PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17511897-6 2007 We then found that CDF and CDI were both depressed and were finally abolished by treatment with a CaM inhibitor chlorpromazine (1-100 microM) in a concentration-dependent manner. Chlorpromazine 112-126 calmodulin-3 Cavia porcellus 98-101 7066603-6 1982 The minimum concentration of chlorpromazine required to suppress the Ca-induced contraction (10-5 M) was 10(-6) M and that of calmodulin to enhance the Ca-induced contraction was 10(-7) M. 5 After skinned muscles had been loaded with Ca, chlorpromazine or calmodulin itself did not induce the contraction by the release of stored Ca in the cell. Chlorpromazine 238-252 calmodulin-3 Cavia porcellus 126-136 7504105-21 1993 Calmodulin inhibitors such as chlorpromazine, W-7 and trifluoperazine inhibited the IACh in a concentration-dependent manner. Chlorpromazine 30-44 calmodulin-3 Cavia porcellus 0-10 2821911-2 1987 The enzyme activity, as assessed by the production of inositol 1,3,4,5-tetrakisphosphate was reversibly activated by free Ca2+ concentrations ranging from 10(-7) to 10(-6)M. The calmodulin antagonists, W-7 and chlorpromazine, inhibited the Ca2+-activated enzyme activity in a dose-dependent fashion, thereby indicating that calmodulin may be involved in the activation by Ca2+. Chlorpromazine 210-224 calmodulin-3 Cavia porcellus 178-188 6280730-2 1982 Activation was measured over a range of calmodulin concentrations, and is antagonised by several tricyclic psychotropic drugs including trifluoperazine, imipramine, chlorpromazine and amitriptyline. Chlorpromazine 165-179 calmodulin-3 Cavia porcellus 40-50 7066603-11 1982 However, a lower concentration of chlorpromazine was required to suppress the Ca influx than to suppress the Ca accumulation into the storage site or the activity of calmodulin in contractile protein. Chlorpromazine 34-48 calmodulin-3 Cavia porcellus 166-176