PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23798440-6 2013 Furthermore, the trophic factor S100beta induces Src-family kinase-mediated tyrosine phosphorylation of hnRNPK and increased SERT expression. Tyrosine 76-84 S100 calcium binding protein B Homo sapiens 32-40 3111527-4 1987 In the absence of calcium, the interaction of melittin and S100b shielded the tryptophan (Trp) of the former protein and exposed cysteine-84 beta (Cys-84 beta) of the latter protein, leaving the tyrosine-16 beta (Tyr-16 beta) of S100b unaffected. Tyrosine 195-203 S100 calcium binding protein B Homo sapiens 59-64 3111527-4 1987 In the absence of calcium, the interaction of melittin and S100b shielded the tryptophan (Trp) of the former protein and exposed cysteine-84 beta (Cys-84 beta) of the latter protein, leaving the tyrosine-16 beta (Tyr-16 beta) of S100b unaffected. Tyrosine 213-216 S100 calcium binding protein B Homo sapiens 59-64 30282749-7 2018 Strikingly, the Nef-induced Lck compartment contains signaling-competent forms (phosphorylated on key Tyr residues) of Lck and some of its downstream effectors, TCRzeta, ZAP70, SLP76, and Vav1, avoiding the proximal LAT adaptor. Tyrosine 102-105 S100 calcium binding protein B Homo sapiens 16-19 21543478-6 2011 The interaction with AP-1 required for CD28 and CD8beta differed from the AP-1 interaction required for MHC-I downmodulation in that it was mediated through the dileucine motif within Nef (LL(164,165)AA) and did not require the tyrosine binding pocket of the AP-1 mu subunit. Tyrosine 228-236 S100 calcium binding protein B Homo sapiens 184-187 18073204-0 2008 The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail. Tyrosine 4-12 S100 calcium binding protein B Homo sapiens 89-92 20020046-3 2009 The CD of MHC-I contains a key tyrosine within the sequence YSQA that is required for down-regulation by Nef, but this sequence does not conform to the canonical AP-binding tyrosine-based motif Yxxphi, which mediates binding to the medium (micro) subunits of AP complexes. Tyrosine 31-39 S100 calcium binding protein B Homo sapiens 105-108 20020046-6 2009 Specifically, the tyrosine residue of the YSQA sequence in the MHC-I CD as well as Nef residues E62-65 and P78 each contributed to the interaction between MHC-I CD/Nef and micro1 in vitro, whereas Nef M20 had little to no role. Tyrosine 18-26 S100 calcium binding protein B Homo sapiens 164-167 19726522-7 2009 Surprisingly, Nef proteins of both groups also strongly reduced TCR-induced actin remodeling and tyrosine phosphorylation on TCR-stimulatory surfaces and TCR-CD3 downmodulation competence by group 2 Nef proteins only slightly elevated these effects. Tyrosine 97-105 S100 calcium binding protein B Homo sapiens 14-17 19726522-7 2009 Surprisingly, Nef proteins of both groups also strongly reduced TCR-induced actin remodeling and tyrosine phosphorylation on TCR-stimulatory surfaces and TCR-CD3 downmodulation competence by group 2 Nef proteins only slightly elevated these effects. Tyrosine 97-105 S100 calcium binding protein B Homo sapiens 199-202 21482738-10 2011 Thus, our study demonstrated that Nef-mediated receptor endocytosis involves the ubiquitination motif and tyrosine motif. Tyrosine 106-114 S100 calcium binding protein B Homo sapiens 34-37 21886773-8 2011 Finally silencing experiments in THP-1 monocytic cells indicate that both TRAF2 and, surprisingly, TRAF6 are required for the Nef-induced tyrosine phosphorylation of STAT1 and STAT2. Tyrosine 138-146 S100 calcium binding protein B Homo sapiens 126-129 18073204-7 2008 The physiologically relevant tyrosine-dependent recruitment of AP-1 to MHC-I, which occurs whether Nef is present in cis or trans, was stabilized by the acidic and polyproline domains within Nef. Tyrosine 29-37 S100 calcium binding protein B Homo sapiens 99-102 18073204-7 2008 The physiologically relevant tyrosine-dependent recruitment of AP-1 to MHC-I, which occurs whether Nef is present in cis or trans, was stabilized by the acidic and polyproline domains within Nef. Tyrosine 29-37 S100 calcium binding protein B Homo sapiens 191-194 18073204-9 2008 Finally, mutation of the tyrosine binding pocket in the mu subunit of AP-1 created a dominant negative inhibitor of Nef-induced down-modulation of HLA-A2 that disrupted binding of wild type AP-1 to the Nef-MHC-I complex. Tyrosine 25-33 S100 calcium binding protein B Homo sapiens 116-119 18073204-9 2008 Finally, mutation of the tyrosine binding pocket in the mu subunit of AP-1 created a dominant negative inhibitor of Nef-induced down-modulation of HLA-A2 that disrupted binding of wild type AP-1 to the Nef-MHC-I complex. Tyrosine 25-33 S100 calcium binding protein B Homo sapiens 202-205 18073204-3 2008 In the case of the Nef-MHC-I complex, a tyrosine in the human leukocyte antigen (HLA)-A2 cytoplasmic tail ((320)YSQA) and a methionine in Nef (Met(20)) are absolutely required for AP-1 binding. Tyrosine 40-48 S100 calcium binding protein B Homo sapiens 19-22 18073204-10 2008 Thus, these data provide evidence that Nef binding to the MHC-I cytoplasmic tail stabilizes the interaction of a tyrosine in the MHC-I cytoplasmic tail with the natural tyrosine binding pocket in AP-1. Tyrosine 113-121 S100 calcium binding protein B Homo sapiens 39-42 18073204-10 2008 Thus, these data provide evidence that Nef binding to the MHC-I cytoplasmic tail stabilizes the interaction of a tyrosine in the MHC-I cytoplasmic tail with the natural tyrosine binding pocket in AP-1. Tyrosine 169-177 S100 calcium binding protein B Homo sapiens 39-42 15892963-5 2005 However, infection with Nef-positive virus led to changes in tyrosine phosphorylation. Tyrosine 61-69 S100 calcium binding protein B Homo sapiens 24-27 16687395-8 2006 During the subsequent maturation phase of the stimulatory contact, Nef interfered with the translocation of N-Wasp to the cell periphery, the overall induction of tyrosine phosphorylation, and the selective recruitment of phosphorylated LAT to stimulatory contacts. Tyrosine 163-171 S100 calcium binding protein B Homo sapiens 67-70 16713973-6 2006 Concomitantly, in HIV-infected cells, tyrosine phosphorylation at the synapse and the patterns of tyrosine phosphorylated proteins were disturbed in a Nef-dependent manner. Tyrosine 38-46 S100 calcium binding protein B Homo sapiens 151-154 16713973-6 2006 Concomitantly, in HIV-infected cells, tyrosine phosphorylation at the synapse and the patterns of tyrosine phosphorylated proteins were disturbed in a Nef-dependent manner. Tyrosine 98-106 S100 calcium binding protein B Homo sapiens 151-154 18057255-8 2008 The data support a cooperative binding model in which Nef functions as a clathrin-associated sorting protein that allows recognition of an incomplete, tyrosine-based mu-binding signal in the MHC-I CD by AP-1. Tyrosine 151-159 S100 calcium binding protein B Homo sapiens 54-57 15892963-7 2005 Furthermore, Lck is required for Nef-mediated c-Cbl tyrosine phosphorylation. Tyrosine 52-60 S100 calcium binding protein B Homo sapiens 33-36 15626739-8 2005 Because of aberrant molecular association, the tyrosine-phosphorylation/activation of the receptor in response to M-CSF was markedly diminished in Nef-active cells. Tyrosine 47-55 S100 calcium binding protein B Homo sapiens 147-150 12941779-3 2003 Here, we demonstrate that S100B, a ligand for the receptor of advanced glycation end products (RAGEs), augmented both Ang II-induced tyrosine phosphorylation of JAK2 and cell proliferation in VSMCs in a receptor-dependent manner. Tyrosine 133-141 S100 calcium binding protein B Homo sapiens 26-31 14597672-8 2003 Searching for molecules involved in Nef-triggered signaling pathways driving the DC maturation, we found that Nef targets Vav and promotes its tyrosine phosphorylation, associated with its nucleus-to-cytoplasm redistribution. Tyrosine 143-151 S100 calcium binding protein B Homo sapiens 36-39 14597672-8 2003 Searching for molecules involved in Nef-triggered signaling pathways driving the DC maturation, we found that Nef targets Vav and promotes its tyrosine phosphorylation, associated with its nucleus-to-cytoplasm redistribution. Tyrosine 143-151 S100 calcium binding protein B Homo sapiens 110-113 15681409-3 2005 To identify the target of the Nef leucine motif, the native sequence was replaced with either leucine- or tyrosine-based AP-binding sequences from cellular proteins, and the interactions with AP subunits were correlated with function. Tyrosine 106-114 S100 calcium binding protein B Homo sapiens 30-33 15681409-4 2005 Tyrosine motifs predictably modulated the interactions between Nef and the mu subunits of AP-1, AP-2, and AP-3; heterologous leucine motifs caused little change in these interactions. Tyrosine 0-8 S100 calcium binding protein B Homo sapiens 63-66 14722262-8 2004 We conclude that the membrane-proximal tyrosine-based sorting motif of gp41 Env is, like Nef, important for optimal viral infectivity and, in the case of MT4 T cells, virion incorporation of Env. Tyrosine 39-47 S100 calcium binding protein B Homo sapiens 89-92 12941779-4 2003 We also found that S100B-RAGE interaction triggered intracellular generation of reactive oxygen species (ROS), VSMC proliferation, and JAK2 tyrosine phosphorylation via activation of phospholipase D (PLD)2. Tyrosine 140-148 S100 calcium binding protein B Homo sapiens 19-24 10224289-6 1999 Expression of FasL through Nef depended upon the integrity of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the TCR zeta chain. Tyrosine 81-89 S100 calcium binding protein B Homo sapiens 27-30 11413332-4 2001 PBj6.6 and PBj6.9 shared a tyrosine substitution at position 17 in the Nef protein that is a major determinant of virulence but differed at one residue in Vpx (C89R), three residues within the envelope (D119G, R871G, G872R), and a single residue in Nef (F252L). Tyrosine 27-35 S100 calcium binding protein B Homo sapiens 71-74 10477559-0 1999 Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4. Tyrosine 57-65 S100 calcium binding protein B Homo sapiens 18-21 10477559-3 1999 A recent report demonstrated the presence of two tyrosine motifs in SIV Nef that contribute to its ability to down-regulate CD4 and to associate with clathrin adaptors. Tyrosine 49-57 S100 calcium binding protein B Homo sapiens 72-75 11137132-4 2001 Pre-treatment of cells with herbimycin A, but not with genistein, significantly abolishes the Nef-induced tyrosine phosphorylation of cellular proteins. Tyrosine 106-114 S100 calcium binding protein B Homo sapiens 94-97 10756028-1 2000 SIVmac Nef contains two N-terminal tyrosines that were proposed to be part of an SH2-ligand domain and/or a tyrosine-based endocytosis signal and a putative SH3-ligand domain (P(104)xxP(107)). Tyrosine 35-44 S100 calcium binding protein B Homo sapiens 7-10 10756028-1 2000 SIVmac Nef contains two N-terminal tyrosines that were proposed to be part of an SH2-ligand domain and/or a tyrosine-based endocytosis signal and a putative SH3-ligand domain (P(104)xxP(107)). Tyrosine 35-43 S100 calcium binding protein B Homo sapiens 7-10 9621081-2 1998 The studies reported here show that viral induction of T-cell proliferation requires accessory cells, such as primary monocytes or Raji B-lymphoma cells, as well as the presence of a putative immunoreceptor tyrosine-based activation motif within the viral Nef protein. Tyrosine 207-215 S100 calcium binding protein B Homo sapiens 256-259 9790524-4 1998 Nef-expressing Tg thymocytes were activated and alpha-CD3 hyperresponsive with respect to tyrosine phosphorylation of several substrates, including LAT and MAPK. Tyrosine 90-98 S100 calcium binding protein B Homo sapiens 0-3 9736718-3 1998 By using a competition assay that functionally discriminates between dileucine-based and tyrosine-based sorting signals, we have categorized the motif through which Nef interacts with the sorting machinery as dileucine-based. Tyrosine 89-97 S100 calcium binding protein B Homo sapiens 165-168 9705913-8 1998 Both the proline motif and phosphorylation of Nef on tyrosine residue were proposed to account for these interactions. Tyrosine 53-61 S100 calcium binding protein B Homo sapiens 46-49 9601497-0 1998 The tyrosine-17 residue of Nef in SIVsmmPBj14 is required for acute pathogenesis and contributes to replication in macrophages. Tyrosine 4-12 S100 calcium binding protein B Homo sapiens 27-30 9601497-14 1998 These results show that the tyrosine-17 residue of Nef is linked to lymphocyte proliferation and disease development, but also suggest that the pathogenic characteristics of SIVsmmPBj14 are dependent upon multiple genetic determinants. Tyrosine 28-36 S100 calcium binding protein B Homo sapiens 51-54 9586638-6 1998 Nef interacts with the medium (mu) subunit of AP adaptor complexes involved in the recognition of tyrosine-based sorting signals, likely facilitating the connection between MHC I and the clathrin-dependent sorting machinery. Tyrosine 98-106 S100 calcium binding protein B Homo sapiens 0-3 9126264-2 1997 SIV-PBj14 differs from other SIV strains by encoding tyrosine at amino acid 17 (Y17) in Nef, which generates an activation motif important for signal transduction. Tyrosine 53-61 S100 calcium binding protein B Homo sapiens 88-91 1420276-0 1992 Long-lived fluorescence lifetime from tyrosine in a peptide derived from S-100b. Tyrosine 38-46 S100 calcium binding protein B Homo sapiens 73-79 8626429-6 1996 A functional proline-rich motif and the tyrosine phosphorylation of Nef were evidenced as likely participants in this interaction. Tyrosine 40-48 S100 calcium binding protein B Homo sapiens 68-71 1420276-8 1992 These fluorescence lifetimes are similar to that observed for a decay component of native S-100b in the red edge of the emission, suggesting that the 1 degrees and 2 degrees features of a heptadecapeptide from S-100b protein has enough structural information when dissolved in solvents of intermediate polarity provide appropriate conditions for long-lived fluorescence from a tyrosine/tyrosinate species to occur. Tyrosine 377-385 S100 calcium binding protein B Homo sapiens 90-96 1420276-8 1992 These fluorescence lifetimes are similar to that observed for a decay component of native S-100b in the red edge of the emission, suggesting that the 1 degrees and 2 degrees features of a heptadecapeptide from S-100b protein has enough structural information when dissolved in solvents of intermediate polarity provide appropriate conditions for long-lived fluorescence from a tyrosine/tyrosinate species to occur. Tyrosine 377-385 S100 calcium binding protein B Homo sapiens 210-216 1633809-6 1992 The low-affinity site (Kd = 800 microM), which, in analogy to S100 beta, seems to involve the N-terminal EF hand, can be followed by the Ca(2+)-dependent decrease in tyrosine fluorescence. Tyrosine 166-174 S100 calcium binding protein B Homo sapiens 62-71