PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15120750-5	2004	In addition, BHA markedly attenuated the production of proinflammatory cytokines IL-1beta and TNF-alpha by both islets of pancreas and peritoneal macrophages.	Butylated Hydroxyanisole	13-16	tumor necrosis factor	Rattus norvegicus	94-103	
10588948-6	1999	In comparison, the antioxidant butylated hydroxyanisole (BHA) completely inhibited the rTNF-alpha-induced cytotoxicity as well as AA release mediated through the TNF receptor p55, while the very similar antioxidant butylated hydroxytoluene had no effect.	Butylated Hydroxyanisole	31-55	tumor necrosis factor	Rattus norvegicus	87-97	
10588948-6	1999	In comparison, the antioxidant butylated hydroxyanisole (BHA) completely inhibited the rTNF-alpha-induced cytotoxicity as well as AA release mediated through the TNF receptor p55, while the very similar antioxidant butylated hydroxytoluene had no effect.	Butylated Hydroxyanisole	57-60	tumor necrosis factor	Rattus norvegicus	87-97	
8152351-1	1994	The mechanisms by which the antioxidant butylated hydroxyanisole (BHA) inhibits recombinant tumor necrosis factor alpha (rTNF-alpha)-induced cytotoxicity have been studied in WEHI 164 clone 13 (WEHI) and L929 fibrosarcoma cells.	Butylated Hydroxyanisole	40-64	tumor necrosis factor	Rattus norvegicus	121-131	
8152351-1	1994	The mechanisms by which the antioxidant butylated hydroxyanisole (BHA) inhibits recombinant tumor necrosis factor alpha (rTNF-alpha)-induced cytotoxicity have been studied in WEHI 164 clone 13 (WEHI) and L929 fibrosarcoma cells.	Butylated Hydroxyanisole	66-69	tumor necrosis factor	Rattus norvegicus	121-131	
8152351-2	1994	When BHA was added simultaneously with rTNF-alpha, it completely inhibited rTNF-alpha cytotoxicity in the WEHI and L929 cells.	Butylated Hydroxyanisole	5-8	tumor necrosis factor	Rattus norvegicus	75-85	
8152351-3	1994	BHA also inhibited the toxicity when added 2 h after rTNF-alpha in WEHI cells, suggesting that BHA inhibits some late intracellular event(s) in rTNF-alpha cytotoxicity.	Butylated Hydroxyanisole	0-3	tumor necrosis factor	Rattus norvegicus	53-63	
8152351-3	1994	BHA also inhibited the toxicity when added 2 h after rTNF-alpha in WEHI cells, suggesting that BHA inhibits some late intracellular event(s) in rTNF-alpha cytotoxicity.	Butylated Hydroxyanisole	0-3	tumor necrosis factor	Rattus norvegicus	144-154	
8152351-3	1994	BHA also inhibited the toxicity when added 2 h after rTNF-alpha in WEHI cells, suggesting that BHA inhibits some late intracellular event(s) in rTNF-alpha cytotoxicity.	Butylated Hydroxyanisole	95-98	tumor necrosis factor	Rattus norvegicus	144-154	
8152351-7	1994	By comparison, BHA completely inhibited the rTNF-alpha-induced release of arachidonic acid, suggesting that BHA somehow inhibits rTNF-alpha-induced activation of phospholipase(s).	Butylated Hydroxyanisole	15-18	tumor necrosis factor	Rattus norvegicus	44-54	
8152351-7	1994	By comparison, BHA completely inhibited the rTNF-alpha-induced release of arachidonic acid, suggesting that BHA somehow inhibits rTNF-alpha-induced activation of phospholipase(s).	Butylated Hydroxyanisole	15-18	tumor necrosis factor	Rattus norvegicus	129-139	
8152351-7	1994	By comparison, BHA completely inhibited the rTNF-alpha-induced release of arachidonic acid, suggesting that BHA somehow inhibits rTNF-alpha-induced activation of phospholipase(s).	Butylated Hydroxyanisole	108-111	tumor necrosis factor	Rattus norvegicus	44-54	
8152351-7	1994	By comparison, BHA completely inhibited the rTNF-alpha-induced release of arachidonic acid, suggesting that BHA somehow inhibits rTNF-alpha-induced activation of phospholipase(s).	Butylated Hydroxyanisole	108-111	tumor necrosis factor	Rattus norvegicus	129-139	
8152351-9	1994	BHA, but not BHT, blocked rTNF-alpha-induced cytotoxicity and rTNF-alpha-induced accumulation of protein-associated TBARS, suggesting that rTNF-alpha cytotoxicity is correlated with protein-associated TBARS.	Butylated Hydroxyanisole	0-3	tumor necrosis factor	Rattus norvegicus	26-36	
8152351-9	1994	BHA, but not BHT, blocked rTNF-alpha-induced cytotoxicity and rTNF-alpha-induced accumulation of protein-associated TBARS, suggesting that rTNF-alpha cytotoxicity is correlated with protein-associated TBARS.	Butylated Hydroxyanisole	0-3	tumor necrosis factor	Rattus norvegicus	62-72	
8152351-9	1994	BHA, but not BHT, blocked rTNF-alpha-induced cytotoxicity and rTNF-alpha-induced accumulation of protein-associated TBARS, suggesting that rTNF-alpha cytotoxicity is correlated with protein-associated TBARS.	Butylated Hydroxyanisole	0-3	tumor necrosis factor	Rattus norvegicus	62-72	
8152351-10	1994	In conclusion, the results suggest that BHA blocks some post receptor event in rTNF-alpha-induced cytotoxicity, and that activation of phospholipase(s) coupled with the enzymatic formation of specific oxidized lipids could be a pivotal event in rTNF-alpha-induced cytotoxicity.	Butylated Hydroxyanisole	40-43	tumor necrosis factor	Rattus norvegicus	79-89	
8152351-10	1994	In conclusion, the results suggest that BHA blocks some post receptor event in rTNF-alpha-induced cytotoxicity, and that activation of phospholipase(s) coupled with the enzymatic formation of specific oxidized lipids could be a pivotal event in rTNF-alpha-induced cytotoxicity.	Butylated Hydroxyanisole	40-43	tumor necrosis factor	Rattus norvegicus	245-255	
1515551-2	1992	Butylated hydroxyanisole (BHA) and 4-hydroxymethyl-2,6-di-t-butylphenol (HBP) were the only two of nine antioxidants that completely inhibited rTNF-alpha-induced cytotoxicity in L929 and WEHI 164 fibrosarcoma cells.	Butylated Hydroxyanisole	0-24	tumor necrosis factor	Rattus norvegicus	143-153	
1515551-2	1992	Butylated hydroxyanisole (BHA) and 4-hydroxymethyl-2,6-di-t-butylphenol (HBP) were the only two of nine antioxidants that completely inhibited rTNF-alpha-induced cytotoxicity in L929 and WEHI 164 fibrosarcoma cells.	Butylated Hydroxyanisole	26-29	tumor necrosis factor	Rattus norvegicus	143-153	
1515551-6	1992	BHA also inhibited rTNF-alpha-induced, but not rIL-1 beta-induced growth enhancement in FS-4 fibroblasts.	Butylated Hydroxyanisole	0-3	tumor necrosis factor	Rattus norvegicus	19-29	
1515551-7	1992	Further, BHA blocked both rTNF-alpha-induced and rIL-1 beta-induced prostaglandin E2 synthesis in FS-4 fibroblasts.	Butylated Hydroxyanisole	9-12	tumor necrosis factor	Rattus norvegicus	26-36	
1515551-8	1992	BHA inhibited the rTNF-alpha-induced release of arachidonic acid in both FS-4 and L929 cells, suggesting that BHA inhibits cellular phospholipase(s).	Butylated Hydroxyanisole	0-3	tumor necrosis factor	Rattus norvegicus	18-28	
1515551-8	1992	BHA inhibited the rTNF-alpha-induced release of arachidonic acid in both FS-4 and L929 cells, suggesting that BHA inhibits cellular phospholipase(s).	Butylated Hydroxyanisole	110-113	tumor necrosis factor	Rattus norvegicus	18-28	
1515551-10	1992	The results indicate that BHA is a specific and potent inhibitor of rTNF-alpha- and rTNF-beta-induced cytotoxicity, as well as of rTNF-alpha-induced growth enhancement.	Butylated Hydroxyanisole	26-29	tumor necrosis factor	Rattus norvegicus	68-78	
1515551-10	1992	The results indicate that BHA is a specific and potent inhibitor of rTNF-alpha- and rTNF-beta-induced cytotoxicity, as well as of rTNF-alpha-induced growth enhancement.	Butylated Hydroxyanisole	26-29	tumor necrosis factor	Rattus norvegicus	130-140