PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1291406-7 1992 With glucose and protein as intraduodenal stimulus (no pancreatin added), the plasma amino acids rose significantly less (by approximately 50% of the control experiment) and the increment in insulin (but not C-peptide) concentrations was significantly reduced by loxiglumide. loxiglumide 263-274 insulin Homo sapiens 191-198 8511500-6 1993 Plasma insulin and glucagon levels in tests with loxiglumide tended to increase, probably owing to accelerated gastric emptying, whereas plasma PP and somatostatin were significantly reduced. loxiglumide 49-60 insulin Homo sapiens 7-14 12358680-7 2002 Loxiglumide accelerated gastric emptying, increased insulin secretion without alteration of glucose profiles, and abolished all phases of the postprandial pancreatic polypeptide response. loxiglumide 0-11 insulin Homo sapiens 52-59 1291406-12 1992 Blocking CCK actions on the exocrine pancreas by loxiglumide, however, can secondarily cause reductions in postprandial insulin profiles by altering insulin clearance. loxiglumide 49-60 insulin Homo sapiens 120-127 1959704-3 1991 The aim of this investigation was therefore to clarify the role of endogenous cholecystokinin in the regulation of insulin release and gastric emptying applying the highly potent and specific cholecystokinin receptor antagonist loxiglumide. loxiglumide 228-239 insulin Homo sapiens 115-122 1959704-9 1991 Simultaneously, loxiglumide induced a more rapid rise in postprandial insulin levels after both meals resulting in significantly higher (p less than 0.05) insulin levels during the first postprandial hour, but similar insulin levels in the second postprandial hour. loxiglumide 16-27 insulin Homo sapiens 70-77 1959704-9 1991 Simultaneously, loxiglumide induced a more rapid rise in postprandial insulin levels after both meals resulting in significantly higher (p less than 0.05) insulin levels during the first postprandial hour, but similar insulin levels in the second postprandial hour. loxiglumide 16-27 insulin Homo sapiens 155-162 1959704-9 1991 Simultaneously, loxiglumide induced a more rapid rise in postprandial insulin levels after both meals resulting in significantly higher (p less than 0.05) insulin levels during the first postprandial hour, but similar insulin levels in the second postprandial hour. loxiglumide 16-27 insulin Homo sapiens 155-162 2022712-9 1991 When CCK-8 was infused with loxiglumide, the insulin and PP responses were similar to the values found with loxiglumide alone. loxiglumide 28-39 insulin Homo sapiens 45-52