PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12826277-5 2003 Exposure of cells to Stx2 for 24hr increased the DNA fragmentation to 11.6+/-0.9%, compared to 3.3+/-0.2% in control cells (P<0.05) but was decreased to approximately 5-7% (P<0.05) in the presence of terbutaline. Terbutaline 206-217 syntaxin 2 Homo sapiens 21-25 12826277-6 2003 Furthermore, Stx2-stimulated apoptosis, detected by TUNEL, annexin V and mitochondrial potential, was inhibited by terbutaline (P<0.05) which was prevented by cAMP-PKA inhibitors and a beta(2)-adrenoceptor antagonist. Terbutaline 115-126 syntaxin 2 Homo sapiens 13-17 12826277-7 2003 However, inhibition of Stx2-mediated caspase activity by terbutaline was partially blocked by cAMP-PKA inhibitors. Terbutaline 57-68 syntaxin 2 Homo sapiens 23-27 12826277-8 2003 On the other hand, p38MAPK inhibition by terbutaline prevented Stx2-induced apoptosis and caspase activity through a cAMP-independent pathway via beta(2)-adrenoceptor. Terbutaline 41-52 syntaxin 2 Homo sapiens 63-67