PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18592005-6 2008 This was supported by the finding that CHFR interacts with alpha-tubulin and can regulate its ubiquitination in response to nocodazole and the amount of acetylated alpha-tubulin, a component of the mitotic spindle. Nocodazole 124-134 checkpoint with forkhead and ring finger domains Homo sapiens 39-43 15631682-1 2004 Chfr, a mitotic stress checkpoint gene, regulates a prophase delay in cells exposed to agents that disrupt microtubules, such as nocodazole and taxol. Nocodazole 129-139 checkpoint with forkhead and ring finger domains Homo sapiens 0-4 14694445-7 2004 Eleven of these 12 (92%) low-CHFR-expressing cell lines had an unusually high number of condensed chromosomes and high mitotic indices in response to nocodazole treatment. Nocodazole 150-160 checkpoint with forkhead and ring finger domains Homo sapiens 29-33 14694445-8 2004 Transfection of CHFR in one of these cancer cell lines lowered the mitotic index after nocodazole treatment. Nocodazole 87-97 checkpoint with forkhead and ring finger domains Homo sapiens 16-20 14694445-9 2004 In conclusion, our data suggested that low CHFR expression associated with high mitotic indices in response to nocodazole treatment were common in the breast cancer cell lines studied. Nocodazole 111-121 checkpoint with forkhead and ring finger domains Homo sapiens 43-47 12538348-1 2003 Chfr, a mitotic stress checkpoint gene, regulates a prophase delay in cells exposed to agents that disrupt microtubules, such as nocodazole and taxol. Nocodazole 129-139 checkpoint with forkhead and ring finger domains Homo sapiens 0-4