PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 184406-4 1976 Norgestrel reduced TeBG binding capacity but not CBG binding capacity. Norgestrel 0-10 sex hormone binding globulin Homo sapiens 19-23 184406-5 1976 Norgestrel competitively inhibited the binding of dihydrotestosterone to TeBG under in vitro conditions. Norgestrel 0-10 sex hormone binding globulin Homo sapiens 73-77 6540031-0 1984 Effects of two estradiol/norgestrel combinations on the ovulatory pattern and on sex hormone binding globulin capacity in women around forty years of age. Norgestrel 25-35 sex hormone binding globulin Homo sapiens 81-109 7195405-4 1981 Computer simulation predicted that by interacting with TeBG, therapeutic levels of danazol, methyltestosterone, fluoxymesterone, and norgestrel could displace 83%, 48%, 43%, and 16%, respectively, of the concentration of testosterone bound to TeBG in a normal man. Norgestrel 133-143 sex hormone binding globulin Homo sapiens 55-59 7195405-4 1981 Computer simulation predicted that by interacting with TeBG, therapeutic levels of danazol, methyltestosterone, fluoxymesterone, and norgestrel could displace 83%, 48%, 43%, and 16%, respectively, of the concentration of testosterone bound to TeBG in a normal man. Norgestrel 133-143 sex hormone binding globulin Homo sapiens 243-247 31689504-5 2020 Protein-ligand complexes, involving dimeric SHBG saturated with two ligands on each subunit, reproduce the experimental affinity tendency and allow the observation that dimerization exerts disparate effects on binding affinity, characteristic of negative cooperativity for E2, DHT, and NOG, whereas 3beta-17alpha-diol and 3beta-17beta-diol lack allostery. Norgestrel 286-289 sex hormone binding globulin Homo sapiens 44-48