PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29224921-8 2018 Level of mRNA was increased for iNOS, SOD1 and SOD2, and decreased for GSTP1, Nrf2 and CYP2E1 in acrylamide-treated Rin-5F cells. Acrylamide 97-107 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 87-93 25989052-4 2015 Acrylamide exerts its reproductive toxicity via its metabolite glycidamide, a product which is only formed via the cytochrome P450 detoxifying enzyme CYP2E1. Acrylamide 0-10 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 150-156 28379345-0 2017 Epididymal CYP2E1 plays a critical role in acrylamide-induced DNA damage in spermatozoa and paternally mediated embryonic resorptions . Acrylamide 43-53 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 11-17 28379345-4 2017 CYP2E1 is the only enzyme responsible for the conversion of acrylamide to the highly reactive metabolite glycidamide, which forms adducts with DNA. Acrylamide 60-70 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 0-6 28379345-8 2017 It was determined that CYP2E1 is additionally expressed within the mouse epididymal epithelium, and this localization is responsible for acrylamide-induced dominant lethality. Acrylamide 137-147 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 23-29 27580987-0 2016 Chronic Acrylamide Exposure in Male Mice Results in Elevated DNA Damage in the Germline and Heritable Induction of CYP2E1 in the Testes. Acrylamide 8-18 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 115-121 27580987-9 2016 This is significant as CYP2E1 is the sole enzyme responsible for conversion of acrylamide to its harmful metabolite glycidamide. Acrylamide 79-89 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 23-29 25989052-11 2015 Resveratrol is an example of an inhibitor of Cyp2e1 which has shown success in reducing damage caused by acrylamide treatment in mice. Acrylamide 105-115 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 45-51 24788432-4 2014 CYP2E1 metabolises acrylamide to glycidamide, which, unlike acrylamide, readily forms adducts with DNA. Acrylamide 19-29 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 0-6 24788432-4 2014 CYP2E1 metabolises acrylamide to glycidamide, which, unlike acrylamide, readily forms adducts with DNA. Acrylamide 60-70 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 0-6 24788432-5 2014 Thus, to investigate the mechanisms of acrylamide toxicity in mouse male germ cells, we examined the expression of the CYP, CYP2E1, which metabolises acrylamide. Acrylamide 39-49 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 124-130 24788432-5 2014 Thus, to investigate the mechanisms of acrylamide toxicity in mouse male germ cells, we examined the expression of the CYP, CYP2E1, which metabolises acrylamide. Acrylamide 150-160 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 124-130 24788432-7 2014 Additionally, CYP2E1 gene expression was upregulated in these cells following in vitro acrylamide exposure (1 microM, 18 h). Acrylamide 87-97 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 14-20 21978862-2 2011 Acrylamide (AA), a widely distributed xenobiotic compound, is converted to its active metabolite glycidamide (GA) by the CYP2E1 enzyme. Acrylamide 0-10 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 121-127 17979661-2 2007 In particular, cytochrome P450 2E1 (CYP2E1) is implicated in the oxidative bioactivation of a variety of small hydrophobic chemicals including a number of epoxide-forming drugs and environmentally important toxicants including urethane, acrylamide, acrylonitrile, benzene, vinyl chloride, styrene, 1-bromopropane, trichloroethylene, dichloroethylene, acetaminophen, and butadiene. Acrylamide 237-247 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 15-34 17979661-6 2007 Data presented in this review demonstrated that the most comprehensive studies using Cyp2e1-/- mice, encompassing the entire paradigm of metabolism to toxicity, genotoxicity, and carcinogenicity were possible when a substrate was primarily metabolized via CYP2E1 (e.g. urethane and acrylamide). Acrylamide 282-292 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 85-91 17979661-6 2007 Data presented in this review demonstrated that the most comprehensive studies using Cyp2e1-/- mice, encompassing the entire paradigm of metabolism to toxicity, genotoxicity, and carcinogenicity were possible when a substrate was primarily metabolized via CYP2E1 (e.g. urethane and acrylamide). Acrylamide 282-292 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 256-262 17979661-2 2007 In particular, cytochrome P450 2E1 (CYP2E1) is implicated in the oxidative bioactivation of a variety of small hydrophobic chemicals including a number of epoxide-forming drugs and environmentally important toxicants including urethane, acrylamide, acrylonitrile, benzene, vinyl chloride, styrene, 1-bromopropane, trichloroethylene, dichloroethylene, acetaminophen, and butadiene. Acrylamide 237-247 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 36-42 16141435-0 2005 Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts. Acrylamide 37-47 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 8-14 15982677-1 2005 Acrylamide, an animal carcinogen and germ cell mutagen present at low (ppm) levels in heated carbohydrate-containing foodstuffs, is oxidized by cytochrome P4502E1 (CYP2E1) to the epoxide glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activity of acrylamide. Acrylamide 0-10 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 164-170 15982677-1 2005 Acrylamide, an animal carcinogen and germ cell mutagen present at low (ppm) levels in heated carbohydrate-containing foodstuffs, is oxidized by cytochrome P4502E1 (CYP2E1) to the epoxide glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activity of acrylamide. Acrylamide 283-293 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 164-170 15982677-9 2005 In those experiments, dose-related increases in dominant lethal mutations were detected in uterine contents of female mice mated to acrylamide-treated wild-type males but not CYP2E1-null males, clearly implicating CYP2E1-mediated formation of glycidamide in the induction of genetic damage in male germ cells. Acrylamide 132-142 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 214-220 15982677-15 2005 These results support the hypothesis that genetic damage in somatic and germ cells of mice-treated with acrylamide is dependent upon metabolism of the parent compound by CYP2E1. Acrylamide 104-114 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 170-176 10563837-0 1999 Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice. Acrylamide 49-59 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 8-27 15355880-0 2005 Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect. Acrylamide 89-99 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 45-51 15355880-5 2005 A key oxidative metabolite of acrylamide is the epoxide glycidamide, generated by cytochrome P4502E1 (CYP2E1). Acrylamide 30-40 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 82-100 15355880-5 2005 A key oxidative metabolite of acrylamide is the epoxide glycidamide, generated by cytochrome P4502E1 (CYP2E1). Acrylamide 30-40 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 102-108 15355880-10 2005 No changes in any fertility parameters were seen in females mated to acrylamide-treated CYP2E1-null mice. Acrylamide 69-79 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 88-94 15355880-11 2005 Our results constitute the first unequivocal demonstration that acrylamide-induced germ cell mutations in male mice require CYP2E1-mediated epoxidation of acrylamide. Acrylamide 64-74 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 124-130 15355880-11 2005 Our results constitute the first unequivocal demonstration that acrylamide-induced germ cell mutations in male mice require CYP2E1-mediated epoxidation of acrylamide. Acrylamide 155-165 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 124-130