PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 127-133 interferon gamma Homo sapiens 23-39 7671317-2 1995 Nickel-reactive T cells described so far display a TH1 lymphokine secretion pattern characterized by high amounts of IFN gamma, but little or no IL-4 and IL-5. Nickel 0-6 interferon gamma Homo sapiens 117-126 7671317-5 1995 These TCC responded to nickel with the production of high levels of IL-5 and variable amounts of IFN-gamma and IL-4 resembling TH2- or TH0-like cytokine secretion pattern. Nickel 23-29 interferon gamma Homo sapiens 97-106 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 127-133 interferon gamma Homo sapiens 41-50 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 178-184 interferon gamma Homo sapiens 23-39 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 178-184 interferon gamma Homo sapiens 41-50 23692034-0 2013 CD4(+) T cells producing interleukin (IL)-17, IL-22 and interferon-gamma are major effector T cells in nickel allergy. Nickel 103-109 interferon gamma Homo sapiens 56-72 2976621-7 1988 In conclusion, nickel-induced peripheral blood mononuclear cell activation in vitro differs from microbial antigen-induced activation with respect to its modest or non-existent IFN-gamma response. Nickel 15-21 interferon gamma Homo sapiens 177-186 23692034-6 2013 In nickel-allergic patients, there was massive cellular infiltration dominated by CD4(+) T cells producing IL-17, IL-22 and IFN-gamma in nickel-challenged skin but not in vehicle-challenged skin. Nickel 3-9 interferon gamma Homo sapiens 124-133 23692034-7 2013 CONCLUSION: CD4(+) T cells producing IL-17, IL-22 and IFN-gamma are important effector cells in the eczematous reactions of nickel-induced allergic contact dermatitis in humans. Nickel 124-130 interferon gamma Homo sapiens 54-63 3093801-0 1986 Nickel chelate chromatography of human immune interferon. Nickel 0-6 interferon gamma Homo sapiens 39-56 23056446-9 2012 In the presence of anti-PD-L1, PGN induced secretion of IFN-gamma and IL-17 in total CCR6(+) cells, while nickel triggered secretion of IFN-gamma and IL-17 exclusively in CCR6(+)/CCR4(+) cells. Nickel 106-112 interferon gamma Homo sapiens 136-145 19572476-3 2009 The aim of the present study was to assess the influence of nickel-specific IFN-gamma secretion (marker of Th1 and Tc1 activity) and IL-5 secretion (Th2 and Tc2) on the clinical outcome (patch test score) in nickel-allergic patients. Nickel 60-66 interferon gamma Homo sapiens 76-85 19572476-3 2009 The aim of the present study was to assess the influence of nickel-specific IFN-gamma secretion (marker of Th1 and Tc1 activity) and IL-5 secretion (Th2 and Tc2) on the clinical outcome (patch test score) in nickel-allergic patients. Nickel 208-214 interferon gamma Homo sapiens 76-85 18482439-7 2008 Interestingly, all subjects with positive patch test to both nickel and palladium (group 3) showed an in vitro response characterized by the release of IFN-gamma after nickel stimulation and production of IL-10 in response to palladium. Nickel 61-67 interferon gamma Homo sapiens 152-161 18482439-0 2008 Nickel, palladium and rhodium induced IFN-gamma and IL-10 production as assessed by in vitro ELISpot-analysis in contact dermatitis patients. Nickel 0-6 interferon gamma Homo sapiens 38-47 18482439-5 2008 RESULTS: We found a specific IFN-gamma response by PBMC upon in vitro stimulation with nickel or palladium in well recognized allergic individuals. Nickel 87-93 interferon gamma Homo sapiens 29-38 18482439-7 2008 Interestingly, all subjects with positive patch test to both nickel and palladium (group 3) showed an in vitro response characterized by the release of IFN-gamma after nickel stimulation and production of IL-10 in response to palladium. Nickel 168-174 interferon gamma Homo sapiens 152-161 18409353-6 2007 Both Th2/Tc2 (IL-4, IL-5, IL-13) and Th1/ Tc1 (IFNgamma) take their part in the development of contact allergy to nickel. Nickel 114-120 interferon gamma Homo sapiens 47-55 17489975-7 2007 RESULTS: In vitro activation of psoriatic as well as antigen (nickel)-specific skin-homing T cells was strongly and dose-dependently impaired by infliximab, in terms both of proliferation and of IFN-gamma release. Nickel 62-68 interferon gamma Homo sapiens 195-204 15270870-5 2004 RESULTS: Only CD4+ CLA+ CD45RO+ and not CD8+ T cells proliferate and produce both type-1 (IFN-gamma) and type-2 (IL-5) cytokines in response to nickel. Nickel 144-150 interferon gamma Homo sapiens 82-99 17642139-11 2006 The concentration of IFNgamma in supernatants from stimulated as well as non-stimulated cells from patients with contact allergy to nickel was higher in comparison to the control group. Nickel 132-138 interferon gamma Homo sapiens 21-29 17642139-13 2006 There was an increase in the production of IFNgamma and IL-5 after NiSO4 stimulation in patients with systemic allergy to nickel. Nickel 122-128 interferon gamma Homo sapiens 43-51 17642139-16 2006 SUMMARY: IFNgamma plays an essential role in the mechanism of developing of contact allergy to nickel; and IFNgamma as well as IL-5 play a role in the mechanism of developing systemic allergy to nickel. Nickel 95-101 interferon gamma Homo sapiens 9-17 17642139-16 2006 SUMMARY: IFNgamma plays an essential role in the mechanism of developing of contact allergy to nickel; and IFNgamma as well as IL-5 play a role in the mechanism of developing systemic allergy to nickel. Nickel 195-201 interferon gamma Homo sapiens 107-115 12207582-9 2002 Using the ELISpot assay, we found that PBMC from nickel-allergic individuals responded to Ni2+ with significantly greater production of interleukin (IL)-4, IL-5, IL-13 and interferon-gamma, but not IL-12, compared with the healthy controls. Nickel 49-55 interferon gamma Homo sapiens 172-188 12859458-8 2003 In nickel-sensitive probands, an average precursor cell frequency of 19x10(5), 1.7x10(5), and 0.7x10(5) could be defined for IFN-gamma, IL-2, and IL-4 producing PBMC, respectively. Nickel 3-9 interferon gamma Homo sapiens 125-134 11145678-1 2001 We have investigated the chemokine receptor expression and migratory behavior of a new subset of nickel-specific skin-homing regulatory CD4(+) T cells (Th(IL-10)) releasing high levels of IL-10, low IFN-gamma, and undetectable IL-4. Nickel 97-103 interferon gamma Homo sapiens 199-208 10651989-3 2000 Here, we examined the properties of a subset of nickel-specific CD4+ T cells displaying the cytokine profile (IL-10 , IL-5 , IFN-gamma+/-, IL-4+/-) of T regulatory cells 1 (Tr1) and with the potential to down-modulate immune responses to nickel. Nickel 48-54 interferon gamma Homo sapiens 125-134 10903743-5 2000 Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3. Nickel 0-6 interferon gamma Homo sapiens 78-87 8993464-10 1996 However, when VIP was added at 10(-6) and 10(-5) mol/L, a higher level of interferon gamma was found in the nickel-treated cell cultures compared to the controls. Nickel 108-114 interferon gamma Homo sapiens 74-90 9292066-5 1997 There was a significant increase in the mRNA expression for interferon-gamma (IFN-gamma), interleukin (IL)-2 and IL-4 together after nickel challenge in both patients (analysis of variance P = 0.007) and non-atopic-individuals (P = 0.005). Nickel 133-139 interferon gamma Homo sapiens 60-76 9292066-5 1997 There was a significant increase in the mRNA expression for interferon-gamma (IFN-gamma), interleukin (IL)-2 and IL-4 together after nickel challenge in both patients (analysis of variance P = 0.007) and non-atopic-individuals (P = 0.005). Nickel 133-139 interferon gamma Homo sapiens 78-87 9886425-3 1999 Skin affected with ACD to nickel and skin-derived, nickel-specific CD4+ T cell lines expressed IFN-gamma, TNF-alpha, and IL-17 mRNAs. Nickel 51-57 interferon gamma Homo sapiens 95-104 9886425-4 1999 Four of seven nickel-specific CD4+ T cell clones positive for the skin-homing receptor, cutaneous lymphocyte-associated Ag, were shown to corelease IL-17, IFN-gamma, and TNF-alpha. Nickel 14-20 interferon gamma Homo sapiens 155-164