PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24337743-6 2014 Using selective inhibitors, we find that, contrary to cPLA2alpha, iPLA2beta spares arachidonate-containing phospholipids and hydrolyzes only those that do not contain arachidonate. Arachidonic Acid 83-95 phospholipase A2, group VI Mus musculus 66-75 27650501-3 2016 Activation of group VIA phospholipase A2 (iPLA2beta) causes accumulation of arachidonic acid, lysophospholipids, and eicosanoids that can promote inflammation and pathologic states. Arachidonic Acid 76-92 phospholipase A2, group VI Mus musculus 42-51 28655161-5 2017 Two members of DNB, PLA2G6 and CYP2C44, along with their associated differentially expressed proteins, were found to induce dysfunction of arachidonic acid metabolism, further activate inflammatory responses through inflammatory mediator regulation of transient receptor potential channels, and finally lead to impairments of liver detoxification and malignant transition to cancer. Arachidonic Acid 139-155 phospholipase A2, group VI Mus musculus 20-26 24337743-6 2014 Using selective inhibitors, we find that, contrary to cPLA2alpha, iPLA2beta spares arachidonate-containing phospholipids and hydrolyzes only those that do not contain arachidonate. Arachidonic Acid 167-179 phospholipase A2, group VI Mus musculus 66-75 20521843-5 2010 Arachidonic acid release and PGI(2) production by stimulated iPLA(2)beta-KO endothelial cells were significantly reduced compared to WT. Arachidonic Acid 0-16 phospholipase A2, group VI Mus musculus 61-72 22637477-4 2012 With cultured vascular smooth muscle cell, angiotensin II, arachidonic acid, and TNF-alpha markedly induce increased expression of IL-6 and TNF-alpha mRNAs, all of which were suppressed by inhibiting iPLA(2)beta activity or expression with bromoenol lactone, antisense oligonucleotides, and genetic deletion, respectively. Arachidonic Acid 59-75 phospholipase A2, group VI Mus musculus 200-211 17627946-4 2007 WT and iPLA(2)beta-null macrophages incorporate [(3)H]arachidonic acid ([(3)H]AA]) into glycerophosphocholine lipids equally rapidly and exhibit identical zymosan-induced, cPLA(2)alpha-catalyzed [(3)H]AA release. Arachidonic Acid 54-70 phospholipase A2, group VI Mus musculus 7-18 18328831-3 2008 Arachidonic acid release appeared to be dependent on calcium-independent phospholipase A(2) activation (iPLA(2)); bromoenol lactone, a specific inhibitor of calcium-independent iPLA(2), blocked arachidonic acid release with an IC(50) of approximately 2 x 10(-7)M. Propanolol, an inhibitor of phosphatidate phosphatase, and RHC-80267, an inhibitor of diglyceride lipase, had no effect on arachidonic acid release. Arachidonic Acid 0-16 phospholipase A2, group VI Mus musculus 104-111 18328831-3 2008 Arachidonic acid release appeared to be dependent on calcium-independent phospholipase A(2) activation (iPLA(2)); bromoenol lactone, a specific inhibitor of calcium-independent iPLA(2), blocked arachidonic acid release with an IC(50) of approximately 2 x 10(-7)M. Propanolol, an inhibitor of phosphatidate phosphatase, and RHC-80267, an inhibitor of diglyceride lipase, had no effect on arachidonic acid release. Arachidonic Acid 0-16 phospholipase A2, group VI Mus musculus 177-184 18328831-3 2008 Arachidonic acid release appeared to be dependent on calcium-independent phospholipase A(2) activation (iPLA(2)); bromoenol lactone, a specific inhibitor of calcium-independent iPLA(2), blocked arachidonic acid release with an IC(50) of approximately 2 x 10(-7)M. Propanolol, an inhibitor of phosphatidate phosphatase, and RHC-80267, an inhibitor of diglyceride lipase, had no effect on arachidonic acid release. Arachidonic Acid 194-210 phospholipase A2, group VI Mus musculus 177-184 18328831-3 2008 Arachidonic acid release appeared to be dependent on calcium-independent phospholipase A(2) activation (iPLA(2)); bromoenol lactone, a specific inhibitor of calcium-independent iPLA(2), blocked arachidonic acid release with an IC(50) of approximately 2 x 10(-7)M. Propanolol, an inhibitor of phosphatidate phosphatase, and RHC-80267, an inhibitor of diglyceride lipase, had no effect on arachidonic acid release. Arachidonic Acid 387-403 phospholipase A2, group VI Mus musculus 177-184 18927078-3 2008 Accordingly, we used iPLA(2)beta(-/-) mice to demonstrate that iPLA(2)beta is responsible for the majority of thapsigargin and ionophore (A23187)-induced arachidonic acid release from SMCs. Arachidonic Acid 154-170 phospholipase A2, group VI Mus musculus 63-74 17895289-9 2008 Arachidonate incorporation into and the phospholipid composition of RIP-iPLA(2)beta-TG islets are normal, but they exhibit reduced Kv2.1 delayed rectifier current and prolonged glucose-induced action potentials and elevations of cytosolic Ca(2+) concentration that suggest a molecular mechanism for the physiological role of iPLA(2)beta to amplify insulin secretion. Arachidonic Acid 0-12 phospholipase A2, group VI Mus musculus 72-83 17922229-7 2007 The data suggest that potentiation of glucose-induced insulin release by BL11282, which is independent of concomitant changes in cytoplasmic free Ca2+ concentration, involves release of arachidonic acid by iPLA2 and its metabolism to epoxyeicosatrienoic acids through the cytochrome P-450 pathway. Arachidonic Acid 186-202 phospholipase A2, group VI Mus musculus 206-211 17613534-8 2007 Both arachidonic acid and lysophosphatidylcholine, products of iPLA2beta action, induce RGS2 mRNA up-regulation. Arachidonic Acid 5-21 phospholipase A2, group VI Mus musculus 63-72 16855215-6 2006 Cell swelling elicited BEL-sensitive arachidonic acid release from the nucleus, to which iPLA(2)-VIA localized. Arachidonic Acid 37-53 phospholipase A2, group VI Mus musculus 89-96 16855215-9 2006 A BEL-sensitive, melittin-induced PLA(2) activity was also detected in lysates devoid of sPLA(2), indicating that both sPLA(2) and iPLA(2) contribute to arachidonic acid release in vivo. Arachidonic Acid 153-169 phospholipase A2, group VI Mus musculus 131-138 16855215-11 2006 It is suggested that in NIH3T3 cells, swelling-induced taurine efflux is dependent at least in part on arachidonic acid release by iPLA(2) and possibly also by sPLA(2), whereas melittin-induced taurine efflux is dependent on arachidonic acid release by sPLA(2) and, to a lesser extent, iPLA(2). Arachidonic Acid 103-119 phospholipase A2, group VI Mus musculus 131-138 15471944-1 2005 Islet Ca2+-independent phospholipase A2 (iPLA2) is postulated to mediate insulin secretion by releasing arachidonic acid in response to insulin secretagogues. Arachidonic Acid 104-120 phospholipase A2, group VI Mus musculus 6-39 16732058-2 2006 It has also been suggested that iPLA(2)beta is a housekeeping enzyme that regulates cell 2-lysophosphatidylcholine (LPC) levels and arachidonate incorporation into phosphatidylcholine (PC). Arachidonic Acid 132-144 phospholipase A2, group VI Mus musculus 32-43 16732058-5 2006 Electrospray ionization mass spectrometric analyses indicate that the abundance of arachidonate-containing PC species of islets, brain, and other tissues from iPLA(2)beta-null mice is virtually identical to that of wild-type mice, and no iPLA(2)beta mRNA was observed in any tissue from iPLA(2)beta-null mice at any age. Arachidonic Acid 83-95 phospholipase A2, group VI Mus musculus 159-170 16732058-5 2006 Electrospray ionization mass spectrometric analyses indicate that the abundance of arachidonate-containing PC species of islets, brain, and other tissues from iPLA(2)beta-null mice is virtually identical to that of wild-type mice, and no iPLA(2)beta mRNA was observed in any tissue from iPLA(2)beta-null mice at any age. Arachidonic Acid 83-95 phospholipase A2, group VI Mus musculus 238-249 16732058-5 2006 Electrospray ionization mass spectrometric analyses indicate that the abundance of arachidonate-containing PC species of islets, brain, and other tissues from iPLA(2)beta-null mice is virtually identical to that of wild-type mice, and no iPLA(2)beta mRNA was observed in any tissue from iPLA(2)beta-null mice at any age. Arachidonic Acid 83-95 phospholipase A2, group VI Mus musculus 238-249 15471944-1 2005 Islet Ca2+-independent phospholipase A2 (iPLA2) is postulated to mediate insulin secretion by releasing arachidonic acid in response to insulin secretagogues. Arachidonic Acid 104-120 phospholipase A2, group VI Mus musculus 41-46 15471944-6 2005 Bromoenol lactone (BEL), a selective inhibitor of iPLA2, inhibited glucose-stimulated insulin secretion from isolated mouse islets; this inhibition was overcome by exogenous arachidonic acid. Arachidonic Acid 174-190 phospholipase A2, group VI Mus musculus 50-55 12421808-4 2003 Inhibition of the endogenous iPLA(2) activity by bromoenol lactone (BEL) decreases basal free arachidonic acid levels and reduces the final free arachidonic acid level after phenylephrine stimulation, without significant effect on the net increase in free arachidonic acid stimulated by phenylephrine. Arachidonic Acid 94-110 phospholipase A2, group VI Mus musculus 29-36 15252026-1 2004 The Group VIA Phospholipase A(2) (iPLA(2)beta) is the first recognized cytosolic Ca(2+)-independent PLA(2) and has been proposed to participate in arachidonic acid (20:4) incorporation into glycerophosphocholine lipids, cell proliferation, exocytosis, apoptosis, and other processes. Arachidonic Acid 147-163 phospholipase A2, group VI Mus musculus 34-45 12421808-4 2003 Inhibition of the endogenous iPLA(2) activity by bromoenol lactone (BEL) decreases basal free arachidonic acid levels and reduces the final free arachidonic acid level after phenylephrine stimulation, without significant effect on the net increase in free arachidonic acid stimulated by phenylephrine. Arachidonic Acid 145-161 phospholipase A2, group VI Mus musculus 29-36 12421808-4 2003 Inhibition of the endogenous iPLA(2) activity by bromoenol lactone (BEL) decreases basal free arachidonic acid levels and reduces the final free arachidonic acid level after phenylephrine stimulation, without significant effect on the net increase in free arachidonic acid stimulated by phenylephrine. Arachidonic Acid 145-161 phospholipase A2, group VI Mus musculus 29-36 12421808-8 2003 Our data provide the first evidence that iPLA(2) is required for maintaining basal free arachidonic acid levels and thus is essential for agonist-induced Ca(2+)-sensitization of contraction in vascular smooth muscle. Arachidonic Acid 88-104 phospholipase A2, group VI Mus musculus 41-48 11278673-2 2001 Many potential iPLA(2)beta functions have been proposed, including a signaling role in beta-cell insulin secretion and a role in generating lysophosphatidylcholine acceptors for arachidonic acid incorporation into P388D1 cell phosphatidylcholine (PC). Arachidonic Acid 178-194 phospholipase A2, group VI Mus musculus 15-26 11563837-3 2001 Enforced expression of either iPLA(2) isoform led to a significant increase in intracellular free fatty acid, lysophosphatidylcholine, and GPC without a concomitant increase in the incorporation of either exogenous arachidonic acid or choline. Arachidonic Acid 215-231 phospholipase A2, group VI Mus musculus 30-37 12093473-1 2002 We previously reported that zymosan-stimulated, protein kinase C (PKC)-dependent arachidonic acid liberation occurs with association of Ca2+-independent phospholipase A2 (iPLA2) with the membranes of macrophage-like P388D1 cells. Arachidonic Acid 81-97 phospholipase A2, group VI Mus musculus 136-169 12093473-1 2002 We previously reported that zymosan-stimulated, protein kinase C (PKC)-dependent arachidonic acid liberation occurs with association of Ca2+-independent phospholipase A2 (iPLA2) with the membranes of macrophage-like P388D1 cells. Arachidonic Acid 81-97 phospholipase A2, group VI Mus musculus 171-176 9361012-11 1997 We show herein that inhibition of iPLA2 expression by a specific antisense oligonucleotide decreases both the steady-state levels of lysophosphatidylcholine and the capacity of the cell to incorporate arachidonic acid into membrane phospholipids. Arachidonic Acid 201-217 phospholipase A2, group VI Mus musculus 34-39 10391937-1 1999 We investigated the possible involvement of group VI Ca2+-independent phospholipase A2 (iPLA2) in arachidonic acid (AA) liberation in zymosan-stimulated macrophage-like P388D1 cells. Arachidonic Acid 98-114 phospholipase A2, group VI Mus musculus 88-93 10318801-2 1999 A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells. Arachidonic Acid 88-104 phospholipase A2, group VI Mus musculus 24-29 10318801-2 1999 A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells. Arachidonic Acid 88-104 phospholipase A2, group VI Mus musculus 175-180 10318801-2 1999 A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells. Arachidonic Acid 226-238 phospholipase A2, group VI Mus musculus 24-29 10318801-2 1999 A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic acid incorporation into phosphatidylcholine (PC) has been proposed because iPLA2 inhibition reduces LPC levels and suppresses arachidonate incorporation and phospholipid remodeling in P388D1 cells. Arachidonic Acid 226-238 phospholipase A2, group VI Mus musculus 175-180