PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28552457-3 2017 The objective of the present study is to investigate the direct effects of butylated hydroxyanisole on rat brain neurosteroidogenic 5alpha-reductase 1 (SRD5A1), 3alpha-hydroxysteroid dehydrogenase (AKR1C14), and retinol dehydrogenase 2 (RDH2). Butylated Hydroxyanisole 75-99 steroid 5 alpha-reductase 1 Rattus norvegicus 152-158 28552457-5 2017 Butylated hydroxyanisole inhibited SRD5A1, AKR1C14, and RDH2 with IC50 values of 4.731+-0.079muM, 5.753+-0.073muM, and over 100muM, respectively. Butylated Hydroxyanisole 0-24 steroid 5 alpha-reductase 1 Rattus norvegicus 35-41 28552457-6 2017 Butylated hydroxyanisole is a competitive inhibitor for both SRD5A1 and AKR1C14. Butylated Hydroxyanisole 0-24 steroid 5 alpha-reductase 1 Rattus norvegicus 61-67 28552457-8 2017 In conclusion, butylated hydroxyanisole is a potent inhibitor of SRD5A1 and AKR1C14, thus reducing the formation of active neurosteroids. Butylated Hydroxyanisole 15-39 steroid 5 alpha-reductase 1 Rattus norvegicus 65-71 27388148-10 2016 In conclusion, BHA directly inhibits the activities of CYP17A1 and HSD3B1, and the expression levels of Hsd17b3 and Srd5a1, leading to the lower production of androgen in Leydig cells. Butylated Hydroxyanisole 15-18 steroid 5 alpha-reductase 1 Rattus norvegicus 116-122