PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12627878-7 2003 Insulin-induced tyrosine phosphorylation of insulin receptor beta subunit (IRbeta) and insulin receptor substrate-1 (IRS-1) and tyrosine/threonine phosphorylation of p44/42 MAPK (ERK-1/2) were evaluated. Tyrosine 128-136 mitogen activated protein kinase 3 Rattus norvegicus 166-169 12710887-7 2003 Moreover, H(C)-TeTx and TeTx also induced phosphorylation of Akt (at Ser(473) and Thr(308)) and of ERK-1/2 (Thr(202)/Tyr(204)), in a time- and concentration-dependent manner. Tyrosine 117-120 mitogen activated protein kinase 3 Rattus norvegicus 99-106 12729803-10 2003 Insulin produced a significant transient increase in the tyrosine phosphorylation of ERK1/2, and PD98059 inhibited this phosphorylation. Tyrosine 57-65 mitogen activated protein kinase 3 Rattus norvegicus 85-91 12671999-6 2003 It also decreased tyrosine phosphorylation of ERK-1, STAT3, and EGF or IGF receptors after treatment with IGF-I or EGF. Tyrosine 18-26 mitogen activated protein kinase 3 Rattus norvegicus 46-51 11505033-6 2001 RESULTS: IGF-I-mediated tyrosine phosphorylation of MAPK was inhibited by ethanol in all cell lines. Tyrosine 24-32 mitogen activated protein kinase 3 Rattus norvegicus 52-56 12176662-5 2002 These interactions included: (i) a central role of tyrosine phosphorylation for stimulation of PKA/CREB, MAPK and PI3-kinase/PKB, (ii) inhibition of PKA/CREB by the MAPK pathway at the level of MAPK kinase-1 or downstream, (iii) activation of MAPK signaling by PI3-kinase and PKA at the level of extracellular-signal regulated kinase 1/2 or upstream, and (iv) activation of PKB by MAPK and PKA signaling at the level of PKB or upstream. Tyrosine 51-59 mitogen activated protein kinase 3 Rattus norvegicus 296-337 12495932-9 2003 These findings suggest that asbestos fibers may activate the ERK signaling pathway by generating ONOO- or other nitrating species that induce tyrosine nitration and phosphorylation of critical signaling molecules. Tyrosine 142-150 mitogen activated protein kinase 3 Rattus norvegicus 61-64 12218049-3 2002 cAMP-induced tyrosine phosphorylation of the EGF receptor is rapid and correlates with ERK1/2 activation. Tyrosine 13-21 mitogen activated protein kinase 3 Rattus norvegicus 87-93 11713247-8 2002 Protein transduction of anti-Tyr(P)(1062) antibodies into cultured cells reduced activation of MAPKs ERK1 and ERK2 and the AKT kinase in response to GDNF and diminished GDNF-dependent neuronal differentiation and survival of embryonic sensory neurons from the nodose ganglion. Tyrosine 29-32 mitogen activated protein kinase 3 Rattus norvegicus 101-105 12372950-11 2002 Serum-induced tyrosine phosphorylation of p44 and p42 ERK was inhibited by Sairei-to, but that of other cellular proteins was not affected. Tyrosine 14-22 mitogen activated protein kinase 3 Rattus norvegicus 42-45 11279262-6 2001 H(2)O(2) stimulated the rapid tyrosine phosphorylation of IRS-1 and p42/p44 MAP kinase, and induced its association with PI 3-kinase. Tyrosine 30-38 mitogen activated protein kinase 3 Rattus norvegicus 72-75 10970806-3 2000 SI resulted in transient dual (Thr/Tyr) phosphorylation of p42/p44-MAPK and p38-MAPK, weak phosphorylation of p46/p54-SAPK, but no phosphorylation of PKB. Tyrosine 35-38 mitogen activated protein kinase 3 Rattus norvegicus 63-66 10970806-3 2000 SI resulted in transient dual (Thr/Tyr) phosphorylation of p42/p44-MAPK and p38-MAPK, weak phosphorylation of p46/p54-SAPK, but no phosphorylation of PKB. Tyrosine 35-38 mitogen activated protein kinase 3 Rattus norvegicus 67-71 10928958-4 2000 Tyrosine phosphorylation of PDGF-Rbeta, PLC-gamma1, ERK1 and ERK2, p125(FAK) and paxillin as well as Sm alpha-actin was examined by the chemiluminescence Western blotting method. Tyrosine 0-8 mitogen activated protein kinase 3 Rattus norvegicus 52-56 10928958-12 2000 Furthermore CTX attenuated the PDGF-BB-induced tyrosine phosphorylation of the PDGF-Rbeta, PI 3"-K, PLC-gamma1 and ERK1/2 indicating an action of cyclic AMP on PDGF-beta receptor. Tyrosine 47-55 mitogen activated protein kinase 3 Rattus norvegicus 115-121 10891597-2 2000 Tyrosine phosphorylation of ERK1 and ERK2 corresponded with the activity of ERK. Tyrosine 0-8 mitogen activated protein kinase 3 Rattus norvegicus 28-32 11282216-5 2000 Hwansodan also prevents DNA fragmentation and caspase-3-like protease activation in serum-deprived PC12 cells and induces the tyrosine phosphorylation of proteins around 44 kDa, which was identified as ERK1 with electrophoretic gel mobility shift by Western blot. Tyrosine 126-134 mitogen activated protein kinase 3 Rattus norvegicus 202-206 10783131-12 2000 These data suggest that V(2)O(5) activation of ERK-1/2 is oxidant-dependent and mediated through tyrosine phosphorylation of EGF-R and an EGF-R substrate which we identified as a 115-kD SH-PTP2-binding protein. Tyrosine 97-105 mitogen activated protein kinase 3 Rattus norvegicus 47-54 10647963-4 1999 The results show that basal tyrosine-phosphorylated ERK1/ERK2 in cortex of 24-month-old rats was reduced by 36%-59%, compared to 6- and 12-month-old rats (p<.05, 24- vs. 12- or 6-month-old rats). Tyrosine 28-36 mitogen activated protein kinase 3 Rattus norvegicus 52-56 10684886-3 2000 Subcutaneous injections of the D(2) receptor agonist quinpirole significantly increased tyrosine-phosphorylated ERK1/2 in lesioned striatum, whereas the D(1) receptor agonist SKF38393 failed to activate ERKs. Tyrosine 88-96 mitogen activated protein kinase 3 Rattus norvegicus 112-118 10519505-3 1999 Carbachol-induced tyrosine-phosphorylated proteins of 44 and 42 kd were determined by Western blot analysis and identified as activated ERK1 and ERK2 using anti-ERK antibody. Tyrosine 18-26 mitogen activated protein kinase 3 Rattus norvegicus 136-140 10449437-9 1999 In contrast, insulin stimulated tyrosine phosphorylation of MAP kinase (ERK-1/2) equally in isolated microvessels of lean and obese rats, although basal tyrosine phosphorylation of ERK-1/2 was higher in the obese rats. Tyrosine 32-40 mitogen activated protein kinase 3 Rattus norvegicus 72-79 10449437-9 1999 In contrast, insulin stimulated tyrosine phosphorylation of MAP kinase (ERK-1/2) equally in isolated microvessels of lean and obese rats, although basal tyrosine phosphorylation of ERK-1/2 was higher in the obese rats. Tyrosine 153-161 mitogen activated protein kinase 3 Rattus norvegicus 181-188 10356288-4 1999 ZAS stimulated the tyrosine phosphorylation and activation of three members of a family of serine/threonine kinases known as the mitogen-activated protein kinases (MAPK), i.e., ERK1 and ERK2, as assessed by immunoblotting, immunoprecipitation, and phosphotransferase activity, and p38 MAPK, as determined by immunoblotting with phospho-specific antibodies. Tyrosine 19-27 mitogen activated protein kinase 3 Rattus norvegicus 177-181 10409724-4 1999 This study shows that in hepatoma cells, the recruitment and tyrosine phosphorylation of SHP-2, but not SHC, is the primary signaling event associated with the activation of MAP kinases (ERK1/2) by gp130. Tyrosine 61-69 mitogen activated protein kinase 3 Rattus norvegicus 187-193 9824810-4 1998 Mitogen-activated protein kinase activation was studied by detection of tyrosine phosphorylation of erk1 and erk2 kinases and enzymatic activity. Tyrosine 72-80 mitogen activated protein kinase 3 Rattus norvegicus 100-104 9681450-2 1998 In this study, we report that mGluR activation in primary cultures of rat cortical glia results in tyrosine phosphorylation of several proteins, including p44/p42 mitogen-activated protein kinases, also referred to as extracellular signal-regulated kinases (ERK1/2). Tyrosine 99-107 mitogen activated protein kinase 3 Rattus norvegicus 155-158 9681450-2 1998 In this study, we report that mGluR activation in primary cultures of rat cortical glia results in tyrosine phosphorylation of several proteins, including p44/p42 mitogen-activated protein kinases, also referred to as extracellular signal-regulated kinases (ERK1/2). Tyrosine 99-107 mitogen activated protein kinase 3 Rattus norvegicus 258-264 9681450-9 1998 Taken together, these results suggest that mGluR5 stimulation results in tyrosine phosphorylation of ERK1/2 and other glial proteins. Tyrosine 73-81 mitogen activated protein kinase 3 Rattus norvegicus 101-107 9397154-8 1998 Phosphoamino acid analysis indicated that ERK1 is phosphorylated on threonine, but not on tyrosine, in oncogene-transformed cells and that vanadate treatment restores tyrosine phosphorylation. Tyrosine 167-175 mitogen activated protein kinase 3 Rattus norvegicus 42-46 9690862-20 1998 Stimulation of SHR derived cells with UTP enhanced the tyrosine phosphorylation of both p42 and p44 MAPK, and the incorporation of [3H]-thymidine into DNA. Tyrosine 55-63 mitogen activated protein kinase 3 Rattus norvegicus 96-104 9516390-4 1998 RESULTS: Tyrosine phosphorylation of several proteins including ERK1 was substantially increased 5 minutes after injury. Tyrosine 9-17 mitogen activated protein kinase 3 Rattus norvegicus 64-68 9395506-9 1997 In each case, the rapid stimulation of Erk 1/2 correlates with tyrosine phosphorylation of Shc but not of FAK. Tyrosine 63-71 mitogen activated protein kinase 3 Rattus norvegicus 39-46 9126327-5 1997 A beta(1-40) induced phosphorylation of p44 and p42 MAP kinases (Erk1 and Erk2) at tyrosine-204, and PD98059, a MEK1 inhibitor, inhibited A beta(1-40)-induced CREB phosphorylation at serine-133. Tyrosine 83-91 mitogen activated protein kinase 3 Rattus norvegicus 40-43 9275188-3 1997 Tyrosine phosphorylation of ERK1 and ERK2 increases gradually, starting after 5 min of treatment, to reach a maximum at 30 min; the kinase activity reaches 250% when measured after 1 hr of treatment. Tyrosine 0-8 mitogen activated protein kinase 3 Rattus norvegicus 28-32 9376223-6 1997 p52 Shc became tyrosine phosphorylated more rapidly than p44MAPK in response to D-ala2-D-leu5-enkephalin and its enhanced tyrosine phosphorylation was maintained for at least 10 min. Tyrosine 122-130 mitogen activated protein kinase 3 Rattus norvegicus 57-64 9239417-9 1997 Immunoprecipitation studies indicated tyrosine phosphorylation of the mitogen activated protein kinases (MAPK) ERK1 and ERK2 and the adaptor protein Shc in lysates of RLMEC exposed to hyperosmolar conditions. Tyrosine 38-46 mitogen activated protein kinase 3 Rattus norvegicus 105-109 9239417-9 1997 Immunoprecipitation studies indicated tyrosine phosphorylation of the mitogen activated protein kinases (MAPK) ERK1 and ERK2 and the adaptor protein Shc in lysates of RLMEC exposed to hyperosmolar conditions. Tyrosine 38-46 mitogen activated protein kinase 3 Rattus norvegicus 111-115 9126327-5 1997 A beta(1-40) induced phosphorylation of p44 and p42 MAP kinases (Erk1 and Erk2) at tyrosine-204, and PD98059, a MEK1 inhibitor, inhibited A beta(1-40)-induced CREB phosphorylation at serine-133. Tyrosine 83-91 mitogen activated protein kinase 3 Rattus norvegicus 65-69 8943310-3 1996 AII stimulates the phosphorylation of MAPK, as determined by Western blot specific for the tyrosine 204 phosphorylated form of the protein. Tyrosine 91-99 mitogen activated protein kinase 3 Rattus norvegicus 38-42 7945229-1 1994 Mitogen-activated protein (MAP) kinase kinases (MKKs) are dual-specificity protein kinases which activate p42mapk and p44mapk by phosphorylation of regulatory tyrosine and threonine residues. Tyrosine 159-167 mitogen activated protein kinase 3 Rattus norvegicus 118-121 8972717-3 1996 OA stimulated glucose transport activity, altered the electrophoretic mobility of IRS-1, increased the phosphorylation of the MAP-kinases ERK 1 and 2 on tyrosine sites, markedly increased MAP kinase activity and also acted synergistically with insulin in activating these enzymes. Tyrosine 153-161 mitogen activated protein kinase 3 Rattus norvegicus 138-149 8769883-6 1996 As in the case of ERK1 and ERK2, tyrosine phosphorylation of ERK4 occurs by a ras-dependent pathway in response to NGF and EGF and shows prolonged kinetics for NGF but not EGF treatment. Tyrosine 33-41 mitogen activated protein kinase 3 Rattus norvegicus 18-22 8526802-8 1995 Both mitogenic treatments stimulated the tyrosine phosphorylation of a weak, 44-kDa protein, which we have identified as the extracellular signal-regulated kinase-1. Tyrosine 41-49 mitogen activated protein kinase 3 Rattus norvegicus 125-164 7980404-6 1994 The observed tyrosine phosphorylation of p42 and p44 was inhibited by genistein, a tyrosine kinase inhibitor, and tyrphostin 23, an epidermal growth factor receptor tyrosine kinase inhibitor. Tyrosine 13-21 mitogen activated protein kinase 3 Rattus norvegicus 49-52 8206880-4 1994 Western blotting with anti-phosphotyrosine antibody showed that VIP stimulated tyrosine phosphorylation of two proteins of 42 and 44 kDa, which may be two isoforms of MAP kinase, erk1 and erk2. Tyrosine 34-42 mitogen activated protein kinase 3 Rattus norvegicus 179-183 8034731-10 1994 Immunoblot analysis demonstrated tyrosine phosphorylation of p44MAPK, and, in addition, we demonstrated for the first time tyrosine phosphorylation of p125FAK, p46SHC, and p56SHC in response to angiotensin II. Tyrosine 33-41 mitogen activated protein kinase 3 Rattus norvegicus 61-68 8177321-1 1994 The mitogen-activated protein (MAP) kinases Erk-1 and Erk-2 are proline-directed kinases that are themselves activated through concomitant phosphorylation of tyrosine and threonine residues. Tyrosine 158-166 mitogen activated protein kinase 3 Rattus norvegicus 44-49 8407983-7 1993 NGF treatment also enhanced the tyrosine phosphorylation of a p75-associated species that co-migrates with ERK1 in Western blots. Tyrosine 32-40 mitogen activated protein kinase 3 Rattus norvegicus 107-111 1384575-6 1992 The tyrosine phosphorylation or activity of several cellular proteins, such as PLC-gamma 1, PI-3 kinase, and Erk1 and the expression of the mRNA for the late response gene transin were also sustained as a consequence of gp140trk overexpression. Tyrosine 4-12 mitogen activated protein kinase 3 Rattus norvegicus 109-113 8387505-10 1993 In both cell systems all effectors tested stimulated ERK1 phosphorylation on both threonine and tyrosine residues in an 1:1 ratio. Tyrosine 96-104 mitogen activated protein kinase 3 Rattus norvegicus 53-57 8385103-4 1993 Specific antibodies were used to identify the AII-stimulated 42- and 44-kDa tyrosine-phosphorylated proteins as the "mitogen-activated protein kinases," p42mapk and p44mapk, respectively. Tyrosine 76-84 mitogen activated protein kinase 3 Rattus norvegicus 165-172 1382473-2 1992 Oncogenic N-ras-induced neuronal differentiation is inhibited by compounds that block ERK protein tyrosine phosphorylation or ERK activity, indicating that ERKs are not only activated by p21ras but serve as the primary downstream effectors of p21ras. Tyrosine 98-106 mitogen activated protein kinase 3 Rattus norvegicus 156-160 1627831-2 1992 ERK1 and ERK2 are phosphorylated on serine in the absence of the stimuli and additionally on tyrosine and threonine residues after exposure to NGF and insulin. Tyrosine 93-101 mitogen activated protein kinase 3 Rattus norvegicus 0-4 1378625-2 1992 Activation of the ERKs requires both threonine and tyrosine phosphorylation suggestive of a key role in mediating intracellular events in response to extracellular cues. Tyrosine 51-59 mitogen activated protein kinase 3 Rattus norvegicus 18-22 1319464-5 1992 Incorporation of 32P into ERK1 and ERK2 occurred primarily on tyrosine and threonine residues and was associated with a single tryptic peptide, which is identical to one whose phosphorylation is increased by treatment of intact PC12 cells with NGF. Tyrosine 62-70 mitogen activated protein kinase 3 Rattus norvegicus 26-30 1627831-3 1992 NGF stimulates tyrosine phosphorylation of ERK1 more rapidly than threonine phosphorylation. Tyrosine 15-23 mitogen activated protein kinase 3 Rattus norvegicus 43-47 1717989-2 1991 Although rat gene ERK1 is believed to encode a serine/threonine kinase based on sequence data and known ERK1 substrate phosphorylation sites, bacterially-produced mouse Erk-1 (bt-Erk-1) autophosphorylated on tyrosine in addition to serine and threonine residues. Tyrosine 208-216 mitogen activated protein kinase 3 Rattus norvegicus 18-22 1654126-2 1991 A kinase with such activity, named extracellular signal-regulated kinase 1 (ERK1), is activated rapidly by numerous extracellular signals, requires phosphorylation on tyrosine to be fully active, and in vitro can activate a kinase (a ribosomal S6 protein kinase) that is downstream in phosphorylation cascades. Tyrosine 167-175 mitogen activated protein kinase 3 Rattus norvegicus 35-74 1645334-0 1991 pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity. Tyrosine 59-67 mitogen activated protein kinase 3 Rattus norvegicus 5-44 1654126-2 1991 A kinase with such activity, named extracellular signal-regulated kinase 1 (ERK1), is activated rapidly by numerous extracellular signals, requires phosphorylation on tyrosine to be fully active, and in vitro can activate a kinase (a ribosomal S6 protein kinase) that is downstream in phosphorylation cascades. Tyrosine 167-175 mitogen activated protein kinase 3 Rattus norvegicus 76-80 30697602-6 2019 Decreased activation of Akt, P70S6K, and Erk1/2 was associated with decreased insulin receptor substrate 2 tyrosine phosphorylation and insulin receptor beta-subunit abundance; neither IGF receptor beta-subunit content nor its phosphorylation were affected. Tyrosine 107-115 mitogen activated protein kinase 3 Rattus norvegicus 41-47 26728129-7 2016 Further, mutation of tyrosine 4 in ZnT10 reduced ZnT3/ZnT10 dityrosine-mediated heterodimerization and zinc transport, as well as MEK and ERK1/2 phosphorylation, which were also reduced by the zinc chelator TPEN. Tyrosine 21-29 mitogen activated protein kinase 3 Rattus norvegicus 138-144 25433071-12 2015 Whereas Ang-II and photolysed [Tyr(DMNB)(4)]Ang-II increased ERK1/2 phosphorylation (via AT1R) and cGMP production (AT2R), caged [Tyr(DMNB)(4)]Ang-II did not. Tyrosine 31-34 mitogen activated protein kinase 3 Rattus norvegicus 61-67 27127657-4 2016 Here we show that a single episode of electroconvulsive seizures (ECS) increased protein expression of membrane-associated STriatal-Enriched protein tyrosine Phosphatase (STEP61) and decreased tyrosine-phosphorylation of its substrates N-methyl D-aspartate receptor (NMDAR) subunit GluN2B and extracellular signal regulated kinase 1/2 (ERK1/2) in the rat hippocampus at 2 days following a single ECS. Tyrosine 149-157 mitogen activated protein kinase 3 Rattus norvegicus 293-334 27127657-4 2016 Here we show that a single episode of electroconvulsive seizures (ECS) increased protein expression of membrane-associated STriatal-Enriched protein tyrosine Phosphatase (STEP61) and decreased tyrosine-phosphorylation of its substrates N-methyl D-aspartate receptor (NMDAR) subunit GluN2B and extracellular signal regulated kinase 1/2 (ERK1/2) in the rat hippocampus at 2 days following a single ECS. Tyrosine 149-157 mitogen activated protein kinase 3 Rattus norvegicus 336-342 23771439-8 2013 A clozapine-induced reduction in ERK1/2 phosphorylation was evident at both tyrosine and threonine residues, suggesting the involvement of dual specificity phosphatases (DUSPs; mitogen-activated protein kinase phosphatases [MKPs]). Tyrosine 76-84 mitogen activated protein kinase 3 Rattus norvegicus 33-39 24217647-10 2013 CONCLUSION: Our findings collectively suggest that periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis through at least two pathways, integrin beta1-Src-Rac1-FAK(Tyr(576/577))-ERK1/2 and integrin beta1-FAK (Tyr(397))-ERK1/2. Tyrosine 238-241 mitogen activated protein kinase 3 Rattus norvegicus 207-213 22528758-7 2013 The FP-I and FP-III containing serum also inhibited the PDGF-induced phosphorylation of tyrosine of ERK1/2 and PKCalpha expression (P <0.01 or P <0.05). Tyrosine 88-96 mitogen activated protein kinase 3 Rattus norvegicus 100-106 24217647-5 2013 Reduction of FAK with targeted shRNA via transfection of NH2-terminal tyrosine phosphorylation-deficient FAK mutant Y397F or Y576F-Y577F abolished periodic mechanical stress-induced chondrocyte proliferation and matrix synthesis, accompanied by attenuated ERK1/2 phosphorylation. Tyrosine 70-78 mitogen activated protein kinase 3 Rattus norvegicus 256-262 19056470-7 2009 In an attempt to characterize the sequential role of CaMK and PI3-kinase, we found that NMDA increased PI3-kinase phosphorylation on Tyr(508), which kinetically corresponded to the ERK1/2 phosphorylation and was blocked by the CaMK inhibitor. Tyrosine 133-136 mitogen activated protein kinase 3 Rattus norvegicus 181-187 24217647-10 2013 CONCLUSION: Our findings collectively suggest that periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis through at least two pathways, integrin beta1-Src-Rac1-FAK(Tyr(576/577))-ERK1/2 and integrin beta1-FAK (Tyr(397))-ERK1/2. Tyrosine 193-196 mitogen activated protein kinase 3 Rattus norvegicus 207-213 24217647-10 2013 CONCLUSION: Our findings collectively suggest that periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis through at least two pathways, integrin beta1-Src-Rac1-FAK(Tyr(576/577))-ERK1/2 and integrin beta1-FAK (Tyr(397))-ERK1/2. Tyrosine 193-196 mitogen activated protein kinase 3 Rattus norvegicus 248-254 22366512-1 2012 The extracellular signal-regulated kinase (ERK) 1/2 protein requires a dual phosphorylation at conserved threonine and tyrosine residues to be fully activated under normal physiological conditions. Tyrosine 119-127 mitogen activated protein kinase 3 Rattus norvegicus 4-51 20537760-5 2010 Area expansion, migration and phosphorylation of PLCgamma1-Tyr(783) and ERK1/2-Thr(202)/Tyr(204) are inhibited (p<0.05) after pretreatment with Src inhibitor (PP2). Tyrosine 88-91 mitogen activated protein kinase 3 Rattus norvegicus 72-78 20537760-6 2010 We further demonstrate that area expansion, migration and phosphorylation of ERK1/2-Thr(202)/Tyr(204) are significantly inhibited (p<0.05) after pretreatment with PLCgamma1 inhibitor (U73122); the phosphorylation site of Src-Tyr(418) is not affected. Tyrosine 93-96 mitogen activated protein kinase 3 Rattus norvegicus 77-83 20537760-6 2010 We further demonstrate that area expansion, migration and phosphorylation of ERK1/2-Thr(202)/Tyr(204) are significantly inhibited (p<0.05) after pretreatment with PLCgamma1 inhibitor (U73122); the phosphorylation site of Src-Tyr(418) is not affected. Tyrosine 228-231 mitogen activated protein kinase 3 Rattus norvegicus 77-83 20537760-7 2010 After pretreatment with an ERK1/2 inhibitor (PD98059), area expansion and migration are inhibited (p<0.05), while the phosphorylation sites of Src-Tyr(418) and PLCgamma1-Tyr(783) are not affected. Tyrosine 150-153 mitogen activated protein kinase 3 Rattus norvegicus 27-33 20537760-7 2010 After pretreatment with an ERK1/2 inhibitor (PD98059), area expansion and migration are inhibited (p<0.05), while the phosphorylation sites of Src-Tyr(418) and PLCgamma1-Tyr(783) are not affected. Tyrosine 173-176 mitogen activated protein kinase 3 Rattus norvegicus 27-33 22797318-9 2012 Activation of ERK1/2 by phosphorylation, GIT1 tyrosine phosphorylation, GIT1-ERK1/2 interaction, and VEGF mRNA expression were all significantly increased in osteoblasts after PDGF stimulation, but all responses were dramatically inhibited by pretreatment with PD98059. Tyrosine 46-54 mitogen activated protein kinase 3 Rattus norvegicus 14-20 22797318-12 2012 In conclusion, tyrosine 321 of GIT1 is a critical phosphorylation site for GIT1 interaction with ERK1/2, regulation of ERK1/2 activation, VEGF expression and angiogenesis at the fracture site. Tyrosine 15-23 mitogen activated protein kinase 3 Rattus norvegicus 97-103 22797318-12 2012 In conclusion, tyrosine 321 of GIT1 is a critical phosphorylation site for GIT1 interaction with ERK1/2, regulation of ERK1/2 activation, VEGF expression and angiogenesis at the fracture site. Tyrosine 15-23 mitogen activated protein kinase 3 Rattus norvegicus 119-125 17404041-12 2007 Microgravity signals may involve two pathways (G protein-coupled receptor-mediated pathway and tyrosine phosphorylation-mediated pathway) that activate Ras, Raf, and MAPK cascades in rat osteoblasts. Tyrosine 95-103 mitogen activated protein kinase 3 Rattus norvegicus 166-170 17229938-6 2007 These data indicate a new signal transduction pathway for IRS-1/PI 3-kinase/Akt/eNOS activation and ERK1/2 by means of JAK2 tyrosine phosphorylation stimulated by ACh in vessels. Tyrosine 124-132 mitogen activated protein kinase 3 Rattus norvegicus 100-106 17762651-7 2007 PSS-M increased tyrosine phosphorylation of several proteins, including SFK and ERK1/2. Tyrosine 16-24 mitogen activated protein kinase 3 Rattus norvegicus 80-86 15564939-3 2004 METHODS: The Na3VO4-induced contraction of rat aortic smooth muscle and tyrosine phosphorylation of proteins including phospholipase Cgamma-1 (PLCgamma-1) and p44/p42 mitogen-activated protein kinase (MAPK) were assessed in the presence of different concentrations of isoflurane, using isometric force measurement and Western blotting methods, respectively. Tyrosine 72-80 mitogen activated protein kinase 3 Rattus norvegicus 159-162 15923313-6 2005 Cyclic stretch induced rapid and sustained (up to 2 h) increases in phosphorylation of FAK at Tyr(397) and ERK1/2 at Thr(202)/Tyr(204). Tyrosine 126-129 mitogen activated protein kinase 3 Rattus norvegicus 107-113 16138568-4 2005 Furthermore, caffeic acid significantly abolished the tyrosine phosphorylation of JAK2 (decreased from 7.4 +/- 0.6-fold to 2.4 +/- 0.6-fold at 2 min) and STAT1 (decreased from 1.8 +/- 0.2-fold to 0.5 +/- 0.1-fold at 2 min) and the phosphorylation of ERK1/2 (decreased from 99.2 +/- 10.2-fold to 49.8 +/- 10.9-fold at 2 min) that were induced by Ang II. Tyrosine 54-62 mitogen activated protein kinase 3 Rattus norvegicus 250-256 15663900-5 2005 The tyrosine phosphorylation of ERK1/2 was examined by immunoprecipitation techniques using anti-phospho-tyrosine antibodies. Tyrosine 4-12 mitogen activated protein kinase 3 Rattus norvegicus 32-38 15663900-5 2005 The tyrosine phosphorylation of ERK1/2 was examined by immunoprecipitation techniques using anti-phospho-tyrosine antibodies. Tyrosine 105-113 mitogen activated protein kinase 3 Rattus norvegicus 32-38 15663900-11 2005 Furthermore immunoprecipitation studies showed that both onychin and genistein markedly inhibited the tyrosine phosphorylation of ERK1/2 induced by 10% NCS. Tyrosine 102-110 mitogen activated protein kinase 3 Rattus norvegicus 130-136 15663900-12 2005 CONCLUSION: Onychin inhibits the proliferation of VSMCs through G1 phase cell cycle arrest by decreasing the tyrosine phosphorylation of ERK1/2, and the expression of cyclin D1 and cyclin E, and sequentially inhibiting Rb phosphorylation. Tyrosine 109-117 mitogen activated protein kinase 3 Rattus norvegicus 137-143 16303771-7 2006 Furthermore, tPA induced rapid tyrosine phosphorylation on the beta subunit of LRP-1, which was followed by the activation of Mek1 and its downstream Erk-1 and -2. Tyrosine 31-39 mitogen activated protein kinase 3 Rattus norvegicus 150-162 15465928-10 2005 These data indicate that Go6976 potentiates agonist-induced ERK1/2 activation through stimulation of tyrosine phosphorylation of the EGF-R. Tyrosine 101-109 mitogen activated protein kinase 3 Rattus norvegicus 60-66 15564939-3 2004 METHODS: The Na3VO4-induced contraction of rat aortic smooth muscle and tyrosine phosphorylation of proteins including phospholipase Cgamma-1 (PLCgamma-1) and p44/p42 mitogen-activated protein kinase (MAPK) were assessed in the presence of different concentrations of isoflurane, using isometric force measurement and Western blotting methods, respectively. Tyrosine 72-80 mitogen activated protein kinase 3 Rattus norvegicus 201-205 14646244-4 2003 Western blotting with anti-phospho-ERK1/2 antibody and anti-ERK1/2 antibody demonstrated that A beta 1-40 or A beta 25-35 induced an increase in the dually (tyrosine and threonine) phosphorylated form of ERK1 and ERK2, with no change in total ERK1/2 level. Tyrosine 157-165 mitogen activated protein kinase 3 Rattus norvegicus 35-41 15590973-6 2004 Increased levels of threonine/tyrosine phosphorylation of ERK1/2 and serine phosphorylation of AKT and p70S6K were also detected. Tyrosine 30-38 mitogen activated protein kinase 3 Rattus norvegicus 58-64 15361284-9 2004 Inhibition of ERK1/2 by U0126 resulted in an increase of CT-1-induced tyrosine phosphorylation of STAT3 and, consequently, the protein-to-DNA ratio and [(3)H]-leucine incorporation. Tyrosine 70-78 mitogen activated protein kinase 3 Rattus norvegicus 14-20 15141098-4 2004 An increased level of phosphorylated extracellular signal-regulated kinases (Erk1/2) at Tyr-204 was observed. Tyrosine 88-91 mitogen activated protein kinase 3 Rattus norvegicus 77-83 14687927-3 2004 In this study we have evaluated the involvement of 1alpha,25(OH)(2)D(3) in the tyrosine phosphorylation of PLCgamma and MAPK (ERK1/2) in enterocytes from young (3 months) and aged (24 months) rats. Tyrosine 79-87 mitogen activated protein kinase 3 Rattus norvegicus 126-132 15209419-1 2004 Activation of the high affinity neurotrophin receptor tropomyosin-related kinase A (TrkA) by nerve growth factor (NGF) leads to phosphorylation of intracellular tyrosine residues of the receptor with subsequent activation of signaling pathways involved in neuronal survival such as the phosphoinositide-3-kinase (PI3-K)/protein kinase B (PKB/Akt) pathway and the mitogen-activated protein kinase (MAPK) cascade. Tyrosine 161-169 mitogen activated protein kinase 3 Rattus norvegicus 397-401 14654226-6 2003 Tyrosine phosphorylation of c-met is strongly stimulated as well as kinase pathways leading to ERK1/2 cascade. Tyrosine 0-8 mitogen activated protein kinase 3 Rattus norvegicus 95-101 14646244-4 2003 Western blotting with anti-phospho-ERK1/2 antibody and anti-ERK1/2 antibody demonstrated that A beta 1-40 or A beta 25-35 induced an increase in the dually (tyrosine and threonine) phosphorylated form of ERK1 and ERK2, with no change in total ERK1/2 level. Tyrosine 157-165 mitogen activated protein kinase 3 Rattus norvegicus 60-66 14646244-4 2003 Western blotting with anti-phospho-ERK1/2 antibody and anti-ERK1/2 antibody demonstrated that A beta 1-40 or A beta 25-35 induced an increase in the dually (tyrosine and threonine) phosphorylated form of ERK1 and ERK2, with no change in total ERK1/2 level. Tyrosine 157-165 mitogen activated protein kinase 3 Rattus norvegicus 35-39 14646244-4 2003 Western blotting with anti-phospho-ERK1/2 antibody and anti-ERK1/2 antibody demonstrated that A beta 1-40 or A beta 25-35 induced an increase in the dually (tyrosine and threonine) phosphorylated form of ERK1 and ERK2, with no change in total ERK1/2 level. Tyrosine 157-165 mitogen activated protein kinase 3 Rattus norvegicus 60-66