PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17985862-5	2007	By leveraging the knowledge of the ligand-BACE-1 recognition features generated from the isocytosines, the dihydroisocytosines were efficiently optimized to submicromolar potency.	isocytosine	89-101	beta-secretase 1	Homo sapiens	42-48	
23562056-0	2013	Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.	isocytosine	77-88	beta-secretase 1	Homo sapiens	39-44