PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25457559-4 2015 Here, we demonstrate that brain neprilysin overexpression induced in vivo by repeated gamma-hydroxybutyrate autoadministration reduces cerebral Abeta contents and prevents cognitive deficits in APPSWE mice. Sodium Oxybate 86-107 amyloid beta (A4) precursor protein Mus musculus 144-149 25457559-5 2015 Oral gamma-hydroxybutyrate also counteracted phosphoramidon-induced brain neprilysin inhibition and Abeta accumulation. Sodium Oxybate 5-26 amyloid beta (A4) precursor protein Mus musculus 100-105 25457559-7 2015 Together, our results suggest that gamma-hydroxybutyrate, acting via HDAC inhibition, upregulates neprilysin to reduce Abeta level and related memory deficits. Sodium Oxybate 35-56 amyloid beta (A4) precursor protein Mus musculus 119-124