PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16837624-6 2006 By investigating how MNS inhibits GPIIb/IIIa activation, we found that MNS potently inhibited the activity of tyrosine kinases (Src and Syk) and prevented protein tyrosine phosphorylation and cytoskeletal association of GPIIb/IIIa and talin, but it had no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes (myosin light chain kinase and calpain), and arachidonic acid metabolism, and it did not affect the cellular levels of cyclic nucleotides. Arachidonic Acid 379-395 integrin subunit alpha 2b Homo sapiens 34-39 7993797-3 1994 Out of 30 monoclonal antibodies reacting with GPIIb/IIIa, one, MA-16N7C2, potently inhibited platelet aggregation induced by ADP, thrombin, arachidonic acid, collagen, U46619, adrenaline and platelet-activating factor, whereas ristocetin-induced aggregation was unaffected. Arachidonic Acid 140-156 integrin subunit alpha 2b Homo sapiens 46-51 3155488-4 1985 A previously described monoclonal antibody specific for the GPIIb/IIIa complex (AP-2) inhibited platelet aggregation induced by ADP, thrombin, collagen, or arachidonic acid (Pidard et al, J Biol Chem 258:12582-12586, 1983). Arachidonic Acid 156-172 integrin subunit alpha 2b Homo sapiens 60-65 30188609-6 2018 We proved the elevated expression of the active form of integrin receptor GPIIb/IIIa, responsible for platelet aggregation, and in the kinetic test we confirmed the increased aggregation of platelets in different intracellular signal pathways (dependent on ADP, collagen, arachidonic acid). Arachidonic Acid 272-288 integrin subunit alpha 2b Homo sapiens 74-79 15461628-3 2004 This is caused by an autoantibody with specificity for platelet GP IIb/IIIa or an epitope close to that of the GP, resulting in partial or complete refractoriness of the patient"s platelets to ADP, collagen and arachidonic acid. Arachidonic Acid 211-227 integrin subunit alpha 2b Homo sapiens 64-70