PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9927194-4 1999 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Nocodazole 79-89 mitogen-activated protein kinase 8 Homo sapiens 118-143 12221076-4 2002 With the loss of the p53 gene, the levels of phosphorylation of Ser-63 of c-Jun and Thr-183/Tyr-185 of JNK1/2 in p53-/- cells did not increase as markedly as in p53+/+ cells in response to a 1-h treatment with nocodazole or other microtubule-disrupting drugs such as vinblastine and colchicine. Nocodazole 210-220 mitogen-activated protein kinase 8 Homo sapiens 103-109 12221076-7 2002 Inhibition of p53 expression by its antisense oligonucleotide also attenuated nocodazole-induced JNK activation in p53+/+ cells. Nocodazole 78-88 mitogen-activated protein kinase 8 Homo sapiens 97-100 12221076-8 2002 Surprisingly, cotransfection of p53+/+ cells with dominant negative mutants of JNK isoforms and treatment of p53+/+ cells with the JNK inhibitor SP600125 actually further enhanced apoptosis in p53+/+ cells by up to 2-fold in response to nocodazole. Nocodazole 237-247 mitogen-activated protein kinase 8 Homo sapiens 79-82 12221076-8 2002 Surprisingly, cotransfection of p53+/+ cells with dominant negative mutants of JNK isoforms and treatment of p53+/+ cells with the JNK inhibitor SP600125 actually further enhanced apoptosis in p53+/+ cells by up to 2-fold in response to nocodazole. Nocodazole 237-247 mitogen-activated protein kinase 8 Homo sapiens 131-134 9927194-4 1999 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Nocodazole 79-89 mitogen-activated protein kinase 8 Homo sapiens 145-149 31906029-5 2019 Application of the c-Jun N-terminal kinase (JNK) inhibitors SP600125 (SP) and JNK inhibitor V (JNKI) significantly reduced TAX- and NOC-induced apoptosis and G2/M arrest of human colon cancer cells. Nocodazole 132-135 mitogen-activated protein kinase 8 Homo sapiens 19-42 31906029-5 2019 Application of the c-Jun N-terminal kinase (JNK) inhibitors SP600125 (SP) and JNK inhibitor V (JNKI) significantly reduced TAX- and NOC-induced apoptosis and G2/M arrest of human colon cancer cells. Nocodazole 132-135 mitogen-activated protein kinase 8 Homo sapiens 44-47 31906029-5 2019 Application of the c-Jun N-terminal kinase (JNK) inhibitors SP600125 (SP) and JNK inhibitor V (JNKI) significantly reduced TAX- and NOC-induced apoptosis and G2/M arrest of human colon cancer cells. Nocodazole 132-135 mitogen-activated protein kinase 8 Homo sapiens 78-81 31906029-6 2019 Interestingly, TAX- and NOC-induced pPERK (Tyr980) protein expression was inhibited by adding the JNK inhibitors, SP and JNKI, and application of the PERK inhibitor GSK2606414 (GSK) significantly reduced apoptosis and G2/M arrest by TAX and NOC, with decreased pPERK (Tyr980) and pJNK, phosphorylated Cdc25C, and Cyc B1 protein expressions in human colon cancer cells. Nocodazole 24-27 mitogen-activated protein kinase 8 Homo sapiens 98-101 31906029-6 2019 Interestingly, TAX- and NOC-induced pPERK (Tyr980) protein expression was inhibited by adding the JNK inhibitors, SP and JNKI, and application of the PERK inhibitor GSK2606414 (GSK) significantly reduced apoptosis and G2/M arrest by TAX and NOC, with decreased pPERK (Tyr980) and pJNK, phosphorylated Cdc25C, and Cyc B1 protein expressions in human colon cancer cells. Nocodazole 241-244 mitogen-activated protein kinase 8 Homo sapiens 98-101 24062531-6 2013 Pre-treatment with inhibitors for PKC or its downstream signalling partners p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) abolished the nocodazole-mediated induction of Zta and EA-D. Interestingly, the effect of nocodazole, as well as colchicine and vinblastine, on lytic gene expression occurred only in NPC epithelial cells but not in cells derived from lymphocytes. Nocodazole 168-178 mitogen-activated protein kinase 8 Homo sapiens 124-147 24062531-6 2013 Pre-treatment with inhibitors for PKC or its downstream signalling partners p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) abolished the nocodazole-mediated induction of Zta and EA-D. Interestingly, the effect of nocodazole, as well as colchicine and vinblastine, on lytic gene expression occurred only in NPC epithelial cells but not in cells derived from lymphocytes. Nocodazole 168-178 mitogen-activated protein kinase 8 Homo sapiens 149-152 22285910-5 2012 Prolonged activation of c-Jun N-terminal kinase (JNK) was required for vinca alkaloid- and nocodazole-induced apoptosis but not cell cycle arrest. Nocodazole 91-101 mitogen-activated protein kinase 8 Homo sapiens 24-47 22285910-5 2012 Prolonged activation of c-Jun N-terminal kinase (JNK) was required for vinca alkaloid- and nocodazole-induced apoptosis but not cell cycle arrest. Nocodazole 91-101 mitogen-activated protein kinase 8 Homo sapiens 49-52 22285910-8 2012 Unlike cisplatin, which causes DNA damage in each phase of the cell cycle, VNR and nocodazole induced aberrant JNK-regulated DNA damage in prometaphase; however, inhibiting ATM (ataxia telangiectasia, mutated) and ATR (ATM and Rad3-related) did not reverse mitotic arrest or apoptosis. Nocodazole 83-93 mitogen-activated protein kinase 8 Homo sapiens 111-114 21825007-7 2011 Treatment with JNK inhibitor decreased Bcl-2 phosphorylation and subsequently reduced nocodazole-induced cell death. Nocodazole 86-96 mitogen-activated protein kinase 8 Homo sapiens 15-18 9478937-3 1998 We have observed that paclitaxel (Taxol), docetaxel (Taxotere), vinblastine, vincristine, nocodazole, and colchicine activate the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) signaling pathway in a variety of human cells. Nocodazole 90-100 mitogen-activated protein kinase 8 Homo sapiens 187-195 31906029-8 2019 Disruption of the mitochondrial membrane potential and an increase in B-cell lymphoma-2 (Bcl-2) protein phosphorylation (pBcl-2; Ser70) by TAX and NOC were prevented by adding the PERK inhibitor GSK and JNK inhibitor SP and JNKI. Nocodazole 147-150 mitogen-activated protein kinase 8 Homo sapiens 203-206 31906029-9 2019 A cross-activation of JNK and PERK by TAX and NOC leading to anti-CRC actions including apoptosis and G2/M arrest was first demonstrated herein. Nocodazole 46-49 mitogen-activated protein kinase 8 Homo sapiens 22-25 19074146-2 2009 Here we report that microtubule-depolymerizing agents such as colchicine or nocodazole induced strong activation of MAP kinases including JNK, ERK, and p38. Nocodazole 76-86 mitogen-activated protein kinase 8 Homo sapiens 138-141