PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15846067-0 2005 Kinase-addiction and bi-phasic sensitivity-resistance of Bcr-Abl- and Raf-1-expressing cells to imatinib and geldanamycin. geldanamycin 109-121 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 57-64 15846067-4 2005 Also, HL/Bcr-Abl cells were hyper-sensitive to geldanamycin (GA), which depletes Bcr-Abl and Raf-1. geldanamycin 47-59 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 9-16 15846067-4 2005 Also, HL/Bcr-Abl cells were hyper-sensitive to geldanamycin (GA), which depletes Bcr-Abl and Raf-1. geldanamycin 47-59 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 81-88 15846067-4 2005 Also, HL/Bcr-Abl cells were hyper-sensitive to geldanamycin (GA), which depletes Bcr-Abl and Raf-1. geldanamycin 61-63 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 9-16 15846067-4 2005 Also, HL/Bcr-Abl cells were hyper-sensitive to geldanamycin (GA), which depletes Bcr-Abl and Raf-1. geldanamycin 61-63 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 81-88 15846067-5 2005 Raf-1 and Bcr-Abl-transfected FDC-P1 hematopoietic cells were selectively sensitive to GA and imatinib, respectively. geldanamycin 87-89 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 10-17 11960322-1 2002 Geldanamycin (GA), herbimycin A and radicicol bind heat-shock protein-90 (Hsp90) and destabilize its client proteins including v-Src, Bcr-Abl, Raf-1, ErbB2, some growth factor receptors and steroid receptors. geldanamycin 0-12 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 134-141 15283151-8 2004 New agents which inhibit the signaling pathway related to BCR-ABL, such as adaphostin (NSC680410), farnesyltransferase inhibitor SCH66336, MAP kinase inhibitor PD184352, PD98059, U0126, and antibiotic geldanamycin, have shown excellent activity combined with imatinib in vitro. geldanamycin 201-213 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 58-65 14529384-2 2003 In the mid 1980s, it was found that the benzoquinone ansamycin antibiotics (herbimycin A, geldanamycin, and macbecin) reversed v-Src transformed cells to normal phenotypes, and Bcr-abl was subsequently suggested to be the molecular target for the treatment of chronic myelogenous leukemia through a study using herbimycin A for its selective antioncogenic activity. geldanamycin 90-102 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 177-184 15126367-2 2004 Targeting hsp90 by the ansamycins geldanamycin and 17-allyl-amino-demethoxygeldanamycin (17-AAG) promotes degradation of several proteins through the ubiquitin-proteasome pathway, including oncogenic Raf, v-Src, erbB2, and BCR-ABL. geldanamycin 34-46 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 223-230 12476305-7 2002 Small molecule inhibitors that downregulate the levels of Bcr-Abl by inhibiting its translation, e.g., arsenic trioxide, or promoting its proteasomal degradation, e.g., geldanamycin analogues, have also been identified. geldanamycin 169-181 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 58-65 11960322-1 2002 Geldanamycin (GA), herbimycin A and radicicol bind heat-shock protein-90 (Hsp90) and destabilize its client proteins including v-Src, Bcr-Abl, Raf-1, ErbB2, some growth factor receptors and steroid receptors. geldanamycin 14-16 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 134-141 11280726-2 2001 Present studies demonstrate that treatment with ansamycin antibiotic geldanamycin (GA), or its less toxic analogue 17-allylamino-17-demethoxygeldanamycin (17-AAG), induces cytosolic accumulation of cytochrome c and cleavage and activities of caspase-9 and caspase-3, triggering apoptosis of HL-60/Bcr-Abl and K562 cells. geldanamycin 69-81 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 297-304 11280726-2 2001 Present studies demonstrate that treatment with ansamycin antibiotic geldanamycin (GA), or its less toxic analogue 17-allylamino-17-demethoxygeldanamycin (17-AAG), induces cytosolic accumulation of cytochrome c and cleavage and activities of caspase-9 and caspase-3, triggering apoptosis of HL-60/Bcr-Abl and K562 cells. geldanamycin 83-85 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 297-304 11280726-3 2001 GA or 17-AAG down-regulated intracellular Bcr-Abl and c-Raf protein levels, as well as reduced Akt kinase activity. geldanamycin 0-2 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 42-49 11280726-6 2001 These data establish the in vitro activity of GA and 17-AAG against Bcr-Abl-positive leukemic cells and support the in vivo investigation of 17-AAG against Bcr-Abl-positive leukemias. geldanamycin 46-48 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 68-75 11587211-0 2001 The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy. geldanamycin 20-32 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 56-63 11587211-2 2001 Geldanamycin (GA), a drug which destabilizes Hsp90-associated proteins, depletes cells of Bcr-Abl, an Hsp90 client, but not of Abl. geldanamycin 0-12 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 90-97 11587211-2 2001 Geldanamycin (GA), a drug which destabilizes Hsp90-associated proteins, depletes cells of Bcr-Abl, an Hsp90 client, but not of Abl. geldanamycin 0-12 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 94-97 11587211-2 2001 Geldanamycin (GA), a drug which destabilizes Hsp90-associated proteins, depletes cells of Bcr-Abl, an Hsp90 client, but not of Abl. geldanamycin 14-16 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 90-97 11587211-2 2001 Geldanamycin (GA), a drug which destabilizes Hsp90-associated proteins, depletes cells of Bcr-Abl, an Hsp90 client, but not of Abl. geldanamycin 14-16 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 94-97 11587211-3 2001 Both HL60 cells transfected with Bcr-Abl and naturally Ph1-positive K562 leukemia cells are resistant to most cytotoxic drugs, but were found to be sensitive to GA. geldanamycin 161-163 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 33-40 11280726-0 2001 Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. geldanamycin 0-12 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 76-83 11280726-0 2001 Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. geldanamycin 0-12 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 136-143