PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16931773-6 2006 S1P-induced activation of the mitogen-activated protein kinase kinase-1 (MEK1)/ERK pathway also contributed to the induction of the actin stress fibers and to the redistribution of paxillin at the focal adhesions through tyrosine phosphorylation of focal adhesion kinase in an MMP-dependent manner. Tyrosine 221-229 mitogen-activated protein kinase kinase 1 Homo sapiens 30-71 23820731-11 2013 The MEK1 inhibitor PD98059 reduced EPO-induced tyrosine phosphorylation, suggesting these substrates are downstream of MEK kinase. Tyrosine 47-55 mitogen-activated protein kinase kinase 1 Homo sapiens 4-8 21454680-0 2011 Mitogen-activated protein kinase kinase 1 (MEK1) stabilizes MyoD through direct phosphorylation at tyrosine 156 during myogenic differentiation. Tyrosine 99-107 mitogen-activated protein kinase kinase 1 Homo sapiens 0-41 21454680-0 2011 Mitogen-activated protein kinase kinase 1 (MEK1) stabilizes MyoD through direct phosphorylation at tyrosine 156 during myogenic differentiation. Tyrosine 99-107 mitogen-activated protein kinase kinase 1 Homo sapiens 43-47 34046359-1 2021 Mitogen-activated protein kinase kinase 1 (MAP2K1) is a dual specificity protein kinase that phosphorylates both threonine and tyrosine residues in ERK. Tyrosine 127-135 mitogen-activated protein kinase kinase 1 Homo sapiens 0-41 34046359-1 2021 Mitogen-activated protein kinase kinase 1 (MAP2K1) is a dual specificity protein kinase that phosphorylates both threonine and tyrosine residues in ERK. Tyrosine 127-135 mitogen-activated protein kinase kinase 1 Homo sapiens 43-49 31830556-4 2020 The ERBB family of receptor tyrosine kinases (EGFR/ERBB1, HER2/ERBB2, ERBB3, and ERBB4) are activated by extracellular ligands, inducing multiple pro-growth signaling cascades; among these, activation of signaling through the RAS GTPase, and the RAF, MEK1/2, and ERK1/2 kinases enhance cell proliferation and restrict apoptosis during renal tubuloepithelial cyst formation. Tyrosine 28-36 mitogen-activated protein kinase kinase 1 Homo sapiens 251-257 31242404-0 2020 Integrin beta 4 (ITGB4) and its tyrosine-1510 phosphorylation promote pancreatic tumorigenesis and regulate the MEK1-ERK1/2 signaling pathway. Tyrosine 32-40 mitogen-activated protein kinase kinase 1 Homo sapiens 112-116 27793200-1 2016 BACKGROUND: MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. Tyrosine 157-165 mitogen-activated protein kinase kinase 1 Homo sapiens 12-16 27793200-1 2016 BACKGROUND: MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. Tyrosine 157-165 mitogen-activated protein kinase kinase 1 Homo sapiens 18-24 26950759-4 2016 ERK2 is activated by the upstream kinases MEK1/2, which phosphorylate both tyrosine 185 and threonine 183. Tyrosine 75-83 mitogen-activated protein kinase kinase 1 Homo sapiens 42-48 18762250-8 2008 Further, pretreatment with the MEK1/ERK inhibitor PD98059 enhanced EGF-induced EGFR loss in cells expressing WT EGFR, but not EGFR T669A, suggesting that the ERK-dependent effects on EGFR downregulation required phosphorylation of (669)T. In signaling experiments, EGFR T669A displayed enhanced acute (15 min) EGFR tyrosine phosphorylation (reflecting EGFR kinase activity) compared to WT EGFR. Tyrosine 315-323 mitogen-activated protein kinase kinase 1 Homo sapiens 31-35 17293484-3 2007 In Hsf1 CT domain-deficient cells, Slt2 still undergoes Mkk1/2-directed dual-Thr/Tyr phosphorylation in response to the heat stimulation of cell integrity pathway signaling, but the low Hsp90 expression level suppresses any corresponding increase in Slt2 kinase activity due to Slt2 being a "client" of the Hsp90 chaperone. Tyrosine 81-84 mitogen-activated protein kinase kinase 1 Homo sapiens 56-60 16931773-6 2006 S1P-induced activation of the mitogen-activated protein kinase kinase-1 (MEK1)/ERK pathway also contributed to the induction of the actin stress fibers and to the redistribution of paxillin at the focal adhesions through tyrosine phosphorylation of focal adhesion kinase in an MMP-dependent manner. Tyrosine 221-229 mitogen-activated protein kinase kinase 1 Homo sapiens 73-77 15020233-0 2004 Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts. Tyrosine 34-42 mitogen-activated protein kinase kinase 1 Homo sapiens 61-65 16148006-1 2005 The two regulatory residues that control the enzymatic activity of the mitogen-activated protein (MAP) kinase ERK2 are phosphorylated by the unique MAP kinase kinases MEK1/2 and dephosphorylated by several tyrosine-specific and dual specificity protein phosphatases. Tyrosine 206-214 mitogen-activated protein kinase kinase 1 Homo sapiens 167-173 15031205-5 2004 We found that MEK1 inhibitors reduce the levels of dominant-negative (DeltaN) p73 proteins and promote the accumulation of endogenous p73alpha through its transcriptional activation and its tyrosine phosphorylation, resulting in p21 up-regulation and significant inhibition of cell growth. Tyrosine 190-198 mitogen-activated protein kinase kinase 1 Homo sapiens 14-18 15020233-3 2004 U0126, a MEK1/2 inhibitor, inhibited tyrosine phosphorylation of GSK-3beta, suggesting that MEK1/2 was involved in the phosphorylation of Tyr(216) in GSK-3beta. Tyrosine 138-141 mitogen-activated protein kinase kinase 1 Homo sapiens 9-15 15020233-3 2004 U0126, a MEK1/2 inhibitor, inhibited tyrosine phosphorylation of GSK-3beta, suggesting that MEK1/2 was involved in the phosphorylation of Tyr(216) in GSK-3beta. Tyrosine 138-141 mitogen-activated protein kinase kinase 1 Homo sapiens 92-98 15020233-4 2004 In vitro kinase assay was carried out using a recombinant human active MEK1 and we found that GSK-3beta was phosphorylated on Tyr(216) by this kinase in a dose- and time-dependent manner. Tyrosine 126-129 mitogen-activated protein kinase kinase 1 Homo sapiens 71-75 15020233-6 2004 These results suggested that MEK1/2 induces tyrosine phosphorylation of GSK-3beta and this cellular event might induce nuclear translocation of GSK-3beta. Tyrosine 44-52 mitogen-activated protein kinase kinase 1 Homo sapiens 29-35 15020233-3 2004 U0126, a MEK1/2 inhibitor, inhibited tyrosine phosphorylation of GSK-3beta, suggesting that MEK1/2 was involved in the phosphorylation of Tyr(216) in GSK-3beta. Tyrosine 37-45 mitogen-activated protein kinase kinase 1 Homo sapiens 9-15 15020233-3 2004 U0126, a MEK1/2 inhibitor, inhibited tyrosine phosphorylation of GSK-3beta, suggesting that MEK1/2 was involved in the phosphorylation of Tyr(216) in GSK-3beta. Tyrosine 37-45 mitogen-activated protein kinase kinase 1 Homo sapiens 92-98 14699120-10 2004 To our knowledge, this is the first report that p56(lck) in presence of H/R regulates MEK-1-dependent ERK1/2 phosphorylation and uPA secretion through tyrosine phosphorylation of EGF receptor, and it further demonstrates that all of these signaling molecules ultimately control the motility of breast cancer cells. Tyrosine 151-159 mitogen-activated protein kinase kinase 1 Homo sapiens 86-91 14674888-12 2003 To investigate a signalling pathway leading to activation of MEK1/2-ERK1/2, we examined the tyrosine phosphorylation of EGFR and Shc adapter protein. Tyrosine 92-100 mitogen-activated protein kinase kinase 1 Homo sapiens 61-67 12554784-3 2003 The MEK1 mutant, which activates ERK, markedly down-regulated expression of the insulin receptor (IR) and its major substrates, IRS-1 and IRS-2, mRNA and protein, and in turn reduced tyrosine phosphorylation of IR as well as IRS-1 and IRS-2 and their associated phosphatidyl inositol 3-kinase (PI3K) activity. Tyrosine 183-191 mitogen-activated protein kinase kinase 1 Homo sapiens 4-8 8798409-9 1996 Treatment of cells with PD98059, a specific inhibitor of MAPKK1, attenuated the inhibitory effects of AII and PMA on IL-6-induced Stat3 tyrosine phosphorylation and SIF-A formation. Tyrosine 136-144 mitogen-activated protein kinase kinase 1 Homo sapiens 57-63 12082107-3 2002 The dual phosphorylation of Thr-183 and Tyr-185 in ERK2 is catalyzed by MAPK/ERK kinase 1 (MEK1). Tyrosine 40-43 mitogen-activated protein kinase kinase 1 Homo sapiens 72-89 12082107-3 2002 The dual phosphorylation of Thr-183 and Tyr-185 in ERK2 is catalyzed by MAPK/ERK kinase 1 (MEK1). Tyrosine 40-43 mitogen-activated protein kinase kinase 1 Homo sapiens 91-95 8034695-10 1994 In contrast, activation of MEK-1 was induced by phorbol esters, and the stimulatory effect of fMLP was blocked by an antagonist of protein kinase C. Stimulation of MEK-1 was also blocked by concentrations of erbstatin that prevent the fMLP-induced accumulation of tyrosine-phosphorylated proteins. Tyrosine 264-272 mitogen-activated protein kinase kinase 1 Homo sapiens 27-32 8034695-10 1994 In contrast, activation of MEK-1 was induced by phorbol esters, and the stimulatory effect of fMLP was blocked by an antagonist of protein kinase C. Stimulation of MEK-1 was also blocked by concentrations of erbstatin that prevent the fMLP-induced accumulation of tyrosine-phosphorylated proteins. Tyrosine 264-272 mitogen-activated protein kinase kinase 1 Homo sapiens 164-169 34247190-0 2021 The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis. Tyrosine 26-34 mitogen-activated protein kinase kinase 1 Homo sapiens 21-25 34247190-0 2021 The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis. Tyrosine 26-34 mitogen-activated protein kinase kinase 1 Homo sapiens 89-93 34247190-8 2021 This study identifies MACC1 as new MEK1 substrate for tyrosine phosphorylation decisively impacting cell motility, tumor growth, and metastasis. Tyrosine 54-62 mitogen-activated protein kinase kinase 1 Homo sapiens 35-39 8393135-2 1993 A MAP kinase kinase (MKK1 or MEK1) has been identified as a dual-specificity protein kinase that is sufficient to phosphorylate MAP kinases p42mapk and p44mapk on the regulatory threonine and tyrosine residues. Tyrosine 192-200 mitogen-activated protein kinase kinase 1 Homo sapiens 21-25 8393135-2 1993 A MAP kinase kinase (MKK1 or MEK1) has been identified as a dual-specificity protein kinase that is sufficient to phosphorylate MAP kinases p42mapk and p44mapk on the regulatory threonine and tyrosine residues. Tyrosine 192-200 mitogen-activated protein kinase kinase 1 Homo sapiens 29-33