PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23277092-1 2013 OBJECTIVE: The objective of the present study was to determine whether genetic variability in UDP-glucuronosyltransferase (UGT) genes, together with clinical factors, contribute to variability in morphine glucuronide (M6G and M3G) to morphine serum concentration ratios in patients with advanced cancer receiving chronic morphine therapy. Glucuronides 205-216 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 94-121 23277092-1 2013 OBJECTIVE: The objective of the present study was to determine whether genetic variability in UDP-glucuronosyltransferase (UGT) genes, together with clinical factors, contribute to variability in morphine glucuronide (M6G and M3G) to morphine serum concentration ratios in patients with advanced cancer receiving chronic morphine therapy. Glucuronides 205-216 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 123-126 23362992-3 2013 Elucidation of the glucuronide isomers allowed a systematic investigation of the regioselectivity of 12 human UGT isozymes, including 8 UGT1A and 4 UGT2B isozymes. Glucuronides 19-30 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 110-113 22814440-1 2012 BACKGROUND AND PURPOSE: Carvedilol is used clinically as a beta-adrenoceptor antagonist for the treatment of chronic heart failure and is primarily metabolized into glucuronides by UDP-glucuronosyltransferase (UGT). Glucuronides 165-177 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 181-208 22050083-1 2012 Uridine-disphosphate glucuronosyl transferase (UGT) enzymes catalyze the formation of glucuronide conjugates of phase II metabolism. Glucuronides 86-97 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 0-45 22050083-1 2012 Uridine-disphosphate glucuronosyl transferase (UGT) enzymes catalyze the formation of glucuronide conjugates of phase II metabolism. Glucuronides 86-97 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 47-50 22982073-10 2012 In conclusion, UGT is a main metabolic pathway for emodin in the intestine, and the MRP family is composed of major efflux transporters responsible for the excretion of emodin glucuronide in the intestine. Glucuronides 176-187 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 15-18 22071170-0 2012 UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP. Glucuronides 206-217 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 29-32 22814440-1 2012 BACKGROUND AND PURPOSE: Carvedilol is used clinically as a beta-adrenoceptor antagonist for the treatment of chronic heart failure and is primarily metabolized into glucuronides by UDP-glucuronosyltransferase (UGT). Glucuronides 165-177 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 210-213 21937736-2 2011 In women, raloxifene is metabolized extensively by different isoforms of UDP-glucuronosyltransferase (UGT) to its glucuronides. Glucuronides 114-126 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 73-100 21937736-2 2011 In women, raloxifene is metabolized extensively by different isoforms of UDP-glucuronosyltransferase (UGT) to its glucuronides. Glucuronides 114-126 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 102-105 18537579-2 2008 As the UDP glucuronosyltransferases metabolize many of these substances to less toxic glucuronides, variations in UGT expression are likely to be important in maintenance of health and therapeutic outcomes. Glucuronides 86-98 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 114-117 21175442-12 2010 CONCLUSIONS: Inhibition of UGT enzymes, especially UGT1A1, by gemfibrozil and its glucuronide is an additional mechanism to consider when rationalizing the interaction between repaglinide and gemfibrozil. Glucuronides 82-93 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 27-30 21622626-2 2011 In this study, we focused on the metabolism of sesamin monocatechol that was further converted into the dicatechol form by cytochrome P450 (P450) or the glucuronide by UDP-glucuronosyltransferase (UGT). Glucuronides 153-164 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 168-195 20713656-6 2010 A correlation analysis of UGT enzymatic activity and the formation rate of glucuronide metabolites from 1"- and 4-hydroxymidazolam in 25 HLMs showed that hydroxymidazolam glucuronidation is correlated with UGT1A4-mediated lamotrigine glucuronidation and UGT2B7-mediated diclofenac glucuronidation activity. Glucuronides 75-86 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 26-29 16595710-1 2006 We identified human UDP-glucuronosyltransferase (UGT) isoforms responsible for producing dihydrotestosterone (DHT) diglucuronide, a novel glucuronide in which the second glucuronosyl moiety is attached at the C2" position of the first glucuronosyl moiety, leading to diglucuronosyl conjugation of a single hydroxyl group of DHT at the C17 position. Glucuronides 117-128 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 20-47 17991766-7 2008 In recombinant human UGT supersomes, for both glucuronides, UGT1A9 exhibited higher activity than UGT1A1, whereas the lowest activity was observed with UGT1A10. Glucuronides 46-58 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 21-24 17446261-10 2007 In conclusion, these findings suggest that the formation of (R)- and (S)-glucuronide from racemic flurbiprofen is catalyzed by the same UGT isozyme, namely UGT2B7. Glucuronides 69-84 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 136-139 16887906-2 2006 Like a huge variety of endo- and xenobiotics, they are eliminated as glucuronide conjugates formed by uridine diphosphate-glucuronosyltransferase (UGT) enzymes. Glucuronides 69-80 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 102-145 16887906-2 2006 Like a huge variety of endo- and xenobiotics, they are eliminated as glucuronide conjugates formed by uridine diphosphate-glucuronosyltransferase (UGT) enzymes. Glucuronides 69-80 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 147-150 16595710-1 2006 We identified human UDP-glucuronosyltransferase (UGT) isoforms responsible for producing dihydrotestosterone (DHT) diglucuronide, a novel glucuronide in which the second glucuronosyl moiety is attached at the C2" position of the first glucuronosyl moiety, leading to diglucuronosyl conjugation of a single hydroxyl group of DHT at the C17 position. Glucuronides 117-128 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 49-52 12639971-7 2003 In summary, our data showed that several members of UGT1A and UGT2B families are capable of converting LA and AA metabolites into glucuronide derivatives, which is considered an irreversible step to inactivation and elimination of endogenous substances from the body. Glucuronides 130-141 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 52-57 15304429-7 2004 In this article the evidence for purported clinical relevance of potent in vitro inhibition of UGT enzymes will be assessed, taking the following into account: in vitro data on the enzymology of glucuronide formation from aglycone, pharmacokinetic principles based on empirical data for inhibition of metabolism, and clinical data on the pharmacokinetic drug-drug interactions of drugs primarily cleared by glucuronidation. Glucuronides 195-206 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 95-98 15535854-4 2004 In opposition to other metabolic pathways of estrogen, the UGT-mediated process leads to the formation of glucuronides that are devoid of biologic activity and are readily excreted from the tissue into the circulation. Glucuronides 106-118 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 59-62 16518089-10 2006 In human plasma, two major metabolites generated by UDP-glucuronosyltransferase (UGT; UGT2B7) and alcohol/aldehyde dehydrogenase (ADH/ALDH) were found, but no glucuronide conjugates were detected in rat or dog plasma. Glucuronides 159-170 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 81-84 15845768-2 2005 The special properties and enzymatic mechanism(s) that enable endoplasmic reticulum-bound UGT isozymes to convert innumerable structurally diverse lipophiles to excretable glucuronides are unknown. Glucuronides 172-184 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 90-93 14744950-3 2004 Screening of 10 cDNA-expressed recombinant human UDP-glucuronosyltransferase (UGT) enzymes showed that only UGT1A4 exhibited catalytic activity with respect to the formation of the glucuronide of posaconazole. Glucuronides 181-192 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 49-76 14744950-3 2004 Screening of 10 cDNA-expressed recombinant human UDP-glucuronosyltransferase (UGT) enzymes showed that only UGT1A4 exhibited catalytic activity with respect to the formation of the glucuronide of posaconazole. Glucuronides 181-192 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 78-81 11355849-4 2001 Detection limits were very low, 0.5-10 pmol, corresponding to UGT activities from 0.04 to 0.8 pmol/min/mg protein depending on UV absorbance of the glucuronide conjugate. Glucuronides 148-159 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 62-65 11134149-1 2000 UDP-glucuronosyltransferase (UGT) enzymes catalyze the transfer of the glucuronide group from UDP-glucuronic acid to several exogenous or endogenous compounds, including steroid hormones. Glucuronides 71-82 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 0-27 11316519-3 2001 UGT prevents the accumulation of potentially toxic compounds and/or their subsequent bioactivation to more toxic intermediates, although biologically active glucuronides are also known. Glucuronides 157-169 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 0-3 11134149-1 2000 UDP-glucuronosyltransferase (UGT) enzymes catalyze the transfer of the glucuronide group from UDP-glucuronic acid to several exogenous or endogenous compounds, including steroid hormones. Glucuronides 71-82 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 29-32 11038168-6 2000 However, UGT1A1 was the only UGT capable of catalyzing the formation of two glucuronides of the catecholic entacapone. Glucuronides 76-88 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 9-12 9406655-5 1997 Inherited deficiencies in UGT forms are deleterious, as exemplified by the debilitating effects of hyperbilirubinaemia and neurotoxicity in subjects with mutations in the enzyme that converts bilirubin to its more polar glucuronide. Glucuronides 220-231 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 26-29 9895303-2 1999 To establish an animal model to investigate the conjugation of steroids by UGT enzymes, previous results revealed that simian and human are unique in having high levels of circulating androsterone glucuronide and androstane-3alpha, 17beta-diol (3d-Diol) glucuronide. Glucuronides 197-208 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 75-78 34192355-3 2021 METHODS: The formation rates for 4-methylumbelliferone (4-MU) glucuronide and trifluoperazine-glucuronide in 12 recombinant human UGT isoforms with or without dabrafenib were measured, and HPLC was used to investigate the inhibitory effects of dabrafenib on UGTs. Glucuronides 62-73 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 130-133 34192355-3 2021 METHODS: The formation rates for 4-methylumbelliferone (4-MU) glucuronide and trifluoperazine-glucuronide in 12 recombinant human UGT isoforms with or without dabrafenib were measured, and HPLC was used to investigate the inhibitory effects of dabrafenib on UGTs. Glucuronides 94-105 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 130-133 34133540-3 2021 Glucuronide conjugation is the major metabolic pathway of sodium valproate, carried out by the enzyme uridine 5"-diphosphate (UDP) glucuronosyl transferase (UGT) whose gene polymorphisms may alter the clinical outcome. Glucuronides 0-11 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 157-160 27405656-2 2017 It is mainly metabolized into glucuronide by UDP-glucuronosyltransferase (UGT) enzymes in mammals. Glucuronides 30-41 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 45-72 33610566-2 2021 However, its glucuronidation, glucuronides excretion, and drug-drug interaction (DDI) involving in human cytochrome P450 (CYP), UDP-glucuronosyltransferase (UGT) enzymes, and efflux transporters (BCRP and MRPs) remains unclear so far. Glucuronides 30-42 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 128-155 31163218-1 2019 S-equol, an active metabolite of the soy isoflavone daidzein, is mainly metabolized into glucuronide(s) by UDP-glucuronosyltransferase (UGT) enzymes in mammals. Glucuronides 89-100 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 107-134 31163218-1 2019 S-equol, an active metabolite of the soy isoflavone daidzein, is mainly metabolized into glucuronide(s) by UDP-glucuronosyltransferase (UGT) enzymes in mammals. Glucuronides 89-100 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 136-139 28266877-4 2017 Therefore, elimination of parent compound via glucuronidation in a metabolic active cell is controlled by two driving forces: the formation of glucuronides by UGT enzymes and the (polarized) excretion of these glucuronides by efflux transporters located on the cell surfaces in various drug disposition organs. Glucuronides 143-155 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 159-162 28266877-4 2017 Therefore, elimination of parent compound via glucuronidation in a metabolic active cell is controlled by two driving forces: the formation of glucuronides by UGT enzymes and the (polarized) excretion of these glucuronides by efflux transporters located on the cell surfaces in various drug disposition organs. Glucuronides 210-222 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 159-162 28266877-7 2017 Taken together, these recent research advances indicate that although UGT determines the rate and extent of glucuronide generation, the efflux and uptake transporters determine the distribution of these glucuronides into blood and then to various organs for elimination. Glucuronides 108-119 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 70-73 28266877-7 2017 Taken together, these recent research advances indicate that although UGT determines the rate and extent of glucuronide generation, the efflux and uptake transporters determine the distribution of these glucuronides into blood and then to various organs for elimination. Glucuronides 203-215 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 70-73 33008919-2 2020 Although UDP-glucuronic acid (UDP-GlcUA) is most commonly employed as the cofactor by UGT1 and UGT2 family enzymes, UGT2B7 and several other enzymes can utilise both UDP-GlcUA and UDP-glucose (UDP-Glc), leading to the formation of glucuronide and glucoside conjugates. Glucuronides 231-242 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 86-90 28500425-2 2017 It is mainly metabolized into glucuronide by UDP-glucuronosyltransferase (UGT) enzymes in humans. Glucuronides 30-41 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 45-72 28500425-2 2017 It is mainly metabolized into glucuronide by UDP-glucuronosyltransferase (UGT) enzymes in humans. Glucuronides 30-41 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 74-77 27405656-2 2017 It is mainly metabolized into glucuronide by UDP-glucuronosyltransferase (UGT) enzymes in mammals. Glucuronides 30-41 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 74-77 26514348-2 2016 MEHP is metabolized into glucuronide by UDP-glucuronosyltransferase (UGT) enzymes in mammals. Glucuronides 25-36 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 40-67 26514348-2 2016 MEHP is metabolized into glucuronide by UDP-glucuronosyltransferase (UGT) enzymes in mammals. Glucuronides 25-36 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 69-72 23888985-7 2014 Glucuronide capacity was present for the substrates 17beta-estradiol (estradiol-3-glucuronide, 2.9 +- 0.2 nmol/mg protein/min) and 4-methylumbelliferone (31.3 +- 3.3 nmol/mg protein/min), assuming that cats have functional homologue enzymes to at least the human UGT1A1 and probably other UGT1A isozymes. Glucuronides 0-11 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 263-268 25684194-5 2015 Ultra-high pressure liquid chromatography coupled to an electrospray ionization time-of-flight mass spectrometer was used to separate the 10 substrates and their UGT-specific glucuronides in less than 6 min. Glucuronides 175-187 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 162-165 25034008-13 2015 These findings collectively indicate that UGT1A3 is the major UGT isoform responsible for the glucuronidation of fimasartan, and this glucuronide is excreted from hepatocytes via MDR1 and BCRP. Glucuronides 134-145 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 42-45 24854283-11 2014 All glucuronides of aloe-emodin, emodin, chrysophanol and physcion were formed by multiple human UGT isoforms with 1A9 being the most prominent in most cases. Glucuronides 4-16 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 97-100