PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10479284-0 1999 5-deazafolate analogues with a rotationally restricted glutamate or ornithine side chain: synthesis and binding interaction with folylpolyglutamate synthetase. 5-deazafolic acid 0-13 folylpolyglutamate synthase Homo sapiens 129-158 12408727-6 2002 These results show that a classical 5-deaza folate partially restricted via a bridge between the N10 and C7 positions retains FPGS substrate activity and that the antitumor activity of classical tricyclic analogues such as 3 would be influenced by FPGS levels in tumor systems. 5-deazafolic acid 36-50 folylpolyglutamate synthase Homo sapiens 126-130 12408727-6 2002 These results show that a classical 5-deaza folate partially restricted via a bridge between the N10 and C7 positions retains FPGS substrate activity and that the antitumor activity of classical tricyclic analogues such as 3 would be influenced by FPGS levels in tumor systems. 5-deazafolic acid 36-50 folylpolyglutamate synthase Homo sapiens 248-252 1578484-1 1992 5-Deazafolate and 5-deazatetrahydrofolate (DATHF) analogues with the glutamic acid side chain replaced by homocysteic acid (HCysA), 2-amino-4-phosphonobutanoic acid (APBA), and ornithine (Orn) were synthesized as part of a larger program directed toward inhibitors of folylpolyglutamate synthetase (FPGS) as probes of the FPGS active site and as potential therapeutic agents. 5-deazafolic acid 0-13 folylpolyglutamate synthase Homo sapiens 299-303 1578484-1 1992 5-Deazafolate and 5-deazatetrahydrofolate (DATHF) analogues with the glutamic acid side chain replaced by homocysteic acid (HCysA), 2-amino-4-phosphonobutanoic acid (APBA), and ornithine (Orn) were synthesized as part of a larger program directed toward inhibitors of folylpolyglutamate synthetase (FPGS) as probes of the FPGS active site and as potential therapeutic agents. 5-deazafolic acid 0-13 folylpolyglutamate synthase Homo sapiens 322-326