PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9165025-6 1997 Simultaneous addition of IL-1alpha and IL-6 with sIL-6R to osteoblast cultures cooperatively induced transcription of COX-2, which was associated with a marked increase in COX activity measured by the conversion of arachidonic acid into PGE2. Arachidonic Acid 215-231 interleukin 6 Mus musculus 39-43 19822443-7 2010 In contrast, overexpression of IL-6 in IL-4-activated HAEC was not affected by inhibiting other ROS generating pathways, such as xanthine oxidase, arachidonic acid metabolism, and the mitochondrial electron transport chain. Arachidonic Acid 147-163 interleukin 6 Mus musculus 31-35 21513770-10 2011 This, in turn, leads to arachidonic acid and lysophosphatidyl choline generation, both of which are potent inducers for IL-6 release. Arachidonic Acid 24-40 interleukin 6 Mus musculus 120-124 22637477-4 2012 With cultured vascular smooth muscle cell, angiotensin II, arachidonic acid, and TNF-alpha markedly induce increased expression of IL-6 and TNF-alpha mRNAs, all of which were suppressed by inhibiting iPLA(2)beta activity or expression with bromoenol lactone, antisense oligonucleotides, and genetic deletion, respectively. Arachidonic Acid 59-75 interleukin 6 Mus musculus 131-135 19950212-0 2010 Effect of arachidonic acid on hypoxia-induced IL-6 production in mouse ES cells: Involvement of MAPKs, NF-kappaB, and HIF-1alpha. Arachidonic Acid 10-26 interleukin 6 Mus musculus 46-50 19950212-1 2010 This study examined the role of arachidonic acid (AA) in hypoxia-induced production of interleukin (IL)-6 and its related signaling pathways in mouse embryonic stem (ES) cells. Arachidonic Acid 32-48 interleukin 6 Mus musculus 87-105 10841042-7 2000 These results strongly suggest that chemical stress induces IL-6 synthesis in osteoblasts, and that the IL-6 synthesis is coupled to the arachidonic acid cascade as well as the HSP27 induction by arsenite. Arachidonic Acid 137-153 interleukin 6 Mus musculus 104-108 10841042-0 2000 Involvement of arachidonic acid in chemical stress-induced interleukin-6 synthesis in osteoblast-like cells: comparison with heat shock protein 27 induction. Arachidonic Acid 15-31 interleukin 6 Mus musculus 59-72