PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30320903-6	2019	Cotreatment of either purvalanol or roscovitine with ERK1/2 inhibitor, U0126, synergistically suppressed cell proliferation, and induced apoptotic action.	purvalanol B	22-32	mitogen-activated protein kinase 3	Homo sapiens	53-59	
30320903-8	2019	This study provides biological evidence about purvalanol and roscovitine have apoptotic and antimetastatic effects via MAPK signaling on prostate cancer cell by activation of GSK3beta signaling and inhibition of phosphoinositide-3-kinase/AKT (PI3K/AKT) pathways involved in the EMT process.	purvalanol B	46-56	mitogen-activated protein kinase 3	Homo sapiens	119-123	
12226745-6	2002	In addition to CDK1, p42/p44 MAPK were found to be two major purvalanol-interacting proteins in five different mammalian cell lines (CCL39, PC12, HBL100, MCF-7 and Jurkat cells), suggesting the generality of the purvalanol/p42/p44 MAPK interaction.	purvalanol B	61-71	mitogen-activated protein kinase 3	Homo sapiens	25-33	
12226745-6	2002	In addition to CDK1, p42/p44 MAPK were found to be two major purvalanol-interacting proteins in five different mammalian cell lines (CCL39, PC12, HBL100, MCF-7 and Jurkat cells), suggesting the generality of the purvalanol/p42/p44 MAPK interaction.	purvalanol B	61-71	mitogen-activated protein kinase 3	Homo sapiens	29-33	
12226745-12	2002	When cells were treated with purvalanol, p42/p44 MAPK and CDK1 activities were inhibited in a dose-dependent manner.	purvalanol B	29-39	mitogen-activated protein kinase 3	Homo sapiens	49-53	
12226745-13	2002	Furthermore, purvalanol inhibited the nuclear accumulation of p42/p44 MAPK, an event dependent on the catalytic activity of these kinases.	purvalanol B	13-23	mitogen-activated protein kinase 3	Homo sapiens	66-74	
12226745-14	2002	We conclude that the anti-proliferative properties of purvalanol are mediated by inhibition of both p42/p44 MAPK and CDKs.	purvalanol B	54-64	mitogen-activated protein kinase 3	Homo sapiens	108-112