PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32912294-9 2020 We describe a class of dormant, p53 bound enhancers that gain H3K27ac under specific conditions, such as after treatment with Nocodazol, or transiently during reprogramming from fibroblasts to pluripotency. Nocodazole 126-135 transformation related protein 53, pseudogene Mus musculus 32-35 9840938-2 1998 When exposed to a spindle-disrupting drug such as nocodazole, fibroblasts derived from mice having wild-type p53 are blocked with a 4N content of DNA. Nocodazole 50-60 transformation related protein 53, pseudogene Mus musculus 109-112 21846807-3 2011 Our results clearly indicate that nocodazole induces senescence only in NIH3T3 cells with a functional p53 but not in I-MEF lacking a functional p53. Nocodazole 34-44 transformation related protein 53, pseudogene Mus musculus 103-106 18971638-5 2008 The effects of nocodazole, a well established tubulin poison, and JJ78:12 on p53 levels are remarkably similar, supporting that tubulin depolymerization is the main mechanism by which JJ78:12 treatment leads to p53 activation in cells. Nocodazole 15-25 transformation related protein 53, pseudogene Mus musculus 77-80 9445009-4 1998 When fibroblasts from p53 knockout mice are treated with the spindle inhibitor nocodazole, a rereplication of DNA occurs without transit through mitosis. Nocodazole 79-89 transformation related protein 53, pseudogene Mus musculus 22-25 9448003-4 1998 However, p53 does play a critical role in nocodazole-treated cells which have exited mitotic arrest without undergoing cytokinesis and have thereby adapted. Nocodazole 42-52 transformation related protein 53, pseudogene Mus musculus 9-12 9448003-5 1998 We have determined that in nocodazole-treated, adapted cells, p53 is required during a specific time window to prevent cells from reentering the cell cycle and initiating another round of DNA synthesis. Nocodazole 27-37 transformation related protein 53, pseudogene Mus musculus 62-65 9448003-7 1998 The mechanism of the p53-dependent arrest in nocodazole-treated adapted cells requires the cyclin-dependent kinase inhibitor p21, as p21-/- fibroblasts fail to arrest in response to nocodazole treatment and become polyploid. Nocodazole 45-55 transformation related protein 53, pseudogene Mus musculus 21-24 9448003-7 1998 The mechanism of the p53-dependent arrest in nocodazole-treated adapted cells requires the cyclin-dependent kinase inhibitor p21, as p21-/- fibroblasts fail to arrest in response to nocodazole treatment and become polyploid. Nocodazole 182-192 transformation related protein 53, pseudogene Mus musculus 21-24 8761295-5 1996 In addition to engaging the apoptotic machinery, the tamoxifen-activated fusion protein exhibited other functions characteristic of wild-type p53, such as induction of WAF1 and MDM2 gene expression and activation of the p53-dependent spindle checkpoint in cells treated with nocodazole. Nocodazole 275-285 transformation related protein 53, pseudogene Mus musculus 142-145