PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14744950-3 2004 Screening of 10 cDNA-expressed recombinant human UDP-glucuronosyltransferase (UGT) enzymes showed that only UGT1A4 exhibited catalytic activity with respect to the formation of the glucuronide of posaconazole. Glucuronides 181-192 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 108-114 16884532-4 2006 METHODS: HPLC was used to detect glucuronide conjugates in microsomes from UGT1A4-overexpressing HK293 cells. Glucuronides 33-44 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 75-81 14744950-4 2004 The formation of glucuronide by human liver microsomes and UGT1A4 was inhibited by bilirubin, a known inhibitor of UGT1A4. Glucuronides 17-28 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 59-65 14744950-4 2004 The formation of glucuronide by human liver microsomes and UGT1A4 was inhibited by bilirubin, a known inhibitor of UGT1A4. Glucuronides 17-28 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 115-121 14744950-5 2004 There was a high correlation (r =0.90) between the rate of formation of glucuronide, determined in 10 human liver microsomal samples, and trifluoperazine glucuronidation catalyzed by UGT1A4. Glucuronides 72-83 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 183-189 23670235-5 2013 RESULTS: UGT1A1, UGT1A4, UGT1A8, UGT2B7, and SULT1A1 were found to be involved in the formation of inactive ABT-751 glucuronide (ABT-751G) and sulfate (ABT-751S). Glucuronides 116-127 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 17-23 11560879-1 2001 In experiments with expressed human UDP-glucuronosyltransferase 1A4 (UGT1A4), the antipsychotic clozapine proved to be conjugated to two different glucuronides, one of which was identified as the quaternary ammonium glucuronide derivatized at the N-methylpiperazine group; this compound had previously been isolated from patient urine. Glucuronides 147-159 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 36-67 11560879-1 2001 In experiments with expressed human UDP-glucuronosyltransferase 1A4 (UGT1A4), the antipsychotic clozapine proved to be conjugated to two different glucuronides, one of which was identified as the quaternary ammonium glucuronide derivatized at the N-methylpiperazine group; this compound had previously been isolated from patient urine. Glucuronides 147-159 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 69-75 10051052-2 1999 This finding was accompanied by a corresponding reduction of the inactive glucuronide metabolite of MPA (MPAG) in patients, suggesting that tacrolimus may effect the conversion of MPA to MPAG by the enzyme UDP-glucuronosyltransferase (UDPGT). Glucuronides 74-85 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 206-233 26176234-4 2015 This descriptive study examines correlations between concentrations of tamoxifen"s glucuronide metabolites and genotypes UGT1A4 Pro24Thr, UGT1A4 Leu48Val, UGT2B7 His268Tyr, UGT2B15 Asp85YTyr UGT2B15 Lys523Thr and UGT2B17del in 132 patients with estrogen receptor-positive breast cancer under treatment with tamoxifen. Glucuronides 83-94 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 121-127 24641623-7 2014 An association between the UGT1A4*3 (Leu48Val) gene polymorphism with the rates of glucuronide formation was also investigated using human liver microsomes isolated from 80 genotyped livers. Glucuronides 83-94 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 27-33 11408353-6 2001 A third previously undefined glucuronide accounted for 31% of the total glucuronides formed from the UGT1A4 expressing microsomes. Glucuronides 29-40 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 101-107 11408353-6 2001 A third previously undefined glucuronide accounted for 31% of the total glucuronides formed from the UGT1A4 expressing microsomes. Glucuronides 72-84 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 101-107 23917319-6 2013 Glucuronide conjugates of rilpivirine and a monomethylhydroxylated metabolite of rilpivirine were also detected and were found to be formed by UDP-glucuronosyltransferases (UGTs) UGT1A4 and UGT1A1, respectively. Glucuronides 0-11 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 179-185 20713656-6 2010 A correlation analysis of UGT enzymatic activity and the formation rate of glucuronide metabolites from 1"- and 4-hydroxymidazolam in 25 HLMs showed that hydroxymidazolam glucuronidation is correlated with UGT1A4-mediated lamotrigine glucuronidation and UGT2B7-mediated diclofenac glucuronidation activity. Glucuronides 75-86 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 206-212 22050083-9 2012 In kidney microsomes the expression of UGT1A3 was below detection limits, but levels of UGT1A4, 1A7, 1A9, and 1A10 protein were higher relative to that of liver, suggesting that renal glucuronidation could be a significant factor in renal elimination of glucuronide conjugates. Glucuronides 254-265 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 88-94 21780761-6 2011 Three glucuronide conjugates were observed in activity assays with UGTs 1A1 and 1A10, while two glucuronides were formed by UGTs 1A7, 1A8, and 1A9, and one glucuronide was made by UGT1A4 and UGT2B7. Glucuronides 6-17 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 180-186 21632963-3 2011 Formation of trifluoperazine glucuronide, serotonin glucuronide, and mycophenolic acid phenolic glucuronide was used as an index reaction for UGT1A4, UGT1A6, and UGT1A9 activities, respectively, in human liver microsomes. Glucuronides 29-40 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 142-148 20713656-7 2010 Taken together, these findings indicate that UGT1A4, 2B4, and 2B7 are major isoforms responsible for glucuronide conjugate formation from 1"- and 4-hydroxymidazolam, which are the two major oxidative metabolites of midazolam. Glucuronides 101-112 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 45-51