PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27763693-5	2016	In the present manuscript, we show by flow cytometry and live-cell immunofluorescence that Norgestrel induces an increase in cytosolic calcium in both healthy and stressed 661Ws over 24 h. Specific PGRMC1 inhibition by AG205 (1 mum) showed this rise to be PGRMC1-dependent, primarily utilizing calcium from extracellular sources, for blockade of L-type calcium channels by verapamil (50 mum) prevented a Norgestrel-induced calcium influx in stressed cells.	Norgestrel	91-101	progesterone receptor membrane component 1	Mus musculus	198-204	
27763693-5	2016	In the present manuscript, we show by flow cytometry and live-cell immunofluorescence that Norgestrel induces an increase in cytosolic calcium in both healthy and stressed 661Ws over 24 h. Specific PGRMC1 inhibition by AG205 (1 mum) showed this rise to be PGRMC1-dependent, primarily utilizing calcium from extracellular sources, for blockade of L-type calcium channels by verapamil (50 mum) prevented a Norgestrel-induced calcium influx in stressed cells.	Norgestrel	91-101	progesterone receptor membrane component 1	Mus musculus	256-262	
27763693-5	2016	In the present manuscript, we show by flow cytometry and live-cell immunofluorescence that Norgestrel induces an increase in cytosolic calcium in both healthy and stressed 661Ws over 24 h. Specific PGRMC1 inhibition by AG205 (1 mum) showed this rise to be PGRMC1-dependent, primarily utilizing calcium from extracellular sources, for blockade of L-type calcium channels by verapamil (50 mum) prevented a Norgestrel-induced calcium influx in stressed cells.	Norgestrel	404-414	progesterone receptor membrane component 1	Mus musculus	198-204	
27763693-7	2016	Notably, we demonstrate PGRMC1-activation is necessary for Norgestrel-induced bFGF upregulation.	Norgestrel	59-69	progesterone receptor membrane component 1	Mus musculus	24-30	
26447367-8	2016	Activated by Norgestrel through nuclear trafficking, siRNA knock down of PGRMC1 abrogated the protective properties of Norgestrel on damaged photoreceptors.	Norgestrel	13-23	progesterone receptor membrane component 1	Mus musculus	73-79	
26447367-8	2016	Activated by Norgestrel through nuclear trafficking, siRNA knock down of PGRMC1 abrogated the protective properties of Norgestrel on damaged photoreceptors.	Norgestrel	119-129	progesterone receptor membrane component 1	Mus musculus	73-79	
26447367-9	2016	Furthermore, specific inhibition of PGRMC1 by AG205 blocked Norgestrel-induced protection in stressed retinal explants.	Norgestrel	60-70	progesterone receptor membrane component 1	Mus musculus	36-42	
26447367-10	2016	Therefore, we conclude that PGRMC1 is crucial to the neuroprotective effects of Norgestrel on stressed photoreceptors.	Norgestrel	80-90	progesterone receptor membrane component 1	Mus musculus	28-34