PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3079606-1	1986	We examined the role of cyclooxygenase (CO)-derived metabolites of arachidonic acid (AA) in the regulation of interleukin 1 (IL 1) production by lipopolysaccharide (LPS)-stimulated murine resident peritoneal macrophages.	Arachidonic Acid	67-83	interleukin 1 complex	Mus musculus	110-129	
3323504-3	1987	Recombinant murine IL-1 was also a potent dose dependent activator of chondrocyte arachidonate metabolism and protease secretion.	Arachidonic Acid	82-94	interleukin 1 complex	Mus musculus	19-23	
3930604-1	1985	Recombinant murine IL 1 stimulated arachidonic acid metabolism by rat liver cells (the C-9 cell line) and squirrel monkey smooth muscle cells, and in the presence of tumor promoters this stimulation was synergistic.	Arachidonic Acid	35-51	interleukin 1 complex	Mus musculus	19-23	
3930604-2	1985	In the rat liver cells that had been prelabeled with [3H]arachidonic acid, the release of 6-keto-PGF1 alpha and arachidonic acid also was stimulated by the IL 1, and this release was synergistic in the presence of TPA.	Arachidonic Acid	57-73	interleukin 1 complex	Mus musculus	156-160	
3930604-4	1985	OAG and TPA mimic the endogenous activator of protein kinase C, 1,2-diacylglycerol, and therefore IL 1 may amplify arachidonic acid metabolism during signal transmission processes.	Arachidonic Acid	115-131	interleukin 1 complex	Mus musculus	98-102	
7579389-10	1995	The potential role of a tyrosine kinase pathway in arachidonate-mediated c-jun expression was further investigated by assaying the tyrosine kinase activity of cells challenged with arachidonic acid, IL-1, and TNF-alpha.	Arachidonic Acid	51-63	interleukin 1 complex	Mus musculus	199-203	
8168971-0	1994	Roles of tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, platelet-activating factor, and arachidonic acid metabolites in interleukin-1-induced resistance to infection in neutropenic mice.	Arachidonic Acid	120-136	interleukin 1 complex	Mus musculus	152-165	
8168971-3	1994	Since IL-1 induces production of tumor necrosis factor alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), platelet-activating factor (PAF), and arachidonic acid metabolites, we investigated the potential role of these substances in IL-1-induced protection.	Arachidonic Acid	171-187	interleukin 1 complex	Mus musculus	6-10	
8070358-8	1994	In the presence of exogenous arachidonic acid, changes in PGHS-2 mRNA levels with IL-1, PTH, and cortisol correlated closely with changes in PGE2 production.	Arachidonic Acid	29-45	interleukin 1 complex	Mus musculus	82-86	
1338333-6	1992	In basal BALB/c 3T3 cells, bradykinin and IL-1 stimulated arachidonate release in the absence of cAMP, but little conversion of released arachidonate to PGE2 occurred.	Arachidonic Acid	58-70	interleukin 1 complex	Mus musculus	42-46	
8070358-11	1994	We conclude that regulation of PGE2 production is predominantly through PGHS-2, rather than PGHS-1; that IL-1 and cortisol may also regulate arachidonic acid release; and that PGE2 may amplify its own production through stimulation of PGHS-2.	Arachidonic Acid	141-157	interleukin 1 complex	Mus musculus	105-109