PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2830903-8 1988 Vasopressin treatment of REF52 cells prelabeled with [3H]arachidonic acid elicited an increase of more than 11-fold in the amount of cellular diacyl[3H]glycerol and a concomitant release of arachidonic acid to the culture medium that was 12-fold higher than controls. Arachidonic Acid 57-73 arginine vasopressin Rattus norvegicus 0-11 3146974-3 1988 In cells labelled with [14C]arachidonate, EGF significantly enhanced the free arachidonate released in response to A23187 or vasopressin without enhancing the production of [14C]arachidonate-labelled diacylglycerol. Arachidonic Acid 78-90 arginine vasopressin Rattus norvegicus 125-136 3146974-3 1988 In cells labelled with [14C]arachidonate, EGF significantly enhanced the free arachidonate released in response to A23187 or vasopressin without enhancing the production of [14C]arachidonate-labelled diacylglycerol. Arachidonic Acid 78-90 arginine vasopressin Rattus norvegicus 125-136 3146974-4 1988 EGF increased the [14C]arachidonate-labelled phosphatidic acid formed in response to vasopressin, but to a much smaller extent than it increased free arachidonate release. Arachidonic Acid 23-35 arginine vasopressin Rattus norvegicus 85-96 3141409-2 1988 Arginine vasopressin (AVP) and phorbol myristate acetate (PMA) both stimulated PLA2 activity as assayed by the release of free arachidonic acid from exogenously added [14C]arachidonyl-phosphatidylcholine. Arachidonic Acid 127-143 arginine vasopressin Rattus norvegicus 0-20 2830903-11 1988 Further, collateral with vasopressin-induced phosphatidylcholine hydrolysis, the cellular release of arachidonic acid occurs. Arachidonic Acid 101-117 arginine vasopressin Rattus norvegicus 25-36 6248605-10 1980 Results also suggest that products of prostaglandin synthesis from arachidonic acid inhibit AVP-sensitive adenylate cyclase activity in MCT but not that located in MAL. Arachidonic Acid 67-83 arginine vasopressin Rattus norvegicus 92-95 3124830-0 1988 Epidermal growth factor is synergistic with phorbol esters and vasopressin in stimulating arachidonate release and prostaglandin production in renal glomerular mesangial cells. Arachidonic Acid 90-102 arginine vasopressin Rattus norvegicus 63-74 3036589-1 1987 Arginine-vasopressin (AVP) stimulated the formation of labelled phosphatidic acid (PA) in [14C]arachidonic acid-prelabelled rat Leydig cells. Arachidonic Acid 95-111 arginine vasopressin Rattus norvegicus 0-20 3036589-1 1987 Arginine-vasopressin (AVP) stimulated the formation of labelled phosphatidic acid (PA) in [14C]arachidonic acid-prelabelled rat Leydig cells. Arachidonic Acid 95-111 arginine vasopressin Rattus norvegicus 22-25 3019633-8 1986 Two-minute pulses of CRF (10 nM), vasopressin (10 nM) and phorbol 12-myristate 13-acetate (100 nM) caused immediate 1.5- to 2-fold increases in [3H]arachidonic acid release, and melittin (100 nM) caused a 5-fold increase in [3H]arachidonic acid release. Arachidonic Acid 148-164 arginine vasopressin Rattus norvegicus 34-45 3019633-8 1986 Two-minute pulses of CRF (10 nM), vasopressin (10 nM) and phorbol 12-myristate 13-acetate (100 nM) caused immediate 1.5- to 2-fold increases in [3H]arachidonic acid release, and melittin (100 nM) caused a 5-fold increase in [3H]arachidonic acid release. Arachidonic Acid 228-244 arginine vasopressin Rattus norvegicus 34-45 2963816-0 1988 Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10. Arachidonic Acid 146-162 arginine vasopressin Rattus norvegicus 0-11 2963816-2 1988 Vasopressin treatment of these cells stimulated the release of arachidonic acid and the formation of diacylglycerol and phosphocholine. Arachidonic Acid 63-79 arginine vasopressin Rattus norvegicus 0-11 3104182-7 1987 It is concluded that the action of vasopressin on hepatocytes is associated with the release of arachidonic acid or metabolites of arachidonic acid but is not accompanied by a general increase in the steady-state concentrations of free fatty acids and lysophospholipids. Arachidonic Acid 96-112 arginine vasopressin Rattus norvegicus 35-46 3104182-7 1987 It is concluded that the action of vasopressin on hepatocytes is associated with the release of arachidonic acid or metabolites of arachidonic acid but is not accompanied by a general increase in the steady-state concentrations of free fatty acids and lysophospholipids. Arachidonic Acid 131-147 arginine vasopressin Rattus norvegicus 35-46 3458352-6 1986 The results support the hypothesis that vasopressin stimulates release of arachidonic acid in the papilla and that urea inhibits the trapping of this prostaglandin precursor in cellular lipids. Arachidonic Acid 74-90 arginine vasopressin Rattus norvegicus 40-51 6439189-3 1984 Cells labelled with [14C]arachidonic acid showed an increase of label in 1,2-diacylglycerol after 15 s and in phosphatidic acid after 30 s upon stimulation with AVP. Arachidonic Acid 25-41 arginine vasopressin Rattus norvegicus 161-164 6436471-3 1984 Arachidonic acid metabolism is stimulated by treatment of the C-9 cells with epidermal growth factor, vasopressin, angiotensin II or thrombin. Arachidonic Acid 0-16 arginine vasopressin Rattus norvegicus 102-113 6088884-4 1984 The stimulatory effect of AVP on arachidonate metabolism was inhibited by the calcium channel antagonist, nifedipine, in a dose-dependent fashion suggesting that cellular uptake of calcium was required. Arachidonic Acid 33-45 arginine vasopressin Rattus norvegicus 26-29 11829735-6 2002 Using the selective inhibitors to resolve the contributions of each Ca(2+) entry pathway during stimulation with AVP, we establish that reciprocal regulation of CCE and NCCE by arachidonic acid ensures that only NCCE is active in the presence of AVP, whereas CCE is active only after its removal. Arachidonic Acid 177-193 arginine vasopressin Rattus norvegicus 113-116 18571395-12 2008 In conclusion, our findings show that centrally administered arachidonic acid increases mean arterial pressure and decreases heart rate in normotensive conscious rats and the increases in plasma adrenaline, noradrenaline, vasopressin levels and renin activity appear to mediate the cardiovascular effects of the drug. Arachidonic Acid 61-77 arginine vasopressin Rattus norvegicus 222-233 16828086-0 2006 Stimulation of arachidonic acid release by vasopressin in A7r5 vascular smooth muscle cells mediated by Ca2+-stimulated phospholipase A2. Arachidonic Acid 15-31 arginine vasopressin Rattus norvegicus 43-54 15363956-3 2004 These results suggest the involvement of brain arachidonic acid in the vasopressin-induced activation of the central adrenomedullary outflow. Arachidonic Acid 47-63 arginine vasopressin Rattus norvegicus 71-82 12459038-1 2003 In A7r5 vascular smooth muscle cells vasopressin, via arachidonic acid, regulates two Ca(2+)-entry pathways. Arachidonic Acid 54-70 arginine vasopressin Rattus norvegicus 37-48 12459038-5 2003 Inhibition of CCE by vasopressin requires NOS III and the requirement lies downstream of arachidonic acid. Arachidonic Acid 89-105 arginine vasopressin Rattus norvegicus 21-32 12459038-7 2003 Stimulation of NCCE by vasopressin also requires NOS III, but the stimulation is neither mimicked by cGMP nor blocked by inhibitors of soluble guanylate cyclase or protein kinase G. We conclude that arachidonic acid formed in response to vasopressin stimulates NOS III. Arachidonic Acid 199-215 arginine vasopressin Rattus norvegicus 23-34 12459038-7 2003 Stimulation of NCCE by vasopressin also requires NOS III, but the stimulation is neither mimicked by cGMP nor blocked by inhibitors of soluble guanylate cyclase or protein kinase G. We conclude that arachidonic acid formed in response to vasopressin stimulates NOS III. Arachidonic Acid 199-215 arginine vasopressin Rattus norvegicus 238-249 18234185-5 2008 In the present experiment, therefore, we examined (1) a role of the brain 2-arachidonoyl-sn-glycerol as a precursor of arachidonic acid in the centrally administered vasopressin-induced elevation of plasma noradrenaline and adrenaline, and (2) a regulatory role of the brain 2-arachidonoyl-sn-glycerol as an endocannabinoid on the vasopressin-induced response, using urethane-anesthetized rats. Arachidonic Acid 119-135 arginine vasopressin Rattus norvegicus 166-177 18234185-18 2008 These results suggest that the brain 2-arachidonoyl-sn-glycerol generated from diacylglycerol plays a role as a precursor of arachidonic acid in the centrally administered vasopressin-induced activation of the adrenomedullary outflow, and also negatively regulates the peptide-induced central response through the brain cannabinoid CB(1) receptors in rats. Arachidonic Acid 125-141 arginine vasopressin Rattus norvegicus 172-183 11829735-6 2002 Using the selective inhibitors to resolve the contributions of each Ca(2+) entry pathway during stimulation with AVP, we establish that reciprocal regulation of CCE and NCCE by arachidonic acid ensures that only NCCE is active in the presence of AVP, whereas CCE is active only after its removal. Arachidonic Acid 177-193 arginine vasopressin Rattus norvegicus 246-249 10098498-0 1999 Signal transduction of arginine vasopressin-induced arachidonic acid release in H9c2 cardiac myoblasts: role of Ca2+ and the protein kinase C-dependent activation of p42 mitogen-activated protein kinase. Arachidonic Acid 52-68 arginine vasopressin Rattus norvegicus 32-43 10226154-0 1999 A non-capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin. Arachidonic Acid 40-56 arginine vasopressin Rattus norvegicus 161-172 10098498-1 1999 The mechanism of arginine vasopressin (AVP)-induced arachidonic acid (AA) release was examined in the cardiac myoblast cell line, H9c2. Arachidonic Acid 52-68 arginine vasopressin Rattus norvegicus 26-37 9915331-0 1999 Effect of propofol on arachidonate cascade by vasopressin in aortic smooth muscle cells: inhibition of PGI2 synthesis. Arachidonic Acid 22-34 arginine vasopressin Rattus norvegicus 46-57 9915331-2 1999 Vasopressin, a potent vasoactive peptide, stimulates the arachidonate cascade and the synthesis of prostacyclin (PGI2; the main metabolite of the cascade in vascular smooth muscle cells). Arachidonic Acid 57-69 arginine vasopressin Rattus norvegicus 0-11 9915331-11 1999 CONCLUSIONS: Propofol suppresses the arachidonate cascade caused by vasopressin at least partly by inhibiting phosphoinositide-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D, resulting in the inhibition of PGI2 synthesis. Arachidonic Acid 37-49 arginine vasopressin Rattus norvegicus 68-79 7752810-0 1995 Arachidonic acid metabolism modulates vasopressin-induced renal vasoconstriction. Arachidonic Acid 0-16 arginine vasopressin Rattus norvegicus 38-49 9065736-12 1997 We conclude that phospholipase C and translocation of cPLA2 can account for arachidonate release with AVP stimulation, whereas neither phospholipase C nor any phospholipase A2 activity appears to be implicated in AlF4(-)-dependent arachidonate release. Arachidonic Acid 76-88 arginine vasopressin Rattus norvegicus 102-105 9117386-0 1996 Arachidonic acid regulation of vasopressin release and intracellular Ca2+ in neurohypophysial nerve endings. Arachidonic Acid 0-16 arginine vasopressin Rattus norvegicus 31-42 9117386-2 1996 Arachidonic acid induced a dose-dependent increase in resting vasopressin (AVP) secretion in both intact and streptolysin-O permeabilized nerve endings. Arachidonic Acid 0-16 arginine vasopressin Rattus norvegicus 62-73 9117386-4 1996 Arachidonic acid also dose-dependently potentiated K+-depolarization evoked vasopressin release. Arachidonic Acid 0-16 arginine vasopressin Rattus norvegicus 76-87 8338143-1 1993 The role of arachidonic acid (AA) and its metabolites in vasopressin (AVP)-induced calcium mobilization in A7r5 aortic smooth muscle cells was explored by intracellular calcium monitoring, [14C]AA labeling, and high-performance liquid chromatography (HPLC) techniques. Arachidonic Acid 12-28 arginine vasopressin Rattus norvegicus 57-68 8227189-0 1993 Vasopressin induces arachidonic acid release through pertussis toxin-sensitive GTP-binding protein in aortic smooth muscle cells: independence from phosphoinositide hydrolysis. Arachidonic Acid 20-36 arginine vasopressin Rattus norvegicus 0-11 8227189-3 1993 In the present study, we investigated the mechanism of vasopressin-induced arachidonic acid release in rat aortic smooth muscle cells. Arachidonic Acid 75-91 arginine vasopressin Rattus norvegicus 55-66 8227189-4 1993 Vasopressin stimulated both the release of arachidonic acid and the formation of IP3 dose dependently in the range between 10 pM and 1 microM. Arachidonic Acid 43-59 arginine vasopressin Rattus norvegicus 0-11 8227189-5 1993 The effect of vasopressin on arachidonic acid release was more potent than that on the formation of IP3. Arachidonic Acid 29-45 arginine vasopressin Rattus norvegicus 14-25 8227189-6 1993 Quinacrine, a phospholipase A2 inhibitor, significantly suppressed the vasopressin-induced arachidonic acid release but had little effect on the formation of inositol phosphates. Arachidonic Acid 91-107 arginine vasopressin Rattus norvegicus 71-82 8227189-7 1993 NaF, a GTP-binding protein activator, mimicked vasopressin by stimulating the arachidonic acid release. Arachidonic Acid 78-94 arginine vasopressin Rattus norvegicus 47-58 8227189-8 1993 The arachidonic acid release stimulated by a combination of vasopressin and NaF was not additive. Arachidonic Acid 4-20 arginine vasopressin Rattus norvegicus 60-71 8227189-9 1993 PTX partially but significantly suppressed the vasopressin-induced arachidonic acid release. Arachidonic Acid 67-83 arginine vasopressin Rattus norvegicus 47-58 1338082-1 1992 METHODS: The effects of arginine vasopressin on the release of arachidonic acid and the synthesis of prostaglandin (PG) E2 and prostacyclin (PGI2) were determined. Arachidonic Acid 63-79 arginine vasopressin Rattus norvegicus 33-44 1338082-4 1992 RESULTS: Arginine vasopressin dose-dependently stimulated arachidonic acid release. Arachidonic Acid 58-74 arginine vasopressin Rattus norvegicus 18-29 1338082-5 1992 TPA and 1-oleoyl-2-acetylglycerol dose-dependently increased the vasopressin-induced arachidonic acid release. Arachidonic Acid 85-101 arginine vasopressin Rattus norvegicus 65-76 1331276-7 1992 In contrast arginine vasopressin stimulated arachidonate release from intact mesangial cells, and this effect was blocked by pretreating cells with pertussis toxin. Arachidonic Acid 44-56 arginine vasopressin Rattus norvegicus 21-32 1331276-10 1992 These data suggest that the release of arachidonic acid by vasopressin in glomerular mesangial cells is linked to a pertussis toxin--sensitive guanosine triphosphate--binding protein and that this activation of phospholipase C in vasopressin is linked to a pertussis toxin--insensitive guanosine triphosphate--binding protein. Arachidonic Acid 39-55 arginine vasopressin Rattus norvegicus 59-70 1331276-10 1992 These data suggest that the release of arachidonic acid by vasopressin in glomerular mesangial cells is linked to a pertussis toxin--sensitive guanosine triphosphate--binding protein and that this activation of phospholipase C in vasopressin is linked to a pertussis toxin--insensitive guanosine triphosphate--binding protein. Arachidonic Acid 39-55 arginine vasopressin Rattus norvegicus 230-241 2369126-0 1990 Possible involvement of arachidonic acid metabolites of cytochrome P450 monooxygenase pathway in vasopressin-stimulated glycogenolysis in isolated rat hepatocytes. Arachidonic Acid 24-40 arginine vasopressin Rattus norvegicus 97-108 1539683-6 1992 A dual labeling study ([3H]myristic acid and [14C]arachidonic acid) suggests that phosphatidylcholine is an important source of diacylglycerol in cells treated with VP and PMA. Arachidonic Acid 50-66 arginine vasopressin Rattus norvegicus 165-167 2170380-4 1990 Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity. Arachidonic Acid 161-177 arginine vasopressin Rattus norvegicus 25-27 2170380-4 1990 Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity. Arachidonic Acid 161-177 arginine vasopressin Rattus norvegicus 269-271 1331276-1 1992 To evaluate the identity of the guanosine triphosphate--binding proteins coupling arginine vasopressin receptor occupancy with activation of phospholipase C, leading to Ca2+ mobilization, and activation of phospholipase A2, leading to arachidonate release and prostanoid formation, we used intact cells, saponin-permeabilized cells, and membranes of the rat mesangial cell. Arachidonic Acid 235-247 arginine vasopressin Rattus norvegicus 91-102 2312525-2 1990 The rat vas deferens releases both PGE2 and PGF2 alpha under basal conditions in vitro but the human vas deferens synthesizes prostaglandins only when arachidonic acid is supplied exogenously. Arachidonic Acid 151-167 arginine vasopressin Rattus norvegicus 101-104 2341411-4 1990 However, arachidonate-containing species of 1,2-diacylglycerol were differentially influenced being increased at 5 min by noradrenaline, and decreased at 20 s and 5 min by vasopressin. Arachidonic Acid 9-21 arginine vasopressin Rattus norvegicus 172-183