71 catenin beta 1 Homo sapiens 91-103 11217445-5 2000 An attempt was made to identify the kinases that participate in the aberrant tyrosine phosphorylation, and c-erbB-2 protein was found to be directly associated with beta-Catenin. Tyrosine 77-85 catenin beta 1 Homo sapiens 165-177 11217445-7 2000 Regulation of the E-Cadherin-mediated cell adhesion system by tyrosine phosphorylation of beta-Catenin is important in determining the biological properties of human cancers. Tyrosine 62-70 catenin beta 1 Homo sapiens 90-102 10593980-8 1999 Transient transfections of different mutants demonstrated that Tyr-654 is phosphorylated in conditions in which adherens junctions are disrupted and evidenced that binding of beta-catenin to E-cadherin in vivo is controlled by phosphorylation of beta-catenin Tyr-654. Tyrosine 63-66 catenin beta 1 Homo sapiens 175-187 10593980-8 1999 Transient transfections of different mutants demonstrated that Tyr-654 is phosphorylated in conditions in which adherens junctions are disrupted and evidenced that binding of beta-catenin to E-cadherin in vivo is controlled by phosphorylation of beta-catenin Tyr-654. Tyrosine 63-66 catenin beta 1 Homo sapiens 246-258 10593980-8 1999 Transient transfections of different mutants demonstrated that Tyr-654 is phosphorylated in conditions in which adherens junctions are disrupted and evidenced that binding of beta-catenin to E-cadherin in vivo is controlled by phosphorylation of beta-catenin Tyr-654. Tyrosine 259-262 catenin beta 1 Homo sapiens 175-187 10508486-7 1999 A rapid tyrosine phosphorylation of E-cadherin and beta-catenin was detected upon IGF-I stimulation. Tyrosine 8-16 catenin beta 1 Homo sapiens 51-63 10462517-0 1999 PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin. Tyrosine 63-71 catenin beta 1 Homo sapiens 87-99 10462517-3 1999 Beta- and gamma-catenin are also major substrates for protein tyrosine kinases, and tyrosine phosphorylation of junctional proteins is correlated with decreased adhesiveness. Tyrosine 62-70 catenin beta 1 Homo sapiens 0-23 10741284-4 2000 Tyrosine phosphorylation of beta-catenin was detected in only one tumour and could, therefore, not have been responsible for the observed increased levels of this protein. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 10462517-6 1999 (2) Platelet-endothelial cell adhesion molecule (PECAM)-1 can function as a reservoir for, and modulator of, tyrosine phosphorylated beta-catenin. Tyrosine 109-117 catenin beta 1 Homo sapiens 133-145 10462517-8 1999 We suggest that PECAM-1 may play a role in modulating beta-catenin tyrosine phosphorylation levels, localization and signaling and by doing so, functions as an important modulator of the endothelium. Tyrosine 67-75 catenin beta 1 Homo sapiens 54-66 10226590-6 1999 Immunoprecipitation studies revealed that HGF/SF elevated the level of tyrosine-phosphorylated beta-catenin within these cells together with reducing the amount of E-cadherin that was observed to co-precipitate with the beta-catenin. Tyrosine 71-79 catenin beta 1 Homo sapiens 95-107 10226596-8 1999 Using immunoprecipitation, HGF/SF induced tyrosine phosphorylation of beta-catenin but not desmoplakin. Tyrosine 42-50 catenin beta 1 Homo sapiens 70-82 10320932-5 1999 Scatter factor/hepatocyte growth factor (SF/HGF), on binding to its c-met tyrosine kinase receptor, can induce invasion through tyrosine phosphorylation of beta-catenin. Tyrosine 74-82 catenin beta 1 Homo sapiens 156-168 9843701-6 1998 Focal adhesion kinase was tyrosine phosphorylated more by basolateral than by apical EGFR; however, beta-catenin was tyrosine phosphorylated to a much greater degree following the activation of mislocalized apical EGFR. Tyrosine 117-125 catenin beta 1 Homo sapiens 100-112 9786960-4 1998 Previous work from our laboratory suggested that a nonreceptor protein tyrosine phosphatase, bound to the cytoplasmic domain of N-cadherin, is responsible for removing tyrosine-bound phosphate residues from beta-catenin, thus maintaining the cadherin-actin connection (). Tyrosine 71-79 catenin beta 1 Homo sapiens 207-219 9786960-8 1998 Furthermore, cadherin is uncoupled from its association with actin, and beta-catenin shows increased phosphorylation on tyrosine residues when compared with parental cells or cells transfected with the wild-type PTP1B. Tyrosine 120-128 catenin beta 1 Homo sapiens 72-84 9790954-4 1998 Two substrates for SPARC-induced tyrosine phosphorylation were identified as beta-catenin and paxillin. Tyrosine 33-41 catenin beta 1 Homo sapiens 77-89 9765619-1 1998 Tyrosine phosphorylation of beta-catenin, an intracytoplasmic E-cadherin-binding protein, has been shown to disrupt the cadherin-mediated cell adhesion system in vitro. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 9765619-7 1998 Tyrosine phosphorylation of beta-catenin was directly confirmed in the protein extracts of one undifferentiated-type gastric cancer. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 9742518-5 1998 This temporal dysfunction of the E-cadherin system observed in colon cancers may be caused by tyrosine phosphorylation of beta-catenin through activated receptor-type tyrosine kinases. Tyrosine 94-102 catenin beta 1 Homo sapiens 122-134 9625748-5 1998 15 minutes to 1 hour after VEGF stimulation the endothelial adherens junction components VE-cadherin, beta-catenin, plakoglobin, and p120 were maximally phosphorylated on tyrosine, while alpha-catenin was not modified. Tyrosine 171-179 catenin beta 1 Homo sapiens 102-114 9426392-6 1997 Tyrosine phosphorylation of beta-catenin was associated with reduced membranous E-cadherin expression, perturbation of intercellular adhesion, and promotion of cell motility. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 9484818-7 1998 It was of interest that up-regulation of tyrosine phosphorylation of beta-catenin was more frequently observed in cancerous tissues than in the matching normal mucosa. Tyrosine 41-49 catenin beta 1 Homo sapiens 69-81 9742518-6 1998 Overexpression of EGF-R and tyrosine phosphorylation of beta-catenin are often observed in "focal dedifferentiated cells" at the invasive front of colorectal cancers. Tyrosine 28-36 catenin beta 1 Homo sapiens 56-68 9426392-8 1997 Tyrosine phosphorylation of beta-catenin and epidermal growth factor receptor seems to be involved in this process. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 9020180-9 1997 Transformation by v-Src does not disrupt the catenin-cadherin complex despite the phosphorylation of E-cadherin and beta-catenin on tyrosine. Tyrosine 132-140 catenin beta 1 Homo sapiens 116-128 9326449-7 1997 Beta-Catenin in late passage cells was tyrosine phosphorylated and was not dephosphorylated following the addition of inhibitors of tyrosine kinases. Tyrosine 39-47 catenin beta 1 Homo sapiens 0-12 9326449-10 1997 In addition, association between E-cadherin and alpha-catenin is suggested to be prevented by the presence of tyrosine phosphorylated beta-catenin which associates with E-cadherin. Tyrosine 110-118 catenin beta 1 Homo sapiens 134-146 9414661-7 1997 While the cellular levels of E-cadherin and beta-catenin did not change significantly following ATRA treatment, the tyrosine residue of beta-catenin was rapidly dephosphorylated. Tyrosine 116-124 catenin beta 1 Homo sapiens 136-148 9414661-9 1997 ATRA-induced clustering of MM-3 cells may be linked to the state of tyrosine phosphorylation of beta-catenin. Tyrosine 68-76 catenin beta 1 Homo sapiens 96-108 9378757-7 1997 Tyrosine phosphorylation of VE-cadherin, beta-catenin and p120, occurred in looser AJ, i.e. in recently confluent cells, and was notably reduced in tightly confluent cultures. Tyrosine 0-8 catenin beta 1 Homo sapiens 41-53 9378757-13 1997 Tyrosine phosphorylation of VE-cadherin and its association to p120 and beta-catenin characterizes early cell contacts, while the formation of mature and cytoskeleton-connected junctions is accompanied by dephosphorylation and plakoglobin association. Tyrosine 0-8 catenin beta 1 Homo sapiens 72-84 9233779-5 1997 beta-Catenin was tyrosine phosphorylated in growing cells at low density but not in quiescent cells at confluence. Tyrosine 17-25 catenin beta 1 Homo sapiens 0-12 9233779-6 1997 Tyrosine phosphorylation of beta-catenin was concomitantly induced with association of beta-catenin with EGF receptor (EGFR) when quiescent cells at confluence were dissociated into single cells by tryptic digestion, being accompanied by dissociation of alpha-catenin from E-cadherin. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 9233779-6 1997 Tyrosine phosphorylation of beta-catenin was concomitantly induced with association of beta-catenin with EGF receptor (EGFR) when quiescent cells at confluence were dissociated into single cells by tryptic digestion, being accompanied by dissociation of alpha-catenin from E-cadherin. Tyrosine 0-8 catenin beta 1 Homo sapiens 87-99 9233779-8 1997 The results suggest that tyrosine phosphorylation of beta-catenin is achieved by EGFR upon tryptic digestion of cells and concurrent with but independent of dissociation of alpha-catenin from E-cadherin. Tyrosine 25-33 catenin beta 1 Homo sapiens 53-65 9233779-9 1997 beta-Catenin thus phosphorylated at tyrosine is suggested to play the role in preventing alpha-catenin once dissociated from reassociating with E-cadherin until cells reach confluence. Tyrosine 36-44 catenin beta 1 Homo sapiens 0-12 8795582-4 1996 By immunoprecipitation with specific antibodies, we found that p125FAK, p120 and beta-catenin were the major components of tyrosine-phosphorylated proteins in the surgical specimens. Tyrosine 123-131 catenin beta 1 Homo sapiens 81-93 8806677-1 1996 Aberrant tyrosine phosphorylation of beta-catenin inactivates the E-cadherin-mediated cell adhesion and invasion suppressor system in cancer cells. Tyrosine 9-17 catenin beta 1 Homo sapiens 37-49 8806677-3 1996 In a human gastric cancer cell line, TMK-1, N-terminally deleted beta-catenin, which binds to c-erbB-2 but not to cadherin, inhibited the association between endogenous beta-catenin and c-erbB-2 protein, and suppressed the tyrosine phosphorylation of beta-catenin. Tyrosine 223-231 catenin beta 1 Homo sapiens 65-77 8806677-3 1996 In a human gastric cancer cell line, TMK-1, N-terminally deleted beta-catenin, which binds to c-erbB-2 but not to cadherin, inhibited the association between endogenous beta-catenin and c-erbB-2 protein, and suppressed the tyrosine phosphorylation of beta-catenin. Tyrosine 223-231 catenin beta 1 Homo sapiens 169-181 8806677-3 1996 In a human gastric cancer cell line, TMK-1, N-terminally deleted beta-catenin, which binds to c-erbB-2 but not to cadherin, inhibited the association between endogenous beta-catenin and c-erbB-2 protein, and suppressed the tyrosine phosphorylation of beta-catenin. Tyrosine 223-231 catenin beta 1 Homo sapiens 169-181 8806677-5 1996 These results suggest that tyrosine phosphorylation of beta-catenin regulated by c-erbB-2 protein may play an important role in the invasion, metastasis and morphogenesis of cancer cells and that inhibition of the aberrant tyrosine phosphorylation of beta-catenin effectively prevents invasion and metastasis of cancer cells. Tyrosine 27-35 catenin beta 1 Homo sapiens 55-67 8806677-5 1996 These results suggest that tyrosine phosphorylation of beta-catenin regulated by c-erbB-2 protein may play an important role in the invasion, metastasis and morphogenesis of cancer cells and that inhibition of the aberrant tyrosine phosphorylation of beta-catenin effectively prevents invasion and metastasis of cancer cells. Tyrosine 27-35 catenin beta 1 Homo sapiens 251-263 8806677-5 1996 These results suggest that tyrosine phosphorylation of beta-catenin regulated by c-erbB-2 protein may play an important role in the invasion, metastasis and morphogenesis of cancer cells and that inhibition of the aberrant tyrosine phosphorylation of beta-catenin effectively prevents invasion and metastasis of cancer cells. Tyrosine 223-231 catenin beta 1 Homo sapiens 55-67 8806677-5 1996 These results suggest that tyrosine phosphorylation of beta-catenin regulated by c-erbB-2 protein may play an important role in the invasion, metastasis and morphogenesis of cancer cells and that inhibition of the aberrant tyrosine phosphorylation of beta-catenin effectively prevents invasion and metastasis of cancer cells. Tyrosine 223-231 catenin beta 1 Homo sapiens 251-263 8830779-3 1996 Tyrosine phosphorylation of beta-catenin, which correlates with a reduction in cadherin-dependent cell adhesion, may provide cells with a mechanism to regulate cadherin activity. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 8830779-10 1996 We propose that changes in tyrosine phosphorylation of beta-catenin mediated by TrkA and LAR-PTPs control cadherin adhesive function during processes such as neurite outgrowth. Tyrosine 27-35 catenin beta 1 Homo sapiens 55-67 21541555-8 1996 Tyrosine-phosphorylated beta-catenin was detected in 13% (2/15) of poorly differentiated carcinomas. Tyrosine 0-8 catenin beta 1 Homo sapiens 24-36 21541555-9 1996 These results suggest that the p53 gene mutations have some correlation with lymph node metastasis, and tyrosine phosphorylation of beta-catenin rather than cadherin/catenin gene mutation is at least partly responsible for the loosening of cell-cell contact and invasiveness of poorly differentiated carcinomas. Tyrosine 104-112 catenin beta 1 Homo sapiens 132-144 9124038-13 1996 Since tyrosine phosphorylation of beta-catenin correlates with the epithelial-mesenchymal transition that is observed, E-cadherin-mediated cell adhesion might be modulated by such a mechanism. Tyrosine 6-14 catenin beta 1 Homo sapiens 34-46 8806075-5 1996 Posttranslational and reversible downregulation may occur by tyrosine phosphorylation of beta-catenin. Tyrosine 61-69 catenin beta 1 Homo sapiens 89-101 8880870-5 1996 Posttranslational and reversible downregulation has been ascribed to tyrosine phosphorylation of beta-catenin. Tyrosine 69-77 catenin beta 1 Homo sapiens 97-109 9183627-7 1996 Finally, we observed tyrosine phosphorylation of beta-catenin induced by EGF. Tyrosine 21-29 catenin beta 1 Homo sapiens 49-61 8635495-8 1996 Instead, EGF tyrosine phosphorylated cadherin/catenin complex components including beta-catenin and increased the detergent solubility of E-cadherin in the parent cells. Tyrosine 13-21 catenin beta 1 Homo sapiens 83-95 7962096-3 1994 EGF induces an immediate tyrosine phosphorylation of beta-catenin and gamma-catenin (plakoglobin). Tyrosine 25-33 catenin beta 1 Homo sapiens 53-65 7542250-9 1995 The tyrosine-phosphorylated beta-catenin also shows increased detergent solubility, suggesting a decreased association with the actin cytoskeleton. Tyrosine 4-12 catenin beta 1 Homo sapiens 28-40 7542250-12 1995 In particular, decreased tyrosine phosphorylation of beta-catenin is accompanied by increased interaction with both E-cadherin and the detergent insoluble cytoskeletal fraction. Tyrosine 25-33 catenin beta 1 Homo sapiens 53-65 7542250-13 1995 These results suggest that elevated tyrosine phosphorylation of proteins such as beta-catenin and p120 Cas contribute to the altered adherens junctions of ras-transformed epithelia. Tyrosine 36-44 catenin beta 1 Homo sapiens 81-93 8012979-7 1994 Furthermore, levels of tyrosine phosphorylation of beta-catenin were elevated in E-cadherin-transfected BT549 and HS578t cells compared to MCF-7 cells. Tyrosine 23-31 catenin beta 1 Homo sapiens 51-63 8076212-4 1993 beta-catenin and plakoglobin possibly play more regulatory roles, as it was shown that their tyrosine phosphorylation correlated with modified cadherin activities. Tyrosine 93-101 catenin beta 1 Homo sapiens 0-12 8081883-0 1994 Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 8081883-7 1994 beta-Catenin, plakoglobin and an unidentified 115-kDa molecule associated with E-cadherin were found to be phosphorylated at tyrosine residues, and these phosphorylations were enhanced by the growth factor treatments. Tyrosine 125-133 catenin beta 1 Homo sapiens 0-12 8983061-10 1994 HGF/SF, and also epidermal growth factor, enhance tyrosine phosphorylation of beta-catenin or plakoglobin in human carcinoma lines as they induce scattering of these cells. Tyrosine 50-58 catenin beta 1 Homo sapiens 78-90 33504020-6 2021 The inhibition of this pathway was due to the modulation of the GSK3beta phosphorylation state (Tyr 216) that induces a proteasomal degradation of beta-catenin. Tyrosine 96-99 catenin beta 1 Homo sapiens 147-159 8144693-4 1993 Furthermore, tyrosine phosphorylation of junctional components (e.g. beta-catenin) appears to play a role in the assembly and disassembly of cell-cell contacts. Tyrosine 13-21 catenin beta 1 Homo sapiens 69-81 33388549-0 2021 RhoA GTPase phosphorylated at tyrosine 42 by src kinase binds to beta-catenin and contributes transcriptional regulation of vimentin upon Wnt3A. Tyrosine 30-38 catenin beta 1 Homo sapiens 65-77 33407765-7 2021 Mechanismly, HOMER3 interacts with both c-Src and beta-Catenin, thus providing a scaffolding platform to facilitate c-Src-induced beta-Catenin tyrosine phosphorylation under growth factor stimulation. Tyrosine 143-151 catenin beta 1 Homo sapiens 50-62 33407765-0 2021 HOMER3 facilitates growth factor-mediated beta-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer. Tyrosine 55-63 catenin beta 1 Homo sapiens 42-54 33407765-7 2021 Mechanismly, HOMER3 interacts with both c-Src and beta-Catenin, thus providing a scaffolding platform to facilitate c-Src-induced beta-Catenin tyrosine phosphorylation under growth factor stimulation. Tyrosine 143-151 catenin beta 1 Homo sapiens 130-142 32231574-3 2020 Kinases such as Src initiate Wnt/beta-catenin signaling by phosphorylating beta-catenin at tyrosine residues, which facilitates beta-catenin accumulation in the nucleus and promotion of fibrosis progression. Tyrosine 91-99 catenin beta 1 Homo sapiens 33-45 32231574-3 2020 Kinases such as Src initiate Wnt/beta-catenin signaling by phosphorylating beta-catenin at tyrosine residues, which facilitates beta-catenin accumulation in the nucleus and promotion of fibrosis progression. Tyrosine 91-99 catenin beta 1 Homo sapiens 75-87 32231574-3 2020 Kinases such as Src initiate Wnt/beta-catenin signaling by phosphorylating beta-catenin at tyrosine residues, which facilitates beta-catenin accumulation in the nucleus and promotion of fibrosis progression. Tyrosine 91-99 catenin beta 1 Homo sapiens 75-87 29355514-2 2018 Using a library of human normal and diseased human lung samples, we identified a distinct signature of nuclear accumulation of beta-catenin phosphorylated at tyrosine 489 and epithelial cell cytosolic localization of beta-catenin phosphorylated at tyrosine 654 in early normal lung development and fibrotic lung diseases BPD and IPF. Tyrosine 158-166 catenin beta 1 Homo sapiens 127-139 29804228-9 2019 A significant decrease in beta-catenin protein levels were inversely associated with increased GSK3beta tyrosine activating phosphorylation, in addition to downstream effects associated with disease progression and cognitive decline. Tyrosine 104-112 catenin beta 1 Homo sapiens 26-38 30155836-6 2018 Mechanistically, RARalpha knockdown inhibited the activity of Wnt/beta-catenin pathway through reducing the phosphorylation level of GSK3beta at Ser-9 and inducing phosphorylation level at Tyr-216, which resulted in downregulation of its downstream targets such as MMP7, MMP9, and P-gP. Tyrosine 189-192 catenin beta 1 Homo sapiens 66-78 31653698-4 2019 We performed an shRNA-based biochemical screen, which identified PTPRR as being responsible for tyrosine dephosphorylation of beta-catenin on Tyr-142, a key site controlling the transcriptional activity of beta-catenin. Tyrosine 96-104 catenin beta 1 Homo sapiens 126-138 31653698-4 2019 We performed an shRNA-based biochemical screen, which identified PTPRR as being responsible for tyrosine dephosphorylation of beta-catenin on Tyr-142, a key site controlling the transcriptional activity of beta-catenin. Tyrosine 96-104 catenin beta 1 Homo sapiens 206-218 31653698-4 2019 We performed an shRNA-based biochemical screen, which identified PTPRR as being responsible for tyrosine dephosphorylation of beta-catenin on Tyr-142, a key site controlling the transcriptional activity of beta-catenin. Tyrosine 142-145 catenin beta 1 Homo sapiens 126-138 31653698-4 2019 We performed an shRNA-based biochemical screen, which identified PTPRR as being responsible for tyrosine dephosphorylation of beta-catenin on Tyr-142, a key site controlling the transcriptional activity of beta-catenin. Tyrosine 142-145 catenin beta 1 Homo sapiens 206-218 31286874-8 2019 Activated c-Src phosphorylated E-cadherin at the tyrosine 797 site to initiate RNF43-mediated E-cadherin ubiquitination at lysine 816 and subsequent degradation, thus allowing the nuclear translocation of beta-catenin and upregulation of Vimentin and RNF43 expression in lung adenocarcinoma cells. Tyrosine 49-57 catenin beta 1 Homo sapiens 205-217 29355514-2 2018 Using a library of human normal and diseased human lung samples, we identified a distinct signature of nuclear accumulation of beta-catenin phosphorylated at tyrosine 489 and epithelial cell cytosolic localization of beta-catenin phosphorylated at tyrosine 654 in early normal lung development and fibrotic lung diseases BPD and IPF. Tyrosine 248-256 catenin beta 1 Homo sapiens 217-229 29355514-5 2018 Nuclear beta-catenin phosphorylated at tyrosine 489 associated with an increased expression of Wnt target gene AXIN2, suggesting that the observed beta-catenin signature is of functional significance during normal development and injury repair. Tyrosine 39-47 catenin beta 1 Homo sapiens 8-20 29355514-5 2018 Nuclear beta-catenin phosphorylated at tyrosine 489 associated with an increased expression of Wnt target gene AXIN2, suggesting that the observed beta-catenin signature is of functional significance during normal development and injury repair. Tyrosine 39-47 catenin beta 1 Homo sapiens 147-159 28821617-3 2017 In this report, we characterize the structural determinants responsible for Jak3 interactions with beta-catenin and determine the functional implications of previously unknown tyrosine residues on beta-catenin phosphorylated by Jak3. Tyrosine 176-184 catenin beta 1 Homo sapiens 197-209 30227954-3 2018 Furthermore, TAZ and the Wnt effector beta-catenin interact cooperatively with tyrosine-dephosphorylated Parafibromin, which synergistically stimulates the co-activator functions of TAZ and beta-catenin. Tyrosine 79-87 catenin beta 1 Homo sapiens 38-50 30227954-3 2018 Furthermore, TAZ and the Wnt effector beta-catenin interact cooperatively with tyrosine-dephosphorylated Parafibromin, which synergistically stimulates the co-activator functions of TAZ and beta-catenin. Tyrosine 79-87 catenin beta 1 Homo sapiens 190-202 29103954-5 2017 During this process, alphaE-catenin accumulated at lamellipodial membranes and then moved toward the rear with the support of a tyrosine-phosphorylated beta-catenin. Tyrosine 128-136 catenin beta 1 Homo sapiens 152-164 28821617-4 2017 We demonstrate that Jak3 autophosphorylation was the rate-limiting step during Jak3 trans-phosphorylation of beta-catenin, where Jak3 directly phosphorylated three tyrosine residues, viz. Tyrosine 164-172 catenin beta 1 Homo sapiens 109-121 28881682-7 2017 An intriguing crosstalk between FAK and the Wnt/beta-catenin pathway was revealed wherein FAK inhibition blocks beta-catenin activation by reducing tyrosine 654 phosphorylation of beta-catenin. Tyrosine 148-156 catenin beta 1 Homo sapiens 48-60 28881682-7 2017 An intriguing crosstalk between FAK and the Wnt/beta-catenin pathway was revealed wherein FAK inhibition blocks beta-catenin activation by reducing tyrosine 654 phosphorylation of beta-catenin. Tyrosine 148-156 catenin beta 1 Homo sapiens 112-124 28881682-7 2017 An intriguing crosstalk between FAK and the Wnt/beta-catenin pathway was revealed wherein FAK inhibition blocks beta-catenin activation by reducing tyrosine 654 phosphorylation of beta-catenin. Tyrosine 148-156 catenin beta 1 Homo sapiens 112-124 28224728-6 2017 Moreover, beta-catenin, a core component of the N-cadherin adhesion complex, inhibits N-cadherin endocytosis by masking the 2 tyrosine-based motifs. Tyrosine 126-134 catenin beta 1 Homo sapiens 10-22 28486134-0 2017 Abl Regulates Planar Polarized Junctional Dynamics through beta-Catenin Tyrosine Phosphorylation. Tyrosine 72-80 catenin beta 1 Homo sapiens 59-71 27226643-0 2016 Regulation of beta-catenin structure and activity by tyrosine phosphorylation. Tyrosine 53-61 catenin beta 1 Homo sapiens 14-26 27941077-4 2017 When Wnt signaling is active, phosphorylation of beta-catenin by tyrosine kinases at activating sites, specifically at tyrosine 489 (Y489), correlates with nuclear localization of beta-catenin. Tyrosine 65-73 catenin beta 1 Homo sapiens 49-61 27941077-4 2017 When Wnt signaling is active, phosphorylation of beta-catenin by tyrosine kinases at activating sites, specifically at tyrosine 489 (Y489), correlates with nuclear localization of beta-catenin. Tyrosine 65-73 catenin beta 1 Homo sapiens 180-192 27761023-9 2016 Furthermore, miR-574-5p enhanced the tyrosine phosphorylation of beta-catenin by repressing PTPRU expression in vitro. Tyrosine 37-45 catenin beta 1 Homo sapiens 65-77 25164010-5 2014 Mutant EGFR preferentially bound to and tyrosine phosphorylated beta-catenin, leading to an increase in beta-catenin-mediated transactivation, particularly in cells harboring the gefitinib/erlotinib-resistant gatekeeper EGFR-T790M mutation. Tyrosine 40-48 catenin beta 1 Homo sapiens 64-76 27255161-5 2016 Mechanistic studies of one novel CCARP which links to multiple cell-cell adhesion proteins, the phosphatase DUSP23, revealed that it promotes dephosphorylation of beta-catenin at Tyr 142 and enhances the interaction between alpha- and beta-catenin. Tyrosine 179-182 catenin beta 1 Homo sapiens 163-175 27255161-5 2016 Mechanistic studies of one novel CCARP which links to multiple cell-cell adhesion proteins, the phosphatase DUSP23, revealed that it promotes dephosphorylation of beta-catenin at Tyr 142 and enhances the interaction between alpha- and beta-catenin. Tyrosine 179-182 catenin beta 1 Homo sapiens 224-247 25423132-8 2015 To determine if Src induced phosphorylation of beta-catenin Tyr-654, Western blot analysis was also performed on nuclear proteins from C6 cells treated with tyrosine kinase inhibitor PP2 using then p- beta-catenin antibody. Tyrosine 60-63 catenin beta 1 Homo sapiens 47-59 25423132-9 2015 RESULTS: After induced by GDNF, C6 cell membrane beta-catenin was phosphorylated at Tyr-654 and subsequently separated from the N-cadherin/beta-catenin complex. Tyrosine 84-87 catenin beta 1 Homo sapiens 49-61 25423132-10 2015 Further study confirmed that the induction by GDNF significantly increased cytoplasmic and nuclear expression of phospho-beta-catenin (Tyr-654) in C6 glioma cells. Tyrosine 135-138 catenin beta 1 Homo sapiens 121-133 25423132-12 2015 Src induced phosphorylation of beta-catenin Tyr-654 induced by GDNF decreased significantly. Tyrosine 44-47 catenin beta 1 Homo sapiens 31-43 25848087-3 2015 Loss of E-cadherin/beta-catenin proteins and tyrosine phosphorylation of E-cadherin/beta-catenin have been postulated in cervical carcinogenesis and cancer invasion. Tyrosine 45-53 catenin beta 1 Homo sapiens 84-96 25130271-6 2015 Moreover, silencing Hsp27 decreases EGF dependent phosphorylation of beta-catenin on tyrosine 142 and 654, enhances beta-catenin ubiquitination and degradation, prevents beta-catenin nuclear translocation and binding to the Slug promoter. Tyrosine 85-93 catenin beta 1 Homo sapiens 69-81 25326580-4 2015 HER2 activation by the ligand neuregulin-1 was associated with tyrosine phosphorylation of beta-catenin, dissociation of beta-catenin from E-cadherin, and decreased E-cadherin-mediated cell adhesion. Tyrosine 63-71 catenin beta 1 Homo sapiens 91-103 25317600-2 2015 Inhibition of the protein tyrosine phosphorylase SH2 domain-containing protein tyrosine phosphatase 2 (SHP2) increases tyrosine phosphorylation of vascular endothelial cadherin and beta-catenin, resulting in disruption of the endothelial monolayer and edema formation in the pulmonary endothelium. Tyrosine 26-34 catenin beta 1 Homo sapiens 181-193 25386896-10 2014 Further, we demonstrate that CD148 reduces the tyrosine phosphorylation of p120 and beta-catenin; causes the dephosphorylation of Y529 suppressive tyrosine residue in Src, a well-known CD148 site, increasing Src activity and enhancing the phosphorylation of Y228 (a Src kinase site) in p120, in E-cadherin contacts. Tyrosine 47-55 catenin beta 1 Homo sapiens 84-96 25088577-8 2014 Furthermore, 126332 inhibited the tyrosine phosphorylation of beta-catenin, inhibited beta-catenin-mediated transcription and DNA binding of TCF. Tyrosine 34-42 catenin beta 1 Homo sapiens 62-74 25143377-0 2014 Tyrosine-based signal mediates LRP6 receptor endocytosis and desensitization of Wnt/beta-catenin pathway signaling. Tyrosine 0-8 catenin beta 1 Homo sapiens 84-96 25164010-5 2014 Mutant EGFR preferentially bound to and tyrosine phosphorylated beta-catenin, leading to an increase in beta-catenin-mediated transactivation, particularly in cells harboring the gefitinib/erlotinib-resistant gatekeeper EGFR-T790M mutation. Tyrosine 40-48 catenin beta 1 Homo sapiens 104-116 24965120-10 2014 Redox-sensitive kinase; PYK2 activation led to increased tyrosine phosphorylation of VE-cadherin and beta-catenin, leading to disruption of junctional assembly. Tyrosine 57-65 catenin beta 1 Homo sapiens 101-113 24896565-2 2014 By analyzing human primary brain microvascular endothelial cells constitutively activated for RhoA, silenced for RhoA or treated with the RhoAK inhibitor Y27632, we found that RhoAK phosphorylated and activated the protein tyrosine phosphatase 1B (PTP1B), which dephosphorylated tyrosine 216 of GSK3, decreasing the GSK3-mediated inhibition of beta-catenin. Tyrosine 223-231 catenin beta 1 Homo sapiens 344-356 24393526-3 2014 Using coimmunoprecipitation and Western blot assay, we found that M3R inhibition increased VE-cadherin and beta-catenin tyrosine phosphorylation without affecting their expression. Tyrosine 120-128 catenin beta 1 Homo sapiens 107-119 24965120-11 2014 The dissociation of tyrosine phosphatases VE-PTP and SHP2 from cadherin complex resulted into increased tyrosine phosphorylation of VE-cadherin and beta-catenin in HIV-1 Tat C treated hBMVECs. Tyrosine 20-28 catenin beta 1 Homo sapiens 148-160 24759800-6 2014 From these findings we conclude that tyrosine phosphorylation of beta-catenin can regulate the cellular distribution of beta-catenin and affect the transcriptional activity of beta-catenin. Tyrosine 37-45 catenin beta 1 Homo sapiens 120-132 24759800-6 2014 From these findings we conclude that tyrosine phosphorylation of beta-catenin can regulate the cellular distribution of beta-catenin and affect the transcriptional activity of beta-catenin. Tyrosine 37-45 catenin beta 1 Homo sapiens 120-132 24759800-0 2014 Tyrosine phosphorylation of beta-catenin affects its subcellular localization and transcriptional activity of beta-catenin in Hela and Bcap-37 cells. Tyrosine 0-8 catenin beta 1 Homo sapiens 28-40 24759800-0 2014 Tyrosine phosphorylation of beta-catenin affects its subcellular localization and transcriptional activity of beta-catenin in Hela and Bcap-37 cells. Tyrosine 0-8 catenin beta 1 Homo sapiens 110-122 24412473-6 2014 We also found that c-Src-mediated Tyr-phosphorylation of delta-catenin increases its stability via decreasing its affinity to GSK3beta and enhances its ability of inducing nuclear distribution of beta-catenin through interrupting the integrity of the E-cadherin. Tyrosine 34-37 catenin beta 1 Homo sapiens 196-208 24759800-1 2014 In order to investigate the relationship between tyrosine phosphorylation of beta-catenin and transcriptional activity of beta-catenin in Hela and Bcap-37 cells, genistein (a tyrosine kinase inhibitor) was used to inhibit tyrosine phosphorylation in cells. Tyrosine 49-57 catenin beta 1 Homo sapiens 77-89 24759800-1 2014 In order to investigate the relationship between tyrosine phosphorylation of beta-catenin and transcriptional activity of beta-catenin in Hela and Bcap-37 cells, genistein (a tyrosine kinase inhibitor) was used to inhibit tyrosine phosphorylation in cells. Tyrosine 49-57 catenin beta 1 Homo sapiens 122-134 24759800-3 2014 Genistein could inhibit tyrosine phosphorylation of beta-catenin and downregulate nuclear beta-catenin expression in Hela and Bcap-37 cells. Tyrosine 24-32 catenin beta 1 Homo sapiens 52-64 24759800-6 2014 From these findings we conclude that tyrosine phosphorylation of beta-catenin can regulate the cellular distribution of beta-catenin and affect the transcriptional activity of beta-catenin. Tyrosine 37-45 catenin beta 1 Homo sapiens 65-77 24436419-4 2014 Btk29A and mammalian Btk directly phosphorylated tyrosine residues of beta-catenin, leading to the up-regulation of its transcriptional activity. Tyrosine 49-57 catenin beta 1 Homo sapiens 70-82 24324366-9 2013 We further demonstrate that EGF can activate TCF4/beta-catenin activity and induce the tyrosine phosphorylation of beta-catenin protein. Tyrosine 87-95 catenin beta 1 Homo sapiens 115-127 23246962-3 2013 Here, we elucidate a signaling pathway that physically and functionally couples tyrosine phosphorylation of beta-catenin to HIF1alpha signaling and HIF1alpha-mediated tumor EMT. Tyrosine 80-88 catenin beta 1 Homo sapiens 108-120