PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31872743-9	2019	The results of two experiments showed that apigenin was the substrate of UGT1 A1 enzyme,which could inhibit the activity of UGT1 A1 enzyme competitively,and there was a risk of drug interaction between apigenin and UGT1 A1 enzyme substrate in clinical use.	Apigenin	43-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	124-131	
31621310-5	2019	For example, 4",5,7-trihydroxyisoflavone (genistein) was AhR-inactive whereas 4",5,7-trihydroxyflavone (apigenin) induced CYP1A1, CYP1B1, and UGT1A1 in Caco2 cells.	Apigenin	104-112	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	142-148	
31872743-9	2019	The results of two experiments showed that apigenin was the substrate of UGT1 A1 enzyme,which could inhibit the activity of UGT1 A1 enzyme competitively,and there was a risk of drug interaction between apigenin and UGT1 A1 enzyme substrate in clinical use.	Apigenin	43-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	73-80	
31872743-1	2019	The purpose of this study was to investigate the effect of apigenin on UGT1 A1 enzyme activity and to predict the potential drug-drug interaction of apigenin in clinical use.	Apigenin	59-67	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	71-78	
31872743-2	2019	First,on the basis of previous experiments,the binding targets and binding strength of apigenin to UGT1 A1 enzyme were predicted by computer molecular docking method.	Apigenin	87-95	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	99-106	
31872743-3	2019	Then the inhibitory effect of apigenin on UGT1 A1 enzyme was evaluated by in vitro human liver microsomal incubation system.	Apigenin	30-38	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	42-49	
31872743-4	2019	Molecular docking results showed that apigenin was docked into the active region of UGT1 A1 enzyme protein F,consistent with the active region of bilirubin docking,with moderate affinity.	Apigenin	38-46	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	84-91	
31872743-8	2019	In vitro inhibition experiments showed that apigenin had a moderate inhibitory effect on UGT1 A1 enzyme in a way of competitive inhibition,which was consistent with the results of molecular docking.	Apigenin	44-52	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	89-96	
31872743-9	2019	The results of two experiments showed that apigenin was the substrate of UGT1 A1 enzyme,which could inhibit the activity of UGT1 A1 enzyme competitively,and there was a risk of drug interaction between apigenin and UGT1 A1 enzyme substrate in clinical use.	Apigenin	43-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	124-131	
31872743-9	2019	The results of two experiments showed that apigenin was the substrate of UGT1 A1 enzyme,which could inhibit the activity of UGT1 A1 enzyme competitively,and there was a risk of drug interaction between apigenin and UGT1 A1 enzyme substrate in clinical use.	Apigenin	202-210	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	73-80	
15090468-0	2004	Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells.	Apigenin	38-46	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	67-73	
15090468-4	2004	The combination of sulforaphane and apigenin resulted in a synergistic induction of UGT1A1 mRNA up to 12-fold, although this interaction was not seen for GSTA1.	Apigenin	36-44	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	84-90	
17927138-5	2007	The results also indicated that well-expressed UGT isoforms in the Caco-2 cells, UGT1A1, UGT1A3, UGT1A6, and UGT2B7, were capable of metabolizing apigenin faster than genistein and that UGT1A6 silencing did not substantially increase the level of expression of genistein-metabolizing UGT isoforms.	Apigenin	146-154	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	81-87