PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32686520-5	2020	Furthermore, extracellular ATP aggravates PA-induced monocyte chemoattractant protein-1 secretion and monocyte infiltration of tubular cells, enlarging the inflammatory response in both macrophages and HK-2 cells via the purinergic P2X7 receptor-mammalian target of rapamycin-forkhead box O1-thioredoxin-interacting protein/NOD-like receptor protein 3 inflammasome pathway.	Palmitic Acid	42-44	C-C motif chemokine ligand 2	Homo sapiens	53-87	
34072916-5	2021	However, auranofin significantly inhibited the levels of NO, monocyte chemoattractant protein-1, and pro-inflammatory cytokines, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, and IL-6, which had been increased by co-treatment with PA and LPS.	Palmitic Acid	246-248	C-C motif chemokine ligand 2	Homo sapiens	61-95	
33747175-10	2021	HSS also reduced the static PA-induced expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1.	Palmitic Acid	28-30	C-C motif chemokine ligand 2	Homo sapiens	91-125	
33135616-6	2021	RESULTS: B. animalis R101-8 inhibited LPS- and palmitic acid-induced protein expression of inflammatory cytokines IL-1beta, IL-6, TNF-alpha concomitant with decreases in chemerin, MCP-1, PEDF, and cellular triglycerides, and blocked NF-kB and AP-1 activation pathway through inhibition of p-IkappaBalpha, pc-Jun, and pc-Fos phosphorylation.	Palmitic Acid	47-60	C-C motif chemokine ligand 2	Homo sapiens	180-185	
24662749-8	2014	In macrophages, palmitic acid increased MCP-1 mRNA expression by 1.8-fold (P<0.05), but oleic acid and elaidic acid had no effects.	Palmitic Acid	16-29	C-C motif chemokine ligand 2	Homo sapiens	40-45	
30463189-3	2018	The results showed that COS pretreatment for 12 h significantly ameliorated lipid accumulation in HepG2 cells exposed to PA for 24 h, accompanied by a reversing of the upregulated mRNA expression of proinflammatory cytokines (IL-6, MCP-1, TNF-alpha) and glucolipid metabolism-related regulators (SCD-1, ACC1, PCK1-alpha).	Palmitic Acid	121-123	C-C motif chemokine ligand 2	Homo sapiens	232-237	
26739470-10	2015	CONCLUSION: Stimulation of hepatocytes by the PA fatty acid in vitro promotes mRNA expression of TNF-alpha, MCP-1 and IL-8, but overexpression of JAZF1 inhibits the PA-induced expression and secretion of these factors.	Palmitic Acid	46-48	C-C motif chemokine ligand 2	Homo sapiens	108-113	
30102465-10	2018	PA enhances the expression of MCP-1, IL-6, and COX-2 genes, while POA downregulates these genes, decreases expression of NFkappaB, and upregulates PPAR-alpha gene expression.	Palmitic Acid	0-2	C-C motif chemokine ligand 2	Homo sapiens	30-35	
29792849-7	2018	The expression and secretion of MCP-1 induced by PA was also similarly prevented by TRAM-34 and KCa3.1 siRNA.	Palmitic Acid	49-51	C-C motif chemokine ligand 2	Homo sapiens	32-37	
29792849-8	2018	These results demonstrate for the first time that PA upregulates KCa3.1 channels through TLR2/4, p38-MAPK and NF-kappaB pathway to promote the expression of MCP-1, and then induce the trans-endothelial migration of monocytes.	Palmitic Acid	50-52	C-C motif chemokine ligand 2	Homo sapiens	157-162	
28554965-2	2017	Here we show that Fetuin-A (FetA) or lipopolysaccharide (LPS) exacerbate palmitic acid-induced podocyte death, which is associated with a strong induction of monocyte chemoattractant protein-1 (MCP-1) and keratinocyte chemoattractant (KC).	Palmitic Acid	73-86	C-C motif chemokine ligand 2	Homo sapiens	158-192	
28554965-2	2017	Here we show that Fetuin-A (FetA) or lipopolysaccharide (LPS) exacerbate palmitic acid-induced podocyte death, which is associated with a strong induction of monocyte chemoattractant protein-1 (MCP-1) and keratinocyte chemoattractant (KC).	Palmitic Acid	73-86	C-C motif chemokine ligand 2	Homo sapiens	194-199	
26748475-7	2016	PGC-1beta inhibited PA induced TNFalpha, MCP-1, and IL-1beta mRNA and protein expressions.	Palmitic Acid	20-22	C-C motif chemokine ligand 2	Homo sapiens	41-46	
26138903-8	2015	Honokiol showed an anti-inflammatory effect in PA-inducted HUVECs by significantly inhibiting the generation of interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1.	Palmitic Acid	47-49	C-C motif chemokine ligand 2	Homo sapiens	143-177	
26016511-5	2015	RESULTS: When HUVEC were exposed to PA, there was an increase in the expression of adhesion molecule, cytokines, and inflammatory protein (ICAM-1, MCP-1, interleukin-6, PTX3).	Palmitic Acid	36-38	C-C motif chemokine ligand 2	Homo sapiens	147-152	
26016511-8	2015	In addition, p21 knockdown suppressed the PA-induced increase in the expression of MCP-1 and ICAM-1.	Palmitic Acid	42-44	C-C motif chemokine ligand 2	Homo sapiens	83-88	
26016511-9	2015	EPA suppressed the PA-induced increase in the expression of ACSL and p21, the enhancement of p65 phosphorylation, as well as the associated increase in the expression of ICAM-1, MCP-1, interleukin-6, and PTX3.	Palmitic Acid	1-3	C-C motif chemokine ligand 2	Homo sapiens	178-183	
24662749-10	2014	The different classes of FFA did not induce MCP-1 mRNA expression or protein secretion in the adipocytes, but the saturated FFA, palmitic acid, induced MCP-1 mRNA expression in macrophages, possibly because of the higher expression level of TLR4 in the macrophages than the adipocytes.	Palmitic Acid	129-142	C-C motif chemokine ligand 2	Homo sapiens	152-157	
22112811-9	2012	Two candidate plasma factors, glucose and the saturated fatty acid palmitic acid, did not affect proliferation or adipocyte differentiation in vitro but were found to increase CCL2 (monocyte chemoattractant protein-1) secretion by adipocytes.	Palmitic Acid	67-80	C-C motif chemokine ligand 2	Homo sapiens	176-180	
22112811-9	2012	Two candidate plasma factors, glucose and the saturated fatty acid palmitic acid, did not affect proliferation or adipocyte differentiation in vitro but were found to increase CCL2 (monocyte chemoattractant protein-1) secretion by adipocytes.	Palmitic Acid	67-80	C-C motif chemokine ligand 2	Homo sapiens	182-216	
17467667-4	2007	Palmitic acid (PA), the predominant saturated FFA released from adipose tissue, but not unsaturated FFA, induced an approximately 6-fold (p<0.05) increase in IP-10 gene expression (and 2- to 4-fold increases in IL-8, MCP-1, COX-2, and MIG).	Palmitic Acid	0-13	C-C motif chemokine ligand 2	Homo sapiens	220-225	
17467667-4	2007	Palmitic acid (PA), the predominant saturated FFA released from adipose tissue, but not unsaturated FFA, induced an approximately 6-fold (p<0.05) increase in IP-10 gene expression (and 2- to 4-fold increases in IL-8, MCP-1, COX-2, and MIG).	Palmitic Acid	15-17	C-C motif chemokine ligand 2	Homo sapiens	220-225