PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27484210-5	2016	CDK inhibitors in the presence or absence of rapamycin induced cell death via modulating upstream PI3K/AKT/mTOR signaling pathway in LNCaP cells, exclusively only treatment of purvalanol have strong potential to inhibit both upstream and downstream targets of mTOR in LNCaP and DU145 cells.	purvalanol B	176-186	mechanistic target of rapamycin kinase	Homo sapiens	260-264	
27484210-7	2016	We confirmed that purvalanol and roscovitine were strong apoptotic and autophagy inducers that based on regulation of PI3K/AKT/mTOR signaling pathway.	purvalanol B	18-28	mechanistic target of rapamycin kinase	Homo sapiens	127-131	
27484210-10	2016	In this point, mTOR is a fine-tuning player in purvalanol and roscovitine-induced apoptosis and autophagy via regulation of PI3K/AKT and the downstream targets, which related with cell proliferation.	purvalanol B	47-57	mechanistic target of rapamycin kinase	Homo sapiens	15-19