PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26672987-0 2015 Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation. Arachidonic Acid 113-129 prostaglandin-endoperoxide synthase 1 Homo sapiens 11-16 26672987-6 2015 In those individuals for whom plasma arachidonic acid (ARA) in the phosphatidylethanolamine (PE) lipid class decreased in response to omega-3 intervention, there was a corresponding decrease in gene expression for PTGS1 and ALOX12. Arachidonic Acid 55-58 prostaglandin-endoperoxide synthase 1 Homo sapiens 214-219 26672987-7 2015 Several oxylipin product/FA precursor ratios (e.g. prostaglandin E2 (PGE2)/ARA for PTGS1 and 12-hydroxyeicosatetraenoic acid (12-HETE)/ARA for ALOX12) were also associated with fold change in gene expression, suggesting an association between enzyme activity and gene expression. Arachidonic Acid 75-78 prostaglandin-endoperoxide synthase 1 Homo sapiens 83-88 24482730-5 2013 Two of these inhibited the oxygenation of arachidonic acid by PGHS-1 and myoglobin and also were shown to be more metabolically stable and exhibited less direct cytotoxicity than acetaminophen. Arachidonic Acid 42-58 prostaglandin-endoperoxide synthase 1 Homo sapiens 62-68 24207016-1 2014 BACKGROUND: Aspirin, a commonly used antiplatelet agent, blocks platelet thromboxane A2 (TXA2) formation from arachidonic acid (AA) by acetylating platelet cyclooxygenase-1 (COX-1). Arachidonic Acid 110-126 prostaglandin-endoperoxide synthase 1 Homo sapiens 156-172 23830213-8 2013 This was associated with marked increases in COX1-dependent responses (arachidonic-acid- and collagen-induced aggregation and platelet recruitment; P<0.0001) but not with differences in ADP- or TRAP-induced aggregation. Arachidonic Acid 71-87 prostaglandin-endoperoxide synthase 1 Homo sapiens 45-49 23473504-1 2013 A key step in the cyclooxygenase reaction cycle of cyclooxygenase 1 (COX-1) is abstraction of the pro-S hydrogen atom of the arachidonic acid by a radical that is formed at the protein residue Tyr-385. Arachidonic Acid 125-141 prostaglandin-endoperoxide synthase 1 Homo sapiens 51-67 23422285-2 2013 It acetylates Ser529 residue in cyclooxygenase-1 (COX-1) and prevents thromboxane A2 (TXA2) formation from arachidonic acid (AA) in platelets. Arachidonic Acid 107-123 prostaglandin-endoperoxide synthase 1 Homo sapiens 32-48 23422285-2 2013 It acetylates Ser529 residue in cyclooxygenase-1 (COX-1) and prevents thromboxane A2 (TXA2) formation from arachidonic acid (AA) in platelets. Arachidonic Acid 107-123 prostaglandin-endoperoxide synthase 1 Homo sapiens 50-55 23473504-1 2013 A key step in the cyclooxygenase reaction cycle of cyclooxygenase 1 (COX-1) is abstraction of the pro-S hydrogen atom of the arachidonic acid by a radical that is formed at the protein residue Tyr-385. Arachidonic Acid 125-141 prostaglandin-endoperoxide synthase 1 Homo sapiens 69-74 21699540-1 2012 Cyclooxygenases (COX)-1 and -2 are key enzymes required for the conversion of arachidonic acid to eicosanoids, potent mediators of inflammation. Arachidonic Acid 78-94 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-30 23985963-5 2013 Platelet COX-1 inhibition was confirmed on <10% platelet aggregation in response to >=1 mmol/L arachidonic acid. Arachidonic Acid 101-117 prostaglandin-endoperoxide synthase 1 Homo sapiens 9-14 23384979-4 2013 In this study the putative structure of human cyclooxygenase-1 was constructed from ovine cyclooxygenase-1 by homology modeling, and the acetylsalicylic acid was docked into the arachidonic acid binding cavity of the enzyme. Arachidonic Acid 178-194 prostaglandin-endoperoxide synthase 1 Homo sapiens 46-62 22481026-1 2012 Prostaglandins, the products of arachidonic acid release and oxidation by phospholipase A(2) and cyclooxygenases (COX) 1 and 2 respectively, are known as important inflammation mediators. Arachidonic Acid 32-48 prostaglandin-endoperoxide synthase 1 Homo sapiens 97-126 22829846-3 2012 While it has been long established that NSAIDs cause inhibition of cyclooxygenase-1 (COX-1), leading to excessive metabolism of arachidonic acid (AA) to cysteinyl-leukotrienes (cys-LTs), there is now evidence that both cytokines and staphylococcus superantigens amplify the inflammatory process exacerbating the disease. Arachidonic Acid 128-144 prostaglandin-endoperoxide synthase 1 Homo sapiens 85-90 22829846-3 2012 While it has been long established that NSAIDs cause inhibition of cyclooxygenase-1 (COX-1), leading to excessive metabolism of arachidonic acid (AA) to cysteinyl-leukotrienes (cys-LTs), there is now evidence that both cytokines and staphylococcus superantigens amplify the inflammatory process exacerbating the disease. Arachidonic Acid 128-144 prostaglandin-endoperoxide synthase 1 Homo sapiens 67-83 22174077-1 2012 In this study, ten anthra-, nine naphtho-, and five benzoquinone compounds of natural origin and five synthetic naphthoquinones were assessed, using an enzymatic in vitro assay, for their potential to inhibit cyclooxygenase-1 and -2 (COX-1 and COX-2), the key enzymes of the arachidonic acid cascade. Arachidonic Acid 275-291 prostaglandin-endoperoxide synthase 1 Homo sapiens 209-232 21467029-1 2011 Prostaglandin endoperoxide H synthases 1 and 2, also known as cyclooxygenases (COXs) 1 and 2, convert arachidonic acid (AA) to prostaglandin endoperoxide H(2). Arachidonic Acid 102-118 prostaglandin-endoperoxide synthase 1 Homo sapiens 62-92 21163909-4 2011 In hPHS-2 cells, with half the activity of hPHS-1 cells, METH (250-1000 muM) cytotoxicity was less than that for hPHS-1 cells but was concentration dependent and increased by exogenous arachidonic acid (AA), which increased hPHS activity. Arachidonic Acid 185-201 prostaglandin-endoperoxide synthase 1 Homo sapiens 43-49 21403766-1 2011 Incubation of prostaglandin H synthase-1 (PGHS-1) under anaerobic conditions with peroxide and arachidonic acid leads to two major radical species: a pentadienyl radical and a radical with a narrow EPR spectrum. Arachidonic Acid 95-111 prostaglandin-endoperoxide synthase 1 Homo sapiens 14-40 21403766-1 2011 Incubation of prostaglandin H synthase-1 (PGHS-1) under anaerobic conditions with peroxide and arachidonic acid leads to two major radical species: a pentadienyl radical and a radical with a narrow EPR spectrum. Arachidonic Acid 95-111 prostaglandin-endoperoxide synthase 1 Homo sapiens 42-48 21127289-1 2011 OBJECTIVE: The rate-limiting step in the biosynthesis of thromboxane A(2) (TxA(2)) and 12-hydroxyeicosatetraenoic acid (12-HETE) by platelets is activation of cytosolic phospholipase A(2alpha) (cPLA(2alpha)), which releases arachidonic acid, which is the substrate for cyclooxygenase-1 (COX-1) and 12-lipoxygenase. Arachidonic Acid 224-240 prostaglandin-endoperoxide synthase 1 Homo sapiens 269-285 21127289-1 2011 OBJECTIVE: The rate-limiting step in the biosynthesis of thromboxane A(2) (TxA(2)) and 12-hydroxyeicosatetraenoic acid (12-HETE) by platelets is activation of cytosolic phospholipase A(2alpha) (cPLA(2alpha)), which releases arachidonic acid, which is the substrate for cyclooxygenase-1 (COX-1) and 12-lipoxygenase. Arachidonic Acid 224-240 prostaglandin-endoperoxide synthase 1 Homo sapiens 287-292 20645164-1 2010 Prostaglandin synthase-1 and 2, also known as cyclooxygenase-1 and 2 (COX) catalyze the rate limiting step in the conversion of arachidonic acid to prostaglandins and other potent lipid mediators. Arachidonic Acid 128-144 prostaglandin-endoperoxide synthase 1 Homo sapiens 46-68 20227521-0 2010 Decrease in expression or activity of cytosolic phospholipase A2alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. Arachidonic Acid 141-157 prostaglandin-endoperoxide synthase 1 Homo sapiens 80-96 20194532-1 2010 Prostaglandin endoperoxide H synthases (PGHS)-1 and -2, also called cyclooxygenases, convert arachidonic acid (AA) to prostaglandin H(2) (PGH(2)) in the committed step of prostaglandin biosynthesis. Arachidonic Acid 93-109 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-54 18670087-6 2008 It is concluded that the cytotoxic compounds 1, 8, and 10 may interfere the conversion of arachidonic acid to prostaglandin (PG)H(2) in the active site of COX-1. Arachidonic Acid 90-106 prostaglandin-endoperoxide synthase 1 Homo sapiens 155-160 19218248-1 2009 Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2, also known as cyclooxygenases (COXs), catalyze the oxygenation of arachidonic acid (AA) in the committed step in prostaglandin (PG) biosynthesis. Arachidonic Acid 122-138 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-54 19028575-2 2009 The model takes into account key features of the complex catalytic mechanism of cyclooxygenase-1, converting arachidonic acid to prostaglandin PGH(2), and includes the description of the enzyme interaction with various types of NSAIDs (reversible/irreversible, non-selective and selective to COX-1/COX-2). Arachidonic Acid 109-125 prostaglandin-endoperoxide synthase 1 Homo sapiens 80-96 19928795-2 2009 AM404 is a derivative of arachidonic acid and has been reported to inhibit arachidonate oxygenation by prostaglandin endoperoxide synthase-1 and -2 (PGHS-1 and -2, respectively). Arachidonic Acid 25-41 prostaglandin-endoperoxide synthase 1 Homo sapiens 103-147 19928795-2 2009 AM404 is a derivative of arachidonic acid and has been reported to inhibit arachidonate oxygenation by prostaglandin endoperoxide synthase-1 and -2 (PGHS-1 and -2, respectively). Arachidonic Acid 25-41 prostaglandin-endoperoxide synthase 1 Homo sapiens 149-162 19928795-2 2009 AM404 is a derivative of arachidonic acid and has been reported to inhibit arachidonate oxygenation by prostaglandin endoperoxide synthase-1 and -2 (PGHS-1 and -2, respectively). Arachidonic Acid 75-87 prostaglandin-endoperoxide synthase 1 Homo sapiens 103-147 19928795-2 2009 AM404 is a derivative of arachidonic acid and has been reported to inhibit arachidonate oxygenation by prostaglandin endoperoxide synthase-1 and -2 (PGHS-1 and -2, respectively). Arachidonic Acid 75-87 prostaglandin-endoperoxide synthase 1 Homo sapiens 149-162 19996015-10 2009 CONCLUSIONS: In this prospective study of 700 aspirin-treated patients presenting for angiographic evaluation of coronary artery disease, residual platelet COX-1 function measured by serum thromboxane B(2) and COX-1-independent platelet function measured by PFA-100 collagen-ADP CT, but not indirect COX-1-dependent assays (arachidonic acid-stimulated platelet markers, shortened PFA-100 collagen-epinephrine CT), correlate with subsequent major adverse cardiovascular events. Arachidonic Acid 324-340 prostaglandin-endoperoxide synthase 1 Homo sapiens 156-161 19433337-5 2009 The cyclooxygenase specific activity and K(M) value for arachidonate of hPGHS-1 were not affected by the Y504F mutation, but the peroxidase specific activity and the K(M) value for peroxide were increased. Arachidonic Acid 56-68 prostaglandin-endoperoxide synthase 1 Homo sapiens 72-79 19210337-1 2009 BACKGROUND AND OBJECTIVE: Prostaglandin E(2), which exerts its actions via EP receptors (EP1, EP2, EP3 and EP4), is a bioactive metabolite of arachidonic acid produced by cyclooxygenase-1 and/or cyclooxygenase-2. Arachidonic Acid 142-158 prostaglandin-endoperoxide synthase 1 Homo sapiens 171-187 18818754-0 2008 Role of linoleic Acid hydroperoxide preformed by cyclooxygenase-1 or -2 on the regulation of prostaglandin formation from arachidonic Acid by the respective enzyme. Arachidonic Acid 122-138 prostaglandin-endoperoxide synthase 1 Homo sapiens 49-71 17301694-1 2007 OBJECTIVE: Cyclooxygenase-1 (COX-1, PTGS1) catalyzes the conversion of arachidonic acid to prostaglandin H2, which is subsequently metabolized to various biologically active prostaglandins. Arachidonic Acid 71-87 prostaglandin-endoperoxide synthase 1 Homo sapiens 11-27 18435972-7 2008 After the 2 aspirin doses, men and women had near complete suppression of platelet aggregation to arachidonic acid in whole blood and in platelet-rich plasma (PRP), the direct cyclo-oxygenase-1 pathway affected by aspirin. Arachidonic Acid 98-114 prostaglandin-endoperoxide synthase 1 Homo sapiens 176-193 18536521-2 2008 Cyclooxygenases (COX) 1 and 2 are two enzymes known to convert arachidonic acid into prostaglandins. Arachidonic Acid 63-79 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-29 17191216-3 2007 Since the discovery of a second isoform of COXs, it has been shown that PGF2alpha can be formed in vivo from arachidonic acid through both isoforms of COXs, namely cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Arachidonic Acid 109-125 prostaglandin-endoperoxide synthase 1 Homo sapiens 164-180 17242290-0 2007 Letter by Kronish et al regarding article, "Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance". Arachidonic Acid 53-69 prostaglandin-endoperoxide synthase 1 Homo sapiens 141-157 17209563-1 2007 Prostaglandin H synthase-1 (PGHS-1) is a bifunctional heme protein catalyzing both a peroxidase reaction, in which peroxides are converted to alcohols, and a cyclooxygenase reaction, in which arachidonic acid is converted into prostaglandin G2. Arachidonic Acid 192-208 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-26 17209563-1 2007 Prostaglandin H synthase-1 (PGHS-1) is a bifunctional heme protein catalyzing both a peroxidase reaction, in which peroxides are converted to alcohols, and a cyclooxygenase reaction, in which arachidonic acid is converted into prostaglandin G2. Arachidonic Acid 192-208 prostaglandin-endoperoxide synthase 1 Homo sapiens 28-34 17301694-1 2007 OBJECTIVE: Cyclooxygenase-1 (COX-1, PTGS1) catalyzes the conversion of arachidonic acid to prostaglandin H2, which is subsequently metabolized to various biologically active prostaglandins. Arachidonic Acid 71-87 prostaglandin-endoperoxide synthase 1 Homo sapiens 29-34 17301694-1 2007 OBJECTIVE: Cyclooxygenase-1 (COX-1, PTGS1) catalyzes the conversion of arachidonic acid to prostaglandin H2, which is subsequently metabolized to various biologically active prostaglandins. Arachidonic Acid 71-87 prostaglandin-endoperoxide synthase 1 Homo sapiens 36-41 17301694-10 2007 CONCLUSIONS: Our findings demonstrate that several genetic variants in human COX-1 significantly alter basal COX-1-mediated arachidonic acid metabolism and indomethacin-mediated inhibition of COX-1 activity in vitro. Arachidonic Acid 124-140 prostaglandin-endoperoxide synthase 1 Homo sapiens 77-82 17301694-10 2007 CONCLUSIONS: Our findings demonstrate that several genetic variants in human COX-1 significantly alter basal COX-1-mediated arachidonic acid metabolism and indomethacin-mediated inhibition of COX-1 activity in vitro. Arachidonic Acid 124-140 prostaglandin-endoperoxide synthase 1 Homo sapiens 109-114 17301694-10 2007 CONCLUSIONS: Our findings demonstrate that several genetic variants in human COX-1 significantly alter basal COX-1-mediated arachidonic acid metabolism and indomethacin-mediated inhibition of COX-1 activity in vitro. Arachidonic Acid 124-140 prostaglandin-endoperoxide synthase 1 Homo sapiens 109-114 16952710-9 2006 Constitutively active cyclooxygenase-1 was then responsible for further metabolism of free arachidonic acid to prostacyclin. Arachidonic Acid 91-107 prostaglandin-endoperoxide synthase 1 Homo sapiens 22-38 16606823-1 2006 Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2 convert arachidonic acid to prostaglandin H2 in the committed step of prostanoid biosynthesis. Arachidonic Acid 63-79 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-54 16785341-0 2006 Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance. Arachidonic Acid 9-25 prostaglandin-endoperoxide synthase 1 Homo sapiens 97-113 16785341-9 2006 CONCLUSIONS: There is a residual arachidonic acid-induced platelet activation in aspirin-treated patients that (1) is caused by underdosing and/or noncompliance in only approximately 2% of patients and (2) in the remaining patients, occurs via a cyclooxygenase-1 and cyclooxygenase-2 independent pathway, in direct proportion to the degree of baseline platelet activation, and is mediated in part by adenosine diphosphate-induced platelet activation. Arachidonic Acid 33-49 prostaglandin-endoperoxide synthase 1 Homo sapiens 246-262 15869467-1 2005 Cyclo-oxygenases-1/2 (COX-1/2) catalyse the oxygenation of AA (arachidonic acid) and related polyunsaturated fatty acids to endoperoxide precursors of prostanoids. Arachidonic Acid 63-79 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-20 16551714-8 2006 However, after aspirin therapy, the percent aggregation to arachidonic acid (the direct COX-1 pathway) decreased more in women than in men (P<.001) and demonstrated near total suppression of residual platelet reactivity in both men and women. Arachidonic Acid 59-75 prostaglandin-endoperoxide synthase 1 Homo sapiens 88-93 15084746-9 2004 Furthermore, the arachidonate-induced up-regulation of PECAM-1 was abrogated by indomethacin [a cyclooxygenase (COX)-1 and -2 inhibitor] or N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide (a COX-2 inhibitor) but not nordihydroguaiaretic acid (a lipoxygenase inhibitor). Arachidonic Acid 17-29 prostaglandin-endoperoxide synthase 1 Homo sapiens 96-125 16433444-5 2005 The fact that the main mediators involved are sulfidoleukotrienes (LTC4, LTD4, LTE4) and that the drugs responsible all inhibit cyclooxygenase-1 (COX-1), pointed to a pharmacogenetic abnormality of arachidonic acid metabolism. Arachidonic Acid 198-214 prostaglandin-endoperoxide synthase 1 Homo sapiens 146-151 15921208-1 2005 BACKGROUND: Cyclooxygenase 1 (Cox-1) plays a key role in arachidonic acid metabolism and in the pathophysiology and immunology of nasal polyposis in patients suffering from aspirin intolerance. Arachidonic Acid 57-73 prostaglandin-endoperoxide synthase 1 Homo sapiens 12-28 15921208-1 2005 BACKGROUND: Cyclooxygenase 1 (Cox-1) plays a key role in arachidonic acid metabolism and in the pathophysiology and immunology of nasal polyposis in patients suffering from aspirin intolerance. Arachidonic Acid 57-73 prostaglandin-endoperoxide synthase 1 Homo sapiens 30-35 12637362-9 2003 Removal of the endothelium or selective blockade of cyclooxygenase-1 with SC-560 abolished estrogen-mediated differences in the effects of arachidonate on vessel diameter and on prostacyclin production by cerebral arteries. Arachidonic Acid 139-151 prostaglandin-endoperoxide synthase 1 Homo sapiens 52-68 12874281-2 2003 They are an abundant source of inflammatory eicosanoids such as prostaglandin E2 (PGE2) and thromboxane A2, which are formed via arachidonic acid (AA) metabolism by cyclooxygenase-1/2 (COX-1/2). Arachidonic Acid 129-145 prostaglandin-endoperoxide synthase 1 Homo sapiens 165-183 12958179-0 2003 Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells. Arachidonic Acid 76-88 prostaglandin-endoperoxide synthase 1 Homo sapiens 124-140 12958179-8 2003 Taken together, these results support the notion that the endogenous PHGPx plays a pivotal role in the regulation of 12(S)-lipoxygenase and cyclooxygenase 1 activities by reducing the level of intracellular lipid hydroperoxides in arachidonate metabolism in A431 cells. Arachidonic Acid 231-243 prostaglandin-endoperoxide synthase 1 Homo sapiens 140-156 14576462-10 2003 In conclusion, the endogenous inhibitor of arachidonate metabolism present in A431 cells is a PHGPx, which plays a functional role in the down-regulation of arachidonate oxygenation catalyzed by 12(S)-lipoxygenase and cyclooxygenase 1 through the reduction of the level of intracellular lipid hydroperoxides. Arachidonic Acid 43-55 prostaglandin-endoperoxide synthase 1 Homo sapiens 218-234 12545150-3 2003 Cyclooxygenase 1 (prostaglandin endoperoxide G/H synthase [PTGS1]) catalyzes the metabolism of arachidonic acid to prostaglandin H(2), which is subsequently metabolized to thromboxane A(2). Arachidonic Acid 95-111 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-16 12545150-3 2003 Cyclooxygenase 1 (prostaglandin endoperoxide G/H synthase [PTGS1]) catalyzes the metabolism of arachidonic acid to prostaglandin H(2), which is subsequently metabolized to thromboxane A(2). Arachidonic Acid 95-111 prostaglandin-endoperoxide synthase 1 Homo sapiens 59-64 15035793-3 2003 At low concentrations of arachidonic acid, COX-2 is the major isoenzyme involved in PG synthesis when both COX-1 and COX-2 are present in cells. Arachidonic Acid 25-41 prostaglandin-endoperoxide synthase 1 Homo sapiens 107-112 15035793-6 2003 A splice variant of COX-1, termed COX-3, may be a site of action of these drugs but, further work, particularly at low concentrations of arachidonic acid is required. Arachidonic Acid 137-153 prostaglandin-endoperoxide synthase 1 Homo sapiens 20-25 14576462-8 2003 Reduction of arachidonate metabolism through 12(S)-lipoxygenase and cyclooxygenase 1 and that of the arsenite-induced generation of reactive oxygen species are observed in cells overexpressing PHGPx. Arachidonic Acid 13-25 prostaglandin-endoperoxide synthase 1 Homo sapiens 68-84 12841340-1 2003 Cytosolic phospholipases A2 (cPLA2) and cyclooxygenases-1 and -2 (COX-1 and -2) play a pivotal role in the metabolism of arachidonic acid (AA) and in eicosanoid production. Arachidonic Acid 121-137 prostaglandin-endoperoxide synthase 1 Homo sapiens 40-64 14576462-10 2003 In conclusion, the endogenous inhibitor of arachidonate metabolism present in A431 cells is a PHGPx, which plays a functional role in the down-regulation of arachidonate oxygenation catalyzed by 12(S)-lipoxygenase and cyclooxygenase 1 through the reduction of the level of intracellular lipid hydroperoxides. Arachidonic Acid 157-169 prostaglandin-endoperoxide synthase 1 Homo sapiens 218-234 12432913-7 2002 Based on the crystal structure of PGHS-1 arachidonate complex, it is now possible to envision how arachidonate is bound and oxygenation occurs. Arachidonic Acid 41-53 prostaglandin-endoperoxide synthase 1 Homo sapiens 34-40 12398900-8 2002 Our results suggest that arachidonic acid not only competes with PGHS-2 inhibitors for binding to the cyclooxygenase site of PGHS-1 but it also reduces the affinities of PGHS-1 for these inhibitors by an additional, as yet unresolved mechanism. Arachidonic Acid 25-41 prostaglandin-endoperoxide synthase 1 Homo sapiens 125-131 12398900-8 2002 Our results suggest that arachidonic acid not only competes with PGHS-2 inhibitors for binding to the cyclooxygenase site of PGHS-1 but it also reduces the affinities of PGHS-1 for these inhibitors by an additional, as yet unresolved mechanism. Arachidonic Acid 25-41 prostaglandin-endoperoxide synthase 1 Homo sapiens 170-176 12432913-7 2002 Based on the crystal structure of PGHS-1 arachidonate complex, it is now possible to envision how arachidonate is bound and oxygenation occurs. Arachidonic Acid 98-110 prostaglandin-endoperoxide synthase 1 Homo sapiens 34-40 11712072-1 2001 Cyclooxygenase, which converts arachidonic acid into prostaglandins, has two types of isoforms, cyclooxygenase-1 and cyclooxygenase-2 (COX-2). Arachidonic Acid 31-47 prostaglandin-endoperoxide synthase 1 Homo sapiens 96-112 11735127-1 2001 Prostaglandin endoperoxide H synthases (PGHSs)-1 and -2 have a cyclooxygenase (COX) activity involved in forming prostaglandin G2 (PGG2) from arachidonic acid and an associated peroxidase (POX) activity that reduces PGG2 to PGH2. Arachidonic Acid 142-158 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-55 11442478-2 2001 To induce platelet aggregation, the platelets" enzyme, prostaglandin endoperoxide H synthase-1 (PGHS-1), first converts arachidonic acid (AA) into prostaglandin H2 (PGH2). Arachidonic Acid 120-136 prostaglandin-endoperoxide synthase 1 Homo sapiens 55-94 11695251-1 2001 The isozymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) catalyze the conversion of arachidonic acid to eicosanoids that play an important role in the maintenance of cardiovascular hemostasis. Arachidonic Acid 94-110 prostaglandin-endoperoxide synthase 1 Homo sapiens 13-29 11602656-1 2001 Cyclooxygenases (COX)-1 and -2 are the key enzymes in the conversion of arachidonic acid to prostaglandins. Arachidonic Acid 72-88 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-30 11442478-2 2001 To induce platelet aggregation, the platelets" enzyme, prostaglandin endoperoxide H synthase-1 (PGHS-1), first converts arachidonic acid (AA) into prostaglandin H2 (PGH2). Arachidonic Acid 120-136 prostaglandin-endoperoxide synthase 1 Homo sapiens 96-102 11422676-1 2001 Cyclooxygenase-1,2 (COX-1,2) or prostaglandin (PG) H synthase, is the first enzyme of the pathway in which arachidonic acid is oxidized to PGs. Arachidonic Acid 107-123 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-18 11121412-4 2001 In the crystal structure of Co(3+)-heme ovine PGHS-1 complexed with arachidonic acid, 19 cyclooxygenase active site residues are predicted to make a total of 50 contacts with the substrate (Malkowski, M. G, Ginell, S., Smith, W. L., and Garavito, R. M. (2000) Science 289, 1933-1937); two of these are hydrophilic, and 48 involve hydrophobic interactions. Arachidonic Acid 68-84 prostaglandin-endoperoxide synthase 1 Homo sapiens 46-52 11121413-3 2001 We report here the x-ray crystal structure of dihomo-gamma-linolenic acid (DHLA) in the cyclooxygenase site of PGHS-1 and the effects of active site substitutions on the oxygenation of DHLA, and we compare these results to those obtained previously with arachidonic acid (AA). Arachidonic Acid 254-270 prostaglandin-endoperoxide synthase 1 Homo sapiens 111-117 11027502-6 2000 In resident liver macrophages, the formation of prostanoids from exogenous arachidonic acid is completely inhibited by SC560 (a specific inhibitor of cyclooxygenase 1), but remains unchanged with SC236 (a specific inhibitor of cyclooxygenase 2). Arachidonic Acid 75-91 prostaglandin-endoperoxide synthase 1 Homo sapiens 150-166 11145613-2 2001 In vitro, prostacyclin is synthesized from arachidonic acid through the activity of cyclooxygenases 1 and 2 and is released from AngII-stimulated adipocytes. Arachidonic Acid 43-59 prostaglandin-endoperoxide synthase 1 Homo sapiens 84-107 10993875-8 2000 PGHS-1-dependent ( small middle dot)NO consumption also occurs during arachidonate, thrombin, or activation of platelets (1-2 microm.min(-1) for typical plasma platelet concentrations) and prevents ( small middle dot)NO stimulation of platelet soluble guanylate cyclase. Arachidonic Acid 70-82 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-6 10988074-2 2000 We have determined the structure of PGHS-1 at 3 angstrom resolution with arachidonic acid (AA) bound in a chemically productive conformation. Arachidonic Acid 73-89 prostaglandin-endoperoxide synthase 1 Homo sapiens 36-42 10193998-2 1999 This is possible because celecoxib is a cyclooxygenase-2 (COX-2)-specific inhibiting agent that inhibits the conversion of arachidonic acid to the prostaglandins that mediate pain and inflammation while having no effect on the formation of the prostaglandins that mediate normal homeostasis in the gastrointestinal tract, kidneys, and platelets and that are formed under the control of cyclooxygenase-1 (COX-1). Arachidonic Acid 123-139 prostaglandin-endoperoxide synthase 1 Homo sapiens 386-402 10585861-12 1999 In the presence of exogenous arachidonic acid the COS-7 cells expressing human PGHS-1 produced substantial amounts of PGE(2) and 8-epi-PGF(2alpha). Arachidonic Acid 29-45 prostaglandin-endoperoxide synthase 1 Homo sapiens 79-85 10514410-1 1999 Cyclooxygenase-1 (Cox-1) and Cox-2 convert arachidonic acid to prostaglandin H(2), the precursor of other prostaglandins and thromboxanes, eicosanoids important in vascular pathophysiology. Arachidonic Acid 43-59 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-16 10514410-1 1999 Cyclooxygenase-1 (Cox-1) and Cox-2 convert arachidonic acid to prostaglandin H(2), the precursor of other prostaglandins and thromboxanes, eicosanoids important in vascular pathophysiology. Arachidonic Acid 43-59 prostaglandin-endoperoxide synthase 1 Homo sapiens 18-23 10493821-6 1999 In contrast, when cells were exposed to the nitric oxide-releasing compound 1-hydroxy-2-oxo-3-[(methylamino)propyl]-3-methyl-1-triazene (NOC-7), PGHS-1 enzyme activity was inhibited in the presence of exogenous arachidonic acid. Arachidonic Acid 211-227 prostaglandin-endoperoxide synthase 1 Homo sapiens 145-151 10400651-1 1999 Prostaglandin H synthase isoform-1 (PGHS-1) cyclooxygenase activity has a cooperative response to arachidonate concentration, whereas the second isoform, PGHS-2, exhibits saturable kinetics. Arachidonic Acid 98-110 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-34 10400651-1 1999 Prostaglandin H synthase isoform-1 (PGHS-1) cyclooxygenase activity has a cooperative response to arachidonate concentration, whereas the second isoform, PGHS-2, exhibits saturable kinetics. Arachidonic Acid 98-110 prostaglandin-endoperoxide synthase 1 Homo sapiens 36-42 10206978-1 1999 The two cyclooxygenase isoforms, cyclooxygenase-1 and cyclooxygenase-2, both metabolize arachidonic acid to prostaglandin H2, which is subsequently processed by downstream enzymes to the various prostanoids. Arachidonic Acid 88-104 prostaglandin-endoperoxide synthase 1 Homo sapiens 33-49 10206978-8 1999 Thus, cyclooxygenase-2 induction leads to a shift in arachidonic acid metabolism from the production of several prostanoids with diverse effects as mediated by cyclooxygenase-1 to the preferential synthesis of two prostanoids, prostacyclin and prostaglandin E2, which evoke common effects at the cellular level. Arachidonic Acid 53-69 prostaglandin-endoperoxide synthase 1 Homo sapiens 160-176 10828979-1 2000 Prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and -2) convert arachidonic acid to prostaglandin H(2) (PGH(2)), the committed step in prostaglandin and thromboxane formation. Arachidonic Acid 72-88 prostaglandin-endoperoxide synthase 1 Homo sapiens 49-62 10813584-1 2000 Cyclooxygenases-1 and -2 are the key enzymes in the conversion of arachidonic acid to prostanoids. Arachidonic Acid 66-82 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-24 10722687-1 2000 Arachidonic acid is converted to prostaglandin G(2) (PGG(2)) by the cyclooxygenase activities of prostaglandin endoperoxide H synthases (PGHSs) 1 and 2. Arachidonic Acid 0-16 prostaglandin-endoperoxide synthase 1 Homo sapiens 97-151 11081405-13 2000 These observations provide insights into the association of the arachidonic acid substrate to the cyclooxygenase active site of PGHS-1. Arachidonic Acid 64-80 prostaglandin-endoperoxide synthase 1 Homo sapiens 128-134 10664933-1 1999 Cyclooxygenase (COX) 1 and 2 are two isoforms of a crucial enzyme in the metabolism of arachidonic acid to prostaglandins, thromboxanes and prostacyclin. Arachidonic Acid 87-103 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-28 11139815-1 1999 Increased prostaglandin (PG) production is associated with many inflammatory pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes: cyclooxygenase-1 or -2 (COX-1 or COX-2). Arachidonic Acid 127-143 prostaglandin-endoperoxide synthase 1 Homo sapiens 170-192 10358065-2 1999 Replacement of Arg-120 of ovine PGHS-1 with a glutamine increases the apparent Km of PGHS-1 for arachidonate by 1,000-fold (Bhattacharyya, D. K., Lecomte, M., Rieke, C. J., Garavito, R. M., and Smith, W. L. (1996) J. Biol. Arachidonic Acid 96-108 prostaglandin-endoperoxide synthase 1 Homo sapiens 32-38 10358065-2 1999 Replacement of Arg-120 of ovine PGHS-1 with a glutamine increases the apparent Km of PGHS-1 for arachidonate by 1,000-fold (Bhattacharyya, D. K., Lecomte, M., Rieke, C. J., Garavito, R. M., and Smith, W. L. (1996) J. Biol. Arachidonic Acid 96-108 prostaglandin-endoperoxide synthase 1 Homo sapiens 85-91 10358065-5 1999 This and other evidence indicate that the guanido group of Arg-120 forms an ionic bond with the carboxylate group of arachidonate and that this interaction is an important contributor to the overall strength of arachidonate binding to PGHS-1. Arachidonic Acid 117-129 prostaglandin-endoperoxide synthase 1 Homo sapiens 235-241 10358065-5 1999 This and other evidence indicate that the guanido group of Arg-120 forms an ionic bond with the carboxylate group of arachidonate and that this interaction is an important contributor to the overall strength of arachidonate binding to PGHS-1. Arachidonic Acid 211-223 prostaglandin-endoperoxide synthase 1 Homo sapiens 235-241 10358065-8 1999 The Km values of PGHS-1 and -2 for arachidonate are the same, and all but one of the core residues of the active sites of the two isozymes are identical. Arachidonic Acid 35-47 prostaglandin-endoperoxide synthase 1 Homo sapiens 17-30 10358065-9 1999 Thus, the results of our studies of Arg-120 of PGHS-1 and -2 imply that interactions involved in the binding of arachidonate to PGHS-1 and -2 are quite different and that residues within the hydrophobic cyclooxygenase channel must contribute more significantly to arachidonate binding to PGHS-2 than to PGHS-1. Arachidonic Acid 112-124 prostaglandin-endoperoxide synthase 1 Homo sapiens 47-60 10358065-9 1999 Thus, the results of our studies of Arg-120 of PGHS-1 and -2 imply that interactions involved in the binding of arachidonate to PGHS-1 and -2 are quite different and that residues within the hydrophobic cyclooxygenase channel must contribute more significantly to arachidonate binding to PGHS-2 than to PGHS-1. Arachidonic Acid 112-124 prostaglandin-endoperoxide synthase 1 Homo sapiens 128-141 10358065-9 1999 Thus, the results of our studies of Arg-120 of PGHS-1 and -2 imply that interactions involved in the binding of arachidonate to PGHS-1 and -2 are quite different and that residues within the hydrophobic cyclooxygenase channel must contribute more significantly to arachidonate binding to PGHS-2 than to PGHS-1. Arachidonic Acid 112-124 prostaglandin-endoperoxide synthase 1 Homo sapiens 47-53 10358065-9 1999 Thus, the results of our studies of Arg-120 of PGHS-1 and -2 imply that interactions involved in the binding of arachidonate to PGHS-1 and -2 are quite different and that residues within the hydrophobic cyclooxygenase channel must contribute more significantly to arachidonate binding to PGHS-2 than to PGHS-1. Arachidonic Acid 264-276 prostaglandin-endoperoxide synthase 1 Homo sapiens 47-60 10224163-1 1999 12-Lipoxygenase and cyclooxygenase 1 are the dominating enzymes that metabolize arachidonic acid in human platelets. Arachidonic Acid 80-96 prostaglandin-endoperoxide synthase 1 Homo sapiens 20-36 10027847-1 1999 Prostaglandin (PG) release in cells expressing constitutive cyclooxygenase-1 is known to be regulated by liberation of arachidonic acid by phospholipase A2 followed by metabolism by cyclooxygenase. Arachidonic Acid 119-135 prostaglandin-endoperoxide synthase 1 Homo sapiens 60-76 10193998-2 1999 This is possible because celecoxib is a cyclooxygenase-2 (COX-2)-specific inhibiting agent that inhibits the conversion of arachidonic acid to the prostaglandins that mediate pain and inflammation while having no effect on the formation of the prostaglandins that mediate normal homeostasis in the gastrointestinal tract, kidneys, and platelets and that are formed under the control of cyclooxygenase-1 (COX-1). Arachidonic Acid 123-139 prostaglandin-endoperoxide synthase 1 Homo sapiens 404-409 9637532-0 1998 Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids. Arachidonic Acid 0-16 prostaglandin-endoperoxide synthase 1 Homo sapiens 83-100 9139685-6 1997 The cooperativity produces a 2-4-fold greater rate of PGHS2-dependent prostaglandin formation compared with PGHS1-dependent prostaglandin formation at arachidonic acid concentrations below 0.5 microM. Arachidonic Acid 151-167 prostaglandin-endoperoxide synthase 1 Homo sapiens 108-113 9461572-1 1998 A tyrosyl radical generated in the peroxidase cycle of prostaglandin H synthase-1 (PGHS-1) can serve as the initial oxidant for arachidonic acid (AA) in the cyclooxygenase reaction. Arachidonic Acid 128-144 prostaglandin-endoperoxide synthase 1 Homo sapiens 55-81 9461572-1 1998 A tyrosyl radical generated in the peroxidase cycle of prostaglandin H synthase-1 (PGHS-1) can serve as the initial oxidant for arachidonic acid (AA) in the cyclooxygenase reaction. Arachidonic Acid 128-144 prostaglandin-endoperoxide synthase 1 Homo sapiens 83-89 9425042-4 1998 By measuring fluorescence quenching due to the energy transfer of the inhibitor fluorescence to the heme prosthetic group of PGHS, we determined these inhibitors bind in the arachidonic acid substrate access channel with an R0 of 35 A for PGHS-1 with the PGHS-1 inhibitor and an R0 of 21 A for PGHS-2 with the PGHS-2 inhibitor. Arachidonic Acid 174-190 prostaglandin-endoperoxide synthase 1 Homo sapiens 239-245 9425042-4 1998 By measuring fluorescence quenching due to the energy transfer of the inhibitor fluorescence to the heme prosthetic group of PGHS, we determined these inhibitors bind in the arachidonic acid substrate access channel with an R0 of 35 A for PGHS-1 with the PGHS-1 inhibitor and an R0 of 21 A for PGHS-2 with the PGHS-2 inhibitor. Arachidonic Acid 174-190 prostaglandin-endoperoxide synthase 1 Homo sapiens 255-261 9351974-2 1997 Mutagenesis studies confirmed that the Arg120 residue of PGHS-1 is critical for binding of substrate and inhibitors through ionic interactions of its guanidinium group with the carboxylate moieties of arachidonic acid and certain NSAIDs. Arachidonic Acid 201-217 prostaglandin-endoperoxide synthase 1 Homo sapiens 57-63 9139685-7 1997 A consequence of the PGHS1 cooperativity is that the affinity of many cyclooxygenase inhibitors for PGHS1 decreases in parallel to the activation by arachidonic acid. Arachidonic Acid 149-165 prostaglandin-endoperoxide synthase 1 Homo sapiens 21-26 9139685-7 1997 A consequence of the PGHS1 cooperativity is that the affinity of many cyclooxygenase inhibitors for PGHS1 decreases in parallel to the activation by arachidonic acid. Arachidonic Acid 149-165 prostaglandin-endoperoxide synthase 1 Homo sapiens 100-105 9139685-9 1997 This results in a dramatic difference in PGHS2/PGHS1 selectivity at different arachidonic acid concentrations. Arachidonic Acid 78-94 prostaglandin-endoperoxide synthase 1 Homo sapiens 47-52 8831759-4 1996 The members of the earlier series exhibited varying degrees of potency as inhibitors of the enzymes of arachidonic acid metabolism, PGHS-1 and 5-LO. Arachidonic Acid 103-119 prostaglandin-endoperoxide synthase 1 Homo sapiens 132-144 9032211-1 1997 Prostaglandin H synthases or cyclooxygenases 1 (PGHS-1) and 2 (PGHS-2) catalyze the conversion of arachidonic acid to prostaglandin endoperoxides, leading to the formation of prostaglandin and thromboxane mediators of inflammation. Arachidonic Acid 98-114 prostaglandin-endoperoxide synthase 1 Homo sapiens 48-61 8831731-4 1996 Exogenous and endogenous arachidonic acid were used as substrates by both CHO [hPGHS-1] and CHO [hPGHS-2] cell lines. Arachidonic Acid 25-41 prostaglandin-endoperoxide synthase 1 Homo sapiens 79-86 33170486-1 2021 Arachidonic acid (AA)-induced platelet aggregation (PA) and serum thromboxane B2 (TxB2) inhibition are widely used to indicate cyclooxygenase-1 activity and the antiplatelet effect of acetylsalicylic acid (ASA). Arachidonic Acid 0-16 prostaglandin-endoperoxide synthase 1 Homo sapiens 127-143 7642610-4 1995 Comparisons of kcat/Km values indicate that the order of efficiency of oxygenation is arachidonate > dihomo-gamma-linolenate > linoleate > alpha-linolenate for both isozymes; while the order of efficiency was the same for hPGHS-1 and hPGHS-2, alpha-linolenate was a particularly poor substrate for hPGHS-1. Arachidonic Acid 86-98 prostaglandin-endoperoxide synthase 1 Homo sapiens 231-238 7642610-4 1995 Comparisons of kcat/Km values indicate that the order of efficiency of oxygenation is arachidonate > dihomo-gamma-linolenate > linoleate > alpha-linolenate for both isozymes; while the order of efficiency was the same for hPGHS-1 and hPGHS-2, alpha-linolenate was a particularly poor substrate for hPGHS-1. Arachidonic Acid 86-98 prostaglandin-endoperoxide synthase 1 Homo sapiens 307-314 8114674-5 1994 The major prostanoid products formed by microsomes from COS-7 cells containing either recombinant hPGHS-1 or hPGHS-2 after incubation with arachidonic acid were prostaglandin D2 and E2, with lower levels of prostaglandin F2 alpha and 6-keto-prostaglandin F1 alpha. Arachidonic Acid 139-155 prostaglandin-endoperoxide synthase 1 Homo sapiens 98-105 33796403-1 2021 Prostaglandin E2 (PGE2), an arachidonic acid pathway metabolite produced by cyclooxygenase (COX)-1/2, has been shown to impair anti-tumor immunity through engagement with one or more E-type prostanoid receptors (EP1-4). Arachidonic Acid 28-44 prostaglandin-endoperoxide synthase 1 Homo sapiens 76-100 8662657-0 1996 Cyclooxygenase-1 and -2 of endothelial cells utilize exogenous or endogenous arachidonic acid for transcellular production of thromboxane. Arachidonic Acid 77-93 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-23 7493972-4 1995 Comparison of microsomal enzyme preparations show that the mutation results in a 20-fold reduction in the specific activity of PGHS-1 and in a 100-fold increase in the apparent Km for arachidonic acid. Arachidonic Acid 184-200 prostaglandin-endoperoxide synthase 1 Homo sapiens 127-133 7493972-10 1995 These data provide biochemical evidence of the importance of the Arg120 residue in PGHS-1 for interaction with arachidonic acid and NSAIDs containing a free carboxylic acid moiety. Arachidonic Acid 111-127 prostaglandin-endoperoxide synthase 1 Homo sapiens 83-89 7737984-4 1995 In this study, we have examined the ability of PGHS isoform-1 (PGHS-1) tyrosyl radicals to react with arachidonate. Arachidonic Acid 102-114 prostaglandin-endoperoxide synthase 1 Homo sapiens 47-61 7737984-4 1995 In this study, we have examined the ability of PGHS isoform-1 (PGHS-1) tyrosyl radicals to react with arachidonate. Arachidonic Acid 102-114 prostaglandin-endoperoxide synthase 1 Homo sapiens 63-69 7737984-5 1995 Anaerobic addition of arachidonate following formation of the peroxide-induced wide doublet or wide singlet tyrosyl radical led to disappearance of the tyrosyl radicals and emergence of a new EPR signal, which is distinct from known PGHS-1 tyrosyl radicals. Arachidonic Acid 22-34 prostaglandin-endoperoxide synthase 1 Homo sapiens 233-239 7737984-10 1995 These observations represent the first direct evidence of chemical coupling between the peroxidase reaction and arachidonate oxygenation in PGHS-1 and support the proposed role for a tyrosyl radical in cyclooxygenase catalysis. Arachidonic Acid 112-124 prostaglandin-endoperoxide synthase 1 Homo sapiens 140-146 8114674-7 1994 Recombinant hPGHS-1 and hPGHS-2 both produced 15- and 11-hydroxyeicosatetraenoic acid (HETE) from arachidonic acid, with 15-HETE production by hPGHS-2 being stimulated 5-fold by preincubation with aspirin. Arachidonic Acid 98-114 prostaglandin-endoperoxide synthase 1 Homo sapiens 12-19 1587858-1 1992 Prostaglandin G/H synthase (PGG/HS) is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins and thromboxanes. Arachidonic Acid 85-101 prostaglandin-endoperoxide synthase 1 Homo sapiens 0-26 1587858-1 1992 Prostaglandin G/H synthase (PGG/HS) is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins and thromboxanes. Arachidonic Acid 85-101 prostaglandin-endoperoxide synthase 1 Homo sapiens 28-34 30314310-1 2018 Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. Arachidonic Acid 75-91 prostaglandin-endoperoxide synthase 1 Homo sapiens 139-144 30888847-3 2019 One important mechanism is driven by cyclooxygenase 1 (COX-1)-mediated conversion of arachidonic acid (AA) to precursor prostaglandins that then mediate proinflammatory responses that trigger growth factor release. Arachidonic Acid 85-101 prostaglandin-endoperoxide synthase 1 Homo sapiens 37-53 30888847-3 2019 One important mechanism is driven by cyclooxygenase 1 (COX-1)-mediated conversion of arachidonic acid (AA) to precursor prostaglandins that then mediate proinflammatory responses that trigger growth factor release. Arachidonic Acid 85-101 prostaglandin-endoperoxide synthase 1 Homo sapiens 55-60 30710016-1 2019 Prostaglandin endoperoxide H synthases-1 and -2, commonly called cyclooxygenases-1 and -2 (COX-1 and -2), catalyze the committed step in prostaglandin biosynthesis-the conversion of arachidonic acid to prostaglandin endoperoxide H2 Both COX isoforms are sequence homodimers that function as conformational heterodimers having allosteric (Eallo) and catalytic (Ecat) subunits. Arachidonic Acid 182-198 prostaglandin-endoperoxide synthase 1 Homo sapiens 65-89 30314310-7 2018 A knowledge-based choice of the most appropriate tumor cell models, and a major effort in investigating the COX-1 issue in the more general context of arachidonic acid metabolic network by using the systems biology approaches, should be strongly encouraged. Arachidonic Acid 151-167 prostaglandin-endoperoxide synthase 1 Homo sapiens 108-113 27845343-5 2016 EVs are then specifically internalized into platelets in a Mac1-dependent fashion, and relocated into intracellular compartments enriched in cyclooxygenase1 (Cox1), an enzyme processing arachidonic acid to synthesize thromboxane A2 (TxA2). Arachidonic Acid 186-202 prostaglandin-endoperoxide synthase 1 Homo sapiens 141-156 27845343-5 2016 EVs are then specifically internalized into platelets in a Mac1-dependent fashion, and relocated into intracellular compartments enriched in cyclooxygenase1 (Cox1), an enzyme processing arachidonic acid to synthesize thromboxane A2 (TxA2). Arachidonic Acid 186-202 prostaglandin-endoperoxide synthase 1 Homo sapiens 158-162 27629384-4 2016 The PTGS-1 variant was associated with functional defects in the arachidonic acid pathway. Arachidonic Acid 65-81 prostaglandin-endoperoxide synthase 1 Homo sapiens 4-10 27629384-18 2016 The PTGS-1 variant was associated with specific functional defects in the arachidonic acid pathway and more severe hemorrhage. Arachidonic Acid 74-90 prostaglandin-endoperoxide synthase 1 Homo sapiens 4-10