PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15219176-10	2004	CONCLUSIONS: Short-term treatment with the combined inhaled corticosteroid and long-acting beta(2)-adrenoceptor agonist fluticasone propionate/salmeterol resulted in greater control of lung function and symptoms than combined ipratropium bromide/albuterol bronchodilator therapy, in patients with COPD.	Ipratropium	226-245	adrenoceptor beta 2	Homo sapiens	91-111	
12578401-7	2003	Current evidence suggests that long-acting beta(2)-adrenoreceptor agonists such as salmeterol and the new long-acting anticholinergic agent tiotropium bromide are more efficacious than their shorter acting equivalents such as salbutamol and ipratropium bromide in terms of bronchodilation, improved well-being and a reduction in acute exacerbation rates.	Ipratropium	241-260	adrenoceptor beta 2	Homo sapiens	43-65	
6448137-3	1980	As with the beta 2-adrenoceptor agonists, the onset of maximum effect with ipratropium (about 1.5 to 2 hours) is slower than with isoprenaline (although significant bronchodilation usually occurs within seconds or minutes of ipratropium inhalation), and the duration of effect (about 4 to 6 hours) is longer.	Ipratropium	75-86	adrenoceptor beta 2	Homo sapiens	12-31	
6448137-4	1980	Studies of concomitant use of ipratropium and other agents such as beta 2-adrenoceptor agonists, theophylline, or sodium cromoglycate, have usually shown a greater response in many patients than with single drug therapy, as might be expected from  the different mechanisms of action of these groups of drugs.	Ipratropium	30-41	adrenoceptor beta 2	Homo sapiens	67-86	
6448137-8	1980	Ipratropium may also be useful in the occasional patient in whom side effects such as palpitations or tremor are troublesome with usual inhaled doses of beta 2-adrenoceptor agonists.	Ipratropium	0-11	adrenoceptor beta 2	Homo sapiens	153-172