PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23651427-2 2013 The goal of this study is to determine whether IRIP regulates the activities of OCT1 and MATE1, and hence the disposition in vivo of their substrate metformin, a therapeutic drug for diabetes and other obesity-related syndromes. Metformin 149-158 yrdC domain containing (E.coli) Mus musculus 47-51 23651427-6 2013 By overexpressing IRIP in mouse liver via hydrodynamic tail vein injection, we demonstrated that increased IRIP expression could cause a significant reduction in hepatic accumulation of metformin (P < 0.01). Metformin 186-195 yrdC domain containing (E.coli) Mus musculus 18-22 23651427-6 2013 By overexpressing IRIP in mouse liver via hydrodynamic tail vein injection, we demonstrated that increased IRIP expression could cause a significant reduction in hepatic accumulation of metformin (P < 0.01). Metformin 186-195 yrdC domain containing (E.coli) Mus musculus 107-111 23651427-7 2013 In addition, we observed that the expression of IRIP was approximately half (P < 0.01) in ob/ob mice when compared to their lean littermates, with significant increases in hepatic Oct1 protein expression and metformin accumulation. Metformin 211-220 yrdC domain containing (E.coli) Mus musculus 48-52