PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2890191-1	1987	The administration of nickel to rats resulted in a dose-dependent increase in the level of hepatic glutathione and in the activities of glutathione reductase and glutathione-S-transferase with a concomitant decrease in the activities of glutathione peroxidase and gamma-glutamyl transpeptidase.	Nickel	22-28	hematopoietic prostaglandin D synthase	Rattus norvegicus	162-187	
8103437-2	1993	The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone.	Nickel	47-53	hematopoietic prostaglandin D synthase	Rattus norvegicus	74-99	
8103437-2	1993	The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone.	Nickel	47-53	hematopoietic prostaglandin D synthase	Rattus norvegicus	101-104	
1977209-4	1990	In the liver, nickel effects included increased LPO (by 30%), decreased CAT and GSH-Px activities (both by 15%), decreased GSH level (by 33%), decreased GSSG-R activity (by 10%) and decreased GST activity (by 35%); SOD, GGT, copper, and iron remained unchanged.	Nickel	14-20	hematopoietic prostaglandin D synthase	Rattus norvegicus	192-195	
10602394-3	1999	Administration of nickel (250 micromol Ni/kg body wt) to female Wistar rats, resulted in increase in the reduced glutathione (GSH) content [kidney (*P<0.05) and liver (**P<0.001)] and Glutathione-S-transferase (GST) and glutathione reductase (GR) activities [kidney and liver, (**P<0.001)].	Nickel	18-24	hematopoietic prostaglandin D synthase	Rattus norvegicus	190-215	
20950607-5	2011	The toxic effect of nickel was also indicated by significantly decreased activities of enzymatic antioxidants like superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and glucose-6-phosphate dehydrogenase and non-enzymatic antioxidants like reduced glutathione, total sulfhydryl groups, vitamin C and vitamin E levels were significantly decreased.	Nickel	20-26	hematopoietic prostaglandin D synthase	Rattus norvegicus	171-196	
20021064-6	2005	However, nickel treatment to normal rats caused a significant increase in the activity of enzymes catalase and GST and in the levels of LPO, whereas the levels of GSH get significantly depressed.	Nickel	9-15	hematopoietic prostaglandin D synthase	Rattus norvegicus	111-114	
15535990-5	2004	Nickel treatment to the normal control animals, resulted in a significant increase in lipid peroxidation and enzyme activities of catalase and glutathione-S-transferase.	Nickel	0-6	hematopoietic prostaglandin D synthase	Rattus norvegicus	143-168	
15535990-8	2004	Interestingly, when Zn was supplemented to nickel treated rats, the activities of catalase, and glutathione-S-transferase and the levels of GSH and lipid peroxidation came back to within normal limits.	Nickel	43-49	hematopoietic prostaglandin D synthase	Rattus norvegicus	96-121	
10602394-3	1999	Administration of nickel (250 micromol Ni/kg body wt) to female Wistar rats, resulted in increase in the reduced glutathione (GSH) content [kidney (*P<0.05) and liver (**P<0.001)] and Glutathione-S-transferase (GST) and glutathione reductase (GR) activities [kidney and liver, (**P<0.001)].	Nickel	18-24	hematopoietic prostaglandin D synthase	Rattus norvegicus	217-220