PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9096130-3 1997 We report here that treating striatal astrocytes in primary culture with IL-1beta for 22-24 hr enhances the ATP-evoked release of arachidonic acid (AA) with no effect on the ATP-induced accumulation of inositol phosphates. Arachidonic Acid 130-146 interleukin 1 beta Mus musculus 73-81 8897766-5 1996 At the present time, it is nuclear how IL-1 beta causes brain injury, but several possible mechanisms include 1) stimulation of an inflammatory response through the activation of glia or the induction of other cytokines and/or endothelial adhesion molecules and 2) release of free radicals through stimulation of arachidonic acid metabolism and/or nitric oxide synthase activity. Arachidonic Acid 313-329 interleukin 1 beta Mus musculus 39-48 21856425-6 2012 Together, these results suggest that endogenous IL-1beta possesses anticonvulsive properties that may be mediated by arachidonic acid metabolites derived from the catalytic action of COX-2. Arachidonic Acid 117-133 interleukin 1 beta Mus musculus 48-56 8824228-4 1996 We now report that BALB/cJ BMMC stimulated with KL + IL-10 + IL-1beta also exhibit the biphasic release of [3H]arachidonic acid with an immediate phase over the first 10 min followed by a delayed phase from 2 to 7 h. The delayed phase of arachidonic acid release and of PGD2 generation was inhibited by heparin, which concomitantly released a phospholipase (PL) A2 from the cells into the supernatant. Arachidonic Acid 111-127 interleukin 1 beta Mus musculus 61-69 8824228-4 1996 We now report that BALB/cJ BMMC stimulated with KL + IL-10 + IL-1beta also exhibit the biphasic release of [3H]arachidonic acid with an immediate phase over the first 10 min followed by a delayed phase from 2 to 7 h. The delayed phase of arachidonic acid release and of PGD2 generation was inhibited by heparin, which concomitantly released a phospholipase (PL) A2 from the cells into the supernatant. Arachidonic Acid 238-254 interleukin 1 beta Mus musculus 61-69