PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15712633-1	2005	Bradykinin mediates acute inflammation by increasing microvascular permeability, vasodilation, leukocyte migration and accumulation, and the production of arachidonic acid via phospholipase A2 activation.	Arachidonic Acid	155-171	phospholipase A2 group IB	Canis lupus familiaris	176-192	
24175472-7	2013	Diminishing content of free arachidonic acid in arterial blood can testify inhibition of cellular membranes phospholipides degradation by phospholipase A2 as a result of flocalin cardioprotection.	Arachidonic Acid	28-44	phospholipase A2 group IB	Canis lupus familiaris	138-154	
41058-4	1979	Phospholipase A2 inhibitors may block not only the release of arachidonic acid and its subsequent conversion into prostaglandins but also the formation of lysophospholipids involved in inflammation and/or platelet aggregation.	Arachidonic Acid	62-78	phospholipase A2 group IB	Canis lupus familiaris	0-16	
7685027-8	1993	We show that inhibition of expression of PKC alpha causes a loss in phospholipase A2-mediated arachidonate release.	Arachidonic Acid	94-106	phospholipase A2 group IB	Canis lupus familiaris	68-84	
10187781-0	1999	Inhibition of phospholipase A2-mediated arachidonic acid release by cyclic AMP defines a negative feedback loop for P2Y receptor activation in Madin-Darby canine kidney D1 cells.	Arachidonic Acid	40-56	phospholipase A2 group IB	Canis lupus familiaris	14-30	
10187781-2	1999	For one class of P2Y receptors, P2Y2 receptors, this stimulation of adenylyl cyclase and increase in cAMP occurs via the conversion of phospholipase A2 (PLA2)-generated arachidonic acid (AA) to prostaglandins (e.g. PGE2).	Arachidonic Acid	169-185	phospholipase A2 group IB	Canis lupus familiaris	135-151	
10187781-2	1999	For one class of P2Y receptors, P2Y2 receptors, this stimulation of adenylyl cyclase and increase in cAMP occurs via the conversion of phospholipase A2 (PLA2)-generated arachidonic acid (AA) to prostaglandins (e.g. PGE2).	Arachidonic Acid	169-185	phospholipase A2 group IB	Canis lupus familiaris	153-157	
8855457-5	1996	Others have hypothesized that the known inflammatory effects of phospholipase A2 are due to the release of arachidonic acid, which is converted to various eicosanoids, including several algesic prostaglandins (PGI2 and PGE2).	Arachidonic Acid	107-123	phospholipase A2 group IB	Canis lupus familiaris	64-80	
1384915-17	1992	We propose that stimulated but not "basal" release of EDRF is dependent on the release of arachidonic acid or one of its non-cyclo-oxygenase metabolites, possibly by Ca2"-dependent activation of phospholipase A2.	Arachidonic Acid	90-106	phospholipase A2 group IB	Canis lupus familiaris	195-211	
1933128-4	1991	Nordihydroguaiaretic acid (NDGA; 5 x 10(-6) M), an inhibitor of lipoxygenase and quinacrine (10(-5) M), which blocks the release of arachidonic acid from phospholipids by inhibiting the enzyme phospholipase A2, blocked hypoxia-induced contractions.	Arachidonic Acid	132-148	phospholipase A2 group IB	Canis lupus familiaris	193-209	
2355013-8	1990	Purified myocardial phospholipase A2 also possessed selectivity for hydrolysis of phospholipids containing arachidonic acid at the sn-2 position in comparison to oleic or palmitic acid.	Arachidonic Acid	107-123	phospholipase A2 group IB	Canis lupus familiaris	20-36	
1846614-2	1991	In the current studies, we have examined several mechanisms to assess their possible contribution to arachidonic acid release in the Madin-Darby canine kidney cell line by agonist stimulation of these receptors: 1) activation of phospholipase A2 (PLA2); 2) sequential activation of phospholipase C, diacylglycerol lipase, and monoacylglycerol lipase; and 3) inhibition of the sequential action of fatty acyl-CoA synthetase and lysophosphatide acyltransferase.	Arachidonic Acid	101-117	phospholipase A2 group IB	Canis lupus familiaris	229-245	
1846614-2	1991	In the current studies, we have examined several mechanisms to assess their possible contribution to arachidonic acid release in the Madin-Darby canine kidney cell line by agonist stimulation of these receptors: 1) activation of phospholipase A2 (PLA2); 2) sequential activation of phospholipase C, diacylglycerol lipase, and monoacylglycerol lipase; and 3) inhibition of the sequential action of fatty acyl-CoA synthetase and lysophosphatide acyltransferase.	Arachidonic Acid	101-117	phospholipase A2 group IB	Canis lupus familiaris	247-251	
1846614-8	1991	1) Hormone-stimulated arachidonic acid release in Madin-Darby canine kidney-D1 cells occurs as a consequence of PLA2 activation.	Arachidonic Acid	22-38	phospholipase A2 group IB	Canis lupus familiaris	112-116	
1846614-9	1991	2) The ability of an agonist both to mobilize Ca2+ and to activate protein kinase C contributes to its efficacy as a stimulator of PLA2-mediated arachidonic acid release.	Arachidonic Acid	145-161	phospholipase A2 group IB	Canis lupus familiaris	131-135