PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35625730-11	2022	In conclusion, PA treatment induced ER stress and activated the inositol-requiring enzyme 1 alpha-spliced XBP1 (IRE1alpha-XBP1s) pathway.	Palmitic Acid	15-17	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	112-127	
31793207-14	2020	Human PNPLA3 was shown to be a target of NF-kB, and PNPLA3 I148M mediated the regulatory effect of NF-kB on inflammation in PA-treated HepG2 cells, most likely via the IRE-1alpha/JNK/c-Jun ER stress pathway.	Palmitic Acid	124-126	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	168-178	
24446069-5	2014	PA treatment induced increased expression of PRKR-like endoplasmic reticulum kinase, inositol-requiring kinase 1alpha (IRE1alpha), activating transcription factor 6 (ATF6), and C/EBP homologous protein (CHOP) mRNA.	Palmitic Acid	0-2	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	119-128	
34179614-0	2021	Combination of Palmitic Acid and Methylseleninic Acid Induces Mitochondria-Dependent Apoptosis via Attenuation of the IRE1alpha Arm and Enhancement of CHOP in Hepatoma.	Palmitic Acid	15-28	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	118-127	
34179614-6	2021	Further experiments revealed that IRE1 inhibition significantly enhanced the PA-induced apoptosis, indicating the prosurvival function of IRE1 in PA treatment of HepG2 cells.	Palmitic Acid	77-79	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	34-38	
34179614-6	2021	Further experiments revealed that IRE1 inhibition significantly enhanced the PA-induced apoptosis, indicating the prosurvival function of IRE1 in PA treatment of HepG2 cells.	Palmitic Acid	77-79	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	138-142	
34179614-6	2021	Further experiments revealed that IRE1 inhibition significantly enhanced the PA-induced apoptosis, indicating the prosurvival function of IRE1 in PA treatment of HepG2 cells.	Palmitic Acid	146-148	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	34-38	
34179614-6	2021	Further experiments revealed that IRE1 inhibition significantly enhanced the PA-induced apoptosis, indicating the prosurvival function of IRE1 in PA treatment of HepG2 cells.	Palmitic Acid	146-148	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	138-142	
34179614-7	2021	The combination of PA and MSeA attenuated the IRE1 pathway and increased the expressions of phospha-eIF2alpha and GADD153/C/EBP homologous protein (CHOP), contributing to the PA/MSeA combination-induced mitochondria-dependent apoptosis in HepG2 cells.	Palmitic Acid	19-21	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	46-50	
34179614-7	2021	The combination of PA and MSeA attenuated the IRE1 pathway and increased the expressions of phospha-eIF2alpha and GADD153/C/EBP homologous protein (CHOP), contributing to the PA/MSeA combination-induced mitochondria-dependent apoptosis in HepG2 cells.	Palmitic Acid	175-177	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	46-50