PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11692173-6 2001 RESULTS: In L6 cells, physiological concentrations of C-peptide (0.3-3 nmol/l) significantly activated insulin receptor tyrosine kinase, IRS-1 tyrosine phosphorylation, PI 3-kinase activity, MAPK phosphorylation, p90Rsk, and GSK3 phosphorylation. Tyrosine 120-128 insulin 2 Rattus norvegicus 54-63 22509386-8 2012 Moreover, cell death increased, and severe oxidative stress, which manifested as increased reactive oxygen species, thioredoxin-interacting protein, and protein tyrosine nitration, occurred in Ins2(+/Akita) beta-cells and/or islets. Tyrosine 161-169 insulin 2 Rattus norvegicus 193-197