PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23651427-2	2013	The goal of this study is to determine whether IRIP regulates the activities of OCT1 and MATE1, and hence the disposition in vivo of their substrate metformin, a therapeutic drug for diabetes and other obesity-related syndromes.	Metformin	149-158	yrdC domain containing (E.coli)	Mus musculus	47-51	
23651427-6	2013	By overexpressing IRIP in mouse liver via hydrodynamic tail vein injection, we demonstrated that increased IRIP expression could cause a significant reduction in hepatic accumulation of metformin (P < 0.01).	Metformin	186-195	yrdC domain containing (E.coli)	Mus musculus	18-22	
23651427-6	2013	By overexpressing IRIP in mouse liver via hydrodynamic tail vein injection, we demonstrated that increased IRIP expression could cause a significant reduction in hepatic accumulation of metformin (P < 0.01).	Metformin	186-195	yrdC domain containing (E.coli)	Mus musculus	107-111	
23651427-7	2013	In addition, we observed that the expression of IRIP was approximately half (P < 0.01) in ob/ob mice when compared to their lean littermates, with significant increases in hepatic Oct1 protein expression and metformin accumulation.	Metformin	211-220	yrdC domain containing (E.coli)	Mus musculus	48-52