PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11543689-0	2001	Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.	Coumarins	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-64	
23931437-7	2013	2) Coumarins, flavonoids, stilbenes, and other natural products are also important AChE inhibitors from natural products.	Coumarins	3-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87	
20677317-1	2010	A large series of substituted coumarins linked through an appropriate spacer to 3-hydroxy-N,N-dimethylanilino or 3-hydroxy-N,N,N-trialkylbenzaminium moieties were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors.	Coumarins	30-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	192-212	
20677317-1	2010	A large series of substituted coumarins linked through an appropriate spacer to 3-hydroxy-N,N-dimethylanilino or 3-hydroxy-N,N,N-trialkylbenzaminium moieties were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors.	Coumarins	30-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	214-218	
18778776-0	2008	Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106.	Coumarins	38-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34	
32370238-4	2020	Moreover, in order to understand the mechanism, the binding interactions between coumarins and their targets: (i) AChE and (ii) Abeta1-42 peptide were investigated in silico.	Coumarins	81-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	114-118	
32370238-5	2020	All coumarins exhibited mild to moderate AChE and self-induced Abeta aggregation inhibitory actions.	Coumarins	4-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-45	
32370238-6	2020	In addition, the coumarins substituted with the long alkyl chain at position 6 or 8 illustrated ability to inhibit AChE-induced Abeta aggregation, resulting from their dual binding site at catalytic anionic site and peripheral active site in AChE.	Coumarins	17-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-119	
32370238-6	2020	In addition, the coumarins substituted with the long alkyl chain at position 6 or 8 illustrated ability to inhibit AChE-induced Abeta aggregation, resulting from their dual binding site at catalytic anionic site and peripheral active site in AChE.	Coumarins	17-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	242-246	
26833890-8	2016	Overall, these results lead to discovery of fused tricyclic coumarins as promising dual binding site inhibitors of acetylcholinesterase and afford multifunctional compounds with potential impact for further pharmacological development in Alzheimer"s therapy.	Coumarins	60-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-135	
23988409-1	2013	A series of fused coumarins namely 5-oxo-4,5-dihydropyrano[3,2-c]chromenes linked to N-benzylpyridinium scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors.	Coumarins	18-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-167	
23988409-1	2013	A series of fused coumarins namely 5-oxo-4,5-dihydropyrano[3,2-c]chromenes linked to N-benzylpyridinium scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors.	Coumarins	18-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	169-173	
22257528-0	2012	A review on coumarins as acetylcholinesterase inhibitors for Alzheimer"s disease.	Coumarins	12-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	25-45	
22257528-2	2012	Coumarins are the phytochemicals with wide range of biological activities including AChE inhibition.	Coumarins	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-88