PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34088368-5 2021 Mechanically, the tyrosine groups on the surface of ECDY can be specifically recognized by tyrosinase and further converted into dopaquinone, which consequently causes the intramolecular fluorescence quenching of the probe through photoinduced electron transfer (PET). Tyrosine 18-26 tyrosinase Mus musculus 91-101 34958200-4 2022 Here, we report a dual-locked NIR probe, MB-m-borate, which releases fluorophore methylene blue (MB) after hydrogen peroxide-tyrosinase (H2O2-TYR) cascade activation. Tyrosine 142-145 tyrosinase Mus musculus 125-135 35278583-11 2022 The results indicate that C-terminal tyrosine residue is important for tyrosinase inhibition. Tyrosine 37-45 tyrosinase Mus musculus 71-81 3146546-1 1988 The enzyme tyrosinase (monophenol,L-dopa:oxygen oxidoreductase; EC 1.14.18.1) catalyzes the first two steps in the conversion of tyrosine to melanin, the major pigment found in melanocytes. Tyrosine 129-137 tyrosinase Mus musculus 11-21 35384748-7 2022 Two significant QTL, Chop2 and Albc2, on Chr 4 and 7 were identified for coat color, with Tyr, encoding tyrosinase, being the causal gene of Albc2. Tyrosine 90-93 tyrosinase Mus musculus 104-114 3111852-2 1987 Murine melanoma melanosomal tyrosinase, solubilised at pH 6.8 and 1% Igepal, exhibits a lag in cresolase activity which increases with increasing concentration of tyrosine. Tyrosine 163-171 tyrosinase Mus musculus 28-38 3327627-1 1987 4-S-cysteinylphenol (4-S-CP), the S-homologue of tyrosine, has been recently synthesized as a selective chemotherapeutic agent against malignant melanoma and has been shown to be a specific substrate for tyrosinase in vitro. Tyrosine 49-57 tyrosinase Mus musculus 204-214 2888748-5 1987 The increase in tyrosinase activity was detectable by three assay methods: tyrosine hydroxylation, melanin synthesis, and by tyrosine decarboxylation. Tyrosine 75-83 tyrosinase Mus musculus 16-26 2888748-5 1987 The increase in tyrosinase activity was detectable by three assay methods: tyrosine hydroxylation, melanin synthesis, and by tyrosine decarboxylation. Tyrosine 125-133 tyrosinase Mus musculus 16-26 3111852-4 1987 When the enzyme was solubilised from a melanosomal fraction with detergent/water without any buffer, significant linear activity for 2 h was seen at an inhibitory concentration of tyrosine, indicating for the first time the presence of a form of tyrosinase without lag and inhibition by excess tyrosine. Tyrosine 180-188 tyrosinase Mus musculus 246-256 3111852-4 1987 When the enzyme was solubilised from a melanosomal fraction with detergent/water without any buffer, significant linear activity for 2 h was seen at an inhibitory concentration of tyrosine, indicating for the first time the presence of a form of tyrosinase without lag and inhibition by excess tyrosine. Tyrosine 294-302 tyrosinase Mus musculus 246-256 3111852-10 1987 Ascorbic acid acts as an effective reductant for the hydroxylation of tyrosine by tyrosinase, while 3,4-dihydroxyphenylalanine is both an effective reductant and counteracts the inhibition by tyrosine at pH 6.8. Tyrosine 70-78 tyrosinase Mus musculus 82-92 6413271-2 1983 The initial steps are the conversion of tyrosine to dihydroxyphenylalanine (dopa) and of dopa to dopaquinone by the enzyme tyrosinase (EC 1.10.3.1). Tyrosine 40-48 tyrosinase Mus musculus 123-133 6435538-2 1984 It occurs by conversion of tyrosine to dopa and dopaquinone in the presence of tyrosinase. Tyrosine 27-35 tyrosinase Mus musculus 79-89 6792273-2 1981 Purified tyrosinase protein was prepared that was capable of oxidizing tyrosine. Tyrosine 71-79 tyrosinase Mus musculus 9-19 6792293-0 1981 Characterization of structural properties for morphological differentiation of melanosomes: I. Purification of tyrosinase by tyrosine affinity chromatography and its characterization in B16 and Harding Passey melanomas. Tyrosine 125-133 tyrosinase Mus musculus 111-121 806638-0 1975 Inability of murine melanoma melanosomal "tyrosinase" (L-dopa oxidase) to oxidize tyrosine to melanin in polyacrylamide gel systems. Tyrosine 82-90 tyrosinase Mus musculus 41-52 6785376-1 1981 The tyrosinase activity of Himalayan mouse skin homogenates was measured over a range of temperatures using two sensitive radiometric assay--namely, (1) the measurement of 14C-tyrosine incorporation into melanin, and (2) the measurement of 3HOH released as a by-product of 3H-tyrosine hydroxylation. Tyrosine 176-184 tyrosinase Mus musculus 4-14 806638-4 1975 These data further support previous studies in our laboratory demonstrating an inability of so-called mamalian "tyrosinase" to convert tyrosine to melanin; since this enzyme readily converts L-dopa to melanin, it seems more reasonable to term this enzyme an L-dopa oxidase. Tyrosine 135-143 tyrosinase Mus musculus 111-122 804529-3 1975 Tyrosinase was capable of utilizing tyrosine as a substrate, as well as dopa, although the Vmax with dopa was much higher than with tyrosine. Tyrosine 36-44 tyrosinase Mus musculus 0-10 804529-3 1975 Tyrosinase was capable of utilizing tyrosine as a substrate, as well as dopa, although the Vmax with dopa was much higher than with tyrosine. Tyrosine 132-140 tyrosinase Mus musculus 0-10 33480093-2 2021 Melanin is synthesized from l-tyrosin in the melanosomes, where tyrosinase and other melanogenic factors are recruited via the vesicle transport system. Tyrosine 28-37 tyrosinase Mus musculus 64-74 27021123-3 2016 In this work, we have developed such a new probe, Mela-TYR, which bears morpholine as a melanosome-targeting group and 4-aminophenol as a tyrosinase reaction group. Tyrosine 55-58 tyrosinase Mus musculus 138-148 31344959-2 2019 Among the isolated compounds, 974-A was demonstrated for the first time to be a potent competitive inhibitor of mushroom tyrosinase activity towards l-tyrosine and l-DOPA (IC50 values = 1.57 +- 0.08 and 3.56 +- 0.22 microM, respectively). Tyrosine 149-159 tyrosinase Mus musculus 121-131 28456625-1 2017 Tyrosinase-catalyzed l-tyrosine oxidation is a key step in melanogenesis, and intense melanin formation is often a problem in chemotherapies or food preservation. Tyrosine 21-31 tyrosinase Mus musculus 0-10 28456625-3 2017 Methyl cinnamate inhibits mushroom tyrosinase-catalyzed l-tyrosine oxidation while the oxidation of l-3,4-dihydroxyphenylalanine (l-DOPA) was not inhibited. Tyrosine 56-66 tyrosinase Mus musculus 35-45 33098271-1 2021 Tyr is the mouse gene that encodes tyrosinase, an enzyme that triggers the first and rate-limiting step in the biosynthesis of melanin. Tyrosine 0-3 tyrosinase Mus musculus 35-45 31659899-5 2019 A molecular dynamics simulation showed that caffeine bound this tyrosinase via Lys379, Lys 376, Asp357, Glu356, Thr308, Gln307, Asp312, and Trp358, thus changing the binding sites of l-tyrosine and the loop conformation adjacent to the active center. Tyrosine 183-193 tyrosinase Mus musculus 64-74 31108882-4 2019 Bromophenols 1 and 3 exhibited potent competitive tyrosinase inhibitory activity against l-tyrosine substrates, with IC50 values of 10.78 +- 0.19 and 2.92 +- 0.04 muM, respectively. Tyrosine 89-99 tyrosinase Mus musculus 50-60 30101816-2 2019 We previously indicated that particular behavioral traits contributing to the genotype at the agouti locus manifest only when possessing a wild-type allele at the albino (i.e., tyrosinase: Tyr) locus. Tyrosine 189-192 tyrosinase Mus musculus 177-187 30579605-3 2019 Tyrosinase, a copper-containing protein, is the rate-limiting enzyme in melanin biosynthesis and first catalyzes the hydroxylation of l-tyrosine to 3,4-dihydroxyphenylalanine (DOPA) and the further oxidization to dopaquinone. Tyrosine 134-144 tyrosinase Mus musculus 0-10 26633377-1 2015 Tyrosinase catalyzes two distinct sequential reactions in melanin biosynthesis: The hydroxylation of tyrosine to dihydroxyphenylalanine (DOPA) and the oxidation of DOPA to dopaquinone. Tyrosine 101-109 tyrosinase Mus musculus 0-10 26750991-2 2016 Tyrosinase, a type-3 copper protein, participates in two distinct reactions, hydroxylation of tyrosine to DOPA and conversion of DOPA to dopaquinone, in melanin biosynthesis. Tyrosine 94-102 tyrosinase Mus musculus 0-10 26748310-4 2016 Furthermore, chaetocin down-regulated both the protein and mRNA levels of tyrosinase, which is a specific enzyme that catalyzes the conversion of tyrosine to melanin. Tyrosine 146-154 tyrosinase Mus musculus 74-84 26544630-1 2015 Tyrosinase catalyzes two distinct sequential reactions in melanin biosynthesis: the hydroxylation of tyrosine to DOPA followed by the oxidation of DOPA to dopaquinone. Tyrosine 101-109 tyrosinase Mus musculus 0-10 26475433-11 2015 CONCLUSION: These results suggest that the age-related coat darkening in black-eyed mutant may be caused by the increased ability of melanocyte differentiation dependent on l-Tyr through the upregulation of tyrosinase, Tyrp1, and Mitf. Tyrosine 173-178 tyrosinase Mus musculus 207-217 23776585-1 2013 Tyrosinase, which catalyzes both the hydroxylation of tyrosine and consequent oxidation of L-DOPA to form melanin in melanocytes, is also expressed in the brain, and oxidizes L-DOPA and dopamine. Tyrosine 54-62 tyrosinase Mus musculus 0-10 25744361-7 2015 In vitro assay was performed with B16 melanoma cells, and affinity for tyrosinase, DNA polymerase and amino acid transport was evaluated using phenylthiourea, thymidine, ouabine and L-tyrosine inhibitor. Tyrosine 182-192 tyrosinase Mus musculus 71-81 24016750-1 2013 BACKGROUND: Melanin for skin pigmentation is synthesized from tyrosine via an enzymatic cascade that is controlled by tyrosinase (TYR), tyrosinase-related protein 1 (TRP1), and dopachrome tautomerase/tyrosinase related protein 2 (Dct/TRP2), which are the targets of microphthalmia-associated transcription factor (MITF). Tyrosine 62-70 tyrosinase Mus musculus 118-128 24016750-1 2013 BACKGROUND: Melanin for skin pigmentation is synthesized from tyrosine via an enzymatic cascade that is controlled by tyrosinase (TYR), tyrosinase-related protein 1 (TRP1), and dopachrome tautomerase/tyrosinase related protein 2 (Dct/TRP2), which are the targets of microphthalmia-associated transcription factor (MITF). Tyrosine 62-70 tyrosinase Mus musculus 130-133 24016750-1 2013 BACKGROUND: Melanin for skin pigmentation is synthesized from tyrosine via an enzymatic cascade that is controlled by tyrosinase (TYR), tyrosinase-related protein 1 (TRP1), and dopachrome tautomerase/tyrosinase related protein 2 (Dct/TRP2), which are the targets of microphthalmia-associated transcription factor (MITF). Tyrosine 62-70 tyrosinase Mus musculus 136-146 24287915-2 2013 Tyrosinase is responsible for the critical steps of melanogenesis, including the rate-limiting step of tyrosine hydroxylation. Tyrosine 103-111 tyrosinase Mus musculus 0-10 23620107-1 2013 We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Tyrosine 107-110 tyrosinase Mus musculus 81-91 26201055-5 2015 The bark extract exhibited significant inhibition on mushroom tyrosinase using L-tyrosine as a substrate and showed diphenolase activity. Tyrosine 79-89 tyrosinase Mus musculus 62-72 22728921-2 2012 N-propionyl-4-S-cysteaminylphenol (NPrCAP), an N-protected sulfur-amine analog of tyrosine, is a good substrate for tyrosinase and is selectively incorporated into melanoma cells, causing cytotoxicity in vitro and in vivo. Tyrosine 82-90 tyrosinase Mus musculus 116-126 23018855-5 2012 Chalcones 1-4 were evaluated for inhibition activity on mushroom tyrosinase using L-tyrosine as the substrate. Tyrosine 82-92 tyrosinase Mus musculus 65-75 22189272-4 2012 Oxidation of resveratrol and inhibition of L-tyrosine oxidation suggested the inhibitory effects of metabolites of resveratrol on tyrosinase. Tyrosine 43-53 tyrosinase Mus musculus 130-140 19772488-2 2009 The lag time of tyrosine oxidation catalyzed by mushroom tyrosinase was obviously lengthened; 0.337 mM of tiliroside resulted in the lag time extension from 46.7 s to 435.1 s. A kinetic analysis shown that tiliroside was a competitive inhibitor for monophenolase and diphenolase with K(i) values of 0.052 mM and 0.26 mM, respectively. Tyrosine 16-24 tyrosinase Mus musculus 57-67 20619644-3 2010 The results of the enzymatic inhibition kinetics by Lineweaver-Burk analysis indicated 5HNB inhibits tyrosinase non-competitively when L-tyrosine was used as the substrate. Tyrosine 135-145 tyrosinase Mus musculus 101-111 22110954-1 2010 Tyrosinase is a bifunctional enzyme which oxidizes the initial step of melanin biosynthesis, that is, conversion of tyrosine to dopa and subsequently dopa to dopaquinone. Tyrosine 116-124 tyrosinase Mus musculus 0-10 19618251-4 2009 The extracts of W. coriacea (bark part of aerial root), P. urinaria (root), and D. petandra (aerial root) showed tyrosinase inhibitory activity of more than 40% using L-tyrosine as a substrate at 500 microg/ml. Tyrosine 167-177 tyrosinase Mus musculus 113-123 15007389-1 2004 The tyrosinase (Tyr) gene encodes the enzyme tyrosinase that catalyses the conversion of L-tyrosine into DOPA (3,4-dihydroxyphenylalanine)-quinone. Tyrosine 89-99 tyrosinase Mus musculus 4-14 18544081-10 2008 Because of its structural similarity, p-coumaric acid may interfere with l-tyrosine action in the control of tyrosinase expression in response to alpha-MSH. Tyrosine 73-83 tyrosinase Mus musculus 109-119 17270032-2 2007 The sulfur homolog of tyrosine, 4-S-cysteaminylphenol (4-S-CAP), was shown to be a substrate of melanoma tyrosinase and can cause selective cytotoxicity of melanocytes and melanoma cells. Tyrosine 22-30 tyrosinase Mus musculus 105-115 19574027-4 2009 Tyrosinase activity was measured by (14)C-tyrosine incorporation, the intracellular reactive oxygen species (ROS) level was monitored by H(2)DCFDA fluorescence labeling, and the cell viability was determined by MTT assay in murine melan-a melanocytes treated with hydroquinone, arbutin and deoxyarbutin in the presence or absence of UVA-induced oxidative stress. Tyrosine 42-50 tyrosinase Mus musculus 0-10 17803599-2 2007 Further addition of l-tyrosine enhances the melanogenesis by increasing the tyrosinase activity. Tyrosine 20-30 tyrosinase Mus musculus 76-86 17083330-1 2007 Mice of the FVB/N strain are severely visual impaired as a result of tyrosinase gene defects, leading to a deficiency of the key enzyme for melanin synthesis in skin and eye and of cyclic guanosine monophosphate phosphodiesterase gene defects, which results in albinism (Tyr(c/c)) and retinal degeneration (Pde6b(rd1/rd1)), respectively. Tyrosine 271-274 tyrosinase Mus musculus 69-79 17532540-8 2007 Excess l-tyrosine (l-Tyr) added to the culture media rescued the reduced activity of proliferation of melanocytes. Tyrosine 7-17 tyrosinase Mus musculus 21-24 15520878-3 2004 This locus is now known to encode tyrosinase, the rate-limiting enzyme in the production of melanin pigment, and the molecular basis of the albino ( Tyr(c)) mutation is known. Tyrosine 149-152 tyrosinase Mus musculus 34-44 15007389-1 2004 The tyrosinase (Tyr) gene encodes the enzyme tyrosinase that catalyses the conversion of L-tyrosine into DOPA (3,4-dihydroxyphenylalanine)-quinone. Tyrosine 89-99 tyrosinase Mus musculus 16-19 15007389-1 2004 The tyrosinase (Tyr) gene encodes the enzyme tyrosinase that catalyses the conversion of L-tyrosine into DOPA (3,4-dihydroxyphenylalanine)-quinone. Tyrosine 89-99 tyrosinase Mus musculus 45-55 11864987-7 2002 The kinetics and mechanism for inhibition of mushroom tyrosinase exhibited the reversibility of oxyresveratrol as a noncompetitive inhibitor with l-tyrosine as the substrate. Tyrosine 146-156 tyrosinase Mus musculus 54-64 14646624-4 2003 The enantiomers of alpha-Me-4-S-CAP and alpha-Et-4-S-CAP were found to be better substrates for tyrosinase than the natural substrate, L-tyrosine. Tyrosine 135-145 tyrosinase Mus musculus 96-106 12624268-3 2003 Using Cyp1b1-/- mice, we identified the tyrosinase gene (Tyr) as a modifier of the drainage structure phenotype, with Tyr deficiency increasing the magnitude of dysgenesis. Tyrosine 57-60 tyrosinase Mus musculus 40-50 12624268-4 2003 The severe dysgenesis in eyes lacking both CYP1B1 and TYR was alleviated by administration of the tyrosinase product dihydroxyphenylalanine (l-dopa). Tyrosine 54-57 tyrosinase Mus musculus 98-108 11384158-9 2001 Adding tyrosine to the medium was found to partially correct tyrosinase trafficking and to reduce secretion; the cysteine protease inhibitor E64 also reduced secretion. Tyrosine 7-15 tyrosinase Mus musculus 61-71 11821691-5 2002 Radioisotope assays were used to measure the total melanin synthesis and the activity of tyrosinase in converting tyrosine to L-3,4-dihydroxyphenylalanine, which is a rate-limiting reaction in melanogenesis. Tyrosine 114-122 tyrosinase Mus musculus 89-99 8525635-4 1995 By replacing the viral enhancer with the tyrosine promoter/enhancer sequences, promoter interference effects which we have previously observed when the tyrosinase promoter was included as an internal promoter within a similar retroviral vector were effectively abolished. Tyrosine 41-49 tyrosinase Mus musculus 152-162 10987861-2 2000 In melanocytes, tyrosinase catalyzes both the hydroxylation of tyrosine and the consequent oxidation of L-DOPA to form melanin. Tyrosine 63-71 tyrosinase Mus musculus 16-26 10536987-0 1999 Sulfur containing tyrosine analogs can cause selective melanocytotoxicity involving tyrosinase-mediated apoptosis. Tyrosine 18-26 tyrosinase Mus musculus 84-94 10536987-1 1999 Sulfur-containing tyrosine analogs such as 4-S-cysteaminylphenol (4-S-CAP) and its N-acetyl derivative, N-acetyl-4-S-CAP, are tyrosinase substrates and can cause selective cytotoxicity or cell death of melanocytes and melanoma cells. Tyrosine 18-26 tyrosinase Mus musculus 126-136 9521852-5 1998 Levels of tyrosinase protein and to a lesser extent of tyrosinase-related protein-1 (TRP-1) were subnormal but rose dramatically following stimulation by tyrosine. Tyrosine 154-162 tyrosinase Mus musculus 10-20 11236829-3 2001 With regard to the latter possibility, the absence of tyrosinase activity (encoded by Tyr) in albinos could alter tyrosine availability and thus the rate-limiting step in catecholamine synthesis. Tyrosine 86-89 tyrosinase Mus musculus 54-64 11236829-3 2001 With regard to the latter possibility, the absence of tyrosinase activity (encoded by Tyr) in albinos could alter tyrosine availability and thus the rate-limiting step in catecholamine synthesis. Tyrosine 114-122 tyrosinase Mus musculus 54-64 9841903-6 1999 Correct sorting of tyrosinase-lysosome-associated membrane protein-1 chimeras is mediated by the interplay of a di-leucine signal and a tyrosine motif of the Y-X-X-O type. Tyrosine 136-144 tyrosinase Mus musculus 19-29 1292015-1 1992 Transgenic fish carrying a reconstructed mouse tyrosinase gene, mg-Tyrs-J, were produced by microinjecting the gene into the oocyte nucleus of an orange-colored variant of medaka (Oryzias latipes). Tyrosine 67-71 tyrosinase Mus musculus 47-57 8610070-2 1995 The melanin-affinic properties are apparently due to binding to intermediates, preferably dopaquinone, produced in the melanin synthetic pathway by tyrosinase-catalysed oxidation of tyrosine. Tyrosine 182-190 tyrosinase Mus musculus 148-158 7479744-1 1995 Cutaneous melanomas of Tyr-SV40E transgenic mice (mice whose transgene consists of the tyrosinase promoter fused to the coding regions of simian virus 40 early genes) strikingly resemble human melanomas in their development and progression. Tyrosine 23-26 tyrosinase Mus musculus 87-97 8432999-2 1993 We constructed a minigene, mg-Tyrs-J, by fusing a tyrosinase cDNA, Tyrs-J, with the 5" upstream region of genomic deoxyribonucleic acid (DNA) clone, G3L, and microinjected this minigene into fertilized eggs from albino BALB/c mice. Tyrosine 30-34 tyrosinase Mus musculus 50-60 1809095-1 1991 A mouse tyrosinase minigene, mg-Tyrs-J, in which genomic 5" noncoding flanking sequence was fused to a mouse tyrosinase cDNA, was introduced into fertilized eggs of BALB/c albino mice. Tyrosine 32-36 tyrosinase Mus musculus 8-18 1812074-0 1991 Tyrosinase exhibits lag at pH 6.8 under steady state concentrations of tyrosine and 3,4-dihydroxy phenyl alanine in melanoma tissue. Tyrosine 71-79 tyrosinase Mus musculus 0-10 1812074-1 1991 Tyrosine to dopa ratio determines the extent of lag in cresolase activity of tyrosinase when assayed at pH 6.8. Tyrosine 0-8 tyrosinase Mus musculus 77-87 1812074-3 1991 Cresolase activity of tyrosinase, when assayed at the above steady state levels of tyrosine and dopa at pH 6.8, exhibited a lag of 5-15 min depending on the amount of enzyme used in the assay mixture and the initial enzyme activity was zero. Tyrosine 83-91 tyrosinase Mus musculus 22-32 1900251-1 1991 We have isolated and characterized tyrosinase-specific cDNAs from wild-type mouse skin, to provide a basis for the structural and functional analysis of mutations at the mouse tyrosinase-encoding (Tyr) locus. Tyrosine 197-200 tyrosinase Mus musculus 35-45 1906010-0 1991 L-tyrosine induces tyrosinase expression via a posttranscriptional mechanism. Tyrosine 0-10 tyrosinase Mus musculus 19-29 1906010-1 1991 Exposure of hamster amelanotic melanoma cells to L-tyrosine caused a time-dependent increase of tyrosinase protein concentrations, tyrosinase activity and level of cell pigmentation. Tyrosine 49-59 tyrosinase Mus musculus 96-106 1906010-1 1991 Exposure of hamster amelanotic melanoma cells to L-tyrosine caused a time-dependent increase of tyrosinase protein concentrations, tyrosinase activity and level of cell pigmentation. Tyrosine 49-59 tyrosinase Mus musculus 131-141 1906010-3 1991 Thus in hamster melanoma cells the stimulation of intracellular tyrosinase concentration by L-tyrosine is mediated mainly via a posttranscriptional mechanism. Tyrosine 92-102 tyrosinase Mus musculus 64-74 1898730-4 1991 By use of immune affinity purification protocols, we have isolated the proteins encoded by the brown and albino loci and have determined that both have the catalytic functions ascribed to tyrosinase, i.e. hydroxylation of tyrosine to 3,4-dihydroxyphenylalanine (DOPA) and the oxidation of DOPA to DOPAquinone. Tyrosine 222-230 tyrosinase Mus musculus 188-198 1900251-1 1991 We have isolated and characterized tyrosinase-specific cDNAs from wild-type mouse skin, to provide a basis for the structural and functional analysis of mutations at the mouse tyrosinase-encoding (Tyr) locus. Tyrosine 197-200 tyrosinase Mus musculus 176-186 2112453-1 1990 We introduced a mouse tyrosinase minigene, mg-Tyrs-J, in which the authentic genomic 5" non-coding flanking sequence was fused to a mouse tyrosinase cDNA, into fertilized egges of albino mice. Tyrosine 46-50 tyrosinase Mus musculus 22-32 2107263-7 1990 The effects of RA were not limited to MSH or to Cloudman melanoma cells since RA blocked cholera toxin-inducible melanogenesis in Cloudman cells, as well as the induction of tyrosinase activity by L-tyrosine in Bomirski hamster melanoma cells. Tyrosine 197-207 tyrosinase Mus musculus 174-184