PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24621501-4 2014 In taxol- and nocodazole-exposed cells, phospho-Bcl-xL(Ser62) also binds to Cdc20- Mad2-, BubR1-, and Bub3-bound complexes, while Bcl-xL(Ser62Ala) does not. Nocodazole 14-24 mitotic arrest deficient 2 like 1 Homo sapiens 83-87 28112196-8 2017 Moreover, in prolonged arrest caused by nocodazole treatment, the overall levels of the CDC20-MAD2 complex are gradually, but significantly, reduced and this is associated with lower levels of cyclin B1, which brings a new insight into the mechanism of mitotic "slippage" of the arrested cells. Nocodazole 40-50 mitotic arrest deficient 2 like 1 Homo sapiens 94-98 26912231-7 2016 A phospho-mimicking Cdc20 mutant restores nocodazole-induced mitotic arrest in cells depleted of Mad2 or BubR1. Nocodazole 42-52 mitotic arrest deficient 2 like 1 Homo sapiens 97-101 22949227-6 2014 In addition, evidence is presented to show that mitotic arrest deficient 2 (MAD2) is a key upstream mediator of the up-regulation of cyclin B1/Cdc2 as well as the subsequent increase in phosphorylationof Bcl-2 and Bcl-XL in nocodazole-treated cancer cells. Nocodazole 224-234 mitotic arrest deficient 2 like 1 Homo sapiens 48-74 22949227-6 2014 In addition, evidence is presented to show that mitotic arrest deficient 2 (MAD2) is a key upstream mediator of the up-regulation of cyclin B1/Cdc2 as well as the subsequent increase in phosphorylationof Bcl-2 and Bcl-XL in nocodazole-treated cancer cells. Nocodazole 224-234 mitotic arrest deficient 2 like 1 Homo sapiens 76-80 17392512-6 2007 We also found that approximately 60% of CENP-C-deficient cells had no Mad2 signals even after treatment with nocodazole, suggesting that lack of CENP-C impairs the Mad2 spindle checkpoint pathway. Nocodazole 109-119 mitotic arrest deficient 2 like 1 Homo sapiens 164-168 21918689-7 2011 In addition, we found that MAD2 knockdown abrogated nocodazole-induced accumulation of cyclin B1 and Cdc2 proteins, which was accompanied by an attenuation of nocodazole-induced prometaphase arrest. Nocodazole 52-62 mitotic arrest deficient 2 like 1 Homo sapiens 27-31 21918689-7 2011 In addition, we found that MAD2 knockdown abrogated nocodazole-induced accumulation of cyclin B1 and Cdc2 proteins, which was accompanied by an attenuation of nocodazole-induced prometaphase arrest. Nocodazole 159-169 mitotic arrest deficient 2 like 1 Homo sapiens 27-31 20516147-7 2010 Cells expressing MAD2L1-84Met and MAD1L1-558His had impaired spindle checkpoint function, with a lower 4N-DNA content and mitotic index when treated with nocodazole. Nocodazole 154-164 mitotic arrest deficient 2 like 1 Homo sapiens 17-23 20442314-5 2010 Bcr-Abl leads to decreased expression of genes involved in the mitotic checkpoint activation--Mad2, Bub1, Bub3, and BubR1, resulting in mitosis perturbances, weakened mitotic checkpoint function, and mitotic slippage after nocodazole treatment. Nocodazole 223-233 mitotic arrest deficient 2 like 1 Homo sapiens 94-98 16112690-6 2005 Overexpression of mutant Mad2 in HeLa cells led to the appearance of aneuploid cells in the presence of nocodazole, and this indicated that these mutations caused a defect in MAD2 protein. Nocodazole 104-114 mitotic arrest deficient 2 like 1 Homo sapiens 25-29 14583462-9 2003 Mitotic arrest deficient 2 (Mad2) signal was, as expected, clearly visible at centromeres of nocodazole-arrested mitotic cells. Nocodazole 93-103 mitotic arrest deficient 2 like 1 Homo sapiens 0-26 15782113-4 2005 Most significantly, a partial repression of either MAD1 or MAD2 confers resistance to nocodazole, a drug that inhibits microtubule attachment. Nocodazole 86-96 mitotic arrest deficient 2 like 1 Homo sapiens 59-63 14583462-9 2003 Mitotic arrest deficient 2 (Mad2) signal was, as expected, clearly visible at centromeres of nocodazole-arrested mitotic cells. Nocodazole 93-103 mitotic arrest deficient 2 like 1 Homo sapiens 28-32 10964468-6 2000 Disruption of the male meiotic spindles with the microtubule depolymerizing agent nocodazole resulted in the appearance of Mad2 at nearly all kinetochores. Nocodazole 82-92 mitotic arrest deficient 2 like 1 Homo sapiens 123-127 12235289-5 2002 By injecting PtK1 cells in nocodazole with GST-Mad1F10 and processing the cells for immunofluorescence microscopy after anaphase sister chromatid separation in nocodazole we found that Mad2, BubR1, cytoplasmic dynein, CENP-E and the 3F3/2 phosphoepitope remain on kinetochores. Nocodazole 27-37 mitotic arrest deficient 2 like 1 Homo sapiens 185-189 12235289-5 2002 By injecting PtK1 cells in nocodazole with GST-Mad1F10 and processing the cells for immunofluorescence microscopy after anaphase sister chromatid separation in nocodazole we found that Mad2, BubR1, cytoplasmic dynein, CENP-E and the 3F3/2 phosphoepitope remain on kinetochores. Nocodazole 160-170 mitotic arrest deficient 2 like 1 Homo sapiens 185-189 31118282-6 2019 The release of Mad2 from checkpoint complexes in extracts from nocodazole-arrested HeLa cells was inhibited by Polo-like kinase 1 (Plk1), as suggested by the effects of selective inhibitors of Plk1. Nocodazole 63-73 mitotic arrest deficient 2 like 1 Homo sapiens 15-19 9736712-5 1998 In contrast, however, this complex is present only in nocodazole-arrested or early mitotic cells and is associated with the APC as a Mad2/p55Cdc/Cdc27 ternary complex. Nocodazole 54-64 mitotic arrest deficient 2 like 1 Homo sapiens 133-137 9606210-16 1998 Here we show that Mad2 is lost from PtK1 cell kinetochores as they accumulate microtubules and re-binds previously attached kinetochores after microtubules are depolymerized with nocodazole. Nocodazole 179-189 mitotic arrest deficient 2 like 1 Homo sapiens 18-22 32905854-2 2020 In this study, we found that NUP62-depleted cells exhibited a defective spindle assembly checkpoint (SAC) and that depletion of NUP62 caused a slight decrease in MAD2 protein levels after nocodazole treatment. Nocodazole 188-198 mitotic arrest deficient 2 like 1 Homo sapiens 162-166 31523901-0 2019 Downregulation of Mad2 and BubR1 increase the malignant potential and nocodazole resistance by compromising spindle assembly checkpoint signaling pathway in cervical carcinogenesis. Nocodazole 70-80 mitotic arrest deficient 2 like 1 Homo sapiens 18-22 31523901-9 2019 In SiHa cells, knockdown of Mad2 and BubR1 increased cell growth, reinforced invasion capacity and migration potency, inhibited apoptosis and decreased G2-phase distribution after nocodazole treatment. Nocodazole 180-190 mitotic arrest deficient 2 like 1 Homo sapiens 28-32 31523901-12 2019 Downregulation of Mad2 and BubR1 increase the malignant behavior and nocodazole resistance of SiHa cells via causing spindle assembly checkpoint defect. Nocodazole 69-79 mitotic arrest deficient 2 like 1 Homo sapiens 18-22