PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8152351-7 1994 By comparison, BHA completely inhibited the rTNF-alpha-induced release of arachidonic acid, suggesting that BHA somehow inhibits rTNF-alpha-induced activation of phospholipase(s). Butylated Hydroxyanisole 15-18 tumor necrosis factor Rattus norvegicus 44-54 10588948-6 1999 In comparison, the antioxidant butylated hydroxyanisole (BHA) completely inhibited the rTNF-alpha-induced cytotoxicity as well as AA release mediated through the TNF receptor p55, while the very similar antioxidant butylated hydroxytoluene had no effect. Butylated Hydroxyanisole 31-55 tumor necrosis factor Rattus norvegicus 87-97 10588948-6 1999 In comparison, the antioxidant butylated hydroxyanisole (BHA) completely inhibited the rTNF-alpha-induced cytotoxicity as well as AA release mediated through the TNF receptor p55, while the very similar antioxidant butylated hydroxytoluene had no effect. Butylated Hydroxyanisole 57-60 tumor necrosis factor Rattus norvegicus 87-97 8152351-1 1994 The mechanisms by which the antioxidant butylated hydroxyanisole (BHA) inhibits recombinant tumor necrosis factor alpha (rTNF-alpha)-induced cytotoxicity have been studied in WEHI 164 clone 13 (WEHI) and L929 fibrosarcoma cells. Butylated Hydroxyanisole 40-64 tumor necrosis factor Rattus norvegicus 121-131 8152351-1 1994 The mechanisms by which the antioxidant butylated hydroxyanisole (BHA) inhibits recombinant tumor necrosis factor alpha (rTNF-alpha)-induced cytotoxicity have been studied in WEHI 164 clone 13 (WEHI) and L929 fibrosarcoma cells. Butylated Hydroxyanisole 66-69 tumor necrosis factor Rattus norvegicus 121-131 8152351-2 1994 When BHA was added simultaneously with rTNF-alpha, it completely inhibited rTNF-alpha cytotoxicity in the WEHI and L929 cells. Butylated Hydroxyanisole 5-8 tumor necrosis factor Rattus norvegicus 75-85 15120750-5 2004 In addition, BHA markedly attenuated the production of proinflammatory cytokines IL-1beta and TNF-alpha by both islets of pancreas and peritoneal macrophages. Butylated Hydroxyanisole 13-16 tumor necrosis factor Rattus norvegicus 94-103 8152351-3 1994 BHA also inhibited the toxicity when added 2 h after rTNF-alpha in WEHI cells, suggesting that BHA inhibits some late intracellular event(s) in rTNF-alpha cytotoxicity. Butylated Hydroxyanisole 0-3 tumor necrosis factor Rattus norvegicus 53-63 8152351-7 1994 By comparison, BHA completely inhibited the rTNF-alpha-induced release of arachidonic acid, suggesting that BHA somehow inhibits rTNF-alpha-induced activation of phospholipase(s). Butylated Hydroxyanisole 15-18 tumor necrosis factor Rattus norvegicus 129-139 8152351-3 1994 BHA also inhibited the toxicity when added 2 h after rTNF-alpha in WEHI cells, suggesting that BHA inhibits some late intracellular event(s) in rTNF-alpha cytotoxicity. Butylated Hydroxyanisole 0-3 tumor necrosis factor Rattus norvegicus 144-154 8152351-7 1994 By comparison, BHA completely inhibited the rTNF-alpha-induced release of arachidonic acid, suggesting that BHA somehow inhibits rTNF-alpha-induced activation of phospholipase(s). Butylated Hydroxyanisole 108-111 tumor necrosis factor Rattus norvegicus 44-54 8152351-3 1994 BHA also inhibited the toxicity when added 2 h after rTNF-alpha in WEHI cells, suggesting that BHA inhibits some late intracellular event(s) in rTNF-alpha cytotoxicity. Butylated Hydroxyanisole 95-98 tumor necrosis factor Rattus norvegicus 144-154 8152351-7 1994 By comparison, BHA completely inhibited the rTNF-alpha-induced release of arachidonic acid, suggesting that BHA somehow inhibits rTNF-alpha-induced activation of phospholipase(s). Butylated Hydroxyanisole 108-111 tumor necrosis factor Rattus norvegicus 129-139 8152351-9 1994 BHA, but not BHT, blocked rTNF-alpha-induced cytotoxicity and rTNF-alpha-induced accumulation of protein-associated TBARS, suggesting that rTNF-alpha cytotoxicity is correlated with protein-associated TBARS. Butylated Hydroxyanisole 0-3 tumor necrosis factor Rattus norvegicus 26-36 8152351-9 1994 BHA, but not BHT, blocked rTNF-alpha-induced cytotoxicity and rTNF-alpha-induced accumulation of protein-associated TBARS, suggesting that rTNF-alpha cytotoxicity is correlated with protein-associated TBARS. Butylated Hydroxyanisole 0-3 tumor necrosis factor Rattus norvegicus 62-72 8152351-9 1994 BHA, but not BHT, blocked rTNF-alpha-induced cytotoxicity and rTNF-alpha-induced accumulation of protein-associated TBARS, suggesting that rTNF-alpha cytotoxicity is correlated with protein-associated TBARS. Butylated Hydroxyanisole 0-3 tumor necrosis factor Rattus norvegicus 62-72 8152351-10 1994 In conclusion, the results suggest that BHA blocks some post receptor event in rTNF-alpha-induced cytotoxicity, and that activation of phospholipase(s) coupled with the enzymatic formation of specific oxidized lipids could be a pivotal event in rTNF-alpha-induced cytotoxicity. Butylated Hydroxyanisole 40-43 tumor necrosis factor Rattus norvegicus 79-89 8152351-10 1994 In conclusion, the results suggest that BHA blocks some post receptor event in rTNF-alpha-induced cytotoxicity, and that activation of phospholipase(s) coupled with the enzymatic formation of specific oxidized lipids could be a pivotal event in rTNF-alpha-induced cytotoxicity. Butylated Hydroxyanisole 40-43 tumor necrosis factor Rattus norvegicus 245-255 1515551-2 1992 Butylated hydroxyanisole (BHA) and 4-hydroxymethyl-2,6-di-t-butylphenol (HBP) were the only two of nine antioxidants that completely inhibited rTNF-alpha-induced cytotoxicity in L929 and WEHI 164 fibrosarcoma cells. Butylated Hydroxyanisole 0-24 tumor necrosis factor Rattus norvegicus 143-153 1515551-2 1992 Butylated hydroxyanisole (BHA) and 4-hydroxymethyl-2,6-di-t-butylphenol (HBP) were the only two of nine antioxidants that completely inhibited rTNF-alpha-induced cytotoxicity in L929 and WEHI 164 fibrosarcoma cells. Butylated Hydroxyanisole 26-29 tumor necrosis factor Rattus norvegicus 143-153 1515551-6 1992 BHA also inhibited rTNF-alpha-induced, but not rIL-1 beta-induced growth enhancement in FS-4 fibroblasts. Butylated Hydroxyanisole 0-3 tumor necrosis factor Rattus norvegicus 19-29 1515551-7 1992 Further, BHA blocked both rTNF-alpha-induced and rIL-1 beta-induced prostaglandin E2 synthesis in FS-4 fibroblasts. Butylated Hydroxyanisole 9-12 tumor necrosis factor Rattus norvegicus 26-36 1515551-8 1992 BHA inhibited the rTNF-alpha-induced release of arachidonic acid in both FS-4 and L929 cells, suggesting that BHA inhibits cellular phospholipase(s). Butylated Hydroxyanisole 0-3 tumor necrosis factor Rattus norvegicus 18-28 1515551-8 1992 BHA inhibited the rTNF-alpha-induced release of arachidonic acid in both FS-4 and L929 cells, suggesting that BHA inhibits cellular phospholipase(s). Butylated Hydroxyanisole 110-113 tumor necrosis factor Rattus norvegicus 18-28 1515551-10 1992 The results indicate that BHA is a specific and potent inhibitor of rTNF-alpha- and rTNF-beta-induced cytotoxicity, as well as of rTNF-alpha-induced growth enhancement. Butylated Hydroxyanisole 26-29 tumor necrosis factor Rattus norvegicus 68-78 1515551-10 1992 The results indicate that BHA is a specific and potent inhibitor of rTNF-alpha- and rTNF-beta-induced cytotoxicity, as well as of rTNF-alpha-induced growth enhancement. Butylated Hydroxyanisole 26-29 tumor necrosis factor Rattus norvegicus 130-140