PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17938578-8	2008	Gossypol-induced cell cycle arrest was accompanied by decreased expression of cyclin D1 in Ramos cells.	Gossypol	0-8	cyclin D1	Homo sapiens	78-87	
26208739-12	2015	Furthermore, the mTOR/p70S6K1 signaling pathway was inhibited in gossypol-treated colon cancer cells, and consequently, cyclin D1 expression was decreased, suggesting an additional mechanism of the observed antiproliferative synergistic interactions.	Gossypol	65-73	cyclin D1	Homo sapiens	120-129	
26208739-14	2015	CONCLUSIONS: These findings suggest that gossypol-mediated down-regulation of TS, cyclin D1, and the mTOR/p70S6K1 signaling pathways enhances the anti-tumor effect of 5-FU.	Gossypol	41-49	cyclin D1	Homo sapiens	82-91	
17094491-9	2006	Furthermore, (-)-gossypol treatment down-regulated cyclin-D1, Rb, CDK4 and CDK6, and up-regulated p21 and TGF-beta1 at the mRNA and/or protein levels.	Gossypol	13-25	cyclin D1	Homo sapiens	51-60	
9218727-0	1997	Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells.	Gossypol	0-8	cyclin D1	Homo sapiens	32-41	
9218727-3	1997	Western blot analysis using anti-human Rb antibodies and anti-human cyclin D1 antibodies in MCF-7 cells and high- and low-expression cyclin D1-transfected fibrosarcoma cells indicated that, after 6 h exposure, gossypol decreased the expression levels of these proteins in a dose-dependent manner.	Gossypol	210-218	cyclin D1	Homo sapiens	68-77	
9218727-3	1997	Western blot analysis using anti-human Rb antibodies and anti-human cyclin D1 antibodies in MCF-7 cells and high- and low-expression cyclin D1-transfected fibrosarcoma cells indicated that, after 6 h exposure, gossypol decreased the expression levels of these proteins in a dose-dependent manner.	Gossypol	210-218	cyclin D1	Homo sapiens	133-142	
9218727-5	1997	Gossypol (10 microM) treated also decreased cyclin D1-associated kinase activity on histone H1 used as a substrate in MCF-7 cells.	Gossypol	0-8	cyclin D1	Homo sapiens	44-53	
9218727-6	1997	These results suggest that gossypol might suppress growth by modulating the expression of cell cycle regulatory proteins Rb and cyclin D1 and the phosphorylation of Rb protein.	Gossypol	27-35	cyclin D1	Homo sapiens	128-137	
11510695-10	2001	Gossypol appears to affect the expression of Rb protein and cyclin D1 in breast cancer metastases at doses achievable, yet had negligible antitumor activity against anthracycline and taxane refractory metastatic breast cancer.	Gossypol	0-8	cyclin D1	Homo sapiens	60-69