PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23153282-0 2012 Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors. 7-hydroxycoumarin 17-30 monoamine oxidase A Homo sapiens 67-86 31557622-0 2019 Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidbeta aggregation, and lipid peroxidation. 7-hydroxycoumarin 0-13 monoamine oxidase A Homo sapiens 70-89 31557622-9 2019 These represent the first experimental and modelling data for hMAO-A/B inhibition by umbelliferone derivatives. 7-hydroxycoumarin 85-98 monoamine oxidase A Homo sapiens 62-70 31557622-11 2019 Umbelliferone derivative 2 is a promising therapeutic lead scaffold for developing anti-neuropsychiatric disorder drugs that function via selective hMAO-A inhibition. 7-hydroxycoumarin 0-13 monoamine oxidase A Homo sapiens 148-154 23182697-1 2013 New series of bioactive 7-oxycoumarin derivatives were synthesized and tested for their in vitro and in vivo monoamine oxidase (MAO) A and B inhibitory effect. 7-hydroxycoumarin 24-37 monoamine oxidase A Homo sapiens 109-134 32357811-4 2020 In the case of MAO-A umbelliferone, curcumin, caffeic acid, quercetin possessed dock score -8.001, -7.941, -7.357, -6.658 respectively. 7-hydroxycoumarin 21-34 monoamine oxidase A Homo sapiens 15-20 32357811-6 2020 Compound umbelliferone was observed as the most active hMAO-A inhibitor (IC50= 10.98+-0.006 microM) and selectivity index of 0.607. 7-hydroxycoumarin 9-22 monoamine oxidase A Homo sapiens 55-61 30430943-5 2018 METHOD: A series of different umbelliferone derivatives was designed and synthesized, and the derivatives were screened for hMAO-A and hMAO-B inhibition. 7-hydroxycoumarin 30-43 monoamine oxidase A Homo sapiens 124-141 23153282-4 2012 The docking experiments carried out on MAO-A and MAO-B structures proved new information about the enzyme-inhibitor interaction and the potential therapeutic application of 7-oxycoumarin scaffold. 7-hydroxycoumarin 173-186 monoamine oxidase A Homo sapiens 39-44